Guus van Dongen

PROF.DR., (Principal Investigator)

1983 …2019
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Research Output 1983 2019

2016

Total body metabolic tumor response in ALK positive non-small cell lung cancer patients treated with ALK inhibition

Kerner, G. S. M. A., Koole, M. J. B., Bongaerts, A. H. H., Pruim, J., Groen, H. J. M., Van Dongen, G., Caldenhoven, E., Coupé, V. M. H., Fischer, A., Groen, H. J. M., Perk, L., Van Herk, M., Elsinga, P. H., Lambin, P., Brakenhoff, R. H., Boellaard, R., Uyl, C., Van Criekinge, W. & CTMM Air Force Consortium, 1 May 2016, In : PLoS ONE. 11, 5, e0149955.

Research output: Contribution to journalArticleAcademicpeer-review

Zr-89-rituximab PET/CT to detect neurolymphomatosis

de Jong, A., Mous, R., van Dongen, G. A. M. S., Hoekstra, O. S., Nievelstein, R. A. J. & de Keizer, B., Jun 2016, In : American Journal of Hematology. 91, 6, p. 649-650

Research output: Contribution to journalArticleAcademicpeer-review

2017

A novel platinum(II)-based bifunctional ADC linker benchmarked using 89Zr-Desferal and auristatin F-conjugated trastuzumab

Sijbrandi, N. J., Merkul, E., Muns, J. A., Waalboer, D. C. J., Adamzek, K., Bolijn, M., Montserrat, V., Somsen, G. W., Haselberg, R., Steverink, P. J. G. M., Houthoff, H. J. & Van Dongen, G. A. M. S., 15 Jan 2017, In : Cancer Research. 77, 2, p. 257-267 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

A PET imaging study to investigate the biodistribution and clearance of an albumin binding domain antibody (AlbudAb (TM)) in healthy subjects

Thorneloe, K., Bergstrom, M., Galinanes-Garcia, L., Galette, P., Al-Azzam, W., Vincent, V., Vugts, D., van Dongen, G., Elsinga, P., Wiegers, J., Glaudemans, A., Renaux, J., Cleveland, M., Davies, M. & Zhang, S., Oct 2017, In : European Journal of Nuclear Medicine and Molecular Imaging. 44, p. S148-S149

Research output: Contribution to journalMeeting AbstractAcademic

Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines

Klein, C., Waldhauer, I., Nicolini, V. G., Freimoser-Grundschober, A., Nayak, T., Vugts, D. J., Dunn, C., Bolijn, M., Benz, J., Stihle, M., Lang, S., Roemmele, M., Hofer, T., van Puijenbroek, E., Wittig, D., Moser, S., Ast, O., Brünker, P., Gorr, I. H., Neumann, S. & 10 othersde Vera Mudry, M. C., Hinton, H., Crameri, F., Saro, J., Evers, S., Gerdes, C., Bacac, M., van Dongen, G., Moessner, E. & Umaña, P., 4 Mar 2017, In : OncoImmunology. 6, 3, e1277306.

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr-immuno-PET

Vugts, D. J., Klaver, C., Sewing, C., Poot, A. J., Adamzek, K., Huegli, S., Mari, C., Visser, G. W. M., Valverde, I. E., Gasser, G., Mindt, T. L. & van Dongen, G. A. M. S., 1 Feb 2017, In : European Journal of Nuclear Medicine and Molecular Imaging. 44, 2, p. 286-295 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development of [11C]vemurafenib employing a carbon-11 carbonylative Stille coupling and preliminary evaluation in mice bearing melanoma tumor xenografts

Slobbe, P., Windhorst, A. D., Adamzek, K., Bolijn, M., Schuit, R. C., Heideman, D. A. M., van Dongen, G. A. M. S. & Poot, A. J., 13 Jun 2017, In : Oncotarget. 8, 24, p. 38337-38350 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

ImmunoPET imaging to assess target engagement: Experience from Zr-89-anti-HER3 mAb (GSK2849330) in patients with solid tumors

Mcgeoch, A., van Oordt, C. M. D. H., Bergstrom, M., McSherry, I., Smith, D., Cleveland, M., Hoekstra, O., Vugts, D., Weber, A., Freedman, I., Huisman, M., Matheny, C., van Dongen, G. & Zhang, S., Oct 2017, In : European Journal of Nuclear Medicine and Molecular Imaging. 44, p. S314-S315

Research output: Contribution to journalMeeting AbstractAcademic

Personalizing NSCLC therapy by characterizing tumors using TKI-PET and immuno-PET

Bahce, I., Yaqub, M., Smit, E. F., Lammertsma, A. A., van Dongen, G. A. M. S. & Hendrikse, N. H., 1 May 2017, In : Lung Cancer. 107, p. 1-13 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: A theragnostic approach

Even, A. J. G., Hamming-Vrieze, O., van Elmpt, W., Winnepenninckx, V. J. L., Heukelom, J., Tesselaar, M. E. T., Vogel, W. V., Hoeben, A., Zegers, C. M. L., Vugts, D. J., van Dongen, G. A. M. S., Bartelink, H., Mottaghy, F. M., Hoebers, F. & Lambin, P., 2017, In : Oncotarget. 8, 3, p. 3870-3880 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Whole body PD-1 and PD-L1 PET in pts with NSCLC

Niemeijer, A-L., Smit, E., Bahce, I., Hoekstra, O., Huisman, M., van Dongen, G. A., Windhorst, B., Hendrikse, N., Poot, A. J., Vugts, D., Leung, D. K., Hayes, W., Smith, R. A., Wilson, L. M., Thunnissen, E. & de langen, J., Sep 2017, In : Annals of Oncology. 28

Research output: Contribution to journalMeeting AbstractAcademic

Whole Body PD-1 and PD-L1 PET in Pts with NSCLC

Niemeijer, A., Smit, E., Van Dongen, G., Windhorst, A. D., Huisman, M., Hendrikse, N., Bahce, I., Lueng, D., Smith, R., Hayes, W., Wilson, L., Bonacorsi, S., Donnelly, D., Morin, P., Poot, A., Vugts, D., Thunnissen, E. & De Langen, J., Nov 2017, In : Journal of Thoracic Oncology. 12, 11, p. S1817-S1817

Research output: Contribution to journalMeeting AbstractAcademic

Whole body PD-1 and PD-L1 PET with Zr-89-nivolumab and F-18-BMS-986192 in pts with NSCLC.

Niemeijer, A-L. N., Smit, E. F., van Dongen, G. A. M. S., Windhorst, A. D., Huisman, M. C., Hendrikse, N. H., Leung, D. K., Smith, R. A., Hayes, W., Thunnissen, E., Poot, A. J. & Vugts, D. J., 20 May 2017, In : Journal of Clinical Oncology. 35

Research output: Contribution to journalMeeting AbstractAcademic

2018

89Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding

van Brummelen, E. M. J., Huisman, M. C., de Wit-van der Veen, L. J., Nayak, T. K., Stokkel, M. P. M., Mulder, E. R., Hoekstra, O. S., Vugts, D. J., Van Dongen, G. A. M. S., Verheul, H. M., Evers, S., Tessier, J. J. L., Saro, J., Schellens, J. H. M. & Menke-van der Houven van Oordt, C. W., 15 May 2018, In : Oncotarget. 9, 37, p. 24737-24749 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody

Jauw, Y. W. S., Huisman, M. C., Nayak, T. K., Vugts, D. J., Christen, R., Naegelen, V. M., Ruettinger, D., Heil, F., Lammertsma, A. A., Verheul, H. M. W., Hoekstra, O. S., van Dongen, G. A. M. S. & van Oordt, C. W. M. D. H., 22 Jan 2018, In : EJNMMI Research. 8, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Differentiation inducers

van Dongen, G. A. M. S. & Braakuis, B. J. M., 2018, The Nude Mouse in Oncology Research. CRC Press, p. 263-275 (The Nude Mouse in Oncology Research).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

High resolution combined molecular and structural optical imaging of colorectal cancer in a xenograft mouse model

Feroldi, F., Verlaan, M., Knaus, H., Davidoiu, V., Vugts, D. J., van Dongen, G. A. M. S., Molthoff, C. F. M. & de Boer, J. F., 1 Dec 2018, In : Biomedical Optics Express. 9, 12, p. 6186-6204

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In vivo characterization of platinum (II)-based linker technology for the development of antibody-drug conjugates: Taking advantage of dual labeling with 195mPt and 89Zr

Muns, J. A., Montserrat, V., Houthoff, H. J., Codée-Van Der Schilden, K., Zwaagstra, O., Sijbrandi, N. J., Merkul, E. & Van Dongen, G. A. M. S., 1 Jul 2018, In : Journal of Nuclear Medicine. 59, 7, p. 1146-1151 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

Niemeijer, A. N., Leung, D., Huisman, M. C., Bahce, I., Hoekstra, O. S., van Dongen, G. A. M. S., Boellaard, R., Du, S., Hayes, W., Smith, R., Windhorst, A. D., Hendrikse, N. H., Poot, A., Vugts, D. J., Thunnissen, E., Morin, P., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M. & 3 othersde Gruijl, T. D., Smit, E. F. & de Langen, A. J., 1 Dec 2018, In : Nature Communications. 9, 1, 4664.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Whole body PD-L1 PET in patients with NSCLC and melanoma.

Leung, D. K., De langen, J., Raunig, D., Niemeijer, A-L. N., Smit, E. F., Boellaard, R., Vallez-Garcia, D., van Dongen, G. A. M. S., Windhorst, A. D., Huisman, M. C., Glaudemans, A. W. J. M., Hendrikse, N. H., Smith, R. A., Poot, A. J., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M., Du, S. & Hayes, W., 2018, In : Journal of Clinical Oncology. 36, 5_suppl, p. 139-139 1 p.

Research output: Contribution to journalMeeting AbstractAcademic

89Zr-immuno-PET: Towards a clinical tool to guide antibody-based therapy in cancer

Jauw, YWS., 19 Sep 2019

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

89 Zr-immuno-PET: towards a non-invasive clinical tool to measure target engagement of therapeutic antibodies in-vivo

Jauw, Y., o'Donoghue, J., Zijlstra, J., Hoekstra, O., Menke-van der Houven van Oordt, C. W., Morschhauser, F., Carrasquillo, J., Zweegman, S., Pandit-Taskar, N., Lammertsma, A., van Dongen, G., Boellaard, R., Weber, W. & Huisman, M., 30 May 2019, In : Journal of Nuclear Medicine. p. jnumed.118.224568

Research output: Contribution to journalArticleAcademicpeer-review

F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach

Bruijnen, S. T. G., Chandrupatla, D. M. S. H., Giovanonni, L., Neri, D., Vugts, D. J., Huisman, M. C., Hoekstra, O. S., Musters, R. J. P., Lammertsma, A. A., van Dongen, G. A. M. S., Jansen, G., Molthoff, C. F. M. & van der Laken, C. J., 7 Jan 2019, In : Molecular Pharmaceutics. 16, 1, p. 273-281

Research output: Contribution to journalArticleAcademicpeer-review

First platinum(II)-based metal-organic linker technology (Lx®) for a plug-and-play development of antibody-drug conjugates (ADCs)

Merkul, E., Sijbrandi, N. J., Muns, J. A., Aydin, I., Adamzek, K., Houthoff, H-J., Nijmeijer, B. & van Dongen, G. A. M. S., 1 Jan 2019, In : Expert Opinion on Drug Delivery. 16, 8, p. 783-793

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fully Automated 89 Zr Labeling and Purification of Antibodies

Poot, A. J., Adamzek, K. W. A., Windhorst, A. D., Vosjan, M. J. W. D., Kropf, S., Wester, H-J., van Dongen, G. A. M. S. & Vugts, D. J., 2019, In : Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60, 5, p. 691-695

Research output: Contribution to journalArticleAcademicpeer-review

Immuno-PET imaging to assess target engagement: Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors

Willemien Menke-van der Houven van Oordt, C., McGeoch, A., Bergstrom, M., McSherry, I., Smith, D. A., Cleveland, M., Al-Azzam, W., Chen, L., Verheul, H., Hoekstra, O. S., Vugts, D. J., Freedman, I., Huisman, M., Matheny, C., van Dongen, G. & Zhang, S., 2019, In : Journal of Nuclear Medicine. 60, 7, p. 902-909

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Interobserver reproducibility of tumor uptake quantification with 89Zr-immuno-PET: a multicenter analysis

Jauw, Y. W. S., Bensch, F., Brouwers, A. H., Hoekstra, O. S., Zijlstra, J. M., Pieplenbosch, S., Schröder, C. P., Zweegman, S., van Dongen, G. A. M. S., Menke-van der Houven van Oordt, C. W., de Vries, E. G. E., de Vet, H. C. W., Boellaard, R. & Huisman, M. C., 1 Aug 2019, In : European Journal of Nuclear Medicine and Molecular Imaging. 46, 9, p. 1840-1849

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans

Thorneloe, K. S., Sepp, A., Zhang, S., Galinanes-Garcia, L., Galette, P., Al-Azzam, W., Vugts, D. J., van Dongen, G., Elsinga, P., Wiegers, J., Glaudemans, A. W. J. M., Vincent, V., Renaux, J., Szapacs, M., Birchler, M., Cleveland, M., Bergstrom, M. & Davies, M., 2019, In : EJNMMI Research. 9, 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The human cytomegalovirus-encoded G protein- coupled receptor UL33 exhibits oncomodulatory properties

van Senten, J. R., Bebelman, M. P., Fan, T. S., Heukers, R., Bergkamp, N. D., van Gasselt, P., Langemeijer, E. V., Slinger, E., Lagerweij, T., Rahbar, A., van Walsum, M. S., Maussang, D., Leurs, R., Musters, R. J. P., van Dongen, G. A. M. S., Söderberg-Nauclér, C., Würdinger, T., Siderius, M. & Smit, M. J., 2019, In : Journal of Biological Chemistry. 294, 44, p. 16297-16308

Research output: Contribution to journalArticleAcademicpeer-review

Open Access