1983 …2019
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Research Output 1983 2019

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Article
2019

89 Zr-immuno-PET: towards a non-invasive clinical tool to measure target engagement of therapeutic antibodies in-vivo

Jauw, Y., o'Donoghue, J., Zijlstra, J., Hoekstra, O., Menke-van der Houven van Oordt, C. W., Morschhauser, F., Carrasquillo, J., Zweegman, S., Pandit-Taskar, N., Lammertsma, A., van Dongen, G., Boellaard, R., Weber, W. & Huisman, M., 30 May 2019, In : Journal of Nuclear Medicine. p. jnumed.118.224568

Research output: Contribution to journalArticleAcademicpeer-review

F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach

Bruijnen, S. T. G., Chandrupatla, D. M. S. H., Giovanonni, L., Neri, D., Vugts, D. J., Huisman, M. C., Hoekstra, O. S., Musters, R. J. P., Lammertsma, A. A., van Dongen, G. A. M. S., Jansen, G., Molthoff, C. F. M. & van der Laken, C. J., Jan 2019, In : Molecular Pharmaceutics. 16, 1, p. 273-281

Research output: Contribution to journalArticleAcademicpeer-review

Fully Automated 89 Zr Labeling and Purification of Antibodies

Poot, A. J., Adamzek, K. W. A., Windhorst, A. D., Vosjan, M. J. W. D., Kropf, S., Wester, H-J., van Dongen, G. A. M. S. & Vugts, D. J., 2019, In : Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60, 5, p. 691-695

Research output: Contribution to journalArticleAcademicpeer-review

Immuno-PET imaging to assess target engagement: Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors

Willemien Menke-van der Houven van Oordt, C., McGeoch, A., Bergstrom, M., McSherry, I., Smith, D. A., Cleveland, M., Al-Azzam, W., Chen, L., Verheul, H., Hoekstra, O. S., Vugts, D. J., Freedman, I., Huisman, M., Matheny, C., van Dongen, G. & Zhang, S., 2019, In : Journal of Nuclear Medicine. 60, 7, p. 902-909

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans

Thorneloe, K. S., Sepp, A., Zhang, S., Galinanes-Garcia, L., Galette, P., Al-Azzam, W., Vugts, D. J., van Dongen, G., Elsinga, P., Wiegers, J., Glaudemans, A. W. J. M., Vincent, V., Renaux, J., Szapacs, M., Birchler, M., Cleveland, M., Bergstrom, M. & Davies, M., 2019, In : EJNMMI Research. 9, 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

89Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding

van Brummelen, E. M. J., Huisman, M. C., de Wit-van der Veen, L. J., Nayak, T. K., Stokkel, M. P. M., Mulder, E. R., Hoekstra, O. S., Vugts, D. J., Van Dongen, G. A. M. S., Verheul, H. M., Evers, S., Tessier, J. J. L., Saro, J., Schellens, J. H. M. & Menke-van der Houven van Oordt, C. W., 15 May 2018, In : Oncotarget. 9, 37, p. 24737-24749 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody

Jauw, Y. W. S., Huisman, M. C., Nayak, T. K., Vugts, D. J., Christen, R., Naegelen, V. M., Ruettinger, D., Heil, F., Lammertsma, A. A., Verheul, H. M. W., Hoekstra, O. S., van Dongen, G. A. M. S. & van Oordt, C. W. M. D. H., 22 Jan 2018, In : EJNMMI Research. 8, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

High resolution combined molecular and structural optical imaging of colorectal cancer in a xenograft mouse model

Feroldi, F., Verlaan, M., Knaus, H., Davidoiu, V., Vugts, D. J., van Dongen, G. A. M. S., Molthoff, C. F. M. & de Boer, J. F., 1 Dec 2018, In : Biomedical Optics Express. 9, 12, p. 6186-6204

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In vivo characterization of platinum (II)-based linker technology for the development of antibody-drug conjugates: Taking advantage of dual labeling with 195mPt and 89Zr

Muns, J. A., Montserrat, V., Houthoff, H. J., Codée-Van Der Schilden, K., Zwaagstra, O., Sijbrandi, N. J., Merkul, E. & Van Dongen, G. A. M. S., 1 Jul 2018, In : Journal of Nuclear Medicine. 59, 7, p. 1146-1151 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

Niemeijer, A. N., Leung, D., Huisman, M. C., Bahce, I., Hoekstra, O. S., van Dongen, G. A. M. S., Boellaard, R., Du, S., Hayes, W., Smith, R., Windhorst, A. D., Hendrikse, N. H., Poot, A., Vugts, D. J., Thunnissen, E., Morin, P., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M. & 3 othersde Gruijl, T. D., Smit, E. F. & de Langen, A. J., 1 Dec 2018, In : Nature Communications. 9, 1, 4664.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A novel platinum(II)-based bifunctional ADC linker benchmarked using 89Zr-Desferal and auristatin F-conjugated trastuzumab

Sijbrandi, N. J., Merkul, E., Muns, J. A., Waalboer, D. C. J., Adamzek, K., Bolijn, M., Montserrat, V., Somsen, G. W., Haselberg, R., Steverink, P. J. G. M., Houthoff, H. J. & Van Dongen, G. A. M. S., 15 Jan 2017, In : Cancer Research. 77, 2, p. 257-267 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines

Klein, C., Waldhauer, I., Nicolini, V. G., Freimoser-Grundschober, A., Nayak, T., Vugts, D. J., Dunn, C., Bolijn, M., Benz, J., Stihle, M., Lang, S., Roemmele, M., Hofer, T., van Puijenbroek, E., Wittig, D., Moser, S., Ast, O., Brünker, P., Gorr, I. H., Neumann, S. & 10 othersde Vera Mudry, M. C., Hinton, H., Crameri, F., Saro, J., Evers, S., Gerdes, C., Bacac, M., van Dongen, G., Moessner, E. & Umaña, P., 4 Mar 2017, In : OncoImmunology. 6, 3, e1277306.

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr-immuno-PET

Vugts, D. J., Klaver, C., Sewing, C., Poot, A. J., Adamzek, K., Huegli, S., Mari, C., Visser, G. W. M., Valverde, I. E., Gasser, G., Mindt, T. L. & van Dongen, G. A. M. S., 1 Feb 2017, In : European Journal of Nuclear Medicine and Molecular Imaging. 44, 2, p. 286-295 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development of [11C]vemurafenib employing a carbon-11 carbonylative Stille coupling and preliminary evaluation in mice bearing melanoma tumor xenografts

Slobbe, P., Windhorst, A. D., Adamzek, K., Bolijn, M., Schuit, R. C., Heideman, D. A. M., van Dongen, G. A. M. S. & Poot, A. J., 13 Jun 2017, In : Oncotarget. 8, 24, p. 38337-38350 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Personalizing NSCLC therapy by characterizing tumors using TKI-PET and immuno-PET

Bahce, I., Yaqub, M., Smit, E. F., Lammertsma, A. A., van Dongen, G. A. M. S. & Hendrikse, N. H., 1 May 2017, In : Lung Cancer. 107, p. 1-13 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: A theragnostic approach

Even, A. J. G., Hamming-Vrieze, O., van Elmpt, W., Winnepenninckx, V. J. L., Heukelom, J., Tesselaar, M. E. T., Vogel, W. V., Hoeben, A., Zegers, C. M. L., Vugts, D. J., van Dongen, G. A. M. S., Bartelink, H., Mottaghy, F. M., Hoebers, F. & Lambin, P., 2017, In : Oncotarget. 8, 3, p. 3870-3880 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models

Jansen, M. H. A., Lagerweij, T., Sewing, A. C. P., Vugts, D. J., van Vuurden, D. G., Molthoff, C. F. M., Caretti, V., Veringa, S. J. E., Petersen, N., Carcaboso, A. M., Noske, D. P., Vandertop, W. P., Wesseling, P., van Dongen, G. A. M. S., Kaspers, G. J. L. & Hulleman, E., 1 Sep 2016, In : Molecular Cancer Therapeutics. 15, 9, p. 2166-2174 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

HDL mimetic CER-001 targets atherosclerotic plaques in patients

Zheng, K. H., van der Valk, F. M., Smits, L. P., Sandberg, M., Dasseux, J-L., Baron, R., Barbaras, R., Keyserling, C., Coolen, B. F., Nederveen, A. J., Verberne, H. J., Nell, T. E., Vugts, D. J., Duivenvoorden, R., Fayad, Z. A., Mulder, W. J. M., van Dongen, G. A. M. S. & Stroes, E. S. G., Aug 2016, In : Atherosclerosis. 251, p. 381-388

Research output: Contribution to journalArticleAcademicpeer-review

Total body metabolic tumor response in ALK positive non-small cell lung cancer patients treated with ALK inhibition

Kerner, G. S. M. A., Koole, M. J. B., Bongaerts, A. H. H., Pruim, J., Groen, H. J. M., Van Dongen, G., Caldenhoven, E., Coupé, V. M. H., Fischer, A., Groen, H. J. M., Perk, L., Van Herk, M., Elsinga, P. H., Lambin, P., Brakenhoff, R. H., Boellaard, R., Uyl, C., Van Criekinge, W. & CTMM Air Force Consortium, 1 May 2016, In : PLoS ONE. 11, 5, e0149955.

Research output: Contribution to journalArticleAcademicpeer-review

Zr-89-rituximab PET/CT to detect neurolymphomatosis

de Jong, A., Mous, R., van Dongen, G. A. M. S., Hoekstra, O. S., Nievelstein, R. A. J. & de Keizer, B., Jun 2016, In : American Journal of Hematology. 91, 6, p. 649-650

Research output: Contribution to journalArticleAcademicpeer-review

A comparative PET imaging study with the reversible and irreversible EGFR tyrosine kinase inhibitors [C-11]erlotinib and [F-18]afatinib in lung cancer-bearing mice

Slobbe, P., Windhorst, A. D., Stigter-van Walsum, M., Smit, E. F., Niessen, H. G., Solca, F., Stehle, G., van Dongen, G. A. M. S. & Poot, A. J., 2015, In : EJNMMI Research. 5, 14.

Research output: Contribution to journalArticleAcademicpeer-review

A Comparative Study of the Hypoxia PET Tracers [F-18] HX4, [F-18] FAZA, and [F-18] FMISO in a Preclinical Tumor Model

Peeters, S. G. J. A., Zegers, C. M. L., Lieuwes, N. G., van Elmpt, W., Eriksson, P. A. J., van Dongen, G. A. M. S., Dubois, L. & Lambin, P., 2015, In : International journal of radiation oncology, biology, physics. 91, 2, p. 351-359

Research output: Contribution to journalArticleAcademicpeer-review

Platinum(II) as Bifunctional Linker in Antibody-Drug Conjugate Formation: Coupling of a 4-Nitrobenzo-2-oxa-1,3-diazole Fluorophore to Trastuzumab as a Model

Waalboer, D. C. J., Muns, J. A., Sijbrandi, N. J., Schasfoort, R. B. M., Haselberg, R., Somsen, G. W., Houthoff, H. J. & van Dongen, G. A. M. S., 2015, In : ChemMedChem. 10, 5, p. 797-803

Research output: Contribution to journalArticleAcademicpeer-review

Tumour targeting and radiation dose of radioimmunotherapy with Y-90-rituximab in CD20+B-cell lymphoma as predicted by Zr-89-rituximab immuno-PET: impact of preloading with unlabelled rituximab

Muylle, K., Flamen, P., Vugts, D., Guiot, T., Ghanem, G., Meuleman, N., Bourgeois, P., Vanderlinden, B., van Dongen, G. A. M. S., Everaert, H., Vaes, M. & Bron, D., 2015, In : European Journal of Nuclear Medicine and Molecular Imaging. 42, 8, p. 1304-1314

Research output: Contribution to journalArticleAcademicpeer-review

Zr-89-cetuximab PET imaging in patients with advanced colorectal cancer

van der Houven van Oordt, C. W., Gootjes, E. C., Huisman, M. C., Vugts, D. J., Roth, C., Luik, A. M., Mulder, E. R., Schuit, R. C., Boellaard, R., Hoekstra, O. S., van Dongen, G. A. M. S. & Verheul, H. M. W., 2015, In : Oncotarget. 6, 30, p. 30384-30393

Research output: Contribution to journalArticleAcademicpeer-review

2014

De schildwachtklierprocedure bij mondholtecarcinomen in een vroeg stadium: huidige stand van zaken en mogelijkheden tot verbetering

Heuveling, D. A., van Dongen, G. A. M. S. & de Bree, R., 2014, In : Nederlands Tijdschrift voor Oncologie. 11, 6, p. 224-230

Research output: Contribution to journalArticleProfessional

Development of [F-18]afatinib as new TKI-PET tracer for EGFR positive tumors

Slobbe, P., Windhorst, A. D., Stigter-van Walsum, M., Schuit, R. C., Smit, E. F., Niessen, H. G., Solca, F., Stehle, G., van Dongen, G. A. M. S. & Poot, A. J., 2014, In : Nuclear Medicine and Biology. 41, 9, p. 749-757

Research output: Contribution to journalArticleAcademicpeer-review

Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling

Cohen, R., Vugts, D. J., Visser, G. W. M., Stigter-van Walsum, M., Bolijn, M., Spiga, M., Lazzari, P., Shankar, S., Sani, M., Zanda, M. & van Dongen, G. A. M. S., 2014, In : Cancer Research. 74, 20, p. 5700-5710

Research output: Contribution to journalArticleAcademicpeer-review

Multicenter Harmonization of Zr-89 PET/CT Performance

Makris, N., Boellaard, R., Visser, E. P., de Jong, J. R., Vanderlinden, B., Wierts, R., van der Veen, B. J., Greuter, H. J. N. M., Vugts, D. J., van Dongen, G. A. M. S., Lammertsma, A. A. & Huisman, M. C., 2014, In : Journal of Nuclear Medicine. 55, 2, p. 264-267

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacokinetics, Brain Delivery, and Efficacy in Brain Tumor-Bearing Mice of Glutathione Pegylated Liposomal Doxorubicin (2B3-101)

Gaillard, P. J., Appeldoorn, C. C. M., van Dorland, R., van Kregten, J., Manca, F., Vugts, D. J., Windhorst, A. D., van Dongen, G. A. M. S., de Vries, H. E., Maussang, D. & van Tellingen, O., 2014, In : PLoS ONE. 9, 1, e82331.

Research output: Contribution to journalArticleAcademicpeer-review

Pilot study of 89Zr-bevacizumab positron emission tomography in patients with advanced non-small cell lung cancer

Bahce, I., Huisman, M. C., Verwer, E. E., Ooijevaar, R., Boutkourt, F., Vugts, D. J., van Dongen, G. A. M. S., Boellaard, R. & Smit, E. F., 1 Dec 2014, In : EJNMMI Research. 4, 1, p. 1-7 7 p., 35.

Research output: Contribution to journalArticleAcademicpeer-review

Preclinical evaluation of Zr-89-labeled anti-CD44 monoclonal antibody RG7356 in mice and cynomolgus monkeys Prelude to Phase 1 clinical studies

Vugts, D. J., Heuveling, D. A., Stigter-van Walsum, M., Weigand, S., Bergstrom, M., van Dongen, G. A. M. S. & Nayak, T. K., 2014, In : MABS. 6, 2, p. 567-575

Research output: Contribution to journalArticleAcademicpeer-review

Sentinel node biopsy in patients with early oral cancer. New developments

de Bree, R., Heuveling, D. A., van Dongen, G. A. M. S. & Hoekstra, O. S., 2014, In : Hellenic Surgical Oncology. 5, p. 9-15

Research output: Contribution to journalArticleAcademic

Three-Dimensional Histologic Validation of High-Resolution SPECT of Antibody Distributions Within Xenografts

Branderhorst, W., Blezer, E. L. A., Houtkamp, M., Ramakers, R. M., van den Brakel, J. H., Witteveen, H., van der Have, F., van Andel, H. A. G., Vastenhouw, B., Wu, C., Stigter-van Walsum, M., van Dongen, G. A. M. S., Viergever, M. A., Bleeker, W. K. & Beekman, F. J., 2014, In : Journal of Nuclear Medicine. 55, 5, p. 830-837

Research output: Contribution to journalArticleAcademicpeer-review

2013

[C-11]Sorafenib: Radiosynthesis and preclinical evaluation in tumor-bearing mice of a new TKI-PET tracer

Poot, A. J., van der Wildt, B., Stigter-van Walsum, M., Rongen, M., Schuit, R. C., Hendrikse, N. H., Eriksson, P. A. J., van Dongen, G. A. M. S. & Windhorst, A. D., 2013, In : Nuclear Medicine and Biology. 40, 4, p. 488-497

Research output: Contribution to journalArticleAcademicpeer-review

EATRIS, a European initiative to boost translational biomedical research

van Dongen, G. A. M. S., Ussi, A. E., De Man, F. H. & Migliaccio, G., 2013, In : American journal of nuclear medicine and molecular imaging. 3, 2, p. 166-174

Research output: Contribution to journalArticleAcademicpeer-review

Imaging of TKI-Target Interactions for Personalized Cancer Therapy

Poot, A. J., Slobbe, P., Hendrikse, N. H., Windhorst, A. D. & van Dongen, G. A. M. S., 2013, In : Clinical Pharmacology & Therapeutics. 93, 3, p. 239-241

Research output: Contribution to journalArticleAcademicpeer-review