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Research Output 1983 2019

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2006

How we do it: Chemo-electroporation in the head and neck for otherwise untreatable patients

Tijink, B. M., De Bree, R., Van Dongen, G. A. M. S. & Leemans, C. R., 1 Oct 2006, In : Clinical Otolaryngology. 31, 5, p. 447-451 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis

Maussang, D., Verzijl, D., Van Walsum, M., Leurs, R., Holl, J., Pleskoff, O., Michel, D., Van Dongen, G. A. M. S. & Smit, M. J., 29 Aug 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 35, p. 13068-13073 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Performance of immuno - positron emission tomography with zirconium-89-labeled chimeric monoclonal antibody U36 in the detection of lymph node metastases in head and neck cancer patients

Börjesson, P. K. E., Jauw, Y. W. S., Boellaard, R., De Bree, R., Comans, E. F. I., Roos, J. C., Castelijns, J. A., Vosjan, M. J. W. D., Kummer, J. A., Leemans, C. R., Lammertsma, A. A. & Van Dongen, G. A. M. S., 1 Apr 2006, In : Clinical Cancer Research. 12, 7 I, p. 2133-2140 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Preparation and evaluation of 89Zr-Zevalin for monitoring of 90Y-Zevalin biodistribution with positron emission tomography

Perk, L. R., Visser, O. J., Stigter-Van Walsum, M., Vosjan, M. J. W. D., Visser, G. W. M., Zijlstra, J. M., Huijgens, P. C. & Van Dongen, G. A. M. S., 1 Nov 2006, In : European Journal of Nuclear Medicine and Molecular Imaging. 33, 11, p. 1337-1345 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Radioimmunotherapy of head and neck cancer xenografts using 131I-labeled antibody L19-SIP for selective targeting of tumor vasculature

Tijink, B. M., Neri, D., Leemans, C. R., Budde, M., Dinkelborg, L. M., Stigter-Van Walsum, M., Zardi, L. & Van Dongen, G. A. M. S., 1 Jul 2006, In : Journal of Nuclear Medicine. 47, 7, p. 1127-1135 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2005

89Zr as a PET surrogate radioisotope for scouting biodistribution of the therapeutic radiometals 90Y and 177Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab

Perk, L. R., Visser, G. W. M., Vosjan, M. J. W. D., Stigter-Van Walsum, M., Tijink, B. M., Leemans, C. R. & Van Dongen, G. A. M. S., 1 Nov 2005, In : Journal of Nuclear Medicine. 46, 11, p. 1898-1906 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

In vitro evaluation of the astatinated chimeric monoclonal antibody U36, a potential candidate for treatment of head and neck squamous cell carcinoma

Nestor, M., Persson, M., Van Dongen, G. A. M. S., Jensen, H. J., Lundqvist, H., Anniko, M. & Tolmachev, V., 1 Nov 2005, In : European Journal of Nuclear Medicine and Molecular Imaging. 32, 11, p. 1296-1304 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2004

Clinical significance of micrometastatic cells detected by E48 (Ly-6D) reverse transcription-polymerase chain reaction in bone marrow of head and neck cancer patients

Colnot, D. R., Nieuwenhuis, E. J. C., Kuik, D. J., Leemans, C. R., Dijkstra, J., Snow, G. B., Van Dongen, G. A. M. S. & Brakenhoff, R. H., 1 Dec 2004, In : Clinical Cancer Research. 10, 23, p. 7827-7833 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

High-quality 124I-labelled monoclonal antibodies for use as PET scouting agents prior to 131I-radioimmunotherapy

Verel, I., Visser, G. W. M., Vosjan, M. J. W. D., Finn, R., Boellaard, R. & Van Dongen, G. A. M. S., 1 Dec 2004, In : European Journal of Nuclear Medicine and Molecular Imaging. 31, 12, p. 1645-1652 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

PET radioimmunoscintigraphy of renal cell cancer using 89Zr-labeled cG250 monoclonal antibody in nude rats

Brouwers, A., Verel, I., Van Eerd, J., Visser, G., Steffens, M., Oosterwijk, E., Corstens, F., Oyen, W., Van Dongen, G. & Boerman, O., 8 Jun 2004, In : Cancer Biotherapy and Radiopharmaceuticals. 19, 2, p. 155-163 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2003

89Zr immuno-PET: Comprehensive procedures for the production of 89Zr-labeled monoclonal antibodies

Verel, I., Visser, G. W. M., Boellaard, R., Walsum, M. S. V., Snow, G. B. & Van Dongen, G. A. M. S., 1 Aug 2003, In : Journal of Nuclear Medicine. 44, 8, p. 1271-1281 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Biodistribution of the chimeric monoclonal antibody U36 radioiodinated with a closo-dodecaborate-containing linker. Comparison with other radioiodination methods

Nestor, M., Persson, M., Cheng, J., Tolmachev, V., Van Dongen, G., Anniko, M. & Kairemo, K., 1 Jul 2003, In : Bioconjugate chemistry. 14, 4, p. 805-810 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma

De Nooij-Van Dalen, A. G., Van Dongen, G. A. M. S., Smeets, S. J., Nieuwenhuis, E. J. C., Stigter-Van Walsum, M., Snow, G. B. & Brakenhoff, R. H., 1 Jan 2003, In : International Journal of Cancer. 103, 6, p. 768-774 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Dosimetric analysis of radioimmunotherapy with 186re-labeled bivatuzumab in patients with head and neck cancer

Postema, E. J., Börjesson, P. K. E., Buijs, W. C. A. M., Roos, J. C., Marres, H. A. M., Boerman, O. C., De Bree, R., Lang, M., Munzert, G., Van Dongen, G. A. M. S. & Oyen, W. J. G., 1 Oct 2003, In : Journal of Nuclear Medicine. 44, 10, p. 1690-1699 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Final results of a phase I radioimmunotherapy trial using 186Re-epratuzumab for the treatment of patients with non-Hodgkin's lymphoma

Postema, E. J., Raemaekers, J. M. M., Oyen, W. J. G., Boerman, O. C., Mandigers, C. M. P. W., Goldenberg, D. M., Van Dongen, G. A. M. S. & Corstens, F. H. M., 1 Oct 2003, In : Clinical Cancer Research. 9, 10 II

Research output: Contribution to journalArticleAcademicpeer-review

Long-lived positron emitters zirconium-89 and iodine-124 for scouting of therapeutic radioimmunoconjugates with PET

Verel, I., Visser, G. W. M., Boerman, O. C., Van Eerd, J. E. M., Finn, R., Boellaard, R., Vosjan, M. J. W. D., Stigter-Van Walsum, M., Snow, G. B. & Van Dongen, G. A. M. S., 1 Jan 2003, In : Cancer Biotherapy and Radiopharmaceuticals. 18, 4, p. 655-661 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phase I therapy study with 186Re-labeled humanized monoclonal antibody BIWA 4 (Bivatuzumab) in patients with head and neck squamous cell carcinoma

Börjesson, P. K. E., Postema, E. J., Roos, J. C., Colnot, D. R., Marres, H. A. M., Van Schie, M. H., Stehle, G., De Bree, R., Snow, G. B., Oyen, W. J. G. & Van Dongen, G. A. M. S., 1 Oct 2003, In : Clinical Cancer Research. 9, 10 II

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative 89Zr immuno-PET for in vivo scouting of 90Y-labeled monoclonal antibodies in xenograft-bearing nude mice

Verel, I., Visser, G. W. M., Boellaard, R., Boerman, O. C., Van Eerd, J., Snow, G. B., Lammertsma, A. A. & Van Dongen, G. A. M. S., 1 Oct 2003, In : Journal of Nuclear Medicine. 44, 10, p. 1663-1670 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Radioimmunodiagnosis of lymph node metastases in head and neck cancer

De Bree, R., Roos, J. C., Verel, I., Van Dongen, G. A. M. S. & Snow, G. B., 1 Sep 2003, In : Oral Diseases. 9, 5, p. 241-248 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Safety, biodistribution, pharmacokinetics, and immunogenicity of 99mTc-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with squamous cell carcinoma of the head and neck

Colnot, D. R., Roos, J. C., De Bree, R., Wilhelm, A. J., Kummer, J. A., Hanft, G., Heider, K. H., Stehle, G., Snow, G. B. & Van Dongen, G. A. M. S., 1 Sep 2003, In : Cancer Immunology, Immunotherapy. 52, 9, p. 576-582 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2002

Comparison of aluminium (III) phthalocyanine tetrasulfonate- and meta-tetrahydroxyphenylchlorin-monoclonal antibody conjugates for their efficacy in photodynamic therapy in vitro

Vrouenraets, M. B., Visser, G. W. M., Stigter, M., Oppelaar, H., Snow, G. B. & van Dongen, G. A. M. S., 10 Apr 2002, In : International Journal of Cancer. 98, 5, p. 793-798 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Human LY-6 antigen E48 (LY-6D) regulates important interaction parameters between endothelial cells and head-and-neck squamous carcinoma cells

Eshel, R., Zanin, A., Kapon, D., Sagi-Assif, O., Brakenhoff, R., Van Dongen, G. & Witz, I. P., 20 Apr 2002, In : International Journal of Cancer. 98, 6, p. 803-810 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Reinfusion of unprocessed, granulocyte colony-stimulating factor-stimulated whole blood allows dose escalation of 186relabeled chimeric monoclonal antibody U36 radioimmunotherapy in a phase I dose escalation study

Colnot, D. R., Ossenkoppele, G. J., Roos, J. C., Quak, J. J., De Bree, R., Börjesson, P. K., Huijgens, P. C., Snow, G. B. & Van Dongen, G. A. M. S., 1 Nov 2002, In : Clinical Cancer Research. 8, 11, p. 3401-3406 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tumor targeting properties of monoclonal antibodies with different affinity for target antigen CD44V6 in nude mice bearing head-and-neck cancer xenografts

Verel, I., Heider, K. H., Siegmund, M., Ostermann, E., Patzelt, E., Sproll, M., Snow, G. B., Adolf, G. R. & Van Dongen, G. A. M. S., 20 May 2002, In : International Journal of Cancer. 99, 3, p. 396-402 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2001

Clonally related but phenotypically divergent human cancer cell lines derived from a single follicular thyroid cancer recurrence (TT2609)

Geldof, A. A., Van der Poest Clement, E. H., Lips, P., Teule, G. J. J., Versteegh, R. T., Van Mourik, J. C., Rooimans, M. A., Arwert, F., Hermsen, M. A. J. A., Schadee-Eestermans, I. L., Van Dongen, G. A. M. S. & Van der Valk, P., 1 Jan 2001, In : Thyroid. 11, 10, p. 909-917 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of limited blood sampling in a preceding 99mTc-labeled diagnostic study to predict the pharmacokinetics and myelotoxicity of 186Re-cMAb U36 radioimmunotherapy

Colnot, D. R., Wilhelm, A. J., Cloos, J., Roos, J. C., De Bree, R., Quak, J. J., Snow, G. B. & Van Dongen, G. A. M. S., 27 Sep 2001, In : Journal of Nuclear Medicine. 42, 9, p. 1364-1367 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Optimal quality 131I-monoclonal antibodies on high-dose labeling in a large reaction volume and temporarily coating the antibody with IODO-GEN

Visser, G. W., Klok, R. P., Gebbinck, J. W. K., Ter Linden, T., Van Dongen, G. A. & Molthoff, C. F., 22 Mar 2001, In : Journal of Nuclear Medicine. 42, 3, p. 509-519 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Radioimmunotherapy in patients with head and neck squamous cell carcinoma: Initial experience

Colnot, D. R., Quak, J. J., Roos, J. C., de Bree, R., Wilhelm, A. J., Snow, G. B. & van Dongen, G. A. M. S., 1 Jan 2001, In : Head and Neck. 23, 7, p. 559-565 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Targeting of aluminum (III) phthalocyanine tetrasulfonate by use of internalizing monoclonal antibodies: Improved efficacy in photodynamic therapy

Vrouenraets, M. B., Visser, G. W. M., Stigter, M., Oppelaar, H., Snow, G. B. & Van Dongen, G. A. M. S., 1 Mar 2001, In : Cancer Research. 61, 5, p. 1970-1975 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2000

Phase I therapy study of 186re-labeled chimeric monoclonal antibody U36 in patients with squamous cell carcinoma of the head and neck

Colnot, D. R., Quak, J. J., Roos, J. C., Van Lingen, A., Wilhelm, A. J., Van Kamp, G. J., Huijgens, P. C., Snow, G. B. & Van Dongen, G. A. M. S., 1 Dec 2000, In : Journal of Nuclear Medicine. 41, 12, p. 1999-2010 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Safety and biodistribution of 99mtechnetium-labeled anti-CD44v6 monoclonal antibody BIWA 1 in head and neck cancer patients

Stroomer, J. W. G., Roos, J. C., Sproll, M., Quak, J. J., Heider, K. H., Wilhelm, B. J., Castelijns, J. A., Meyer, R., Kwakkelstein, M. O., Snow, G. B., Adolf, G. R. & Van Dongen, G. A. M. S., 1 Aug 2000, In : Clinical Cancer Research. 6, 8, p. 3046-3055 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Targeting of a hydrophilic photosensitizer by use of internalizing monoclonal antibodies: A new possibility for use in photodynamic therapy

Vrouenraets, M. B., Visser, G. W. M., Loup, C., Meunier, B., Stigter, M., Oppelaar, H., Stewart, F. A., Snow, G. B. & van DONGEN, G. A. M. S., 18 Sep 2000, In : International Journal of Cancer. 88, 1, p. 108-114 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The GPI-linked Ly-6 antigen E48 regulates expression levels of the FX enzyme and of E-selectin ligands on head and neck squamous carcinoma cells

Eshel, R., Zanin, A., Sagi-Assif, O., Meshel, T., Smorodinsky, N. I., Dwir, O., Alon, R., Brakenhoff, R., Van Dongen, G. & Witz, I. P., 28 Apr 2000, In : Journal of Biological Chemistry. 275, 17, p. 12833-12840 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

1999

Characterization of CD44v6 isoforms in head-and-neck squamous-cell carcinoma

Van Hal, N. L. W., Van Dongen, G. A. M. S., Stigter-Van Walsum, M., Snow, G. B. & Brakenhoff, R. H., 23 Aug 1999, In : International Journal of Cancer. 82, 6, p. 837-845 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development of meta-tetrahydroxyphenylchlorin-monoclonal antibody conjugates for photoimmunotherapy

Vrouenraets, M. B., Visser, G. W. M., Stewart, F. A., Stigter, M., Oppelaar, H., Postmus, P. E., Snow, G. B. & Van Dongen, G. A. M. S., 1 Apr 1999, In : Cancer Research. 59, 7, p. 1505-1513 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of soluble CD44v6 as a potential serum marker for head and neck squamous cell carcinoma

Van Hal, N. L. W., Van Dongen, G. A. M. S., Ten Brink, C. B. M., Heider, K. H., Rech-Weichselbraun, I., Snow, G. B. & Brakenhoff, R. H., 1 Nov 1999, In : Clinical Cancer Research. 5, 11, p. 3534-3541 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Radioimmunotherapy with rhenium-186-labeled chimeric monoclonal antibody U36 in patients with head and neck squamous cell carcinoma

Colnot, D. R., Quak, J. J., De Bree, R., Roos, J. C., Wilhelm, A. J., Snow, G. B. & Van Dongen, G. A. M. S., 1 Dec 1999, In : Acta oto-rhino-laryngologica belgica. 53, 4, 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Sensitive detection of squamous cells in bone marrow and blood of head and neck cancer patients by E48 reverse transcriptase-polymerase chain reaction

Brakenhoff, R. H., Stroomer, J. G. W., Ten Brink, C., De Bree, R., Weima, S. M., Snow, G. B. & Van Dongen, G. A. M. S., 1 Apr 1999, In : Clinical Cancer Research. 5, 4, p. 725-732 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

1998

[186Re]-labeled mouse and chimeric monoclonal antibody 323/A3: A comparison of the efficacy in experimental human ovarian cancer

Kievit, E., Van Gog, F. B., Schlüper, H. M. M., Van Dongen, G. A. M. S., Pinedo, H. M. & Boven, E., 1 Jan 1998, In : Nuclear Medicine and Biology. 25, 1, p. 37-45 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Perspectives of combined radioimmunotherapy and anti-EGFR antibody therapy for the treatment of residual head and neck cancer

Van Gog, F. B., Brakenhoff, R. H., Stigter-van Walsum, M., Snow, G. B. & Van Dongen, G. A. M. S., 3 Jul 1998, In : International Journal of Cancer. 77, 1, p. 13-18 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synthesis and evaluation of 99mTc/99Tc-MAG3-biotin conjugates for antibody pretargeting strategies

Van Gog, F. B., Visser, G. W. M., Gowrising, R. W. A., Snow, G. B. & Van Dongen, G. A. M. S., 1 Oct 1998, In : Nuclear Medicine and Biology. 25, 7, p. 611-619 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The impact of tumour volume and other characteristics on uptake of radiolabelled monoclonal antibodies in tumour tissue of head and neck cancer patients

De Bree, R., Kuik, D. J., Quak, J. J., Roos, J. C., Van Den Brekel, M. W. M., Castelijns, J. A., Van Wagtendonk, F. W., Greuter, H., Snow, G. B. & Van Dongen, G. A. M. S., 14 Nov 1998, In : European Journal of Nuclear Medicine. 25, 11, p. 1562-1565 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

1997

Comparison of the biodistribution and the efficacy of monoclonal antibody 323/A3 labeled with either 131I or 186Re in human ovarian cancer xenografts

Kievit, E., Van Gog, F. B., Schlüper, H. M. M., Van Dongen, G. A. M. S., Pinedo, H. M. & Boven, E., 1 Jul 1997, In : International Journal of Radiation Oncology Biology Physics. 38, 4, p. 813-823 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

High dose rhenium-186-labeling of monoclonal antibodies for clinical application pitfalls and solutions

Van Gog, F. B., Visser, G. W. M., Stroomer, J. W. G., Roos, J. C., Snow, G. B. & Van Dongen, G. A. M. S., 15 Dec 1997, In : Cancer. 80, 12 SUPPL., p. 2360-2370 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prospects for future studies in head and neck cancer

Van Dongen, G. A. M. S. & Snow, G. B., 1 Jan 1997, In : European Journal of Surgical Oncology. 23, 6, p. 486-491 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Rapid elimination of mouse/human chimeric monoclonal antibodies in nude mice

Van Gog, F. B., Brakenhoff, R. H., Snow, G. B. & Van Dongen, G. A. M. S., 22 May 1997, In : Cancer Immunology Immunotherapy. 44, 2, p. 103-111 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Selection of monoclonal antibody E48 IgG or U36 IgG for adjuvant radioimmunotherapy in head and neck cancer patients

De Bree, R., Roos, J. C., Plaizier, M. A. B. D., Quak, J. J., Van Kamp, G. J., Den Hollander, W., Snow, G. B. & Van Dongen, G. A. M. S., 1 Jan 1997, In : British Journal of Cancer. 75, 7, p. 1049-1060 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Sequence variation in the monoclonal-antibody-U36-defined CD44v6 epitope

Van Hal, N. L. W., Van Dongen, G. A. M. S., Ten Brink, C. B. M., Herron, J. N., Snow, G. B. & Brakenhoff, R. H., 2 Dec 1997, In : Cancer Immunology Immunotherapy. 45, 2, p. 88-92 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

1996

Monoclonal antibodies labeled with rhenium-186 using the MAG3 chelate: Relationship between the number of chelated groups and biodistribution characteristics

Van Gog, F. B., Visser, G. W. M., Klok, R., Van Der Schors, R., Snow, G. B. & Van Dongen, G. A. M. S., 1 Feb 1996, In : Journal of Nuclear Medicine. 37, 2, p. 352-362 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Monoclonal antibody U36, a suitable candidate for clinical immunotherapy of squamous-cell carcinoma, recognizes a CD44 isoform

Van Hal, N. L. W., Van Dongen, G. A. M. S., Rood-Knippels, E. M. C., Van der Valk, P., Snow, G. B. & Brakenhoff, R. H., 21 Dec 1996, In : International Journal of Cancer. 68, 4, p. 520-527 8 p.

Research output: Contribution to journalArticleAcademicpeer-review