20082019

Research output per year

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Research Output

2019

Activation of CD8⁺ T Cell Responses after Melanoma Antigen Targeting to CD169⁺ Antigen Presenting Cells in Mice and Humans

van Dinther, D., Lopez Venegas, M., Veninga, H., Olesek, K., Hoogterp, L., Revet, M., Ambrosini, M., Kalay, H., Stöckl, J., van Kooyk, Y. & den Haan, J. M. M., 5 Feb 2019, In : Cancers. 11, 2, 183.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells

Dusoswa, S. A., Horrevorts, S. K., Ambrosini, M., Kalay, H., Paauw, N. J., Nieuwland, R., Pegtel, M. D., Würdinger, T., van Kooyk, Y. & Garcia-Vallejo, J. J., 1 Jan 2019, In : Journal of Extracellular Vesicles. 8, 1, 1648995.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Glyco-dendrimers as intradermal anti-tumor vaccine targeting multiple skin DC subsets

Duinkerken, S., Horrevorts, S. K., Kalay, H., Ambrosini, M., Rutte, L., de Gruijl, T. D., Garcia-Vallejo, J. J. & van Kooyk, Y., 1 Jan 2019, In : Theranostics. 9, 20, p. 5797-5809

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells

Blanas, A., Cornelissen, LAM., Kotsias, M., Horst, J., Vrugt, H., Kalay, H., Spencer, D., Kozak, R. & van Vliet, SJ., 1 Feb 2019, In : Glycobiology. 29, 2, p. 137-150

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Comparison of Protein and Peptide Targeting for the Development of a CD169-Based Vaccination Strategy Against Melanoma

van Dinther, D., Veninga, H., Revet, M., Hoogterp, L., Olesek, K., Grabowska, J., Borg, E. G. F., Kalay, H., van Kooyk, Y. & den Haan, J. M. M., 2018, In : Frontiers in Immunology. 9, p. 1997

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming

van Dinther, D., Veninga, H., Iborra, S., Borg, E. G. F., Hoogterp, L., Olesek, K., Beijer, M. R., Schetters, S. T. T., Kalay, H., Garcia-Vallejo, J. J., Franken, K. L., Cham, L. B., Lang, K. S., van Kooyk, Y., Sancho, D., Crocker, P. R. & den Haan, J. M. M., 6 Feb 2018, In : Cell Reports. 22, 6, p. 1484-1495 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mouse DC-SIGN/CD209a as Target for Antigen Delivery and Adaptive Immunity

Schetters, S. T. T., Kruijssen, L. J. W., Crommentuijn, M. H. W., Kalay, H., Ochando, J., den Haan, J. M. M., Garcia-Vallejo, J. J. & van Kooyk, Y., 7 May 2018, In : Frontiers in Immunology. 9, p. 990

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeting Mycobacterium tuberculosis antigens to dendritic cells via the DC-specific-ICAM3-grabbing-nonintegrin receptor induces strong T-helper 1 immune responses

Velasquez, L. N., Stüve, P., Gentilini, M. V., Swallow, M., Bartel, J., Lycke, N. Y., Barkan, D., Martina, M., Lujan, H. D., Kalay, H., van Kooyk, Y., Sparwasser, T. D. & Berod, L., 2018, In : Frontiers in Immunology. 9, MAR, p. 471 471.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy

Rodríguez, E., Kalay, H., Noya, V., Brossard, N., Giacomini, C., van Kooyk, Y., García-Vallejo, J. J. & Freire, T., 24 Apr 2017, In : Scientific Reports. 7, p. 46748

Research output: Contribution to journalArticleAcademicpeer-review

The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells

Laan, L. C., Williams, A. R., Stavenhagen, K., Giera, M., Kooij, G., Vlasakov, I., Kalay, H., Kringel, H., Nejsum, P., Thamsborg, S. M., Wuhrer, M., Dijkstra, C. D., Cummings, R. D. & Van Die, I., 1 Feb 2017, In : FASEB Journal. 31, 2, p. 719-731 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells

Streng-Ouwehand, I., Ho, N. I., Litjens, M., Kalay, H., Boks, M. A., Cornelissen, L. A. M., Singh, S. K., Saeland, E., Garcia-Vallejo, J. J., Ossendorp, F. A., Unger, W. W. J. & van Kooyk, Y., 21 Mar 2016, In : eLife. 5

Research output: Contribution to journalArticleAcademicpeer-review

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

Perdicchio, M., Ilarregui, J. M., Verstege, M. I., Cornelissen, L. A. M., Schetters, S. T. T., Engels, S., Ambrosini, M., Kalay, H., Veninga, H., den Haan, JMM., van Berkel, L. A., Samsom, J. N., Crocker, P. R., Sparwasser, T., Berod, L., Garcia-Vallejo, J. J., van Kooyk, Y. & Unger, W. W. J., 22 Mar 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. 3329-3334

Research output: Contribution to journalArticleAcademicpeer-review

2015

Antigen targeting reveals splenic CD169(+) macrophages as promoters of germinal center B-cell responses

Veninga, H., Borg, E. G. F., Vreeman, K., Taylor, P. R., Kalay, H., van Kooyk, Y., Kraal, G., Martinez-Pomares, L. & den Haan, J. M. M., 2015, In : European Journal of Immunology. 45, 3, p. 747-757

Research output: Contribution to journalArticleAcademicpeer-review

Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression

Unger, W. W. J., Mayer, C. T., Engels, S., Hesse, C., Perdicchio, M., Puttur, F., Streng-Ouwehand, I., Litjens, M., Kalay, H., Berod, L., Sparwasser, T. & van Kooyk, Y., 2015, In : OncoImmunology. 4, 8, e970462.

Research output: Contribution to journalArticleAcademicpeer-review

Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens

Fehres, C. M., Kalay, H., Bruijns, S. C. M., Musaafir, S. A. M., Ambrosini, M., van Bloois, L., van Vliet, S. J., Storm, G., Garcia Vallejo, J. J. & van Kooyk, Y., 2015, In : Journal of Controlled Release. 203, p. 67-76

Research output: Contribution to journalArticleAcademicpeer-review

In situ Delivery of Antigen to DC-SIGN(+)D14(+) Dermal Dendritic Cells Results in Enhanced CD8(+) T-Cell Responses

Fehres, C. M., van Beelen, A. J., Bruijns, S. C. M., Ambrosini, M., Kalay, H., van Bloois, L., Unger, W. W. J., Garcia Vallejo, J. J., Storm, G., de Gruijl, T. D. & van Kooyk, Y., 2015, In : Journal of Investigative Dermatology. 135, 9, p. 2228-2236

Research output: Contribution to journalArticleAcademicpeer-review

In situ Delivery of Tumor Antigen- and Adjuvant-Loaded Liposomes Boosts Antigen-Specific T-Cell Responses by Human Dermal Dendritic Cells

Boks, M. A., Bruijns, S. C. M., Ambrosini, M., Kalay, H., van Bloois, L., Storm, G., de Gruijl, T. D. & van Kooyk, Y., 2015, In : Journal of Investigative Dermatology. 135, 11, p. 2697-2704

Research output: Contribution to journalArticleAcademicpeer-review

MPLA incorporation into DC-targeting glycoliposomes favours anti-tumour T cell responses

Boks, M. A., Ambrosini, M., Bruijns, S. C. M., Kalay, H., van Bloois, L., Storm, G., Garcia Vallejo, J. J. & van Kooyk, Y., 2015, In : Journal of Controlled Release. 216, p. 37-46

Research output: Contribution to journalArticleAcademicpeer-review

Phenotypic and Functional Properties of Human Steady State CD14(+) and CD1a(+) Antigen Presenting Cells and Epidermal Langerhans Cells

Fehres, C. M., Bruijns, S. C. M., Sotthewes, B. N., Kalay, H., Schaffer, L., Head, S. R., de Gruijl, T. D., Garcia Vallejo, J. J. & van Kooyk, Y., 2015, In : PLoS ONE. 10, 11, e0143519.

Research output: Contribution to journalArticleAcademicpeer-review

2014

CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG

Garcia-Vallejo, J. J., Ilarregui, J. M., Kalay, H., Chamorro, S., Koning, N., Unger, W. W. J., Ambrosini, M., Montserrat, V., Fernandes, R. J., Bruijns, S. C. M., van Weering, J. R. T., Paauw, N. J., O'Toole, T. G., van Horssen, J., van der Valk, P., Nazmi, K., Bolscher, J. G., Bajramovic, J., Dijkstra, C. D., 't Hart, B. A. & 1 others, van Kooyk, Y., 2014, In : Journal of Experimental Medicine. 211, 7, p. 1465-1483

Research output: Contribution to journalArticleAcademicpeer-review

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8(+) T-cell cross-priming

Fehres, C. M., Bruijns, S. C. M., van Beelen, A. J., Kalay, H., Ambrosini, M., Hooijberg, E., Unger, W. W. J., de Gruijl, T. D. & van Kooyk, Y., 2014, In : European Journal of Immunology. 44, 8, p. 2415-2424

Research output: Contribution to journalArticleAcademicpeer-review

2013

Glycan-based DC-SIGN targeting to enhance antigen cross-presentation in anticancer vaccines

Garcia Vallejo, J. J., Unger, W. W. J., Kalay, H. & van Kooyk, Y., 2013, In : OncoImmunology. 2, 2, e23040.

Research output: Contribution to journalArticleAcademicpeer-review

Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation

van Kooyk, Y., Unger, W. W. J., Fehres, C. M., Kalay, H. & Garcia Vallejo, J. J., 2013, In : Molecular Immunology. 55, 2, p. 143-145

Research output: Contribution to journalArticleAcademicpeer-review

Glycodendrimers prevent HIV transmission via DC-SIGN on dendritic cells

Garcia Vallejo, J. J., Koning, N., Ambrosini, M., Kalay, H., Vuist, I., Sarrami-Forooshani, R., Geijtenbeek, T. B. H. & van Kooyk, Y., 2013, In : International Immunology. 25, 4, p. 221-233

Research output: Contribution to journalArticleAcademicpeer-review

In vivo targeting of human DC-SIGN drastically enhances CD8(+) T-cell-mediated protective immunity

Hesse, C., Ginter, W., Forg, T., Mayer, C. T., Baru, A. M., Arnold-Schrauf, C., Unger, W. W. J., Kalay, H., van Kooyk, Y., Berod, L. & Sparwasser, T., 2013, In : European Journal of Immunology. 43, 10, p. 2543-2553

Research output: Contribution to journalArticleAcademicpeer-review

MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-alpha secretion

van Vliet, S. J., Bay, S., Vuist, I. M., Kalay, H., Garcia Vallejo, J. J., Leclerc, C. & van Kooyk, Y., 2013, In : Journal of Leukocyte Biology. 94, 2, p. 315-323

Research output: Contribution to journalArticleAcademicpeer-review

Multivalent glycopeptide dendrimers for the targeted delivery of antigens to dendritic cells

Garcia Vallejo, J. J., Ambrosini, M., Overbeek, A., van Riel, W. E., Bloem, K., Unger, W. W. J., Chiodo, F., Bolscher, J. G., Nazmi, K., Kalay, H. & van Kooyk, Y., 2013, In : Molecular Immunology. 53, 4, p. 387-397

Research output: Contribution to journalArticleAcademicpeer-review

2012

Glycan-modified liposomes boost CD4(+) and CD8(+) T-cell responses by targeting DC-SIGN on dendritic cells

Unger, W. W. J., van Beelen, A. J., Bruijns, S. C. M., Joshi, M., Fehres, C. M., van Bloois, L., Verstege, M. I., Ambrosini, M., Kalay, H., Nazmi, K., Bolscher, J. G., Hooijberg, E., de Gruijl, T. D., Storm, G. & van Kooyk, Y., 2012, In : Journal of Controlled Release. 160, 1, p. 88-95

Research output: Contribution to journalArticleAcademicpeer-review

Online nanoliquid chromatography-mass spectrometry and nanofluorescence detection for high-resolution quantitative N-glycan analysis

Kalay, H., Ambrosini, M., van Berkel, P. H. C., Parren, P. W. H. I., van Kooyk, Y. & Garcia Vallejo, J. J., 2012, In : Analytical Biochemistry. 423, 1, p. 153-162

Research output: Contribution to journalArticleAcademicpeer-review

2011

DC-SIGN mediated antigen-targeting using glycan-modified liposomes: Formulation considerations

Joshi, M. D., Unger, W. W. J., van Beelen, A. J., Bruijns, S. C. M., Litjens, M., van Bloois, L., Kalay, H., van Kooyk, Y. & Storm, G., 2011, In : International journal of pharmaceutics. 416, 2, p. 426-432

Research output: Contribution to journalArticleAcademicpeer-review

Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization

Singh, S. K., Ouwehand, I., Litjens, M., Kalay, H., Burgdorf, S., Saeland, E., Kurts, C., Unger, W. W. J. & van Kooyk, Y., 2011, In : European Journal of Immunology. 41, 4, p. 916-925

Research output: Contribution to journalArticleAcademicpeer-review

Tumour-associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses

Singh, S. K., Ouwehand, I., Litjens, M., Kalay, H., Saeland, E. & van Kooyk, Y., 2011, In : International Journal of Cancer. 128, 6, p. 1371-1383

Research output: Contribution to journalArticleAcademicpeer-review

2009

Chemoenzymatic synthesis of multivalent neoglycoconjugates carrying the helminth glycan antigen LDNF

Tefsen, B., van Stijn, C. M. W., van den Broek, M. M. P., Kalay, H., Knol, J. C., Jimenez, C. R. & van Die, I. M., 2009, In : Carbohydrate Research. 344, 12, p. 1501-1507

Research output: Contribution to journalArticleAcademicpeer-review

MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells

Saeland, E., de Jong, M. A. W. P., Nabatov, A., Kalay, H., van Kooyk, Y. & Geijtenbeek, T. B. H., 2009, In : Molecular Immunology. 46, 11-12, p. 2309-2316

Research output: Contribution to journalArticleAcademicpeer-review

Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation

Singh, S. K., Stephani, J., Schaefer, M., Kalay, H., Garcia Vallejo, J. J., den Haan, J. M. M., Saeland, E., Sparwasser, T. & van Kooyk, Y., 2009, In : Molecular Immunology. 47, 2-3, p. 164-174

Research output: Contribution to journalArticleAcademicpeer-review

2008

Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay

Oudhoff, M. J., Bolscher, J. G. M., Nazmi, K., Kalay, H., Hof, W., Amerongen, A. V. N. & Veerman, E. C. I., 2008, In : FASEB Journal. 22, 11, p. 3805-3812

Research output: Contribution to journalArticleAcademicpeer-review