Hans Joenje

PROF.DR.

1984 …2018

Research output per year

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Research Output

2018

A "late-but-fitter revertant cell" explains the high frequency of revertant mosaicism in epidermolysis bullosa

van den Akker, P. C., Pasmooij, A. M. G., Joenje, H., Hofstra, R. M. W., te Meerman, G. J. & Jonkman, M. F., 2018, In : PLoS ONE. 13, 2, e0192994.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A strategy for molecular diagnostics of Fanconi anemia in Brazilian patients

Pilonetto, D. V., Pereira, N. F., Bonfim, C. M. S., Ribeiro, L. L., Bitencourt, M. A., Kerkhoven, L., Floor, K., Ameziane, N., Joenje, H., Gille, J. J. P. & Pasquini, R., 2017, In : Molecular Genetics and Genomic Medicine. 5, 4, p. 360-372 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Letter to the editor for "Update of the human and mouse Fanconi anemia genes"

Nebert, D. W., Dong, H., Bruford, E. A., Thompson, D. C., Vasiliou, V. & Joenje, H., 4 Jul 2016, In : Human Genomics. 10

Research output: Contribution to journalLetterAcademicpeer-review

Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma

Braakhuis, B. J. M., Nieuwint, A. W. M., Oostra, A. B., Joenje, H., Flach, G. B., Graveland, A. P., Brakenhoff, R. H. & Leemans, C. R., Mar 2016, In : Journal of Oral Pathology and Medicine. 45, 3, p. 189-192

Research output: Contribution to journalArticleAcademicpeer-review

2015

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

Ameziane, N., May, P., Haitjema, A., van der Vrugt, H. J., van Rossum-Fikkert, S. E., Ristic, D., Williams, G. J., Balk, J., Rockx, D., Li, H., Rooimans, M. A., Oostra, A. B., Velleuer, E., Dietrich, R., Bleijerveld, O. B., Altelaar, A. F. M., Meijers-Heijboer, H., Joenje, H., Glusman, G., Roach, J. & 9 others, Hood, L., Galas, D., Wyman, C., Balling, R., den Dunnen, J., de Winter, J. P., Kanaar, R., Gelinas, R. & Dorsman, J. C., 2015, In : Nature Communications. 6, 8829.

Research output: Contribution to journalArticleAcademicpeer-review

A reason for intermittent fasting to suppress the awakening of dormant breast tumors.

Lankelma, J., Kooi, B. W., Krab, K., Dorsman, J. C., Joenje, H. & Westerhoff, H. V., 2015, In : BioSystems. 127, p. 1-6

Research output: Contribution to journalArticleAcademicpeer-review

Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer

Stoepker, C., Ameziane, N., van der Lelij, P., Kooi, I. E., Oostra, A. B., Rooimans, M. A., van Mil, S. E., van den Brink, A., Dietrich, R., Balk, J. A., Ylstra, B., Joenje, H., Feller, S. M. & Brakenhoff, R. H., 2015, In : Cancer Research. 75, 17, p. 3543-3553

Research output: Contribution to journalArticleAcademicpeer-review

The iron-sulfur cluster assembly network component NARFL is a key element in the cellular defense against oxidative stress

Corbin, M. V., Rockx, D. A. P., Oostra, A. B., Joenje, H. & Dorsman, J. C., 2015, In : Free Radical Biology and Medicine. 89, p. 863-872

Research output: Contribution to journalArticleAcademicpeer-review

Update of the human and mouse Fanconi anemia genes

Dong, H. B., Nebert, D. W., Bruford, E. A., Thompson, D. C., Joenje, H. & Vasiliou, V., 2015, In : Human Genomics. 9, 32.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Coregulation of FANCA and BRCA1 in human cells

Haitjema, A., Mol, B. M., Kooi, E. I., Massink, M. P. G., Jorgensen, J. A. L., Rockx, D. A. P., Rooimans, M. A., de Winter, J. P., Meijers-Heijboer, H., Joenje, H. & Dorsman, J. C., 2014, In : SpringerPlus. 3, 381.

Research output: Contribution to journalArticleAcademicpeer-review

2013

A Protein Prioritization Approach Tailored for the FA/BRCA Pathway

Haitjema, A., Brandt, B. W., Ameziane, N., May, P., Heringa, J., de Winter, J. P., Joenje, H. & Dorsman, J. C., 2013, In : PLoS ONE. 8, 4, e62017.

Research output: Contribution to journalArticleAcademicpeer-review

Fanconi Anemia

de Winter, J. P. & Joenje, H., 2013, Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., p. 17-20 (Brenner's Encyclopedia of Genetics: Second Edition).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

2012

A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites

de Vries, Y., Lwiwski, N., Levitus, M., Kuyt, B., Israels, S. J., Arwert, F., Zwaan, M., Greenberg, C. R., Alter, B. P., Joenje, H. & Meijers-Heijboer, E. J., 2012, In : Anemia. 2012, 865170.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
59 Downloads (Pure)

A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network

Yan, Z. J., Guo, R., Paramasivam, M., Shen, W. P., Ling, C., Fox, D., Wang, Y. C., Oostra, A. B., Kuehl, J., Lee, D. Y., Takata, M., Hoatlin, M. E., Schindler, D., Joenje, H., de Winter, J. P., Li, L., Seidman, M. M. & Wang, W. D., 2012, In : Molecular Cell. 47, 1, p. 61-75

Research output: Contribution to journalArticleAcademicpeer-review

Diagnosis of fanconi anemia: chromosomal breakage analysis

Oostra, A. B., Nieuwint, A. W. M., Joenje, H. & de Winter, J. P., 2012, In : Anemia. 2012, 238731.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
58 Downloads (Pure)

Diagnosis of Fanconi Anemia: Mutation Analysis by Multiplex Ligation-Dependent Probe Amplification and PCR-Based Sanger Sequencing

Gille, J. J. P., Floor, K., Kerkhoven, L., Ameziane, N., Joenje, H. & de Winter, J. P., 2012, In : Anemia. 2012, 603253.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
60 Downloads (Pure)

Diagnosis of fanconi anemia: mutation analysis by next-generation sequencing

Ameziane, N., Sie, D. L. S., Dentro, S., Ariyurek, Y., Kerkhoven, L., Joenje, H., Dorsman, J. C., Ylstra, B., Gille, J. J. P., Sistermans, E. A. & de Winter, J. P., 2012, In : Anemia. 2012, 132856.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
54 Downloads (Pure)

Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma

Smetsers, S., Muter, J., Bristow, C., Patel, L., Chandler, K., Bonney, D., Wynn, R. F., Whetton, A. D., Will, A. M., Rockx, D., Joenje, H., Strathdee, G., Shanks, J., Klopocki, E., Gille, J. J. P., Dorsman, J. C. & Meyer, S., 2012, In : Familial Cancer. 11, 4, p. 661-665

Research output: Contribution to journalArticleAcademicpeer-review

2011

Evidence for complete epistasis of null mutations in murine Fanconi anemia genes Fanca and Fancg

van der Vrugt, H. J., Koomen, M., Bakker, S., Berns, M. A. D., Cheng, N. C., van der Valk, M. A., de Vries, Y., Rooimans, M. A., Oostra, A. B., Hoatlin, M. E., te Riele, H. P. J., Joenje, H. & Arwert, F., 2011, In : DNA Repair. 10, 12, p. 1252-1261

Research output: Contribution to journalArticleAcademicpeer-review

METABOLISM Alcohol, DNA and disease

Joenje, H., 2011, In : Nature. 475, 7354, p. 45-46

Research output: Contribution to journalArticleAcademicpeer-review

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

Stoepker, C., Hain, K., Schuster, B., Hilhorst-Hofstee, Y., Rooimans, M. A., Steltenpool, J., Oostra, A. B., Eirich, K., Korthof, E. T., Nieuwint, A. W. M., Jaspers, N. G. J., Bettecken, T., Joenje, H., Schindler, D., Rouse, J. & de Winter, J. P., 2011, In : Nature Genetics. 43, 2, p. 138-141

Research output: Contribution to journalArticleAcademicpeer-review

Spontaneous abrogation of the G(2) DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients

Ceccaldi, R., Briot, D., Larghero, J., Vasquez, N., d'Enghien, C. D., Chamousset, D., Noguera, M. E., Waisfisz, Q., Hermine, O., Pondarre, C., Leblanc, T., Gluckman, E., Joenje, H., Stoppa-Lyonnet, D., Socie, G. & Soulier, J., 2011, In : Journal of Clinical Investigation. 121, 1, p. 184-194

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
52 Downloads (Pure)
2010

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

Yan, Z. J., Delannoy, M., Ling, C., Daee, D., Osman, F., Muniandy, P. A., Shen, X., Oostra, A. B., Du, H. S., Steltenpool, J., Lin, T., Schuster, B., Decaillet, C., Stasiak, A., Stasiak, A. Z., Stone, S., Hoatlin, M. E., Schindler, D., Woodcock, C. L., Joenje, H. & 8 others, Sen, R., de Winter, J. P., Li, L., Seidman, M. M., Whitby, M. C., Myung, K., Constantinou, A. & Wang, W., 2010, In : Molecular Cell. 37, 6, p. 865-878

Research output: Contribution to journalArticleAcademicpeer-review

Ectopic ESCO2 Expression in Roberts Syndrome Fibroblasts Corrects Cohesion Defects and Sensitivity to DNA Damaging Agents

van der Lelij, P., van Gosliga, D., Oostra, A. B., Steltenpool, J., de Groot, J., Waisfisz, Q., Scheper, R. J., Darroudi, F., Godthelp, B. C., Joenje, H. & de Winter, J. P., 2010, In : American Journal of Medical Genetics Part A. 152A, 7, p. 1635-1636

Research output: Contribution to journalMeeting AbstractOther research output

Ectopic ESCO2 Expression in Roberts Syndrome Fibroblasts Corrects Cohesion Defects and Sensitivity to DNA Damaging Agents

van der Lelij, P., van Gosliga, D., Oostra, A. B., Steltenpool, J., de Groot, J., Waisfisz, Q., Scheper, R. J., Darroudi, F., Godthelp, B. C., Joenje, H. & de Winter, J. P., Jul 2010, In : American Journal of Medical Genetics Part A. 152A, 7, p. 1635-1636

Research output: Contribution to journalMeeting AbstractAcademic

Fanconi anaemie: uit de kinderschoenen

Smetsers, S. E., Zwaan, C. M., Sonnevelt, M. C., Brakenhoff, R. H., Smiers, F. J., Best, J. D., Joenje, H. & Bierings, M. B., 2010, In : Nederlands Tijdschrift voor Hematologie. 7, p. 258-263

Research output: Contribution to journalArticleProfessional

Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling

van Harn, T., Foijer, F., van Vugt, M., Banerjee, R., Yang, F. T., Oostra, A. B., Joenje, H. & te Riele, H., 2010, In : Genes and Development. 24, 13, p. 1377-1388

Research output: Contribution to journalArticleAcademicpeer-review

Warsaw Breakage Syndrome, a Cohesinopathy Associated with Mutations in the XPD Helicase Family Member DDX11/ChIR1

van der Lelij, P., Chrzanowska, K. H., Godthelp, B. C., Rooimans, M. A., Ostra, A. B., Stumm, M., Zdzienicka, MZ., Joenje, H. & de Winter, J. P., 2010, In : American journal of human genetics. 86, 2, p. 262-266

Research output: Contribution to journalArticleAcademicpeer-review

2009

Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M

Bakker, S. T., van der Vrugt, H. J., Rooimans, M. A., Oostra, A., Steltenpool, J., Delzenne-Goette, E., van der Wal, A., van de Valk, M., Joenje, H., te Riele, H. P. J. & de Winter, J. P., 2009, In : Human Molecular Genetics. 18, 18, p. 3484-3495

Research output: Contribution to journalArticleAcademicpeer-review

Fanconi Anemia: Recent Advances and Perspectives

Joenje, H., Dorsman, J. C., Waisfisz, Q., de Winter, J. P. & Bierings, M., 2009, In : Haematologica. 94, p. S7-S7

Research output: Contribution to journalMeeting AbstractOther research output

Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M

Singh, T. R., Bakker, S. D., Agarwal, S., Jansen, M. H. A., Grassman, E., Godthelp, B. C., Ali, A. M., Du, C., Rooimans, M. A., Fan, Q., Wahengbam, K., Steltenpool, J., Andreassen, P. R., Williams, D. J., Joenje, H., de Winter, J. P. & Meetei, AR., 2009, In : Blood. 114, 1, p. 174-180

Research output: Contribution to journalArticleAcademicpeer-review

Lack of large genomic deletions in BRIP1, PALB2, and FANCD2 genes in BRCA1/2 negative familial breast cancer

Ameziane, N., van den Ouweland, A. M. W., Adank, M. A., Vijzelaar, R. N. C. P., Errami, A., Dorsman, J. C., Joenje, H., Meijers, J. H. C. & Waisfisz, Q., 2009, In : Breast Cancer Research and Treatment. 118, 3, p. 651-653

Research output: Contribution to journalArticleAcademicpeer-review

No evidence for FANCF gene silencing in head-and-neck squamous cell carcinomas

Ameziane, N., Chen, F., Leemans, C. R., Brakenhoff, R. H. & Joenje, H., 2009, In : Cellular Oncology. 31, 1, p. 53-56

Research output: Contribution to journalArticleAcademicpeer-review

The Cellular Phenotype of Roberts Syndrome Fibroblasts as Revealed by Ectopic Expression of ESCO2

van der Lelij, P., Godthelp, B. C., van Zon, W., van Gosliga, D., Oostra, A. B., Steltenpool, J., de Groot, J., Scheper, R. J., Wolthuis, R. M., Waisfisz, Q., Darroudi, F., Joenje, H. & de Winter, J. P., 2009, In : PLoS ONE. 4, 9

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
39 Downloads (Pure)

The genetic and molecular basis of Fanconi anemia

de Winter, J. P. & Joenje, H., 2009, In : Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 668, 1-2, p. 11-19

Research output: Contribution to journalArticleAcademicpeer-review

2008

Clinical and Molecular Characteristics of Squamous Cell Carcinomas From Fanconi Anemia Patients

van Zeeburg, H. J., Snijders, P. J. F., Wu, T., Gluckman, E., Soulier, J., Surralles, J., Castella, M., van der Wal, J. E., Wennerberg, J., Califano, J., Velleuer, E., Dietrich, R., Ebell, W., Bloemena, E., Joenje, H., Leemans, C. R. & Brakenhoff, R. H., 2008, In : Journal of the National Cancer Institute. 100, 22, p. 1649-1653

Research output: Contribution to journalArticleAcademicpeer-review

Fanconi-anemie, DNA-herstel en kanker

Joenje, H., Dorsman, J. C., Waisfisz, Q. & de Winter, J. P., 2008, In : Tijdschrift Kanker. 32, p. 24-27

Research output: Contribution to journalArticleProfessional

Genetic subtyping of Fanconi anemia by comprehensive mutation screening

Ameziane, N., Errami, A., Leveille, F., Fontaine, C., de Vries, Y., van Spaendonk, R. M. L., de Winter, J. P., Pals, G. & Joenje, H., 2008, In : Human Mutation. 29, 1, p. 159-166

Research output: Contribution to journalArticleAcademicpeer-review

Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia

Hess, C. J., Ameziane, N., Schuurhuis, G. J., Errami, A., Denkers, F., Kaspers, G. J. L., Cloos, J., Joenje, H., Reinhardt, D., Ossenkoppele, G. J., Zwaan, C. M. & Waisfisz, Q., 2008, In : Cellular Oncology. 30, 4, p. 299-306

Research output: Contribution to journalArticleAcademicpeer-review

Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer

van der Groep, P., Hoelzel, M., Buerger, H., Joenje, H., de Winter, J. P. & van Diest, P. J., 2008, In : Breast Cancer Research and Treatment. 107, 1, p. 41-47

Research output: Contribution to journalArticleAcademicpeer-review

2007

Identification of the Fanconi anemia complementation group I gene, FANCI

Dorsman, J. C., Levitus, M., Rockx, D., Rooimans, M. A., Oostra, A. B., Haitjema, A., Bakker, S. T., Steltenpool, J., Schuler, D., Mohan, S., Schindler, D., Arwert, F., Pals, G., Mathew, C. G., Waisfisz, Q., de Winter, J. P. & Joenje, H., 2007, In : Cellular Oncology. 29, 3, p. 211-218

Research output: Contribution to journalArticleAcademicpeer-review

Roberts syndrome-SC phocomeliia: Clinical and molecular findings

Vega, H., Jabs, E. W., Gordillo, M., Trainer, A., Luque, R., Kayserili, H., Skovby, F., Hennekam, R., Uzielli, M., Schnur, R., Manouvrier, S., Paznekas, W. A., Chang, S., Waisfisz, Q., Joenje, H., Hou, F. & Zou, H., 15 Jun 2007, In : American Journal of Medical Genetics Part A. 143A, 12, p. 1298-1299

Research output: Contribution to journalMeeting AbstractAcademic

2006

Hypermethylation of FANCC and FANCL resulting in a mitomycine-C (MMC) sensitive cellular phenotype in sporadic acute leukemia.

Hess, C. J., Ameziane, N., Schuurhuis, G. J., Errami, A., Denkers, F., Hubeeck, I., Kaspers, G. J. L., Joenje, H., Reinhardt, D., Ossenkoppele, G. J., Zwaan, C. M. & Waisfisz, Q., 16 Nov 2006, In : Blood. 108, 11, p. 630A-630A

Research output: Contribution to journalMeeting AbstractAcademic

Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2

Godthelp, BC., Wiegant, WW., Waisfisz, Q., Medhurst, AL., Arwert, F., Joenje, H. & Zdzienicka, MZ., 22 Feb 2006, In : Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 594, 1-2, p. 39-48

Research output: Contribution to journalArticleAcademicpeer-review

2005

A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and Biallelic FANCDI/BRCA2 mutations

Meyer, S., Fergusson, WD., Oostra, AB., Medhurst, AL., Waisfisz, Q., de Winter, JP., Chen, F., Carr, TF., Clayton-Smith, J., Clancy, T., Green, M., Barber, L., Eden, OB., Will, AM., Joenje, H. & Taylor, GM., Apr 2005, In : Genes, Chromosomes and Cancer. 42, 4, p. 404-415

Research output: Contribution to journalArticleAcademicpeer-review

Persistent chromosomal instability and cross-linker sensitivity in Fanconi anaemia derived leukaemia cell lines with bi-allelic FANCD1/BRCA2 mutations

Meyer, S., Tonnies, H., Fergusson, WF., Oostra, AB., Medhurst, AL., Waisfisz, Q., De Winter, JP., Chen, F., Carr, TF., Green, M., Barber, L., Eden, OB., Will, AM., Joenje, H. & Taylor, GM., Apr 2005, In : British Journal of Haematology. 129, p. 81-81

Research output: Contribution to journalMeeting AbstractAcademic

Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion

Vega, H., Waisfisz, Q., Gordillo, M., Sakai, N., Yanagihara, I., Yamada, M., van Gosliga, D., Kayserili, H., Xu, CZ., Ozono, K., Jabs, EW., Inui, K. & Joenje, H., May 2005, In : Nature Genetics. 37, 5, p. 468-470

Research output: Contribution to journalArticleAcademicpeer-review

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

Levitus, M., Waisfisz, Q., Godthelp, BC., de Vries, Y., Hussain, S., Wiegant, WW., Elghalbzouri-Maghrani, E., Steltenpool, J., Rooimans, MA., Pals, G., Arwert, F., Mathew, CG., Zdzienicka, MZ., Hiom, K., De Winter, JP. & Joenje, H., Sep 2005, In : Nature Genetics. 37, 9, p. 934-935

Research output: Contribution to journalArticleAcademicpeer-review

2004

A Fanconi anemia core complex contains a ubiquitin ligase and is required for monoubiquitination of FANCD2

Meetei, A. R., de Winter, J., Medhurst, A., Wallisch, M., Waisfisz, Q., van de Vrugt, H., Oostra, A., Yan, Z., Ling, C., Bishop, C., Hoatlin, M., Joenje, H. & Wang, OW., May 2004, In : CELL STRUCTURE AND FUNCTION. 29, p. 11-11

Research output: Contribution to journalMeeting AbstractAcademic

Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypes

Levitus, M., Rooimans, MA., Steltenpool, J., Cool, NFC., Oostra, AB., Mathew, CG., Hoatlin, ME., Waisfisz, Q., Arwert, F., de Winter, JP. & Joenje, H., 1 Apr 2004, In : Blood. 103, 7, p. 2498-2503

Research output: Contribution to journalArticleAcademicpeer-review