Hans Joenje

PROF.DR.

1984 …2018
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Research Output 1984 2018

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Article
2018

A "late-but-fitter revertant cell" explains the high frequency of revertant mosaicism in epidermolysis bullosa

van den Akker, P. C., Pasmooij, A. M. G., Joenje, H., Hofstra, R. M. W., te Meerman, G. J. & Jonkman, M. F., 2018, In : PLoS ONE. 13, 2, e0192994.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A strategy for molecular diagnostics of Fanconi anemia in Brazilian patients

Pilonetto, D. V., Pereira, N. F., Bonfim, C. M. S., Ribeiro, L. L., Bitencourt, M. A., Kerkhoven, L., Floor, K., Ameziane, N., Joenje, H., Gille, J. J. P. & Pasquini, R., 2017, In : Molecular Genetics and Genomic Medicine. 5, 4, p. 360-372 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma

Braakhuis, B. J. M., Nieuwint, A. W. M., Oostra, A. B., Joenje, H., Flach, G. B., Graveland, A. P., Brakenhoff, R. H. & Leemans, C. R., Mar 2016, In : Journal of Oral Pathology and Medicine. 45, 3, p. 189-192

Research output: Contribution to journalArticleAcademicpeer-review

2015

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

Ameziane, N., May, P., Haitjema, A., van der Vrugt, H. J., van Rossum-Fikkert, S. E., Ristic, D., Williams, G. J., Balk, J., Rockx, D., Li, H., Rooimans, M. A., Oostra, A. B., Velleuer, E., Dietrich, R., Bleijerveld, O. B., Altelaar, A. F. M., Meijers-Heijboer, H., Joenje, H., Glusman, G., Roach, J. & 9 othersHood, L., Galas, D., Wyman, C., Balling, R., den Dunnen, J., de Winter, J. P., Kanaar, R., Gelinas, R. & Dorsman, J. C., 2015, In : Nature Communications. 6, 8829.

Research output: Contribution to journalArticleAcademicpeer-review

A reason for intermittent fasting to suppress the awakening of dormant breast tumors.

Lankelma, J., Kooi, B. W., Krab, K., Dorsman, J. C., Joenje, H. & Westerhoff, H. V., 2015, In : BioSystems. 127, p. 1-6

Research output: Contribution to journalArticleAcademicpeer-review

Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer

Stoepker, C., Ameziane, N., van der Lelij, P., Kooi, I. E., Oostra, A. B., Rooimans, M. A., van Mil, S. E., van den Brink, A., Dietrich, R., Balk, J. A., Ylstra, B., Joenje, H., Feller, S. M. & Brakenhoff, R. H., 2015, In : Cancer Research. 75, 17, p. 3543-3553

Research output: Contribution to journalArticleAcademicpeer-review

The iron-sulfur cluster assembly network component NARFL is a key element in the cellular defense against oxidative stress

Corbin, M. V., Rockx, D. A. P., Oostra, A. B., Joenje, H. & Dorsman, J. C., 2015, In : Free Radical Biology and Medicine. 89, p. 863-872

Research output: Contribution to journalArticleAcademicpeer-review

Update of the human and mouse Fanconi anemia genes

Dong, H. B., Nebert, D. W., Bruford, E. A., Thompson, D. C., Joenje, H. & Vasiliou, V., 2015, In : Human Genomics. 9, 32.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Coregulation of FANCA and BRCA1 in human cells

Haitjema, A., Mol, B. M., Kooi, E. I., Massink, M. P. G., Jorgensen, J. A. L., Rockx, D. A. P., Rooimans, M. A., de Winter, J. P., Meijers-Heijboer, H., Joenje, H. & Dorsman, J. C., 2014, In : SpringerPlus. 3, 381.

Research output: Contribution to journalArticleAcademicpeer-review

2013

A Protein Prioritization Approach Tailored for the FA/BRCA Pathway

Haitjema, A., Brandt, B. W., Ameziane, N., May, P., Heringa, J., de Winter, J. P., Joenje, H. & Dorsman, J. C., 2013, In : PLoS ONE. 8, 4, e62017.

Research output: Contribution to journalArticleAcademicpeer-review

2012
52 Downloads (Pure)

A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites

de Vries, Y., Lwiwski, N., Levitus, M., Kuyt, B., Israels, S. J., Arwert, F., Zwaan, M., Greenberg, C. R., Alter, B. P., Joenje, H. & Meijers-Heijboer, E. J., 2012, In : Anemia. 2012, 865170.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network

Yan, Z. J., Guo, R., Paramasivam, M., Shen, W. P., Ling, C., Fox, D., Wang, Y. C., Oostra, A. B., Kuehl, J., Lee, D. Y., Takata, M., Hoatlin, M. E., Schindler, D., Joenje, H., de Winter, J. P., Li, L., Seidman, M. M. & Wang, W. D., 2012, In : Molecular Cell. 47, 1, p. 61-75

Research output: Contribution to journalArticleAcademicpeer-review

51 Downloads (Pure)

Diagnosis of fanconi anemia: chromosomal breakage analysis

Oostra, A. B., Nieuwint, A. W. M., Joenje, H. & de Winter, J. P., 2012, In : Anemia. 2012, 238731.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
53 Downloads (Pure)

Diagnosis of Fanconi Anemia: Mutation Analysis by Multiplex Ligation-Dependent Probe Amplification and PCR-Based Sanger Sequencing

Gille, J. J. P., Floor, K., Kerkhoven, L., Ameziane, N., Joenje, H. & de Winter, J. P., 2012, In : Anemia. 2012, 603253.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
49 Downloads (Pure)

Diagnosis of fanconi anemia: mutation analysis by next-generation sequencing

Ameziane, N., Sie, D. L. S., Dentro, S., Ariyurek, Y., Kerkhoven, L., Joenje, H., Dorsman, J. C., Ylstra, B., Gille, J. J. P., Sistermans, E. A. & de Winter, J. P., 2012, In : Anemia. 2012, 132856.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma

Smetsers, S., Muter, J., Bristow, C., Patel, L., Chandler, K., Bonney, D., Wynn, R. F., Whetton, A. D., Will, A. M., Rockx, D., Joenje, H., Strathdee, G., Shanks, J., Klopocki, E., Gille, J. J. P., Dorsman, J. C. & Meyer, S., 2012, In : Familial Cancer. 11, 4, p. 661-665

Research output: Contribution to journalArticleAcademicpeer-review

2011

Evidence for complete epistasis of null mutations in murine Fanconi anemia genes Fanca and Fancg

van der Vrugt, H. J., Koomen, M., Bakker, S., Berns, M. A. D., Cheng, N. C., van der Valk, M. A., de Vries, Y., Rooimans, M. A., Oostra, A. B., Hoatlin, M. E., te Riele, H. P. J., Joenje, H. & Arwert, F., 2011, In : DNA Repair. 10, 12, p. 1252-1261

Research output: Contribution to journalArticleAcademicpeer-review

METABOLISM Alcohol, DNA and disease

Joenje, H., 2011, In : Nature. 475, 7354, p. 45-46

Research output: Contribution to journalArticleAcademicpeer-review

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

Stoepker, C., Hain, K., Schuster, B., Hilhorst-Hofstee, Y., Rooimans, M. A., Steltenpool, J., Oostra, A. B., Eirich, K., Korthof, E. T., Nieuwint, A. W. M., Jaspers, N. G. J., Bettecken, T., Joenje, H., Schindler, D., Rouse, J. & de Winter, J. P., 2011, In : Nature Genetics. 43, 2, p. 138-141

Research output: Contribution to journalArticleAcademicpeer-review

47 Downloads (Pure)

Spontaneous abrogation of the G(2) DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients

Ceccaldi, R., Briot, D., Larghero, J., Vasquez, N., d'Enghien, C. D., Chamousset, D., Noguera, M. E., Waisfisz, Q., Hermine, O., Pondarre, C., Leblanc, T., Gluckman, E., Joenje, H., Stoppa-Lyonnet, D., Socie, G. & Soulier, J., 2011, In : Journal of Clinical Investigation. 121, 1, p. 184-194

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2010

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

Yan, Z. J., Delannoy, M., Ling, C., Daee, D., Osman, F., Muniandy, P. A., Shen, X., Oostra, A. B., Du, H. S., Steltenpool, J., Lin, T., Schuster, B., Decaillet, C., Stasiak, A., Stasiak, A. Z., Stone, S., Hoatlin, M. E., Schindler, D., Woodcock, C. L., Joenje, H. & 8 othersSen, R., de Winter, J. P., Li, L., Seidman, M. M., Whitby, M. C., Myung, K., Constantinou, A. & Wang, W., 2010, In : Molecular Cell. 37, 6, p. 865-878

Research output: Contribution to journalArticleAcademicpeer-review

Fanconi anaemie: uit de kinderschoenen

Smetsers, S. E., Zwaan, C. M., Sonnevelt, M. C., Brakenhoff, R. H., Smiers, F. J., Best, J. D., Joenje, H. & Bierings, M. B., 2010, In : Nederlands Tijdschrift voor Hematologie. 7, p. 258-263

Research output: Contribution to journalArticleProfessional

Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling

van Harn, T., Foijer, F., van Vugt, M., Banerjee, R., Yang, F. T., Oostra, A. B., Joenje, H. & te Riele, H., 2010, In : Genes and Development. 24, 13, p. 1377-1388

Research output: Contribution to journalArticleAcademicpeer-review

Warsaw Breakage Syndrome, a Cohesinopathy Associated with Mutations in the XPD Helicase Family Member DDX11/ChIR1

van der Lelij, P., Chrzanowska, K. H., Godthelp, B. C., Rooimans, M. A., Ostra, A. B., Stumm, M., Zdzienicka, MZ., Joenje, H. & de Winter, J. P., 2010, In : American journal of human genetics. 86, 2, p. 262-266

Research output: Contribution to journalArticleAcademicpeer-review

2009

Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M

Bakker, S. T., van der Vrugt, H. J., Rooimans, M. A., Oostra, A., Steltenpool, J., Delzenne-Goette, E., van der Wal, A., van de Valk, M., Joenje, H., te Riele, H. P. J. & de Winter, J. P., 2009, In : Human Molecular Genetics. 18, 18, p. 3484-3495

Research output: Contribution to journalArticleAcademicpeer-review

Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M

Singh, T. R., Bakker, S. D., Agarwal, S., Jansen, M. H. A., Grassman, E., Godthelp, B. C., Ali, A. M., Du, C., Rooimans, M. A., Fan, Q., Wahengbam, K., Steltenpool, J., Andreassen, P. R., Williams, D. J., Joenje, H., de Winter, J. P. & Meetei, AR., 2009, In : Blood. 114, 1, p. 174-180

Research output: Contribution to journalArticleAcademicpeer-review

Lack of large genomic deletions in BRIP1, PALB2, and FANCD2 genes in BRCA1/2 negative familial breast cancer

Ameziane, N., van den Ouweland, A. M. W., Adank, M. A., Vijzelaar, R. N. C. P., Errami, A., Dorsman, J. C., Joenje, H., Meijers, J. H. C. & Waisfisz, Q., 2009, In : Breast Cancer Research and Treatment. 118, 3, p. 651-653

Research output: Contribution to journalArticleAcademicpeer-review

No evidence for FANCF gene silencing in head-and-neck squamous cell carcinomas

Ameziane, N., Chen, F., Leemans, C. R., Brakenhoff, R. H. & Joenje, H., 2009, In : Cellular Oncology. 31, 1, p. 53-56

Research output: Contribution to journalArticleAcademicpeer-review

37 Downloads (Pure)

The Cellular Phenotype of Roberts Syndrome Fibroblasts as Revealed by Ectopic Expression of ESCO2

van der Lelij, P., Godthelp, B. C., van Zon, W., van Gosliga, D., Oostra, A. B., Steltenpool, J., de Groot, J., Scheper, R. J., Wolthuis, R. M., Waisfisz, Q., Darroudi, F., Joenje, H. & de Winter, J. P., 2009, In : PLoS ONE. 4, 9

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

The genetic and molecular basis of Fanconi anemia

de Winter, J. P. & Joenje, H., 2009, In : Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 668, 1-2, p. 11-19

Research output: Contribution to journalArticleAcademicpeer-review

2008

Clinical and Molecular Characteristics of Squamous Cell Carcinomas From Fanconi Anemia Patients

van Zeeburg, H. J., Snijders, P. J. F., Wu, T., Gluckman, E., Soulier, J., Surralles, J., Castella, M., van der Wal, J. E., Wennerberg, J., Califano, J., Velleuer, E., Dietrich, R., Ebell, W., Bloemena, E., Joenje, H., Leemans, C. R. & Brakenhoff, R. H., 2008, In : Journal of the National Cancer Institute. 100, 22, p. 1649-1653

Research output: Contribution to journalArticleAcademicpeer-review

Fanconi-anemie, DNA-herstel en kanker

Joenje, H., Dorsman, J. C., Waisfisz, Q. & de Winter, J. P., 2008, In : Tijdschrift Kanker. 32, p. 24-27

Research output: Contribution to journalArticleProfessional

Genetic subtyping of Fanconi anemia by comprehensive mutation screening

Ameziane, N., Errami, A., Leveille, F., Fontaine, C., de Vries, Y., van Spaendonk, R. M. L., de Winter, J. P., Pals, G. & Joenje, H., 2008, In : Human Mutation. 29, 1, p. 159-166

Research output: Contribution to journalArticleAcademicpeer-review

Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia

Hess, C. J., Ameziane, N., Schuurhuis, G. J., Errami, A., Denkers, F., Kaspers, G. J. L., Cloos, J., Joenje, H., Reinhardt, D., Ossenkoppele, G. J., Zwaan, C. M. & Waisfisz, Q., 2008, In : Cellular Oncology. 30, 4, p. 299-306

Research output: Contribution to journalArticleAcademicpeer-review

Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer

van der Groep, P., Hoelzel, M., Buerger, H., Joenje, H., de Winter, J. P. & van Diest, P. J., 2008, In : Breast Cancer Research and Treatment. 107, 1, p. 41-47

Research output: Contribution to journalArticleAcademicpeer-review

2007

Identification of the Fanconi anemia complementation group I gene, FANCI

Dorsman, J. C., Levitus, M., Rockx, D., Rooimans, M. A., Oostra, A. B., Haitjema, A., Bakker, S. T., Steltenpool, J., Schuler, D., Mohan, S., Schindler, D., Arwert, F., Pals, G., Mathew, C. G., Waisfisz, Q., de Winter, J. P. & Joenje, H., 2007, In : Cellular Oncology. 29, 3, p. 211-218

Research output: Contribution to journalArticleAcademicpeer-review

2006

Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2

Godthelp, BC., Wiegant, WW., Waisfisz, Q., Medhurst, AL., Arwert, F., Joenje, H. & Zdzienicka, MZ., 22 Feb 2006, In : Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 594, 1-2, p. 39-48

Research output: Contribution to journalArticleAcademicpeer-review

2005

A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and Biallelic FANCDI/BRCA2 mutations

Meyer, S., Fergusson, WD., Oostra, AB., Medhurst, AL., Waisfisz, Q., de Winter, JP., Chen, F., Carr, TF., Clayton-Smith, J., Clancy, T., Green, M., Barber, L., Eden, OB., Will, AM., Joenje, H. & Taylor, GM., Apr 2005, In : Genes, Chromosomes and Cancer. 42, 4, p. 404-415

Research output: Contribution to journalArticleAcademicpeer-review

Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion

Vega, H., Waisfisz, Q., Gordillo, M., Sakai, N., Yanagihara, I., Yamada, M., van Gosliga, D., Kayserili, H., Xu, CZ., Ozono, K., Jabs, EW., Inui, K. & Joenje, H., May 2005, In : Nature Genetics. 37, 5, p. 468-470

Research output: Contribution to journalArticleAcademicpeer-review

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

Levitus, M., Waisfisz, Q., Godthelp, BC., de Vries, Y., Hussain, S., Wiegant, WW., Elghalbzouri-Maghrani, E., Steltenpool, J., Rooimans, MA., Pals, G., Arwert, F., Mathew, CG., Zdzienicka, MZ., Hiom, K., De Winter, JP. & Joenje, H., Sep 2005, In : Nature Genetics. 37, 9, p. 934-935

Research output: Contribution to journalArticleAcademicpeer-review

2004

Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypes

Levitus, M., Rooimans, MA., Steltenpool, J., Cool, NFC., Oostra, AB., Mathew, CG., Hoatlin, ME., Waisfisz, Q., Arwert, F., de Winter, JP. & Joenje, H., 1 Apr 2004, In : Blood. 103, 7, p. 2498-2503

Research output: Contribution to journalArticleAcademicpeer-review

16 Downloads (Pure)

The Fanconi anemia gene product FANCF is a flexible adaptor protein

Leveille, F., Blom, E., Medhurst, AL., Bier, P., Laghmani, EH., Johnson, M., Rooimans, MA., Sobeck, A., Waisfisz, Q., Arwert, F., Patel, KJ., Hoatlin, ME., Joenje, H. & de Winter, JP., 17 Sep 2004, In : Journal of Biological Chemistry. 279, 38, p. 39421-39430

Research output: Contribution to journalArticleAcademicpeer-review

File
2003

A novel ubiquitin ligase is deficient in Fanconi anemia

Meetei, AR., de Winter, JP., Medhurst, AL., Wallisch, M., Waisfisz, Q., van de Vrugt, HJ., Oostra, AB., Yan, ZJ., Ling, C., Bishop, CE., Hoatlin, ME., Joenje, H. & Wang, WD., Oct 2003, In : Nature Genetics. 35, 2, p. 165-170

Research output: Contribution to journalArticleAcademicpeer-review

Bi-allelic silencing of the Fanconi anaemia gene FANCF in acute myeloid leukaemia

Tischkowitz, M., Ameziane, N., Waisfisz, Q., De Winter, JP., Harris, R., Taniguchi, T., D'Andrea, A., Hodgson, SV., Mathew, CG. & Joenje, H., Nov 2003, In : British Journal of Haematology. 123, 3, p. 469-471

Research output: Contribution to journalArticleAcademicpeer-review

Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2

Ikeda, H., Matsushita, M., Waisfisz, Q., Kinoshita, A., Oostra, AB., Nieuwint, AWM., de Winter, JP., Hoatlin, ME., Kawai, Y., Sasaki, MS., D'Andrea, AD., Kawakami, Y. & Joenje, H., 15 May 2003, In : Cancer Research. 63, 10, p. 2688-2694

Research output: Contribution to journalArticleAcademicpeer-review

Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport

Reuter, TY., Medhurst, AL., Waisfisz, Q., Zhi, Y., Herterich, S., Hoehn, H., Gross, HJ., Joenje, H., Hoatlin, ME., Mathew, CG. & Huber, PA., 1 Oct 2003, In : Experimental Cell Research. 289, 2, p. 211-221

Research output: Contribution to journalArticleAcademicpeer-review

2000

Aberrant Fanconi anaemia protein profiles in acute myeloid leukaemia cells

Xie, Y., de Winter, JP., Waisfisz, Q., Nieuwint, AWM., Scheper, RJ., Arwert, F., Hoatlin, ME., Ossenkoppele, GJ., Schuurhuis, GJ. & Joenje, H., Dec 2000, In : British Journal of Haematology. 111, 4, p. 1057-1064

Research output: Contribution to journalArticleAcademicpeer-review

Complementation analysis in Fanconi anemia: Assignment of the reference FA-H patient to group A

Joenje, H., Levitus, M., Waisfisz, Q., D'Andrea, A., Garcia-Higuera, I., Pearson, T., van Berkel, CGM., Rooimans, MA., Morgan, N., Mathew, CG. & Arwert, F., Sep 2000, In : American journal of human genetics. 67, 3, p. 759-762

Research output: Contribution to journalArticleAcademicpeer-review

The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM

de Winter, JP., Rooimans, MA., van der Weel, L., van Berkel, CGM., Alon, N., Bosnoyan-Collins, L., de Groot, J., Zhi, Y., Waisfisz, Q., Pronk, JC., Arwert, F., Mathew, CG., Scheper, RJ., Hoatlin, ME., Buchwald, M. & Joenje, H., Jan 2000, In : Nature Genetics. 24, 1, p. 15-16

Research output: Contribution to journalArticleAcademicpeer-review

1999

A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA

Waisfisz, Q., de Winter, JP., Kruyt, FAE., de Groot, J., van der Weel, L., Dijkmans, LM., Zhi, Y., Arwert, F., Scheper, RJ., Youssoufian, H., Hoatlin, ME. & Joenje, H., 31 Aug 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 18, p. 10320-10325

Research output: Contribution to journalArticleAcademicpeer-review