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Research Output 1993 2019

2019

Anatomy, Function, and Dysfunction of the Right Ventricle: JACC State-of-the-Art Review

Sanz, J., Sánchez-Quintana, D., Bossone, E., Bogaard, H. J. & Naeije, R., 2019, In : Journal of the American College of Cardiology. 73, 12, p. 1463-1482 20 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Assembly 13: placing the pulmonary circulation in the heart of ERS

Vonk Noordegraaf, A., Delcroix, M., Jiminez, D., Sitbon, O. & Bogaard, H. J., Mar 2019, In : Breathe. 15, 1, p. 88-89 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bosutinib Protects against Vascular Leakage by Improving Endothelial Cell-Matrix Adhesion

Botros, L., Pronk, M., Juschten, J., Liddle, J., Tuinman, P. R., van Bezu, J., Huveneers, S., Bogaard, H. J., van Hinsbergh, V., Hordijk, P. & Aman, J., 2019, In : Journal of Vascular Research. 56, p. 15-15

Research output: Contribution to journalMeeting AbstractAcademic

Is Myocardial Fibrosis Impairing Right Heart Function?

Bogaard, H. J. & Voelkel, N. F., 4 Jan 2019, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

Rol, N., de Raaf, M. A., Sun, X. Q., Kuiper, V. P., da Silva Gonçalves Bos, D., Happé, C., Kurakula, K., Dickhoff, C., Thuillet, R., Tu, L., Guignabert, C., Schalij, I., Lodder, K., Pan, X., Herrmann, F. E., van Nieuw Amerongen, G. P., Koolwijk, P., Vonk-Noordegraaf, A., de Man, F. S., Wollin, L. & 3 othersGoumans, M-J., Szulcek, R. & Bogaard, H. J., 2019, In : Cardiovascular Research. 115, 2, p. 432-439

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The ADAMTS13–VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension

Newnham, M., South, K., Bleda, M., Auger, W. R., Barberà, J. A., Bogaard, H., Bunclark, K., Cannon, J. E., Delcroix, M., Hadinnapola, C., Howard, L. S., Jenkins, D., Mayer, E., Ng, C., Rhodes, C. J., Screaton, N., Sheares, K., Simpson, M. A., Southwood, M., Su, L. & 12 othersTaboada, D., Traylor, M., Trembath, R. C., Villar, S. S., Wilkins, M. R., Wharton, J., Gräf, S., Pepke-Zaba, J., Laffan, M., Lane, D. A., Morrell, N. W. & Toshner, M., 2019, In : The European respiratory journal. 53, 3, 1801805.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Usefulness of standard computed tomography pulmonary angiography performed for acute pulmonary embolism for identification of chronic thromboembolic pulmonary hypertension: results of the InShape III study

Ende-Verhaar, Y. M., Meijboom, L. J., Kroft, L. J. M., Beenen, L. F. M., Boon, G. J. A. M., Middeldorp, S., Nossent, E. J., Symersky, P., Huisman, M. V., Bogaard, H. J., Noordegraaf, A. V. & Klok, F. A., 1 Jan 2019, In : Journal of Heart and Lung Transplantation.

Research output: Contribution to journalArticleAcademicpeer-review

2018

3'-Deoxy-3'-[18F]Fluorothymidine Positron Emission Tomography Depicts Heterogeneous Proliferation Pathology in Idiopathic Pulmonary Arterial Hypertension Patient Lung

Ashek, A., Spruijt, O. A., Harms, H. J., Lammertsma, A. A., Cupitt, J., Dubois, O., Wharton, J., Dabral, S., Pullamsetti, S. S., Huisman, M. C., Frings, V., Boellaard, R., de Man, F. S., Botros, L., Jansen, S., Vonk Noordegraaf, A., Wilkins, M. R., Bogaard, H. J. & Zhao, L., 2018, In : Circulation. Cardiovascular imaging. 11, 8, p. e007402

Research output: Contribution to journalArticleAcademicpeer-review

Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement

American Thoracic Society Assembly on Pulmonary Circulation, 15 Aug 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 4, p. e15-e43

Research output: Contribution to journalArticleAcademicpeer-review

Chronic thromboembolic pulmonary hypertension from the perspective of patients with pulmonary embolism

Klok, F. A., Delcroix, M. & Bogaard, H. J., Jun 2018, In : Journal of Thrombosis and Haemostasis. 16, 6, p. 1040-1051 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Contribution of impaired parasympathetic activity to right ventricular dysfunction and pulmonary vascular remodeling in pulmonary arterial hypertension

Da Silva Gonçalves Bós, D., Van Der Bruggen, C. E. E., Kurakula, K., Sun, X. Q., Casali, K. R., Casali, A. G., Rol, N., Szulcek, R., Dos Remedios, C., Guignabert, C., Tu, L., Dorfmüller, P., Humbert, M., Wijnker, P. J. M., Kuster, D. W. D., Van Der Velden, J., Goumans, M. J., Bogaard, H. J., Vonk-Noordegraaf, A., De Man, F. S. & 1 othersHandoko, M. L., 1 Jan 2018, In : Circulation. 137, 9, p. 910-924 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Diagnostic workup, etiologies and management of acute right ventricle failure: A state-of-the-art paper

Vieillard-Baron, A., Naeije, R., Haddad, F., Bogaard, H. J., Bull, T. M., Fletcher, N., Lahm, T., Magder, S., Orde, S., Schmidt, G. & Pinsky, M. R., 1 Jun 2018, In : Intensive Care Medicine. 44, 6, p. 774-790 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

DNGR1-driven A20/TNFAIP3 deletion in conventional dendritic cells induces lung inflammation and pulmonary hypertension

Koudstaal, T., van Hulst, J., Das, T., Heukels, P., Merkus, D., de Raaf, M., Bergen, I., Bogaard, H. J., Reis e Sousa, C., van Loo, G., Hendriks, R. W., Boomars, K. & Kool, M., May 2018, In : European Journal of Immunology. 48, p. 57-57

Research output: Contribution to journalMeeting AbstractAcademic

Endothelial dysfunction in pulmonary arterial hypertension: loss of cilia length regulation upon cytokine stimulation

Dummer, A., Rol, N., Szulcek, R., Kurakula, K., Pan, X., Visser, B. I., Bogaard, H. J., DeRuiter, M. C., Goumans, M-J. & Hierck, B. P., 27 Feb 2018, In : Pulmonary Circulation. 8, 2, p. 2045894018764629

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

UK NIHR BioResource Rare Diseases Consortium, 5 Dec 2018, In : Lancet respiratory medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Healthcare utilization in chronic thromboembolic pulmonary hypertension after acute pulmonary embolism

Ende-Verhaar, Y. M., van den Hout, W. B., Bogaard, H. J., Meijboom, L. J., Huisman, M. V., Symersky, P., Vonk-Noordegraaf, A. & Klok, F. A., Nov 2018, In : Journal of Thrombosis and Haemostasis. 16, 11, p. 2168-2174

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Graf, S., Haimel, M., Bleda, M., Hadinnapola, C., Southgate, L., Li, W., Hodgson, J., Liu, B., Salmon, R. M., Southwood, M., Machado, R. D., Martin, J. M., Treacy, C. M., Yates, K., Daugherty, L. C., Shamardina, O., Whitehorn, D., Holden, S., Aldred, M., Bogaard, H. J. & 45 othersChurch, C., Coghlan, G., Condliffe, R., Corris, P. A., Danesino, C., Eyries, M., Gall, H., Ghio, S., Ghofrani, H-A., Gibbs, J. S. R., Girerd, B., Houweling, A. C., Howard, L., Humbert, M., Kiely, D. G., Kovacs, G., Ross, R. V. M., Moledina, S., Montani, D., Newnham, M., Olschewski, A., Olschewski, H., Peacock, A. J., Pepke-Zaba, J., Prokopenko, I., Rhodes, C. J., Scelsi, L., Seeger, W., Soubrier, F., Stein, D. F., Suntharalingam, J., Swietlik, E. M., Toshner, M. R., van Heel, D. A., Noordegraaf, A. V., Waisfisz, Q., Wharton, J., Wort, S. J., Ouwehand, W. H., Soranzo, N., Lawrie, A., Upton, P. D., Wilkins, M. R., Trembath, R. C. & Morrell, N. W., 12 Apr 2018, In : Nature Communications. 9

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension

Bohnen, M. S., Ma, L., Zhu, N., Qi, H., McClenaghan, C., Gonzaga-Jauregui, C., Dewey, F. E., Overton, J. D., Reid, J. G., Shuldiner, A. R., Baras, A., Sampson, K. J., Bleda, M., Hadinnapola, C., Haimel, M., Bogaard, H. J., Church, C., Coghlan, G., Corris, P. A., Eyries, M. L. & 30 othersGibbs, J. S. R., Girerd, B., Houweling, A. C., Humbert, M., Guignabert, C., Kiely, D. G., Lawrie, A., MacKenzie Ross, R. V., Martin, J. M., Montani, D., Peacock, A. J., Pepke-Zaba, J., Soubrier, F., Suntharalingam, J., Toshner, M., Treacy, C. M., Trembath, R. C., Vonk Noordegraaf, A., Wharton, J., Wilkins, M. R., Wort, S. J., Yates, K., Gräf, S., Morrell, N. W., Krishnan, U., Rosenzweig, E. B., Shen, Y., Nichols, C. G., Kass, R. S. & Chung, W. K., 2018, In : Circulation. Genomic and precision medicine. 11, 10, p. e002087

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacological activation of nuclear receptor Nur77 decreases endothelial cell dysfunction and reduces experimental pulmonary hypertension

Kurakula, K. B., Sun, X., Happe, C., Goumans, M. J. & Bogaard, H. J., Apr 2018, In : Cardiovascular Research. 114, p. S139-S140

Research output: Contribution to journalMeeting AbstractAcademic

Pulmonary vascular remodeling patterns and expression of general control nonderepressible 2 (GCN2) in pulmonary veno-occlusive disease

Nossent, E. J., Antigny, F., Montani, D., Bogaard, H. J., Ghigna, M. R., Lambert, M., Thomas de Montpre´ville, V., Girerd, B., Jai¨s, X., Savale, L., Mercier, O., Fadel, E., Soubrier, F., Sitbon, O., Simonneau, G., Noordegraaf, A. V., Humbert, M., Perros, F. & Dorfmu¨ller, P., 1 May 2018, In : Journal of Heart and Lung Transplantation. 37, 5, p. 647-655 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome

Schimmel, L., van der Stoel, M., Rianna, C., van Stalborch, A-M., de Ligt, A., Hoogenboezem, M., Tol, S., van Rijssel, J., Szulcek, R., Bogaard, H. J., Hofmann, P., Boon, R., Radmacher, M., de Waard, V., Huveneers, S. & van Buul, J. D., 18 Sep 2018, In : Cell Reports. 24, 12, p. 3115-3124 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

TGF-β and BMPR2 Signaling in PAH: Two Black Sheep in One Family

Rol, N., Kurakula, K. B., Happé, C., Bogaard, H. J. & Goumans, M-J., 31 Aug 2018, In : International Journal of Molecular Sciences. 19, 9

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Update in Pulmonary Vascular Disease 2016 and 2017

Brittain, E. L., Thennapan, T., Maron, B. A., Chan, S. Y., Austin, E. D., Spiekerkoetter, E., Bogaard, H. J., Guignabert, C., Paulin, R., Machado, R. F. & Yu, P. B., 1 Jul 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 1, p. 13-23 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Activation On Nuclear Receptor Nur77 Decreases Experimental Pulmonary Hypertension

Kurakula, K., Sun, X., Happe, C., De Vries, C., Bogaard, H. J. & Goumans, M. T. H., 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, p. A4229

Research output: Contribution to journalMeeting AbstractAcademic

Assessing right ventricular function and the pulmonary circulation in pulmonary hypertension

Spruijt, OA., 2017, 226 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access

Bilateral proximal CTEPH is associated with worse RV function and RV (mal)adaptation

Ruigrok, D., Kreft, M., 't Veld, A. H. I., Nossent, E. J., Symersky, P., Noordegraaf, A. V., Meijboom, L. J. & Bogaard, H. J., 1 Sep 2017, In : European Respiratory Journal. 50

Research output: Contribution to journalMeeting AbstractAcademic

Chronische trombo-embolische pulmonale hypertensie

Ruigrok, D., Symersky, P., Elbers, P. W. G., Kamminga, S., Meijboom, L. J. & Bogaard, H. J., 2017, In : Nederlands Tijdschrift voor Geneeskunde. 161, 0, p. D1597

Research output: Contribution to journalReview articleAcademicpeer-review

GENOME-WIDE ASSOCIATION STUDY IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION REVEALS NEW INSIGHTS INTO AETIOLOGY

Newnham, M., Toshner, M., Bleda, M., Auger, W. R., Barbera, J. A., Bogaard, H. J., Cannon, J., Coghlan, G., Corris, P. A., Delcroix, M., Dunning, J., Elding, H., Gibbs, S., Hadinnapola, C., Jenkins, D., Kiely, D., Lang, I., Maher, E., Ng, C., Peacock, A. & 12 othersScreaton, N., Sheares, K., Simpson, M., Soranzo, N., Taboada, D., Trembath, R., Tsui, S., Wilkins, M. R., Wort, S. J., Graf, S., Pepke-Zaba, J. & Morrell, N. W., Dec 2017, In : Thorax. 72, p. A66-A66

Research output: Contribution to journalMeeting AbstractAcademic

Hypoxic pulmonary vasoconstriction in COPD-associated pulmonary hypertension: Been there, done that?

Bogaard, H. J., 1 Jul 2017, In : European Respiratory Journal. 50, 1, 1701191.

Research output: Contribution to journalEditorialAcademicpeer-review

Levosimendan Prevents and Reverts Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension

Hansen, M. S., Andersen, A., Holmboe, S., Schultz, J. G., Ringgaard, S., Simonsen, U., Happé, C., Bogaard, H. J. & Nielsen-Kudsk, J. E., 1 Oct 2017, In : Journal of Cardiovascular Pharmacology. 70, 4, p. 232-238 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

P38 mapk inhibition improves heart function in pressure-loaded right ventricular hypertrophy

Kojonazarov, B., Novoyatleva, T., Boehm, M., Happe, C., Sibinska, Z., Tian, X., Sajjad, A., Luitel, H., Kriechling, P., Posern, G., Evans, S. M., Grimminger, F., Ghofrani, H. A., Weissmann, N., Bogaard, H. J., Seeger, W. & Schermuly, R. T., 1 Nov 2017, In : American Journal of Respiratory Cell and Molecular Biology. 57, 5, p. 603-614 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD

Mizuno, S., Ishizaki, T., Kadowaki, M., Akai, M., Shiozaki, K., Iguchi, M., Oikawa, T., Nakagawa, K., Osanai, K., Toga, H., Gomez-Arroyo, J., Kraskauskas, D., Cool, C. D., Bogaard, H. J. & Voelkel, N. F., 1 Jul 2017, In : Chest. 152, 1, p. 58-69 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension

Hadinnapola, C., Bleda, M., Haimel, M., Screaton, N., Swift, A., Dorfmüller, P., Preston, S. D., Southwood, M., Hernandez-Sanchez, J., Martin, J., Treacy, C., Yates, K., Bogaard, H., Church, C., Coghlan, G., Condliffe, R., Corris, P. A., Gibbs, S., Girerd, B., Holden, S. & 24 othersHumbert, M., Kiely, D. G., Lawrie, A., Machado, R., MacKenzie Ross, R., Moledina, S., Montani, D., Newnham, M., Peacock, A., Pepke-Zaba, J., Rayner-Matthews, P., Shamardina, O., Soubrier, F., Southgate, L., Suntharalingam, J., Toshner, M., Trembath, R., Noordegraaf, A. V., Wilkins, M. R., Wort, S. J., Wharton, J., Gräf, S., Morrell, N. W. & NIHR BioResource–Rare Diseases Consortium; UK National Cohort Study of Idiopathic and Heritable PAH, 21 Nov 2017, In : Circulation. 136, 21, p. 2022-2033 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary endarterectomy for calcified amorphous tumour-related pulmonary hypertension

Bonta, P. I., Bogaard, H. J., van den Berk, I., Niessen, H. W. M., van der Wal, A. & Symersky, P., Jun 2017, In : Thorax. 72, 6, p. 584-585 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary hypertension with warm hands

Botros, L., Aman, J., Bogaard, H. J. & Vonk Noordegraaf, A., 1 Dec 2017, In : Thorax. 72, 12, p. 1164-1166 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

da Silva Gonçalves Bos, D., Happé, C., Schalij, I., Pijacka, W., Paton, J. F. R., Guignabert, C., Tu, L., Thuillet, R., Bogaard, H. J., van Rossum, A. C., Vonk-Noordegraaf, A., de Man, F. S. & Handoko, M. L., 2017, In : JACC: Basic to Translational Science. 2, 1, p. 22-35 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Right ventricular recovery after bilateral lung transplantation for pulmonary arterial hypertension

Gorter, T. M., Verschuuren, E. A. M., Van Veldhuisen, D. J., Hoendermis, E. S., Erasmus, M. E., Bogaard, H. J., Vonk Noordegraaf, A., Berger, R. M. F., Van Melle, J. P. & Willems, T. P., 1 Jun 2017, In : Interactive Cardiovascular and Thoracic Surgery. 24, 6, p. 890-897 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Role of cardiac inflammation in right ventricular failure

Sun, X. Q., Abbate, A. & Bogaard, H. J., 1 Oct 2017, In : Cardiovascular Research. 113, 12, p. 1441-1452 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets

Best, M. G., Sol, N., In ‘t Veld, S. G. J. G., Vancura, A., Muller, M., Niemeijer, A. L. N., Fejes, A. V., Tjon Kon Fat, L. A., Huis In ‘t Veld, A. E., Leurs, C., Le Large, T. Y., Meijer, L. L., Kooi, I. E., Rustenburg, F., Schellen, P., Verschueren, H., Post, E., Wedekind, L. E., Bracht, J., Esenkbrink, M. & 33 othersWils, L., Favaro, F., Schoonhoven, J. D., Tannous, J., Meijers-Heijboer, H., Kazemier, G., Giovannetti, E., Reijneveld, J. C., Idema, S., Killestein, J., Heger, M., de Jager, S. C., Urbanus, R. T., Hoefer, I. E., Pasterkamp, G., Mannhalter, C., Gomez-Arroyo, J., Bogaard, H. J., Noske, D. P., Vandertop, W. P., van den Broek, D., Ylstra, B., Nilsson, R. J. A., Wesseling, P., Karachaliou, N., Rosell, R., Lee-Lewandrowski, E., Lewandrowski, K. B., Tannous, B. A., de Langen, A. J., Smit, E. F., van den Heuvel, M. M. & Wurdinger, T., 14 Aug 2017, In : Cancer Cell. 32, 2, p. 238-252.e9

Research output: Contribution to journalArticleAcademicpeer-review