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Research Output 1993 2019

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2019

Assembly 13: placing the pulmonary circulation in the heart of ERS

Vonk Noordegraaf, A., Delcroix, M., Jiminez, D., Sitbon, O. & Bogaard, H. J., Mar 2019, In : Breathe. 15, 1, p. 88-89 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Is Myocardial Fibrosis Impairing Right Heart Function?

Bogaard, H. J. & Voelkel, N. F., 4 Jan 2019, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension

Van der Feen, D. E., Kurakula, K., Tremblay, E., Boucherat, O., Bossers, G. PL., Szulcek, R., Bourgeois, A., Lampron, M-C., Habbout, K., Martineau, S., Paulin, R., Kulikowski, E., Jahagirdar, R., Schalij, I., Bogaard, H. J., Bartelds, B., Provencher, S., Berger, R. M. F., Bonnet, S. & Goumans, M-J., May 2019, In : American Journal of Respiratory and Critical Care Medicine. p. rccm.201812-2275OC

Research output: Contribution to journalArticleAcademicpeer-review

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

Rol, N., de Raaf, M. A., Sun, X. Q., Kuiper, V. P., da Silva Gonçalves Bos, D., Happé, C., Kurakula, K., Dickhoff, C., Thuillet, R., Tu, L., Guignabert, C., Schalij, I., Lodder, K., Pan, X., Herrmann, F. E., van Nieuw Amerongen, G. P., Koolwijk, P., Vonk-Noordegraaf, A., de Man, F. S., Wollin, L. & 3 othersGoumans, M-J., Szulcek, R. & Bogaard, H. J., 2019, In : Cardiovascular Research. 115, 2, p. 432-439

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone

Andersen, S., Birkmose Axelsen, J., Ringgaard, S., Randel Nyengaard, J., Holm Nielsen, S., Genovese, F., Asser Karsdal, M., Adler Hyldebrandt, J., Brandt Sørensen, C., de Man, F. S., Jan Bogaard, H., Erik Nielsen-Kudsk, J. & Andersen, A., Apr 2019, In : Pulmonary Circulation. 9, 2, p. 204589401984865

Research output: Contribution to journalArticleAcademicpeer-review

The ADAMTS13–VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension

Newnham, M., South, K., Bleda, M., Auger, W. R., Barberà, J. A., Bogaard, H., Bunclark, K., Cannon, J. E., Delcroix, M., Hadinnapola, C., Howard, L. S., Jenkins, D., Mayer, E., Ng, C., Rhodes, C. J., Screaton, N., Sheares, K., Simpson, M. A., Southwood, M., Su, L. & 12 othersTaboada, D., Traylor, M., Trembath, R. C., Villar, S. S., Wilkins, M. R., Wharton, J., Gräf, S., Pepke-Zaba, J., Laffan, M., Lane, D. A., Morrell, N. W. & Toshner, M., 2019, In : The European respiratory journal. 53, 3, 1801805.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Usefulness of standard computed tomography pulmonary angiography performed for acute pulmonary embolism for identification of chronic thromboembolic pulmonary hypertension: results of the InShape III study

Ende-Verhaar, Y. M., Meijboom, L. J., Kroft, L. J. M., Beenen, L. F. M., Boon, G. J. A. M., Middeldorp, S., Nossent, E. J., Symersky, P., Huisman, M. V., Bogaard, H. J., Noordegraaf, A. V. & Klok, F. A., 1 Jan 2019, In : Journal of Heart and Lung Transplantation.

Research output: Contribution to journalArticleAcademicpeer-review

2018

3'-Deoxy-3'-[18F]Fluorothymidine Positron Emission Tomography Depicts Heterogeneous Proliferation Pathology in Idiopathic Pulmonary Arterial Hypertension Patient Lung

Ashek, A., Spruijt, O. A., Harms, H. J., Lammertsma, A. A., Cupitt, J., Dubois, O., Wharton, J., Dabral, S., Pullamsetti, S. S., Huisman, M. C., Frings, V., Boellaard, R., de Man, F. S., Botros, L., Jansen, S., Vonk Noordegraaf, A., Wilkins, M. R., Bogaard, H. J. & Zhao, L., 2018, In : Circulation. Cardiovascular imaging. 11, 8, p. e007402

Research output: Contribution to journalArticleAcademicpeer-review

Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement

American Thoracic Society Assembly on Pulmonary Circulation, 15 Aug 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 4, p. e15-e43

Research output: Contribution to journalArticleAcademicpeer-review

Contribution of impaired parasympathetic activity to right ventricular dysfunction and pulmonary vascular remodeling in pulmonary arterial hypertension

Da Silva Gonçalves Bós, D., Van Der Bruggen, C. E. E., Kurakula, K., Sun, X. Q., Casali, K. R., Casali, A. G., Rol, N., Szulcek, R., Dos Remedios, C., Guignabert, C., Tu, L., Dorfmüller, P., Humbert, M., Wijnker, P. J. M., Kuster, D. W. D., Van Der Velden, J., Goumans, M. J., Bogaard, H. J., Vonk-Noordegraaf, A., De Man, F. S. & 1 othersHandoko, M. L., 1 Jan 2018, In : Circulation. 137, 9, p. 910-924 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Endothelial dysfunction in pulmonary arterial hypertension: loss of cilia length regulation upon cytokine stimulation

Dummer, A., Rol, N., Szulcek, R., Kurakula, K., Pan, X., Visser, B. I., Bogaard, H. J., DeRuiter, M. C., Goumans, M-J. & Hierck, B. P., 27 Feb 2018, In : Pulmonary Circulation. 8, 2, p. 2045894018764629

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

UK NIHR BioResource Rare Diseases Consortium, 5 Dec 2018, In : Lancet respiratory medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Healthcare utilization in chronic thromboembolic pulmonary hypertension after acute pulmonary embolism

Ende-Verhaar, Y. M., van den Hout, W. B., Bogaard, H. J., Meijboom, L. J., Huisman, M. V., Symersky, P., Vonk-Noordegraaf, A. & Klok, F. A., Nov 2018, In : Journal of Thrombosis and Haemostasis. 16, 11, p. 2168-2174

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Graf, S., Haimel, M., Bleda, M., Hadinnapola, C., Southgate, L., Li, W., Hodgson, J., Liu, B., Salmon, R. M., Southwood, M., Machado, R. D., Martin, J. M., Treacy, C. M., Yates, K., Daugherty, L. C., Shamardina, O., Whitehorn, D., Holden, S., Aldred, M., Bogaard, H. J. & 45 othersChurch, C., Coghlan, G., Condliffe, R., Corris, P. A., Danesino, C., Eyries, M., Gall, H., Ghio, S., Ghofrani, H-A., Gibbs, J. S. R., Girerd, B., Houweling, A. C., Howard, L., Humbert, M., Kiely, D. G., Kovacs, G., Ross, R. V. M., Moledina, S., Montani, D., Newnham, M., Olschewski, A., Olschewski, H., Peacock, A. J., Pepke-Zaba, J., Prokopenko, I., Rhodes, C. J., Scelsi, L., Seeger, W., Soubrier, F., Stein, D. F., Suntharalingam, J., Swietlik, E. M., Toshner, M. R., van Heel, D. A., Noordegraaf, A. V., Waisfisz, Q., Wharton, J., Wort, S. J., Ouwehand, W. H., Soranzo, N., Lawrie, A., Upton, P. D., Wilkins, M. R., Trembath, R. C. & Morrell, N. W., 12 Apr 2018, In : Nature Communications. 9

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension

Bohnen, M. S., Ma, L., Zhu, N., Qi, H., McClenaghan, C., Gonzaga-Jauregui, C., Dewey, F. E., Overton, J. D., Reid, J. G., Shuldiner, A. R., Baras, A., Sampson, K. J., Bleda, M., Hadinnapola, C., Haimel, M., Bogaard, H. J., Church, C., Coghlan, G., Corris, P. A., Eyries, M. L. & 30 othersGibbs, J. S. R., Girerd, B., Houweling, A. C., Humbert, M., Guignabert, C., Kiely, D. G., Lawrie, A., MacKenzie Ross, R. V., Martin, J. M., Montani, D., Peacock, A. J., Pepke-Zaba, J., Soubrier, F., Suntharalingam, J., Toshner, M., Treacy, C. M., Trembath, R. C., Vonk Noordegraaf, A., Wharton, J., Wilkins, M. R., Wort, S. J., Yates, K., Gräf, S., Morrell, N. W., Krishnan, U., Rosenzweig, E. B., Shen, Y., Nichols, C. G., Kass, R. S. & Chung, W. K., 2018, In : Circulation. Genomic and precision medicine. 11, 10, p. e002087

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary vascular remodeling patterns and expression of general control nonderepressible 2 (GCN2) in pulmonary veno-occlusive disease

Nossent, E. J., Antigny, F., Montani, D., Bogaard, H. J., Ghigna, M. R., Lambert, M., Thomas de Montpre´ville, V., Girerd, B., Jai¨s, X., Savale, L., Mercier, O., Fadel, E., Soubrier, F., Sitbon, O., Simonneau, G., Noordegraaf, A. V., Humbert, M., Perros, F. & Dorfmu¨ller, P., 1 May 2018, In : Journal of Heart and Lung Transplantation. 37, 5, p. 647-655 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome

Schimmel, L., van der Stoel, M., Rianna, C., van Stalborch, A-M., de Ligt, A., Hoogenboezem, M., Tol, S., van Rijssel, J., Szulcek, R., Bogaard, H. J., Hofmann, P., Boon, R., Radmacher, M., de Waard, V., Huveneers, S. & van Buul, J. D., 18 Sep 2018, In : Cell Reports. 24, 12, p. 3115-3124 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Update in Pulmonary Vascular Disease 2016 and 2017

Brittain, E. L., Thennapan, T., Maron, B. A., Chan, S. Y., Austin, E. D., Spiekerkoetter, E., Bogaard, H. J., Guignabert, C., Paulin, R., Machado, R. F. & Yu, P. B., 1 Jul 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 1, p. 13-23 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Levosimendan Prevents and Reverts Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension

Hansen, M. S., Andersen, A., Holmboe, S., Schultz, J. G., Ringgaard, S., Simonsen, U., Happé, C., Bogaard, H. J. & Nielsen-Kudsk, J. E., 1 Oct 2017, In : Journal of Cardiovascular Pharmacology. 70, 4, p. 232-238 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

P38 mapk inhibition improves heart function in pressure-loaded right ventricular hypertrophy

Kojonazarov, B., Novoyatleva, T., Boehm, M., Happe, C., Sibinska, Z., Tian, X., Sajjad, A., Luitel, H., Kriechling, P., Posern, G., Evans, S. M., Grimminger, F., Ghofrani, H. A., Weissmann, N., Bogaard, H. J., Seeger, W. & Schermuly, R. T., 1 Nov 2017, In : American Journal of Respiratory Cell and Molecular Biology. 57, 5, p. 603-614 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD

Mizuno, S., Ishizaki, T., Kadowaki, M., Akai, M., Shiozaki, K., Iguchi, M., Oikawa, T., Nakagawa, K., Osanai, K., Toga, H., Gomez-Arroyo, J., Kraskauskas, D., Cool, C. D., Bogaard, H. J. & Voelkel, N. F., 1 Jul 2017, In : Chest. 152, 1, p. 58-69 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension

Hadinnapola, C., Bleda, M., Haimel, M., Screaton, N., Swift, A., Dorfmüller, P., Preston, S. D., Southwood, M., Hernandez-Sanchez, J., Martin, J., Treacy, C., Yates, K., Bogaard, H., Church, C., Coghlan, G., Condliffe, R., Corris, P. A., Gibbs, S., Girerd, B., Holden, S. & 24 othersHumbert, M., Kiely, D. G., Lawrie, A., Machado, R., MacKenzie Ross, R., Moledina, S., Montani, D., Newnham, M., Peacock, A., Pepke-Zaba, J., Rayner-Matthews, P., Shamardina, O., Soubrier, F., Southgate, L., Suntharalingam, J., Toshner, M., Trembath, R., Noordegraaf, A. V., Wilkins, M. R., Wort, S. J., Wharton, J., Gräf, S., Morrell, N. W. & NIHR BioResource–Rare Diseases Consortium; UK National Cohort Study of Idiopathic and Heritable PAH, 21 Nov 2017, In : Circulation. 136, 21, p. 2022-2033 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary endarterectomy for calcified amorphous tumour-related pulmonary hypertension

Bonta, P. I., Bogaard, H. J., van den Berk, I., Niessen, H. W. M., van der Wal, A. & Symersky, P., Jun 2017, In : Thorax. 72, 6, p. 584-585 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary hypertension with warm hands

Botros, L., Aman, J., Bogaard, H. J. & Vonk Noordegraaf, A., 1 Dec 2017, In : Thorax. 72, 12, p. 1164-1166 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

da Silva Gonçalves Bos, D., Happé, C., Schalij, I., Pijacka, W., Paton, J. F. R., Guignabert, C., Tu, L., Thuillet, R., Bogaard, H. J., van Rossum, A. C., Vonk-Noordegraaf, A., de Man, F. S. & Handoko, M. L., 2017, In : JACC: Basic to Translational Science. 2, 1, p. 22-35 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Right ventricular recovery after bilateral lung transplantation for pulmonary arterial hypertension

Gorter, T. M., Verschuuren, E. A. M., Van Veldhuisen, D. J., Hoendermis, E. S., Erasmus, M. E., Bogaard, H. J., Vonk Noordegraaf, A., Berger, R. M. F., Van Melle, J. P. & Willems, T. P., 1 Jun 2017, In : Interactive Cardiovascular and Thoracic Surgery. 24, 6, p. 890-897 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets

Best, M. G., Sol, N., In ‘t Veld, S. G. J. G., Vancura, A., Muller, M., Niemeijer, A. L. N., Fejes, A. V., Tjon Kon Fat, L. A., Huis In ‘t Veld, A. E., Leurs, C., Le Large, T. Y., Meijer, L. L., Kooi, I. E., Rustenburg, F., Schellen, P., Verschueren, H., Post, E., Wedekind, L. E., Bracht, J., Esenkbrink, M. & 33 othersWils, L., Favaro, F., Schoonhoven, J. D., Tannous, J., Meijers-Heijboer, H., Kazemier, G., Giovannetti, E., Reijneveld, J. C., Idema, S., Killestein, J., Heger, M., de Jager, S. C., Urbanus, R. T., Hoefer, I. E., Pasterkamp, G., Mannhalter, C., Gomez-Arroyo, J., Bogaard, H. J., Noske, D. P., Vandertop, W. P., van den Broek, D., Ylstra, B., Nilsson, R. J. A., Wesseling, P., Karachaliou, N., Rosell, R., Lee-Lewandrowski, E., Lewandrowski, K. B., Tannous, B. A., de Langen, A. J., Smit, E. F., van den Heuvel, M. M. & Wurdinger, T., 14 Aug 2017, In : Cancer Cell. 32, 2, p. 238-252.e9

Research output: Contribution to journalArticleAcademicpeer-review

Vascular narrowing in pulmonary arterial hypertension is heterogeneous: rethinking resistance

Rol, N., Timmer, E. M., Faes, T. J. C., Noordegraaf, A. V., Grünberg, K., Bogaard, H. J. & Westerhof, N., 1 Mar 2017, In : Physiological Reports. 5, 6, e13159.

Research output: Contribution to journalArticleAcademicpeer-review

Vascular remodelling in the pulmonary circulation after major lung resection

Rol, N., Happe, C., Belien, J. A. M., de Man, F. S., Westerhof, N., Vonk-Noordegraaf, A., Grunberg, K. & Bogaard, H. J., 1 Aug 2017, In : European Respiratory Journal. 50, 2, 1700806.

Research output: Contribution to journalArticleAcademicpeer-review

2016

A critical appraisal of transpulmonary and diastolic pressure gradients

Handoko, M. L., De Man, F. S., Oosterveer, F. P. T., Bogaard, H-J., Vonk-Noordegraaf, A. & Westerhof, N., Sep 2016, In : Physiological Reports. 4, 17, e12910.

Research output: Contribution to journalArticleAcademicpeer-review

Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension A View on the Right Ventricle

van der Bruggen, C. E., Happe, C. M., Dorfmueller, P., Trip, P., Spruijt, O. A., Rol, N., Hoevenaars, F. P., Houweling, A. C., Girerd, B., Marcus, J. T., Mercier, O., Humbert, M., Handoko, M. L., van der Velden, J., Noordegraaf, A. V., Bogaard, H. J., Goumans, M-J. & de Man, F. S., 3 May 2016, In : Circulation. 133, 18, p. 1747-1760

Research output: Contribution to journalArticleAcademicpeer-review

Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage

Szulcek, R., Happe, C. M., Rol, N., Fontijn, R. D., Dickhoff, C., Hartemink, K. J., Grunberg, K., Tu, L., Timens, W., Nossent, G. D., Paul, M. A., Leyen, T. A., Horrevoets, A. J., de Man, F. S., Guignabert, C., Yu, P. B., Vonk-Noordegraaf, A., van Nieuw Amerongen, G. & Bogaard, H. J., 15 Jun 2016, In : American Journal of Respiratory and Critical Care Medicine. 193, 12, p. 1410-1420

Research output: Contribution to journalArticleAcademicpeer-review

Exercise pulmonary haemodynamics: a test in search of purpose

Coghlan, J. G. & Bogaard, H. J., 2016, In : European Respiratory Journal. 47, 5, p. 1315-7 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pneumonectomy combined with SU5416 induces severe pulmonary hypertension in rats

Happe, C. M., de Raaf, M. A., Rol, N., Schalij, I., Vonk Noordegraaf, A., Westerhof, N., Voelkel, N. F., de Man, F. S. & Bogaard, H. J., 1 Jun 2016, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 310, 11, p. L1088-L1097

Research output: Contribution to journalArticleAcademicpeer-review

PulmoCor: national registry for pulmonary hypertension

Post, M. C., van Dijk, A. P. J., Hoendermis, E. S., Bogaard, H. J., Van Empel, V. & Boomars, K. A., Jun 2016, In : Netherlands Heart Journal. 24, 6, p. 425-426

Research output: Contribution to journalArticleAcademicpeer-review

Reconciling paradigms of abnormal pulmonary blood flow and quasi-malignant cellular alterations in pulmonary arterial hypertension

Happe, C. M., Szulcek, R., Voelkel, N. F. & Bogaard, H. J., Aug 2016, In : Vascular Pharmacology. 83, p. 17-25

Research output: Contribution to journalArticleAcademicpeer-review

Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension

Manders, E., Bonta, P. I., Kloek, J. J., Symersky, P., Bogaard, H-J., Hooijman, P. E., Jasper, J. R., Malik, F. I., Stienen, G., Vonk-Noordegraaf, A., de Man, F. S. & Ottenheijm, C. A. C., 1 Jul 2016, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 311, 1, p. L20-L28

Research output: Contribution to journalArticleAcademicpeer-review

Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis

Sun, X-Q., Zhang, R., Zhang, H-D., Yuan, P., Wang, X-J., Zhao, Q-H., Wang, L., Jiang, R., Bogaard, H. J. & Jing, Z-C., May 2016, In : HYPERTENSION RESEARCH. 39, 5, p. 302-311

Research output: Contribution to journalArticleAcademicpeer-review

Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension Relative Contribution of Fibrosis and Myofibril Stiffness

Rain, S., Andersen, S., Najafi, A., Schultz, J. G., Bos, D. D. S. G., Handoko, M. L., Bogaard, H-J., Vonk-Noordegraaf, A., Andersen, A., van der Velden, J., Ottenheijm, C. A. C. & de Man, F. S., Jul 2016, In : Circulation. Heart failure. 9, 7, e002636.

Research output: Contribution to journalArticleAcademicpeer-review