Harm-Jan de Grooth — Amsterdam UMC - Vrije Universiteit Amsterdam

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Specialisation

Methodology and statistics for intensive care-specific clinical research issues

Research interests

Which pitfalls of observational studies are especially relevant for intensive care research?
What makes a good endpoint for intensive care studies?
What are the largest threats to generalizability and transportability of study results to real-world populations?

Observational Research for Therapies Titrated to Effect and Associated With Severity of Illness: Misleading Results From Commonly Used Statistical Methods
de Grooth, H-J., Girbes, A. R. J., van der Ven, F., Oudemans-van Straaten, H. M., Tuinman, P. R. & de Man, A. M. E., 1 Dec 2020, In: Critical Care Medicine. 48, 12, p. 1720-1728 9 p.
Research output: Contribution to journal › Article › Academic › peer-review
Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial
Gelissen, H., de Grooth, H-J., Smulders, Y., Wils, E-J., de Ruijter, W., Vink, R., Smit, B., Röttgering, J., Atmowihardjo, L., Girbes, A., Elbers, P., Tuinman, P-R., Oudemans-van Straaten, H. & de Man, A., 14 Sep 2021, In: JAMA - Journal of the American Medical Association. 326, 10, p. 940-948 9 p.
Research output: Contribution to journal › Article › Academic › peer-review
Between-trial heterogeneity in ARDS research
Juschten, J., Tuinman, P. R., Guo, T., Juffermans, N. P., Schultz, M. J., Loer, S. A., Girbes, A. R. J. & de Grooth, H. J., Apr 2021, In: Intensive Care Medicine. 47, 4, p. 422-434 13 p.
Research output: Contribution to journal › Review article › Academic › peer-review

Open Access
The effect of small versus large clog size on emergency response time: A randomized controlled trial
Elbers, P. W. G., de Grooth, H. J. & Girbes, A. R. J., Dec 2020, In: Journal of Critical Care. 60, p. 116-119 4 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
Should we rely on trials with disease- rather than patient-oriented endpoints?
de Grooth, H. J., Parienti, J. J. & Oudemans-van Straaten, H. M., 2018, In: Intensive Care Medicine. 44, p. 464-466 3 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access