Henricus Broxterman

DR.

19952018
If you made any changes in Pure these will be visible here soon.

Research Output 1995 2018

  • 20 Article
  • 1 Chapter
  • 1 Meeting Abstract
  • 1 Research VU University Amsterdam, graduation VU University Amsterdam
2018

Hypoxia Impairs Initial Outgrowth of Endothelial Colony Forming Cells and Reduces Their Proliferative and Sprouting Potential

Tasev, D., Dekker-Vroling, L., van Wijhe, M., Broxterman, H. J., Koolwijk, P. & van Hinsbergh, V. W. M., 20 Dec 2018, In : Frontiers in medicine. 5, 356.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

A functional bioassay to determine the activity of anti-VEGF antibody therapy in blood of patients with cancer

Wentink, M. Q., Broxterman, H. J., Lam, S. W., Boven, E., Walraven, M., Griffioen, A. W., Pili, R., van der Vliet, H. J., de Gruijl, T. D. & Verheul, H. M. W., 11 Oct 2016, In : British Journal of Cancer. 115, 8, p. 940-948

Research output: Contribution to journalArticleAcademicpeer-review

Sunitinib activates Axl signaling in renal cell cancer

van der Mijn, J. C., Broxterman, H. J., Knol, J. C., Piersma, S. R., De Haas, R. R., Dekker, H., Pham, T. V., Van Beusechem, V. W., Halmos, B., Mier, J. W., Jimenez, C. R. & Verheul, H. M. W., 15 Jun 2016, In : International Journal of Cancer. 138, 12, p. 3002-3010

Research output: Contribution to journalArticleAcademicpeer-review

2015

Cross-resistance to clinically used tyrosine kinase inhibitors sunitinib, sorafenib and pazopanib

Gotink, K. J., Rovithi, M. N., de Haas, R. R., Honeywell, R. J., Dekker, H., Poel, D., Azijli, K., Peters, G. J., Broxterman, H. J. & Verheul, H. M. W., 2015, In : Cellular Oncology. 38, 2, p. 119-129

Research output: Contribution to journalArticleAcademicpeer-review

2014

Acquired tumor cell resistance to sunitinib causes resistance in a HT-29 human colon cancer xenograft mouse model without affecting sunitinib biodistribution or the tumor microvasculature

Gotink, K. J., Broxterman, H. J., Honeywell, R. J., Dekker, H., de Haas, R. R., Miles, K. M., Adelaiye, R., Griffioen, A. W., Peters, G. J., Pili, R. & Verheul, H. M. W., 2014, In : Oncoscience. 1, 12, p. 844-853

Research output: Contribution to journalArticleAcademicpeer-review

High-dose, intermittent sunitinib as an alternative treatment strategy

Rovithi, M., de Haas, R. R., Honeywell, R. J., Voortman, J., Griffioen, A. W., Labots, M., Luik, A. M., Peters, G. J., Broxterman, H. J. & Verheul, H. M. W., 1 Oct 2014, In : Cancer Research. 74, 19

Research output: Contribution to journalMeeting AbstractAcademic

Predictive biomarkers in renal cell cancer: insights in drug resistance mechanisms

van der Mijn, J. C., Mier, J. W., Broxterman, H. J. & Verheul, H. M., 2014, In : Drug Resistance Updates. 17, 4-6, p. 77-88

Research output: Contribution to journalArticleAcademicpeer-review

2012

Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancer

van der Veldt, A. A. M., Vroling, L., de Haas, R. R., Koolwijk, P., van den Eertwegh, A. J. M., Haanen, J. B. A. G., van Hinsbergh, V. W. M., Broxterman, H. J. & Boven, E., 2012, In : International Journal of Cancer. 131, 4, p. E484-E493

Research output: Contribution to journalArticleAcademicpeer-review

2011
60 Downloads (Pure)

Circulating endothelial and progenitor cells during anti-angiogenic treatment in cancer patients

Vroling, L., 2011

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance

Gotink, K. J., Broxterman, H. J., Labots, M., de Haas, R. R., Dekker, H., Honeywell, R. J., Rudek, M. A., Beerepoot, L. V., Musters, R. J. P., Jansen, G., Griffioen, A. W., Assaraf, Y. G., Pili, R., Peters, G. J. & Verheul, H. M. W., 2011, In : Clinical Cancer Research. 17, 23, p. 7337-7346

Research output: Contribution to journalArticleAcademicpeer-review

Nanomedicine for targeted cancer therapy: Towards the overcoming of drug resistance

Shapira, A., Livney, Y. D., Broxterman, H. J. & Assaraf, Y. G., 2011, In : Drug Resistance Updates. 14, 3, p. 150-163

Research output: Contribution to journalArticleAcademicpeer-review

2010
39 Downloads (Pure)

CD133(+) circulating haematopoietic progenitor cells predict for response to sorafenib plus erlotinib in non-small cell lung cancer patients

Vroling, L., Lind, J. S. W., de Haas, R. R., Verheul, H. M. W., van Hinsbergh, V. W. M., Broxterman, H. J. & Smit, E. F., 2010, In : British Journal of Cancer. 102, 2, p. 268-275

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2009

CD133+hematopoietic progenitor cells in non-small cell lung cancer patients as indicator of an anti-angiogenic therapeutic response

Vroling, L., Lind, J. S. W., Smit, E. F., Verheul, H. M. W., Haas, RJ. & Broxterman, H. J., 2009, In : Journal of Thoracic Oncology. 4, 9, p. S501-S501

Research output: Contribution to journalArticleAcademicpeer-review

35 Downloads (Pure)

Increased numbers of small circulating endothelial cells in renal cell cancer patients treated with sunitinib

Vroling, L., van der Veldt, A. A. M., de Haas, R. R., Haanen, J. B., Schuurhuis, G. J., Kuik, D. J., van Cruijsen, H., Verheul, H. M. W., van den Eertwegh, A. J. M., Hoekman, K., Boven, E., van Hinsbergh, V. W. M. & Broxterman, H. J., 2009, In : Angiogenesis. 12, 1, p. 69-79

Research output: Contribution to journalArticleAcademicpeer-review

File

Proteomics of the TRAP-induced platelet releasate

Piersma, S. R., Broxterman, H. J., Kapci, M., Haas, RJ., Hoekman, K., Verheul, H. M. W. & Jimenez, C. R., 2009, In : Journal of Proteomics. 72, 1, p. 91-109

Research output: Contribution to journalArticleAcademicpeer-review

Sunitinib-Induced Hemoglobin Changes Are Related to the Dosing Schedule

van der Veldt, A. A. M., Boven, E., Vroling, L., Broxterman, H. J., van den Eertwegh, A. J. M. & Haanen, JB., 2009, In : Journal of Clinical Oncology. 27, 8, p. 1339-1340

Research output: Contribution to journalArticleAcademicpeer-review

Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib

Broxterman, H. J., Gotink, K. J. & Verheul, H. M. W., 2009, In : Drug Resistance Updates. 12, 4-5, p. 114-126

Research output: Contribution to journalArticleAcademicpeer-review

2008

Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival

van Cruijsen, H., van der Veldt, A. A. M., Vroling, L., Oosterhoff, D., Broxterman, H. J., Scheper, R. J., Giaccone, G., Haanen, J. B., van den Eertwegh, A. J. M., Boven, E., Hoekman, K. & de Gruijl, T. D., 2008, In : Clinical Cancer Research. 14, 18, p. 5884-5892

Research output: Contribution to journalArticleAcademicpeer-review

2007

VEGFR2 expressing circulating (progenitor) cell populations in volunteers and cancer patients

Vroling, L., Yuana, Y., Schuurhuis, G. J., van Hinsbergh, V. W. M., Gundy, C., de Haas, R., van Cruijsen, H., Boven, E., Hoekman, K. & Broxterman, H. J., 1 Aug 2007, In : Thrombosis and Haemostasis. 98, 2, p. 440-450 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

1999

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2

Hooijberg, J. H., Broxterman, H. J., Kool, M., Assaraf, Y. G., Peters, G. J., Noordhuis, P., Scheper, R. J., Borst, P., Pinedo, H. M. & Jansen, G., 1 Jun 1999, In : Cancer Research. 59, 11, p. 2532-5 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

1995

The impact of transport-associated resistance in anticancer therapy

Broxterman, HJ., Jansen, G., Linn, S. C. & Lankelma, J., 1995, In: "Drug transport in antimicrobial and anticancer chemotherapy". Georgopapadakou, NH. (ed.). Marcel Dekker, Inc, NY, p. 21-62 42 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional