20092020

Research output per year

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Personal profile

Research interests

My focus is on stratification and rational treatment development in neurodevelopmental disorders (NDDs). Scientific progress in the last decade has revealed treatment targets and physiological handles for rational therapies but their implementation has not yet been successful.Patients now receive far from optimal trial-and-error therapies often with detrimental effects. 

In 2015 I founded a transitional research & care program in the UMC Utrecht (‘zorgprogramma Prikkelverwerking’) and implemented a transdiagnostic approach in clinical practice. The initiative of the program was a co-creation with stakeholders (multiple awards by patient organisations) The current cohort is one of the largest NDD EEG cohorts world-wide consisting of 300 children.

The cornerstone of my research is the clinical implementation of novel EEG biomarkers that have been developed through an intense partnership with the lab of Klaus Linkenkaer-Hansen, physicist and neuroscientist at the CNCR at the VU. This collaboration has resulted in a patent application and a spin-off company (Aspect-Neuroprofiles) that we use to improve quality control, project management, shorter EEG clinical profiles processing times and more focus on the needs of the market. 

Together with Matthijs Verhage of CNCR at the VU, I have established the NewTDec consortium with experts of radically different backgrounds (from clinical phenotypes and EEG to  the measurement neuronal activity in human induced pluripotent stem cells to nano-chips) around a common interest to better understand and treat NDDs.

In addition, I have designed an extensive preclinical project (TOP-grant) in collaboration with Martien Kas (Groningen), Corette Wierenga (UU) and Christian Lohman (NiN) to test hypotheses on synaptic biology in NDD in relation to clinical outcome.

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Research Output

  • 22 Article
  • 3 Review article
  • 2 Comment/Letter to the editor
  • 1 Chapter

Measurement of excitation-inhibition ratio in autism spectrum disorder using critical brain dynamics

Bruining, H., Hardstone, R., Juarez-Martinez, E. L., Sprengers, J., Avramiea, A. E., Simpraga, S., Houtman, S. J., Poil, S. S., Dallares, E., Palva, S., Oranje, B., Matias Palva, J., Mansvelder, H. D. & Linkenkaer-Hansen, K., 1 Dec 2020, In : Scientific Reports. 10, 1, 9195.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): a Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase 2, Superiority Trial

Sprengers, J., Van Andel, D. M., Zuithoff, N. P. A., Keijzer-Veen, M. G., Schulp, A. J. A., Scheepers, F. E., Lilien, M. R., Oranje, B. & Bruining, H., 2020, (Accepted/In press) In : Journal of the American Academy of Child and Adolescent Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Genetic mapping in mice reveals the involvement of Pcdh9 in long-term social and object recognition and sensorimotor development

Bruining, H., Matsui, A., Oguro-Ando, A., Kahn, R. S., Van'T Spijker, H. M., Akkermans, G., Stiedl, O., Van Engeland, H., Koopmans, B., Van Lith, H. A., Oppelaar, H., Tieland, L., Nonkes, L. J., Yagi, T., Kaneko, R., Burbach, J. P. H., Yamamoto, N. & Kas, M. J., 1 Oct 2015, In : Biological Psychiatry. 78, 7, p. 485-495 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice

Molenhuis, R. T., Bruining, H., Brandt, M. J. V., Van Soldt, P. E., Abu-Toamih Atamni, H. J., Burbach, J. P. H., Iraqi, F. A., Mott, R. F. & Kas, M. J. H., 13 Dec 2018, In : Molecular Autism. 9, 1, 63.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The parent-of-origin of the extra X chromosome may differentially affect psychopathology in klinefelter syndrome

Bruining, H., Van Rijn, S., Swaab, H., Giltay, J., Kates, W., Kas, M. J. H., Van Engeland, H. & De Sonneville, L., 15 Dec 2010, In : Biological Psychiatry. 68, 12, p. 1156-1162 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Activities

  • 1 Membership of committee

Pediatrics (Organisational unit)

Hilgo Bruining (Chair)
20182021

Activity: MembershipMembership of committee

Press / Media

Interview Vrij Nederland on precision psychiatry

Hilgo Bruining

17/06/2020

1 Media contribution

Press/Media: Interview

Interview Balans magazine on drug development for autism

Hilgo Bruining

01/02/2018

1 Media contribution

Press/Media: Interview

Interview Dutch television (MAX, NPO 1) “Geef om je Hersenen”

Hilgo Bruining

01/08/2017

1 Media contribution

Press/Media: Public Engagement Activities

Interview Hersenmagazine on sensory processing

Hilgo Bruining

01/08/2017

1 Media contribution

Press/Media: Interview

Prizes