20022020

Research output per year

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Research Output

2014

What Explains Gray Matter Atrophy in Long-standing Multiple Sclerosis?

Steenwijk, M. D., Daams, M., Pouwels, P. J. W., Balk, L. J., Tewarie, P. K., Killestein, J., Uitdehaag, B. M. J., Geurts, J. J. G., Barkhof, F. & Vrenken, H., 2014, In : Radiology. 272, 3, p. 832-842

Research output: Contribution to journalArticleAcademicpeer-review

2013

Accurate white matter lesion segmentation by k nearest neighbor classification with tissue type priors (kNN-TTPs)

Steenwijk, M. D., Pouwels, P. J., Daams, M., van Dalen, J. W., Caan, M. W., Richard, E., Barkhof, F. & Vrenken, H., 2013, In : NeuroImage: Clinical. 3, p. 462-469

Research output: Contribution to journalArticleAcademicpeer-review

Brain atrophy and lesion load predict long term disability in multiple sclerosis

Popescu, V., Agosta, F., Hulst, H. E., Sluimer, I. C., Knol, D. L., Sormani, M. P., Enzinger, C., Ropele, S., Alonso, J., Sastre-Garriga, J., Rovira, A., Montalban, X., Bodini, B., Ciccarelli, O., Khaleeli, Z., Chard, D. T., Matthews, L., Palace, J., Giorgio, A., De Stefano, N. & 9 others, Eisele, P., Gass, A., Polman, C. H., Uitdehaag, B. M. J., Messina, M. J., Comi, G., Filippi, M., Barkhof, F. & Vrenken, H., 2013, In : Journal of Neurology, Neurosurgery and Psychiatry. 84, 10, p. 1082-1091

Research output: Contribution to journalArticleAcademicpeer-review

Different patterns of gray matter atrophy in early- and late-onset Alzheimer's disease

Möller, C., Vrenken, H., Jiskoot, L., Versteeg, A., Barkhof, F., Scheltens, P. & van der Flier, W. M., 2013, In : Neurobiology of Aging. 34, 8, p. 2014-2022

Research output: Contribution to journalArticleAcademicpeer-review

Functional connectivity changes in multiple sclerosis patients: A graph analytical study of MEG resting state data

Schoonheim, M. M., Geurts, J. J. G., Landi, D., Douw, L., van der Meer, M. L., Vrenken, H., Polman, C. H., Barkhof, F. & Stam, C. J., 2013, In : Human Brain Mapping. 34, 1, p. 52-61

Research output: Contribution to journalArticleAcademicpeer-review

Metabolite changes in radiologically isolated syndrome: more pathology than meets the eye?

Okuda, D. T. & Vrenken, H., 2013, In : Neurology. 80, 23, p. 2084-2085

Research output: Contribution to journalArticleAcademicpeer-review

Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis

Vrenken, H., Jenkinson, M., Horsfield, M. A., Battaglini, M., van Schijndel, R. A., Rostrup, E., Geurts, J. J. G., Fisher, E., Zijdenbos, A., Ashburner, J., Miller, D. H., Filippi, M., Fazekas, F., Rovaris, M., Rovira, A., Barkhof, F. & De Stefano, N., 2013, In : Journal of Neurology. 260, 10, p. 2458-2471

Research output: Contribution to journalArticleAcademicpeer-review

Relevance of Spinal Cord Abnormalities to Clinical Disability in Multiple Sclerosis: MR Imaging Findings in a Large Cohort of Patients

Lukas, C., Sombekke, M. H., Bellenberg, B., Hahn, H. K., Popescu, V., Bendfeldt, K., Radue, E. W., Gass, A., Borgwardt, S. J., Kappos, L., Naegelin, Y., Knol, D. L., Polman, C. H., Geurts, J. J. G., Barkhof, F. & Vrenken, H., 2013, In : Radiology. 269, 2, p. 541-551

Research output: Contribution to journalArticleAcademicpeer-review

Single-Subject Grey Matter Graphs in Alzheimer's Disease

Tijms, B. M., Moller, C., Vrenken, H., Wink, A. M., de Haan, W., van der Flier, W. M., Stam, C. J., Scheltens, P. & Barkhof, F., 2013, In : PLoS ONE. 8, 3, p. e58921 e58921.

Research output: Contribution to journalArticleAcademicpeer-review

Spinal cord lesions in patients with clinically isolated syndrome A powerful tool in diagnosis and prognosis

Sombekke, M. H., Wattjes, M. P., Balk, L. J., Nielsen, J. M., Vrenken, H., Uitdehaag, B. M. J., Polman, C. H. & Barkhof, F., 2013, In : Neurology. 80, 1, p. 69-75

Research output: Contribution to journalArticleAcademicpeer-review

2012

Can the performance of the FSL/Siena whole brain atrophy measure be improved at 3T and 1.5T on ADNI back-to-back MPRAGES by using a non-default settings?

Cover, K., van Schijndel, R., Popescu, V., van Dijk, B., Redolfi, A., Knol, D., Frisoni, G. B., Barkhof, F. & Vrenken, H., 19 Jul 2012, p. P338.

Research output: Contribution to conferenceAbstractAcademic

Gender-related differences in functional connectivity in multiple sclerosis

Schoonheim, M. M., Hulst, H. E., Landi, D., Ciccarelli, O., Roosendaal, S. D., Sanz-Arigita, E. J., Vrenken, H., Polman, C. H., Stam, C. J., Barkhof, F. & Geurts, J. J. G., 2012, In : Multiple Sclerosis. 18, 2, p. 164-173

Research output: Contribution to journalArticleAcademicpeer-review

Longitudinal gray matter changes in multiple sclerosisuDifferential scanner and overall disease-related effects

Bendfeldt, K., Hofstetter, L., Kuster, P., Traud, S., Mueller-Lenke, N., Naegelin, Y., Kappos, L., Gass, A., Nichols, T. E., Barkhof, F., Vrenken, H., Roosendaal, S. D., Geurts, J. J. G., Radue, E. W. & Borgwardt, S. J., 2012, In : Human Brain Mapping. 33, 5, p. 1225-1245

Research output: Contribution to journalArticleAcademicpeer-review

Optimizing parameter choice for FSL-Brain Extraction Tool (BET) on 3D T1 images in multiple sclerosis

Popescu, V., Battaglini, M., Hoogstrate, W. S., Verfaillie, S. C. J., Sluimer, I. C., van Schijndel, R. A., van Dijk, B. W., Cover, K. S., Knol, D. L., Jenkinson, M., Barkhof, F., De Stefano, N. & Vrenken, H., 2012, In : NeuroImage. 61, 4, p. 1484-1494

Research output: Contribution to journalArticleAcademicpeer-review

Spatiotemporal distribution of white matter lesions in relapsing-remitting and secondary progressive multiple sclerosis

Filli, L., Hofstetter, L., Kuster, P., Traud, S., Mueller-Lenke, N., Naegelin, Y., Kappos, L., Gass, A., Sprenger, T., Nichols, T. E., Vrenken, H., Barkhof, F., Polman, C. H., Radue, E. W., Borgwardt, S. J. & Bendfeldt, K., 2012, In : Multiple Sclerosis. 18, 11, p. 1577-1584

Research output: Contribution to journalArticleAcademicpeer-review

Subcortical atrophy and cognition Sex effects in multiple sclerosis

Schoonheim, M. M., Popescu, V., Lopes, F. C. R., Wiebenga, O. T., Vrenken, H., Douw, L., Polman, C. H., Geurts, J. J. G. & Barkhof, F., 2012, In : Neurology. 79, 17, p. 1754-1761

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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The spatial distribution of age-related white matter changes as a function of vascular risk factors-Results from the LADIS study

Rostrup, E., Gouw, A. A., Vrenken, H., van Straaten, E. C. W., Ropele, S., Pantoni, L., Inzitari, D., Barkhof, F. & Waldemar, G., 2012, In : NeuroImage. 60, 3, p. 1597-1607

Research output: Contribution to journalArticleAcademicpeer-review

2011

Assessing the reproducibility of the SienaX and Siena brain atrophy measures using the ADNI back-to-back MP-RAGE MRI scans

Cover, K. S., van Schijndel, R. A., van Dijk, B. W., Redolfi, A., Knol, D. L., Frisoni, G. B., Barkhof, F. & Vrenken, H., 2011, In : Psychiatry Research: Neuroimaging. 193, 3, p. 182-190

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of the back-to-back reproducibility of the Siena/FSL whole brain atrophy measurement at 3T and 1.5T using the ADNI MPRAGE MRIs

Cover, K., van Schijndel, R., van Dijk, B., Redolfi, A., Knol, D., Frisoni, G. B., Barkhof, F. & Vrenken, H., 2 Aug 2011, p. S65-S66.

Research output: Contribution to conferenceAbstractAcademic

Genetic Correlations of Brain Lesion Distribution in Multiple Sclerosis: An Exploratory Study.

Sombekke, M. H., Vellinga, M. M., Uitdehaag, B. M., Barkhof, F., Polman, C. H., Arteta, D., Tejedor, D., Martinez, A., Crusius, J. B., Pena, A. S., Geurts, J. J. G. & Vrenken, H., 2011, In : American Journal of Neuroradiology. 32, 4, p. 695-703

Research output: Contribution to journalArticleAcademicpeer-review

Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability

Roosendaal, S. D., Bendfeldt, K., Vrenken, H., Polman, C. H., Borgwardt, S., Radue, E. W., Kappos, L., Pelletier, D., Hauser, S. L., Matthews, P. M., Barkhof, F. & Geurts, J. J. G., 2011, In : Multiple Sclerosis. 17, 9, p. 1098-1106

Research output: Contribution to journalArticleAcademicpeer-review

Identification of biomarkers for diagnosis and progression of MS by MALDI-TOF mass spectrometry

Teunissen, C. E., Koel-Simmelink, M. J. A., Pham, T. V., Knol, J. C., Khalil, M., Trentini, A., Killestein, J., Nielsen, J. M., Vrenken, H., Popescu, V., Dijkstra, C. D. & Jimenez, C. R., 2011, In : Multiple Sclerosis. 17, 7, p. 838-850

Research output: Contribution to journalArticleAcademicpeer-review

Imaging the tip of the iceberg: visualization of cortical lesions in multiple sclerosis

Seewann, A. M., Vrenken, H., Kooi, E. J., van der Valk, P., Knol, D. L., Polman, C. H., Pouwels, P. J. W., Barkhof, F. & Geurts, J. J. G., 2011, In : Multiple Sclerosis. 17, 10, p. 1202-1210

Research output: Contribution to journalArticleAcademicpeer-review

Relevance of IL7R genotype and mRNA expression in Dutch patients with multiple sclerosis

Sombekke, M. H., van der Voort, L. F., Kragt, J. J., Nielsen, J. M., Guzel, H., Visser, A., Oudejans, C. B. M., Crusius, J. B. A., Pena, A. S., Vrenken, H., Polman, C. H. & Killestein, J., 2011, In : Multiple Sclerosis. 17, 8, p. 922-930

Research output: Contribution to journalArticleAcademicpeer-review

Structural and molecular changes along the continuum of Alzheimer's disease

Ossenkoppele, R., Vrenken, H., Tolboom, N., Versteeg, A., van Schijndel, R., Yaqub, M., Boellaard, R., Van der Flier, W., Barkhof, F., Lammertsma, A., Scheltens, P. & van Berckel, B. N. M., 2 Aug 2011, p. S77.

Research output: Contribution to conferenceAbstractAcademic

2010

Brain volume changes in type 1 diabetes mellitus patients with microangiopathy are related to poorer cognitive functioning

Serné, E. H., Sluimer, I. C., Vrenken, H., van Duinkerken, E., IJzerman, R. G., Klein, M., Snoek, F. J., Barkhof, F. & Diamant, M., 2010, In : Diabetologia. 53

Research output: Contribution to journalMeeting AbstractOther research output

Early central atrophy rate predicts 5 year clinical outcome in multiple sclerosis

Lukas, C., Minneboo, A., de Groot, V., Moraal, B., Knol, D. L., Barkhof, F. & Vrenken, H., 2010, In : Journal of Neurology, Neurosurgery and Psychiatry. 81, p. 1351-1356

Research output: Contribution to journalArticleAcademicpeer-review

Improved Detection of Active Multiple Sclerosis Lesions: 3D Subtraction Imaging

Moraal, B., Wattjes, M. P., Geurts, J. J. G., Knol, D. L., van Schijndel, R. A., Pouwels, P. J. W., Vrenken, H. & Barkhof, F., 2010, In : Radiology. 255, 1, p. 154-163

Research output: Contribution to journalArticleAcademicpeer-review

Incidence of cerebral microbleeds A longitudinal study in a memory clinic population

Goos, J. D. C., Henneman, W. J. P., Sluimer, J. D., Vrenken, H., Sluimer, I. C., Barkhof, F., Blankenstein, M. A., Scheltens, P. & van der Flier, W. M., 2010, In : Neurology. 74, 24, p. 1954-1960

Research output: Contribution to journalArticleAcademicpeer-review

Lesional magnetization transfer ratio: a feasible outcome for remyelinating treatment trials in multiple sclerosis

van den Elskamp, I. J., Knol, D. L., Vrenken, H., Karas, G., Meijerman, A., Filippi, M., Kappos, L., Fazekas, F., Wagner, K., Pohl, C., Sandbrink, R., Polman, C. H., Uitdehaag, B. M. J. & Barkhof, F., 2010, In : Multiple Sclerosis. 16, 6, p. 660-669

Research output: Contribution to journalArticleAcademicpeer-review

Long-Interval T2-Weighted Subtraction Magnetic Resonance Imaging A Powerful New Outcome Measure in Multiple Sclerosis Trials

Moraal, B., van den Elskamp, I. J., Knol, D. L., Uitdehaag, B. M. J., Geurts, J. J. G., Vrenken, H., Pouwels, P. J. W., van Schijndel, R. A., Meier, D. S., Guttmann, C. R. G. & Barkhof, F., 2010, In : Annals of Neurology. 67, 5, p. 667-675

Research output: Contribution to journalArticleAcademicpeer-review

Neurological Signs in Relation to White Matter Hyperintensity Volumes in Memory Clinic Patient

Staekenborg, S. S., de Waal, H., Admiraal-Behloul, F., Barkhof, F., Reiber, J. H. C., Scheltens, P., Pijnenburg, Y. A. L., Vrenken, H. & van der Flier, W. M., 2010, In : Dementia and Geriatric Cognitive Disorders. 29, 4, p. 301-308

Research output: Contribution to journalArticleAcademicpeer-review

Reduced Orbitofrontal and Parietal Gray Matter in Chronic Insomnia: A Voxel-Based Morphometric Study

Altena, E., Vrenken, H., van der Werf, Y. D., van den Heuvel, O. A. & van Someren, E. J. W., 2010, In : Biological Psychiatry. 67, 2, p. 182-185

Research output: Contribution to journalArticleAcademicpeer-review

Structural and Functional Hippocampal Changes in Multiple Sclerosis Patients with Intact Memory Function

Roosendaal, S. D., Hulst, H. E., Vrenken, H., Feenstra, H. E. M., Castelijns, J. A., Pouwels, P. J. W., Barkhof, F. & Geurts, J. J. G., 2010, In : Radiology. 255, 2, p. 595-604

Research output: Contribution to journalArticleAcademicpeer-review

Toward understanding cortical lesions in multiple sclerosis

Geurts, J. J. G. & Vrenken, H., 2010, In : Neurology. 75, 14, p. 1224-1225

Research output: Contribution to journalArticleAcademicpeer-review

Whole-brain atrophy rate and CSF biomarker levels in MCI and AD: A longitudinal study

Sluimer, J. D., Bouwman, F. H., Vrenken, H., Blankenstein, M. A., Barkhof, F., van der Flier, W. M. & Scheltens, P., 2010, In : Neurobiology of Aging. 31, 5, p. 758-764

Research output: Contribution to journalArticleAcademicpeer-review

2009

Accelerating regional atrophy rates in the progression from normal aging to Alzheimer's disease

Sluimer, J. D., van der Flier, W. M., Karas, G., van Schijndel, R. A., Barnes, J., Boyes, R. G., Cover, K. S., Olabarriaga, S. D., Fox, N. C. I., Scheltens, P., Vrenken, H. & Barkhof, F., 2009, In : European Radiology. 19, 12, p. 2826-2833

Research output: Contribution to journalArticleAcademicpeer-review

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A search for new MRI criteria for dissemination in space in subjects with a clinically isolated syndrome

Korteweg, T., Tintore, M., Uitdehaag, B. M. J., Knol, D. L., Vrenken, H., Rovira, A., Frederiksen, J., Miller, D. H., Fernando, K., Filippi, M., Agosta, F., Rocca, M. A., Fazekas, F., Enzinger, C., Parry, A., Polman, C. H., Montalban, X. & Barkhof, F., 2009, In : European Radiology. 19, 9, p. 2244-2248

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Association between MRI parameters and the MS severity scale: a 12 year follow-up study

Minneboo, A., Uitdehaag, B. M. J., Jongen, P., Vrenken, H., Knol, D. L., van Walderveen, M. A. A., Polman, C. H., Castelijns, J. A. & Barkhof, F., 2009, In : Multiple Sclerosis. 15, 5, p. 632-637

Research output: Contribution to journalArticleAcademicpeer-review

Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease

Henneman, W. J. P., Vrenken, H., Barnes, J., Sluimer, J. D., Verwey, N. A., Blankenstein, M. A., Klein, M., Fox, N. C. I., Scheltens, P., Barkhof, F. & van der Flier, W. M., 2009, In : Neurology. 73, 12, p. 935-940

Research output: Contribution to journalArticleAcademicpeer-review

Can rate of brain atrophy in multiple sclerosis be explained by clinical and MRI characteristics?

Korteweg, T., Rovaris, M., Neacsu, V., Filippi, M., Comi, G., Uitdehaag, B. M., Knol, D., Polman, C. H., Barkhof, F. & Vrenken, H., 2009, In : Multiple Sclerosis. 15, 4, p. 465-471

Research output: Contribution to journalArticleAcademicpeer-review

Clinical Correlations of Brain Lesion Distribution in Multiple Sclerosis

Vellinga, M. M., Geurts, J. J. G., Rostrup, E., Uitdehaag, B. M. J., Polman, C. H., Barkhof, F. & Vrenken, H., 2009, In : Journal of Magnetic Resonance Imaging. 29, 4, p. 768-773

Research output: Contribution to journalArticleAcademicpeer-review

Diagnostic Imaging of Patients in a Memory Clinic: Comparison of MR Imaging and 64-Detector Row CT

Wattjes, M. P., Henneman, W. J. P., van der Flier, W. M., de Vries, O. J., Traber, F., Geurts, J. J. G., Scheltens, P., Vrenken, H. & Barkhof, F., 2009, In : Radiology. 253, 1, p. 174-183

Research output: Contribution to journalArticleAcademicpeer-review

Diffusely Abnormal White Matter in Chronic Multiple Sclerosis Imaging and Histopathologic Analysis

Seewann, A. M., Vrenken, H., van der Valk, P., Blezer, E. L. A., Knol, D. L., Castelijns, J. A., Polman, C. H., Pouwels, P. J. W., Barkhof, F. & Geurts, J. J. G., 2009, In : Archives of Neurology. 66, 5, p. 601-609

Research output: Contribution to journalArticleAcademicpeer-review

Diffusely abnormal white matter in progressive multiple sclerosis: in vivo quantitative MR characterisation and comparison between disease types

Vrenken, H., Seewann, A. M., Knol, D. L., Polman, C. H., Barkhof, F. & Geurts, J. J. G., 2009, In : Multiple Sclerosis. 15, 9, p. S110-S111

Research output: Contribution to journalMeeting AbstractOther research output