Iris Jansen

20112019
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Research Output 2011 2019

  • 23 Article
  • 1 Research VU University Amsterdam, graduation VU University Amsterdam
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Article
2019

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB) & The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease

Broce, I. J., Tan, C. H., Fan, C. C., Jansen, I., Savage, J. E., Witoelar, A., Wen, N., Hess, C. P., Dillon, W. P., Glastonbury, C. M., Glymour, M., Yokoyama, J. S., Elahi, F. M., Rabinovici, G. D., Miller, B. L., Mormino, E. C., Sperling, R. A., Bennett, D. A., McEvoy, L. K., Brewer, J. B. & 14 othersFeldman, H. H., Hyman, B. T., Pericak-Vance, M., Haines, J. L., Farrer, L. A., Mayeux, R., Schellenberg, G. D., Yaffe, K., Sugrue, L. P., Dale, A. M., Posthuma, D., Andreassen, O. A., Karch, C. M. & Desikan, R. S., 11 Feb 2019, In : Acta Neuropathologica. 137, 2, p. 209-226 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

Jansen, I. E., Savage, J. E., Watanabe, K., Bryois, J., Williams, D. M., Steinberg, S., Sealock, J., Karlsson, I. K., Hägg, S., Athanasiu, L., Voyle, N., Proitsi, P., Witoelar, A., Stringer, S., Aarsland, D., Almdahl, I. S., Andersen, F., Bergh, S., Bettella, F., Bjornsson, S. & 33 othersBrækhus, A., Bråthen, G., de Leeuw, C., Desikan, R. S., Djurovic, S., Dumitrescu, L., Fladby, T., Hohman, T. J., Jonsson, P. V., Kiddle, S. J., Rongve, A., Saltvedt, I., Sando, S. B., Selbæk, G., Shoai, M., Skene, N. G., Snaedal, J., Stordal, E., Ulstein, I. D., Wang, Y., White, L. R., Hardy, J., Hjerling-Leffler, J., Sullivan, P. F., van der Flier, W. M., Dobson, R., Davis, L. K., Stefansson, H., Stefansson, K., Pedersen, N. L., Ripke, S., Andreassen, O. A. & Posthuma, D., 2019, In : Nature Genetics.

Research output: Contribution to journalArticleAcademicpeer-review

Repeat length variations in ATXN1 and AR modify disease expression in Alzheimer's disease

Gardiner, S. L., Harder, A. V. E., Campman, Y. J. M., Trompet, S., Gussekloo, J., van Belzen, M. J., Boogaard, M. W., Roos, R. A. C., Jansen, I. E., Pijnenburg, Y. A. L., Scheltens, P., van der Flier, W. M. & Aziz, N. A., 1 Jan 2019, In : Neurobiology of Aging. 73, p. 230.e9-230.e17

Research output: Contribution to journalArticleAcademicpeer-review

2018

The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects

Blauwendraat, C., Wilke, C., Simón-Sánchez, J., Jansen, I. E., Reifschneider, A., Capell, A., Haass, C., Castillo-Lizardo, M., Biskup, S., Maetzler, W., Rizzu, P., Heutink, P. & Synofzik, M., Feb 2018, In : Genetics in Medicine. 20, 2, p. 240-249 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Cerebrospinal Fluid Progranulin, but Not Serum Progranulin, Is Reduced in GRN-Negative Frontotemporal Dementia

Wilke, C., Gillardon, F., Deuschle, C., Hobert, M. A., Jansen, I. E., Metzger, F. G., Heutink, P., Gasser, T., Maetzler, W., Blauwendraat, C. & Synofzik, M., 1 Feb 2017, In : Neurodegenerative Diseases. 17, 2-3, p. 83-88 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

Jansen, I. E., Ye, H., Heetveld, S., Lechler, M. C., Michels, H., Seinstra, R. I., Lubbe, S., Drouet, V., Lesage, S., Majounie, E., Gibbs, J. R., Nalls, M. A., Ryten, M., Botia, J. A., Vandrovcova, J., Simon-Sanchez, J., Castillo-Lizardo, M., Rizzu, P., Blauwendraat, C., Chouhan, A. K. & 13 othersLi, Y., Yogi, P., Amin, N., van Duijn, C. M., Morris, H. R., Brice, A., Singleton, A. B., David, D. C., Nollen, E. A., Jain, S., Shulman, J. M., Heutink, P. & International Parkinson's Disease Genetics Consortium (IPGDC), 30 Jan 2017, In : Genome Biology. 18, 1, 22.

Research output: Contribution to journalArticleAcademicpeer-review

Establishing the role of rare coding variants in known Parkinson's disease risk loci

Jansen, I. E., Gibbs, J. R., Nalls, M. A., Price, T. R., Lubbe, S., van Rooij, J., Uitterlinden, A. G., Kraaij, R., Williams, N. M., Brice, A., Hardy, J., Wood, N. W., Morris, H. R., Gasser, T., Singleton, A. B., Heutink, P., Sharma, M. & International Parkinson's Disease Genomics Consortium, 1 Nov 2017, In : Neurobiology of Aging. 59, p. 220.e11-220.e18

Research output: Contribution to journalArticleAcademicpeer-review

Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease

Robak, L. A., Jansen, I. E., van Rooij, J., Uitterlinden, A. G., Kraaij, R., Jankovic, J., Heutink, P., Shulman, J. M., International Parkinson’s Disease Genomics Consortium (IPDGC), IPDGC Consortium members & International Parkinson’s Disease Genomics Consortium (IPDGC), 1 Dec 2017, In : Brain : a journal of neurology. 140, 12, p. 3191-3203 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genome-wide pleiotropy between Parkinson disease and autoimmune diseases

Witoelar, A., Jansen, I. E., Wang, Y., Desikan, R. S., Gibbs, J. R., Blauwendraat, C., Thompson, W. K., Hernandez, D. G., Djurovic, S., Schork, A. J., Bettella, F., Ellinghaus, D., Franke, A., Lie, B. A., McEvoy, L. K., Karlsen, T. H., Lesage, S., Morris, H. R., Brice, A., Wood, N. W. & 8 othersHeutink, P., Hardy, J., Singleton, A. B., Dale, A. M., Gasser, T., Andreassen, O. A., Sharma, M. & or the International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), and United Kingdom Brain Expression Consortium (UKBEC) Investigators, 1 Jul 2017, In : JAMA Neurology. 74, 7, p. 780-792 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lack of evidence for a role of genetic variation in TMEM230 in the risk for Parkinson's disease in the Caucasian population

Giri, A., Mok, K. Y., Jansen, I., Sharma, M., Tesson, C., Mangone, G., Lesage, S., Bras, J. M., Shulman, J. M., Sheerin, U. M., Díez-Fairen, M., Pastor, P., Martí, M. J., Ezquerra, M., Tolosa, E., Correia-Guedes, L., Ferreira, J., Amin, N., van Duijn, C. M., van Rooij, J. & 5 othersUitterlinden, A. G., Kraaij, R., Nalls, M., Simón-Sánchez, J. & International Parkinson's Disease Consortium (IPDGC), 1 Feb 2017, In : Neurobiology of Aging. 50, p. 167.e11-167.e13

Research output: Contribution to journalArticleAcademicpeer-review

Prediction of cognition in Parkinson's disease with a clinical–genetic score: a longitudinal analysis of nine cohorts

Liu, G., Locascio, J. J., Corvol, J. C., Boot, B., Liao, Z., Page, K., Franco, D., Burke, K., Jansen, I. E., Trisini-Lipsanopoulos, A., Winder-Rhodes, S., Tanner, C. M., Lang, A. E., Eberly, S., Elbaz, A., Brice, A., Mangone, G., Ravina, B., Shoulson, I., Cormier-Dequaire, F. & 6 othersHeutink, P., van Hilten, J. J., Barker, R. A., Williams-Gray, C. H., Marinus, J. & Scherzer, C. R., 1 Aug 2017, In : The Lancet Neurology. 16, 8, p. 620-629 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: Evidence for oligogenic inheritance

Lubbe, S. J., Escott-Price, V., Gibbs, J. R., Nalls, M. A., Bras, J., Price, T. R., Nicolas, A., Jansen, I. E., Mok, K. Y., Pittman, A. M., Tomkins, J. E., Lewis, P. A., Noyce, A. J., Lesage, S., Sharma, M., Schiff, E. R., Levine, A. P., Brice, A., Gasser, T., Hardy, J. & 5 othersHeutink, P., Wood, N. W., Singleton, A. B., Williams, N. M. & Morris, H. R., 15 Dec 2016, In : Human Molecular Genetics. 25, 24, p. 5483-5489 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe

Blauwendraat, C., Francescatto, M., Gibbs, J. R., Jansen, I. E., Simón-Sánchez, J., Hernandez, D. G., Dillman, A. A., Singleton, A. B., Cookson, M. R., Rizzu, P. & Heutink, P., 10 Jun 2016, In : Genome Medicine. 8, 1, 65.

Research output: Contribution to journalArticleAcademicpeer-review

Pilot whole-exome sequencing of a German early-onset Alzheimer's disease cohort reveals a substantial frequency of PSEN2 variants

Blauwendraat, C., Wilke, C., Jansen, I. E., Schulte, C., Simón-Sánchez, J., Metzger, F. G., Bender, B., Gasser, T., Maetzler, W., Rizzu, P., Heutink, P. & Synofzik, M., 1 Jan 2016, In : Neurobiology of Aging. 37, p. 208.e11-208.e18

Research output: Contribution to journalArticleAcademicpeer-review

Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's

Liu, G., Boot, B., Locascio, J. J., Jansen, I. E., Winder-Rhodes, S., Eberly, S., Elbaz, A., Brice, A., Ravina, B., van Hilten, J. J., Cormier-Dequaire, F., Corvol, J. C., Barker, R. A., Heutink, P., Marinus, J., Williams-Gray, C. H., Scherzer, C. R., Scherzer, C., Hyman, B. T., Ivinson, A. J. & 67 othersTrisini-Lipsanopoulos, A., Franco, D., Burke, K., Sudarsky, L. R., Hayes, M. T., Umeh, C. C., Growdon, J. H., Schwarzschild, M. A., Hung, A. Y., Flaherty, A. W., Wills, A. M., Mejia, N. I., Gomperts, S. N., Khurana, V., Selkoe, D. J., Yi, T., Page, K., Liao, Z., Barker, R., Foltynie, T., Williams-Gray, C. H., Mason, S., Winder-Rhodes, S., Barker, R., Williams-Gray, C. H., Breen, D., Cummins, G., Evans, J., Winder-Rhodes, S., Corvol, J. C., Brice, A., Elbaz, A., Mallet, A., Vidailhet, M., Bonnet, A. M., Bonnet, C., Grabli, D., Hartmann, A., Klebe, S., Lacomblez, L., Mangone, G., Bourdain, F., Brandel, J. P., Derkinderen, P., Durif, F., Mesnage, V., Pico, F., Rascol, O., Forlani, S., Lesage, S., Tahiri, K., van Hilten, J. J., Marinus, J., Liao, Z., Page, K., Franco, D., Duong, K., Yi, T., Trisini-Lipsanopoulos, A., Dong, X., Sudarsky, L. R., Hutten, S. J., Amr, S. S., Shoulson, I., Tanner, C. M., Lang, A. E. & Nalls, M. A., 1 Nov 2016, In : Annals of Neurology. 80, 5, p. 674-685 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015

CHCHD2 and Parkinson's disease

Jansen, I. E., Bras, J. M., Lesage, S., Schulte, C., Gibbs, J. R., Nalls, M. A., Brice, A., Wood, N. W., Morris, H., Hardy, J. A., Singleton, A. B., Gasser, T., Heutink, P. & Sharma, M., 2015, In : Lancet Neurology. 14, 7, p. 678-679

Research output: Contribution to journalArticleAcademicpeer-review

EIF4G1 mutations do not cause Parkinson's disease

Nichols, N., Bras, J. M., Hernandez, D. G., Jansen, I. E., Lesage, S., Lubbe, S. & Singleton, A. B., 2015, In : Neurobiology of Aging. 36, 8, p. 2444.e1-2444.e4

Research output: Contribution to journalArticleAcademicpeer-review

NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases

Nalls, M. A., Bras, J., Hernandez, D. G., Keller, M. F., Majounie, E., Renton, A. E., Saad, M., Jansen, I. E., Guerreiro, R., Lubbe, S., Plagnol, V., Gibbs, J. R., Schulte, C., Pankratz, N., Sutherland, M., Bertram, L., Lill, C. M., DeStefano, A. L., Faroud, T., Eriksson, N. & 14 othersTung, J. Y., Edsall, C., Nichols, N., Brooks, J., Arepalli, S., Pliner, H., Letson, C., Heutink, P., Martinez, M., Gasser, T., Traynor, B. J., Wood, N., Hardy, J. & Singleton, A. B., 2015, In : Neurobiology of Aging. 36, 3, p. 1605.e7-1605.e12

Research output: Contribution to journalArticleAcademicpeer-review

2014

A Twin-Sibling Study on the Relationship Between Exercise Attitudes and Exercise Behavior

Huppertz, C., Bartels, M., Jansen, I. E., Boomsma, D. I., Willemsen, G., de Moor, M. H. M. & de Geus, E. J. C., 2014, In : Behavior Genetics. 44, 1, p. 45-55 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

C9orf72; abnormal RNA expression is the key

Heutink, P., Jansen, I. E. & Lynes, E. M., 2014, In : Experimental Neurology. 262, p. 102-110

Research output: Contribution to journalArticleAcademicpeer-review

2011

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

Renton, A. E., Majounie, E., Waite, A., Simon-Sanchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., Kalimo, H., Paetau, A., Abramzon, Y., Remes, A. M., Kaganovich, A., Scholz, S. W., Duckworth, J., Ding, J. H., Harmer, D. W., Hernandez, D. G. & 56 othersJohnson, J. O., Mok, K., Ryten, M., Trabzuni, D., Guerreiro, R. J., Orrell, R. W., Neal, J., Murray, A., Pearson, J., Jansen, I. E., Sondervan, D., Seelaar, H., Blake, D., Young, K., Halliwell, N., Callister, J. B., Toulson, G., Richardson, A., Gerhard, A., Snowden, J., Mann, D., Neary, D., Nalls, M. A., Peuralinna, T., Jansson, L., Isoviita, V. M., Kaivorinne, A. L., Holtta-Vuori, M., Ikonen, E., Sulkava, R., Benatar, M., Wuu, J., Chio, A., Restagno, G., Borghero, G., Sabatelli, M., Heckerman, D., Rogaeva, E., Zinman, L., Rothstein, J. D., Sendtner, M., Drepper, C., Eichler, E. E., Alkan, C., Abdullaev, Z., Pack, S. D., Dutra, A., Pak, E., Hardy, J., Singleton, A., Williams, N. M., Heutink, P., Pickering-Brown, S., Morris, H. R., Tienari, P. J. & Traynor, B. J., 2011, In : Neuron. 72, 2, p. 257-268

Research output: Contribution to journalArticleAcademicpeer-review