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Personal profile

Research interests

Prof. Middeldorp has a biochemistry (MSc 1980) and transplantation infectious disease background (University Hospital Groningen; PhD 1985).
He specialized in molecular virology-immunology with the aim of understanding virus-driven diseases and developing novel diagnostic and therapeutic approaches.
Following a 15 year carrier in diagnostic industry (Organon - bioMérieux), he founded a spin-off company (www.cyto-barr.com) in 2000 and returned for 0.5fte to academics (VU University medical center, Amsterdam) to further explore the molecular basis of multiple EBV-linked diseases and associated diagnostic -therapeutic applications, with a special focus on EBV-driven cancers.
He is (co-)author on >250 peer-reviewed publications and (co-) inventor on 8 patent families.

External positions

CEO, Cyto-Barr BV

1 Apr 2000 → …

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Research Output

Differences in the Epstein-Barr Virus gp350 IgA Antibody Response Are Associated With Increased Risk for Coinfection With a Second Strain of Epstein-Barr Virus

Smith, N. A., Baresel, P. C., Jackson, C. L., Ogolla, S., Toko, E. N., Heit, S., Piriou, E., Sumba, O. P., Middeldorp, J. M., Colborn, K. L. & Rochford, R., 2019, In : Journal of Infectious Diseases. 219, 6, p. 955-963

Research output: Contribution to journalArticleAcademicpeer-review

Multilaboratory Assessment of Epstein-Barr Virus Serologic Assays: the Case for Standardization

Liu, Z., Yu, K. J., Coghill, A. E., Brenner, N., Cao, S-M., Chen, C-J., Chen, Y., Doolan, D. L., Hsu, W-L., Labo, N., Middeldorp, J. M., Miley, W., Simon, J., Wang, C-P., Waterboer, T., Whitby, D., Xie, S-H., Ye, W. & Hildesheim, A., 1 Jan 2019, In : Journal of Clinical Microbiology. 57, 11, e01107-19.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Reactivation of Epstein-Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function

Jiang, L., Lung, H. L., Huang, T., Lan, R., Zha, S., Chan, L. S., Thor, W., Tsoi, T-H., Chau, H-F., Boreström, C., Cobb, S. L., Tsao, S. W., Bian, Z-X., Law, G-L., Wong, W-T., Tai, W. C-S., Chau, W. Y., du, Y., Tang, L. H. X., Chiang, A. K. S. & 5 others, Middeldorp, J. M., Lo, K-W., Mak, N. K., Long, N. J. & Wong, K-L., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 52, p. 26614-26624

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Vesicle-bound EBV-BART13-3p miRNA in circulation distinguishes nasopharyngeal from other head and neck cancer and asymptomatic EBV-infections

Ramayanti, O., Verkuijlen, S. A. W. M., Novianti, P., Scheepbouwer, C., Misovic, B., Koppers-Lalic, D., van Weering, J., Beckers, L., Adham, M., Martorelli, D., Middeldorp, J. M. & Pegtel, D. M., 15 May 2019, In : International Journal of Cancer. 144, 10, p. 2555-2566 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

Verweij, F. J., Bebelman, M. P., Jimenez, C. R., Garcia-Vallejo, J. J., Janssen, H., Neefjes, J., Knol, J. C., de Goeij-de Haas, R., Piersma, S. R., Baglio, S. R., Verhage, M., Middeldorp, J. M., Zomer, A., van Rheenen, J., Coppolino, M. G., Hurbain, I., Raposo, G., Smit, M. J., Toonen, R. F. G., van Niel, G. & 1 others, Pegtel, D. M., 5 Mar 2018, In : Journal of Cell Biology. 217, 3, p. 1157

Research output: Contribution to journalErratumAcademicpeer-review