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Personal profile

Research interests

Prof. Middeldorp has a biochemistry (MSc 1980) and transplantation infectious disease background (University Hospital Groningen; PhD 1985).
He specialized in molecular virology-immunology with the aim of understanding virus-driven diseases and developing novel diagnostic and therapeutic approaches.
Following a 15 year carrier in diagnostic industry (Organon - bioMérieux), he founded a spin-off company (www.cyto-barr.com) in 2000 and returned for 0.5fte to academics (VU University medical center, Amsterdam) to further explore the molecular basis of multiple EBV-linked diseases and associated diagnostic -therapeutic applications, with a special focus on EBV-driven cancers.
He is (co-)author on >250 peer-reviewed publications and (co-) inventor on 8 patent families.

External positions

CEO, Cyto-Barr BV

1 Apr 2000 → …

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Research Output

Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom

Kuri, A., Jacobs, B. M., Jacobs, B. M., Vickaryous, N., Pakpoor, J., Middeldorp, J., Giovannoni, G., Dobson, R. & Dobson, R., 12 Jun 2020, In : BMC Public Health. 20, 1, 912.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Conventional and novel diagnostic biomarkers and approaches for detection of nasopharyngeal carcinoma

Chen, H., Ji, M., Zong, J. F., Ko, J. M. Y., Dai, W., Lung, M. L. & Middeldorp, J. M., 1 Jan 2019, Nasopharyngeal Carcinoma: From Etiology to Clinical Practice. Elsevier, p. 129-153 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Differences in the Epstein-Barr Virus gp350 IgA Antibody Response Are Associated With Increased Risk for Coinfection With a Second Strain of Epstein-Barr Virus

Smith, N. A., Baresel, P. C., Jackson, C. L., Ogolla, S., Toko, E. N., Heit, S., Piriou, E., Sumba, O. P., Middeldorp, J. M., Colborn, K. L. & Rochford, R., 2019, In : Journal of Infectious Diseases. 219, 6, p. 955-963

Research output: Contribution to journalArticleAcademicpeer-review

Multilaboratory Assessment of Epstein-Barr Virus Serologic Assays: the Case for Standardization

Liu, Z., Yu, K. J., Coghill, A. E., Brenner, N., Cao, S-M., Chen, C-J., Chen, Y., Doolan, D. L., Hsu, W-L., Labo, N., Middeldorp, J. M., Miley, W., Simon, J., Wang, C-P., Waterboer, T., Whitby, D., Xie, S-H., Ye, W. & Hildesheim, A., 1 Jan 2019, In : Journal of Clinical Microbiology. 57, 11, e01107-19.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Reactivation of Epstein-Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function

Jiang, L., Lung, H. L., Huang, T., Lan, R., Zha, S., Chan, L. S., Thor, W., Tsoi, T-H., Chau, H-F., Boreström, C., Cobb, S. L., Tsao, S. W., Bian, Z-X., Law, G-L., Wong, W-T., Tai, W. C-S., Chau, W. Y., du, Y., Tang, L. H. X., Chiang, A. K. S. & 5 others, Middeldorp, J. M., Lo, K-W., Mak, N. K., Long, N. J. & Wong, K-L., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 52, p. 26614-26624

Research output: Contribution to journalArticleAcademicpeer-review

Open Access