Jack van Horssen

DR., (Principal Investigator)

20012020

Research output per year

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Research Output

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2020

Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination

Houben, E., Janssens, K., Hermans, D., Vandooren, J., van den Haute, C., Schepers, M., Vanmierlo, T., Lambrichts, I., van Horssen, J., Baekelandt, V., Opdenakker, G., Baron, W., Broux, B., Slaets, H. & Hellings, N., 3 Mar 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 5028-5038 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2019

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology

Derada Troletti, C., Fontijn, R. D., Gowing, E., Charabati, M., van Het Hof, B., Didouh, I., van der Pol, S. M. A., Geerts, D., Prat, A., van Horssen, J., Kooij, G. & de Vries, H. E., 1 Feb 2019, In : Cell Death and Disease. 10, 2, 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions

Wetzels, S., Vanmierlo, T., Scheijen, J. L. J. M., van Horssen, J., Amor, S., Somers, V., Schalkwijk, C. G., Hendriks, J. J. A. & Wouters, K., 2019, In : Frontiers in Immunology. 10, p. 855

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Reactive astrocytes in multiple sclerosis impair neuronal outgrowth through TRPM7-mediated chondroitin sulfate proteoglycan production

Kamermans, A., Planting, K. E., Jalink, K., van Horssen, J. & de Vries, H. E., 1 Jan 2019, In : GLIA. 67, 1, p. 68-77 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype

Kamermans, A., Verhoeven, T., van het Hof, B., Koning, J. J., Borghuis, L., Witte, M., van Horssen, J., de Vries, H. E. & Rijnsburger, M., 4 Oct 2019, In : Frontiers in Immunology. 10, 2312.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Active liver X receptor signaling in phagocytes in multiple sclerosis lesions

Mailleux, J., Vanmierlo, T., Bogie, J. F., Wouters, E., Lütjohann, D., Hendriks, J. J. & van Horssen, J., Mar 2018, In : Multiple Sclerosis. 24, 3, p. 279-289 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy

Chakraborty, A., Kamermans, A., van Het Hof, B., Castricum, K., Aanhane, E., van Horssen, J., Thijssen, V. L., Scheltens, P., Teunissen, C. E., Fontijn, R. D., van der Flier, W. M. & de Vries, H. E., 2018, In : Brain : a journal of neurology. 141, 12, p. 3377-3388 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis

Bogie, J. F., Boelen, E., Louagie, E., Delputte, P., Elewaut, D., van Horssen, J., Hendriks, J. J. & Hellings, N., Mar 2018, In : Multiple Sclerosis. 24, 3, p. 290-300 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

Leurs, C. E., Podlesniy, P., Trullas, R., Balk, L., Steenwijk, M. D., Malekzadeh, A., Piehl, F., Uitdehaag, B. M., Killestein, J., van Horssen, J. & Teunissen, C. E., 1 Apr 2018, In : Multiple Sclerosis. 24, 4, p. 472-480 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Galectin-4, a Negative Regulator of Oligodendrocyte Differentiation, Is Persistently Present in Axons and Microglia/Macrophages in Multiple Sclerosis Lesions

de Jong, C. G. H. M., Stancic, M., Pinxterhuis, T. H., van Horssen, J., van Dam, A-M., Gabius, H-J. & Baron, W., 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 11, p. 1024-1038 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Spillage of bacterial products during colon surgery increases the risk of liver metastases development in a rat colon carcinoma model

Grewal, S., Korthouwer, R., Bögels, M., Braster, R., Heemskerk, N., Budding, A. E., Pouw, S. M., van Horssen, J., Ankersmit, M., Meijerink, J., van den Tol, P., Oosterling, S., Bonjer, J., Gül, N. & van Egmond, M., 2018, In : OncoImmunology. 7, 9, p. e1461302

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?

van Horssen, J., van Schaik, P. & Witte, M., 2017, (Accepted/In press) In : Neuroscience Letters.

Research output: Contribution to journalArticleAcademicpeer-review

Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia

Lepka, K., Volbracht, K., Bill, E., Schneider, R., Rios, N., Hildebrandt, T., Ingwersen, J., Prozorovski, T., Lillig, C. H., van Horssen, J., Steinman, L., Hartung, H. P., Radi, R., Holmgren, A., Aktas, O. & Berndt, C., 1 Sep 2017, In : GLIA. 65, 9, p. 1521-1534 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Low-density lipoprotein receptor deficiency attenuates neuroinflammation through the induction of apolipoprotein E

Mailleux, J., Timmermans, S., Nelissen, K., Vanmol, J., Vanmierlo, T., van Horssen, J., Bogie, J. F. J. & Hendriks, J. J. A., 30 Nov 2017, In : Frontiers in Immunology. 8, NOV, 1701.

Research output: Contribution to journalArticleAcademicpeer-review

Oxidative injury and iron redistribution are pathological hallmarks of marmoset experimental autoimmune encephalomyelitis

Dunham, J., Bauer, J., Campbell, G. R., Mahad, D. J., van Driel, N., van der Pol, S. M. A., 't Hart, B. A., Lassmann, H., Laman, J. D., van Horssen, J. & Kap, Y. S., 2017, In : Journal of Neuropathology and Experimental Neurology. 76, 6, p. 467-478 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Oxidative stress and antioxidants in neurological diseases: Is there still hope?

Carvalho, A. N., Firuzi, O., Gama, M. J., van Horssen, J. & Saso, L., 2017, In : Current Drug Targets. 18, 6, p. 705 - 718 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination

Kuipers, H. F., Yoon, J., Van Horssen, J., Han, M. H., Bollyky, P. L., Palmer, T. D. & Steinman, L., 28 Feb 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. E1745-E1754

Research output: Contribution to journalArticleAcademicpeer-review

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

Beaino, W., Janssen, B., Kooij, G., van der Pol, S. M. A., van Het Hof, B., van Horssen, J., Windhorst, A. D. & de Vries, H. E., 22 Dec 2017, In : Journal of Neuroinflammation. 14, 1, p. 259

Research output: Contribution to journalArticleAcademicpeer-review

2016

B cells of multiple sclerosis patients induce autoreactive proinflammatory T cell responses

Fraussen, J., Claes, N., Van Wijmeersch, B., van Horssen, J., Stinissen, P., Hupperts, R. & Somers, V., Dec 2016, In : Clinical Immunology. 173, p. 124-132

Research output: Contribution to journalArticleAcademicpeer-review

Down-regulation of neuronal L1 cell adhesion molecule expression alleviates inflammatory neuronal injury

Menzel, L., Paterka, M., Bittner, S., White, R., Bobkiewicz, W., van Horssen, J., Schachner, M., Witsch, E., Kuhlmann, T., Zipp, F. & Schaefer, M. K. E., Nov 2016, In : Acta Neuropathologica. 132, 5, p. 703-720

Research output: Contribution to journalArticleAcademicpeer-review

Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis

van Horssen, J., van der Pol, S., Nijland, P., Amor, S. & Perron, H., Jul 2016, In : Multiple Sclerosis and Related Disorders. 8, p. 11-18

Research output: Contribution to journalArticleAcademicpeer-review

Oxidative stress and its impact on neurons and glia in multiple sclerosis lesions

Lassmann, H. & van Horssen, J., Mar 2016, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1862, 3, p. 506-510

Research output: Contribution to journalArticleAcademicpeer-review

Protandim protects oligodendrocytes against an oxidative insult

Lim, J. L., van der Pol, S. M. A., Baron, W., McCord, J. M., de Vries, H. E. & van Horssen, J., 1 Sep 2016, In : Antioxidants and Redox Signaling. 5, 3, 30.

Research output: Contribution to journalArticleAcademicpeer-review

S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis

Barateiro, A., Afonso, V., Santos, G., Cerqueira, J. J., Brites, D., van Horssen, J. & Fernandes, A., Aug 2016, In : Molecular Neurobiology. 53, 6, p. 3976-3991

Research output: Contribution to journalArticleAcademicpeer-review

S-Glutathionylation of Keap1: A new role for glutathione S-transferase pi in neuronal protection

Carvalho, A. N., Marques, C., Guedes, R. C., Castro-Caldas, M., Rodrigues, E., Van Horssen, J. & Gama, M. J., 1 May 2016, In : FEBS Letters. 590, 10, p. 1455-1466 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions

Nijland, P. G., Molenaar, R. J., van der Pol, S. M. A., van der Valk, P., van Noorden, C. J. F., de Vries, H. E. & van Horssen, J., 4 Dec 2015, In : Acta Neuropathologica Communinications. 3, 79.

Research output: Contribution to journalArticleAcademicpeer-review

IL-15 Amplifies the Pathogenic Properties of CD4(+)CD28(-) T Cells in Multiple Sclerosis

Broux, B., Mizee, M. R., Vanheusden, M., van der Pol, S. M. A., van Horssen, J., Van Wijmeersch, B., Somers, V., de Vries, H. E., Stinissen, P. & Hellings, N., 2015, In : Journal of Immunology. 194, 5, p. 2099-2109

Research output: Contribution to journalArticleAcademicpeer-review

Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis

Janssens, K., Van den Haute, C., Baekelandt, V., Lucas, S., van Horssen, J., Somers, V., Van Wijmeersch, B., Stinissen, P., Hendriks, J. J. A., Slaets, H. & Hellings, N., 2015, In : Brain Behavior and Immunity. 45, p. 180-188

Research output: Contribution to journalArticleAcademicpeer-review

Protective effects of monomethyl fumarate at the inflamed blood-brain barrier

Lim, J. L., van der Pol, S. M. A., Di Dio, F., van het Hof, B., Kooij, G., de Vries, H. E. & van Horssen, J., 2015, In : Microvascular Research. 105, p. 61-68

Research output: Contribution to journalArticleAcademicpeer-review

Role of Sortilin in Models of Autoimmune Neuroinflammation

Reuter, E., Weber, J., Paterka, M., Ploen, R., Breiderhoff, T., van Horssen, J., Willnow, T. E., Siffrin, V. & Zipp, F., 2015, In : Journal of Immunology. 195, 12, p. 5762-5769

Research output: Contribution to journalArticleAcademicpeer-review

Visual pathway neurodegeneration winged by mitochondrial dysfunction

Petzold, A. F. S., Nijland, P. G., Balk, L. J., Amorini, A. M., Lazzarino, G., Wattjes, M. P., Gasperini, C., van der Valk, P., Tavazzi, B. & van Horssen, J., 2015, In : Annals of Clinical and Translational Neurology. 2, 2, p. 140-150

Research output: Contribution to journalArticleAcademicpeer-review

Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis

Mizee, M. R., Nijland, P. G., van der Pol, S. M. A., Drexhage, J. A. R., Hof, B., Mebius, R., van der Valk, P., van Horssen, J., Reijerkerk, A. & de Vries, H. E., 2014, In : Acta Neuropathologica. 128, 5, p. 691-703

Research output: Contribution to journalArticleAcademicpeer-review

Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

Nijland, P. G., Witte, M. E., van het Hof, B., van der Pol, S. M. A., Bauer, J., Lassmann, H., van der Valk, P., de Vries, H. E. & van Horssen, J., 2014, In : Acta Neuropathologica Communinications. 2, p. 170 170.

Research output: Contribution to journalArticleAcademicpeer-review

ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy

Carrano, A., Snkhchyan, H., Kooij, G., van der Pol, S., van Horssen, J., Veerhuis, R., Hoozemans, J. J. M., Rozemuller, A. J. M. & de Vries, H. E., 2014, In : Neurobiology of Aging. 35, 3, p. 565-575

Research output: Contribution to journalArticleAcademicpeer-review

Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions

Nijland, P. G., Michailidou, I., Witte, M. E., Mizee, M. R., van der Pol, SM., Hof, B., Reijerkerk, A., Pellerin, L., van der Valk, P., de Vries, H. E. & van Horssen, J., 2014, In : GLIA. 62, 7, p. 1125-1141

Research output: Contribution to journalArticleAcademicpeer-review

CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG

Garcia-Vallejo, J. J., Ilarregui, J. M., Kalay, H., Chamorro, S., Koning, N., Unger, W. W. J., Ambrosini, M., Montserrat, V., Fernandes, R. J., Bruijns, S. C. M., van Weering, J. R. T., Paauw, N. J., O'Toole, T. G., van Horssen, J., van der Valk, P., Nazmi, K., Bolscher, J. G., Bajramovic, J., Dijkstra, C. D., 't Hart, B. A. & 1 others, van Kooyk, Y., 2014, In : Journal of Experimental Medicine. 211, 7, p. 1465-1483

Research output: Contribution to journalArticleAcademicpeer-review

Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-gamma and alpha B-crystallin

Bsibsi, M., Peferoen, L. A. N., Holtman, I. R., Nacken, P. J., Gerritsen, W. H., Witte, M. E., van Horssen, J., Eggen, B. J. L., van der Valk, P., Amor, S. & van Noort, J. M., 2014, In : Acta Neuropathologica. 128, 2, p. 215-229

Research output: Contribution to journalArticleAcademicpeer-review

Glutathione in multiple sclerosis: More than just an antioxidant?

Carvalho, A. N., Lim, J. L., Nijland, P. G., Witte, M. E. & van Horssen, J., 2014, In : Multiple Sclerosis. 20, 11, p. 1425-1431

Research output: Contribution to journalArticleAcademicpeer-review

Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis

Witte, M. E., Mahad, D. J., Lassmann, H. & van Horssen, J., 2014, In : Trends in Molecular Medicine. 20, 3, p. 179-187

Research output: Contribution to journalArticleAcademicpeer-review

Sperm-Associated Antigen 16 Is a Novel Target of the Humoral Autoimmune Response in Multiple Sclerosis

de Bock, L., Somers, K., Fraussen, J., Hendriks, J. J. A., van Horssen, J., Rouwette, M., Hellings, N., Villar, L. M., varez-Cermeno, J. C., Espino, M., Hupperts, R., Jongen, P., Damoiseaux, J., Verbeek, M. M., de Deyn, P. P., D'Hooghe, M., Van Wijmeersch, B., Stinissen, P. & Somers, V., 2014, In : Journal of Immunology. 193, 5, p. 2147-2156

Research output: Contribution to journalArticleAcademicpeer-review

2013

Dimethyl fumarate: a novel oral front-line therapy for multiple sclerosis treatment

van Horssen, J. & de Vries, H. E., 2013, In : Future Neurology. 8, 3, p. 247-254

Research output: Contribution to journalArticleAcademicpeer-review

Human Endogenous Retrovirus Type W Envelope Protein Inhibits Oligodendroglial Precursor Cell Differentiation

Kremer, D., Schichel, T., Forster, M., Tzekova, N., Bernard, C., van der Valk, P., van Horssen, J., Hartung, H. P., Perron, H. & Kury, P., 2013, In : Annals of Neurology. 74, 5, p. 721-732

Research output: Contribution to journalArticleAcademicpeer-review

Identification of coronin-1a as a novel antibody target for clinically isolated syndrome and multiple sclerosis

Rouwette, M., Noben, J. P., van Horssen, J., Van Wijmeersch, B., Hupperts, R., Jongen, P. J., Verbeek, M. M., de Deyn, P. P., Stinissen, P. & Somers, V., 2013, In : Journal of Neurochemistry. 126, 4, p. 483-492

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

Vogel, D. Y. S., Vereyken, E. J. F., Glim, J. E., Heijnen, D. A. M., Moeton, M., van der Valk, P., Amor, S., Teunissen, C. E., van Horssen, J. & Dijkstra, C. D., 2013, In : Journal of Neuroinflammation. 10, p. 35 35.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Myelin alters the inflammatory phenotype of macrophages by activating PPARs

Bogie, J. F., Jorissen, W., Mailleux, J., Nijland, P. G., Zelcer, N., Vanmierlo, T., van Horssen, J., Stinissen, P., Hellings, N. & Hendriks, JJ., 2013, In : Acta Neuropathologica Communinications. 1, 1, 43.

Research output: Contribution to journalArticleAcademicpeer-review

Reduced expression of PGC-1 alpha partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex

Witte, M. E., Nijland, P. G., Drexhage, J. A. R., Gerritsen, W. H., Geerts, D., Hof, B. V., Reijerkerk, A., de Vries, H. E., van der Valk, P. & van Horssen, J., 2013, In : Acta Neuropathologica. 125, 2, p. 231-243

Research output: Contribution to journalArticleAcademicpeer-review

Roles for HB-EGF and CD9 in multiple sclerosis

Schenk, G. J., Dijkstra, S., van Het Hof, A. J., van der Pol, S. M. A., Drexhage, J. A. R., van der Valk, P., Reijerkerk, A., van Horssen, J. & de Vries, H. E., 2013, In : GLIA. 61, 11, p. 1890-1905

Research output: Contribution to journalArticleAcademicpeer-review

2012

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

van Horssen, J., Singh, S., van der Pol, S. M. A., Kipp, M., Lim, J. L., Peferoen, L. A. N., Gerritsen, W. H., Kooi, E. J., Witte, M. E., Geurts, J. J. G., de Vries, H. E., Peferoen-Baert, R., van den Elsen, P. J., van der Valk, P. & Amor, S., 2012, In : Journal of Neuroinflammation. 9, p. 156 156.

Research output: Contribution to journalArticleAcademicpeer-review