• Amsterdam UMC, Vrije Universiteit Amsterdam, Hematology Laboratory, Cancer Center Amsterdam, De Boelelaan 1117 Amsterdam The Netherlands

1993 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS

Ossenkoppele, G. J., Breems, D. A., Stuessi, G., van Norden, Y., Bargetzi, M., Biemond, B. J., A von dem Borne, P., Chalandon, Y., Cloos, J., Deeren, D., Fehr, M., Gjertsen, B. T., Graux, C., Huls, G., Janssen, J. J. J. W., Jaspers, A., Jongen-Lavrencic, M., de Jongh, E., Klein, S. K., Van der Klift, M. & 14 others, Van Marwijk Kooy, M., Maertens, J., Micheaux, L., van der Poel, M. W. M., Van Rhenen, A., Tick, L., Valk, P., Vekemans, M. C., van der Velden, W. J. F. M., de Weerdt, O., Pabst, T., Manz, M., Löwenberg, B. & for the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON) and Swiss Group for Clinical Cancer Research (SAKK), 1 Jan 2020, In : Leukemia.

Research output: Contribution to journalArticleAcademicpeer-review

Re: Myeloblasts in normal bone marrows expressing leukaemia-associated immunophenotypes

Hanekamp, D., Bachas, C., van de Loosdrecht, A., Ossenkoppele, G. & Cloos, J., 2020, In : Pathology. 52, 2, p. 289-291 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

2019

Can we incorporate MRD assessment into clinical practice in AML?

Ossenkoppele, G., Schuurhuis, G. J., van de Loosdrecht, A. & Cloos, J., 1 Jun 2019, In : Best Practice and Research: Clinical Haematology. 32, 2, p. 186-191 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

CD34+CD38 leukemic stem cell frequency to predict outcome in acute myeloid leukemia

Zeijlemaker, W., Grob, T., Meijer, R., Hanekamp, D., Kelder, A., Carbaat-Ham, J. C., Oussoren-Brockhoff, Y. J. M., Snel, A. N., Veldhuizen, D., Scholten, W. J., Maertens, J., Breems, D. A., Pabst, T., Manz, M. G., van der Velden, V. H. J., Slomp, J., Preijers, F., Cloos, J., van de Loosdrecht, A. A., Löwenberg, B. & 4 others, Valk, P. J. M., Jongen-Lavrencic, M., Ossenkoppele, G. J. & Schuurhuis, G. J., 1 May 2019, In : Leukemia. 33, 5, p. 1102-1112 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Immunophenotypic Detection of Measurable Residual (Stem Cell) Disease Using LAIP Approach in Acute Myeloid Leukemia

Zeijlemaker, W., Kelder, A., Cloos, J. & Schuurhuis, G. J., 1 Dec 2019, In : Current Protocols in Cytometry. 91, 1, e66.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Minimal residual disease and stem cell transplantation outcomes

Cloos, J., Ossenkoppele, G. J. & Dillon, R., 2019, In : Hematology. American Society of Hematology. Education Program. 2019, 1, p. 617-625

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Relationship between CD34/CD38 and side population (SP) defined leukemia stem cell compartments in acute myeloid leukemia

Moshaver, B., Wouters, R. F., Kelder, A., Ossenkoppele, G. J., Westra, G. A. H., Kwidama, Z., Rutten, A. R., Kaspers, G. J. L., Zweegman, S., Cloos, J. & Schuurhuis, G. J., 2019, In : Leukemia Research. 81, p. 27-34

Research output: Contribution to journalArticleAcademicpeer-review

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma

Sciarrillo, R., Wojtuszkiewicz, A., El Hassouni, B., Funel, N., Gandellini, P., Lagerweij, T., Buonamici, S., Blijlevens, M., Zeeuw van der Laan, E. A., Zaffaroni, N., Deraco, M., Kusamura, S., Würdinger, T., Peters, G. J., Molthoff, C. F. M., Jansen, G., Kaspers, G. J. L., Cloos, J. & Giovannetti, E., Jan 2019, In : EBioMedicine. 39, p. 215-225

Research output: Contribution to journalArticleAcademicpeer-review

TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment

Depreter, B., Weening, K. E., Vandepoele, K., Essand, M., De Moerloose, B., Themeli, M., Cloos, J., Hanekamp, D., Moors, I., D' Hont, I., Denys, B., Uyttebroeck, A., Van Damme, A., Dedeken, L., Snauwaert, S., Goetgeluk, G., De Munter, S., Kerre, T., Vandekerckhove, B., Lammens, T. & 1 others, Philippé, J., 1 Aug 2019, In : Haematologica.

Research output: Contribution to journalArticleAcademicpeer-review

TP53 mutations and relevance of expression of TP53 pathway genes in paediatric acute myeloid leukaemia

Cucchi, D. G. J., Bachas, C., Klein, K., Huttenhuis, S., Zwaan, C. M., Ossenkoppele, G. J., Janssen, J. M. W. M., Kaspers, G. L. & Cloos, J., 6 Oct 2019, In : British Journal of Haematology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

An effective modestly intensive re-induction regimen with bortezomib in relapsed or refractory paediatric acute lymphoblastic leukaemia

Kaspers, G. J. L., Niewerth, D., Wilhelm, B. A. J., Scholte-van Houtem, P., Lopez-Yurda, M., Berkhof, J., Cloos, J., de Haas, V., Mathôt, R. A., Attarbaschi, A., Baruchel, A., de Bont, E. S., Fagioli, F., Rössig, C., Klingebiel, T., De Moerloose, B., Nelken, B., Palumbo, G., Reinhardt, D., Rohrlich, P. S. & 3 others, Simon, P., von Stackelberg, A. & Zwaan, C. M., 1 May 2018, In : British Journal of Haematology. 181, 4, p. 523-527 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Cloos, J., Harris, J. R., Janssen, J. J. W. M., Kelder, A., Huang, F., Sijm, G., Vonk, M., Snel, A. N., Scheick, J. R., Scholten, W. J., Carbaat-Ham, J., Veldhuizen, D., Hanekamp, D., Oussoren-Brockhoff, Y. J. M., Kaspers, G. J. L., Schuurhuis, G. J., Sasser, A. K. & Ossenkoppele, G., 5 Mar 2018, In : Journal of Visualized Experiments. 2018, 133, e56386.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?

Jaramillo Mantilla, CA., Al Saig, F., Cloos, J., Jansen, G. & Peters, GJ., 19 Mar 2018, In : Cancer Drug Resistance. 1, p. 6-29 24 p., DOI: 10.20517/cdr.2018.02.

Research output: Contribution to journalReview articleAcademicpeer-review

Induction response criteria in acute myeloid leukaemia: implications of a flow cytometric measurable residual disease negative test in refractory adults

Cloos, J., Kelder, A., Ossenkoppele, G. J., Schuurhuis, G. J., on behalf of the UK NCRI AML Trial Group & on behalf of the HOVON AML Trial Group, 1 Jan 2018, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticleAcademicpeer-review

Leukaemic stem cell load at diagnosis predicts the development of relapse in young acute myeloid leukaemia patients

Hanekamp, D., Denys, B., Kaspers, G. J. L., te Marvelde, J. G., Schuurhuis, G. J., de Haas, V., de Moerloose, B., de Bont, E. S., Zwaan, C. M., de Jong, A., Depreter, B., Lammens, T., Philippé, J., Cloos, J. & van der Velden, V. H. J., 2018, In : British Journal of Haematology. 183, 3, p. 512-516

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

Measurable residual disease in acute myeloid leukemia using flow cytometry: approaches for harmonization/standardization

Schuurhuis, G. J., Ossenkoppele, G. J., Kelder, A. & Cloos, J., 2 Dec 2018, In : Expert Review of Hematology. 11, 12, p. 921-935 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party

Schuurhuis, G. J., Heuser, M., Freeman, S., Béné, M-C., Buccisano, F., Cloos, J., Grimwade, D., Haferlach, T., Hills, R. K., Hourigan, C. S., Jorgensen, J. L., Kern, W., Lacombe, F., Maurillo, L., Preudhomme, C., van der Reijden, B. A., Thiede, C., Venditti, A., Vyas, P., Wood, B. L. & 4 others, Walter, R. B., Döhner, K., Roboz, G. J. & Ossenkoppele, G. J., 22 Mar 2018, In : Blood. 131, 12, p. 1275-1291 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Molecular Minimal Residual Disease in Acute Myeloid Leukemia

Jongen-Lavrencic, M., Grob, T., Hanekamp, D., Kavelaars, F. G., Al Hinai, A., Zeilemaker, A., Erpelinck-Verschueren, C. A. J., Gradowska, P. L., Meijer, R., Cloos, J., Biemond, B. J., Graux, C., van Marwijk Kooy, M., Manz, M. G., Pabst, T., Passweg, J. R., Havelange, V., Ossenkoppele, G. J., Sanders, M. A., Schuurhuis, G. J. & 2 others, Löwenberg, B. & Valk, P. J. M., 29 Mar 2018, In : New England Journal of Medicine. 378, 13, p. 1189-1199 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MR Imaging Features of Retinoblastoma: Association with Gene Expression Profiles

Jansen, R. W., de Jong, M. C., Kooi, I. E., Sirin, S., Göricke, S., Brisse, H. J., Maeder, P., Galluzzi, P., van der Valk, P., Cloos, J., Eekhout, I., Castelijns, J. A., Moll, A. C., Dorsman, J. C. & de Graaf, P., Aug 2018, In : Radiology. 288, 2, p. 506-515 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Ontwikkeling van een LC-MS/MS methode voor de bepaling van folylpolyglutamaat synthetase (FPGS)

Muller, IB., Struys, EA., Lems, WF., Cloos, J., Jansen, G. & de Jonge, R., Oct 2018, In : Analyse. 73, 5, p. 101-103 3 p.

Research output: Contribution to journalArticleProfessional

Positioning of proteasome inhibitors in therapy of solid malignancies

Roeten, M. S. F., Cloos, J. & Jansen, G., 1 Feb 2018, In : Cancer Chemotherapy and Pharmacology. 81, 2, p. 227-243 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide

Oerlemans, R., Berkers, C. R., Assaraf, Y. G., Scheffer, G. L., Peters, G. J., Verbrugge, S. E., Cloos, J., Slootstra, J., Meloen, R. H., Shoemaker, R. H., Dijkmans, B. A. C., Scheper, R. J., Ovaa, H. & Jansen, G., 1 Oct 2018, In : Investigational New Drugs. 36, 5, p. 797-809 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The interference of genetic associations in establishing the prognostic value of the immunophenotype in acute myeloid leukemia

van Solinge, T. S., Zeijlemaker, W., Ossenkoppele, G. J., Cloos, J. & Schuurhuis, G. J., 1 Jan 2018, In : Cytometry Part B. Clinical Cytometry. 94, 1, p. 151-158 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

(Immuno)proteasomes as therapeutic target in acute leukemia

Cloos, J., Roeten, M. S. F., Franke, N. E., van Meerloo, J., Zweegman, S., Kaspers, G. J. L. & Jansen, G., Dec 2017, In : Cancer and Metastasis Reviews. p. 1-17 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bortezomib resistance in multiple myeloma is associated with increased serine synthesis

Zaal, E. A., Wu, W., Jansen, G., Zweegman, S., Cloos, J. & Berkers, C. R., 2017, In : CANCER & METABOLISM. 5, 1, p. 7 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genomic landscape of retinoblastoma in Rb−/−p130−/− mice resembles human retinoblastoma

Kooi, I. E., van Mil, S. E., MacPherson, D., Mol, B. M., Moll, A. C., Meijers-Heijboer, H., Kaspers, G. J. L., Cloos, J., te Riele, H. & Dorsman, J. C., 1 Mar 2017, In : Genes Chromosomes and Cancer. 56, 3, p. 231-242 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

In silico and preclinical drug screening identifies dasatinib as a targeted therapy for T-ALL

Laukkanen, S., Grönroos, T., Pölönen, P., Kuusanmäki, H., Mehtonen, J., Cloos, J., Ossenkoppele, G., Gjertsen, B., Øystein, B., Heckman, C., Heinäniemi, M., Kontro, M. & Lohi, O., 8 Sep 2017, In : Blood cancer journal. 7, 9, p. e604

Research output: Contribution to journalArticleAcademicpeer-review

LEUKEMIC STEM CELL FREQUENCY COMBINED WITH MRD IS AN IMPORTANT BIOMARKER TO PREDICT RELAPSE IN ACUTE MYELOID LEUKEMIA. RESULTS FROM A PROSPECTIVE H102 STUDY

Zeijlemaker, W., Meijer, R., Kelder, A., Carbaat-Ham, J., Oussoren-brockhoff, Y., Snel, S., Veldhuizen, D., Scholten, W., Maertens, J., Breems, D., Pabst, T., Manz, M., Van der Velden, V., Slomp, J., Valk, P., Cloos, J., Lowenberg, B., Ossenkoppele, G. & Schuurhuis, G. J., 26 Jun 2017, In : Haematologica. 102, p. 7-8

Research output: Contribution to journalMeeting AbstractAcademic

Leukemic stem cells: identification and clinical application

Hanekamp, D., Cloos, J. & Schuurhuis, G. J., May 2017, In : American Journal of Hematology. 105, 5, p. 549-557 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Phosphatase Sequencing of Pediatric Acute Myeloid Leukemia Reveals a Novel Mutation in the Phosphatase Gene PTPN4

Cloos, J., Cucchi, DGJ., Irandoust, M., Assaraf, Y. G., Kaspers, GJL., Akyuz, M., Broekhuizen, A. J. F., Heijmans, N., Abels, E. R., Parigger, J., Kwidama, ZJ., van den Berg, T. K., de Haas, V., Reinhardt, D., M van den Heuvel-Eibrink, M., De Bont, E. S. J. M., Zwaan, C. M., Cuppen, E. & de Bruijn, E., 6 Nov 2017, In : Journal of Molecular and Clinical Medicine. 1, 1, p. 1-6 6 p., DOI: 10.31083/j.jmcm.2018.01.001.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Re-emerging antimetabolites with novel mechanism of action with respect to epigenetic regulation: Basic aspects

Sarkisjan, D., Steenbergen, R. D. M., Cloos, J. & Peters, G. J., 17 Apr 2017, Chemotherapy for Leukemia: Novel Drugs and Treatment. Springer Singapore, p. 311-326 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Trimethylation of H3K27 during human cerebellar development in relation to medulloblastoma

Mir, S. E., Smits, M., Biesmans, D., Julsing, M., Bugiani, M., Aronica, E., Kaspers, G. J. L., Cloos, J., Würdinger, T. & Hulleman, E., 2017, In : Oncotarget. 8, 45, p. 78978-78988 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer

Lagerweij, T., Hiddingh, L., Biesmans, D., Crommentuijn, M. H. W., Cloos, J., Li, X-N., Kogiso, M., Tannous, B. A., Vandertop, W. P., Noske, D. P., Kaspers, G. J. L., Wurdinger, T. & Hulleman, E., 14 Jun 2016, In : Oncotarget. 7, 24, p. 35776-35788

Research output: Contribution to journalArticleAcademicpeer-review

A clinical update on the role of carfilzomib in the treatment of relapsed or refractory multiple myeloma

Franken, B., van de Donk, N. W. C. J., Cloos, J. C., Zweegman, S. & Lokhorst, H. M., Dec 2016, In : THERAPEUTIC ADVANCES IN HEMATOLOGY. 7, 6, p. 330-344

Research output: Contribution to journalArticleAcademicpeer-review

A Meta-Analysis of Retinoblastoma Copy Numbers Refines the List of Possible Driver Genes Involved in Tumor Progression

Kooi, I. E., Mol, B. M., Massink, M. P. G., de Jong, M. C., de Graaf, P., van der Valk, P., Meijers-Heijboer, H., Kaspers, G. J. L., Moll, A. C., te Riele, H., Cloos, J. & Dorsman, J. C., 26 Apr 2016, In : PLoS ONE. 11, 4

Research output: Contribution to journalArticleAcademicpeer-review

A simple one-tube assay for immunophenotypical quantification of leukemic stem cells in acute myeloid leukemia

Zeijlemaker, W., Kelder, A., Oussoren-Brockhoff, Y. J. M., Scholten, W., Snel, A. N., Veldhuizen, D., Cloos, J., Ossenkoppele, G. J. & Schuurhuis, G. J., Feb 2016, In : Leukemia. 30, 2, p. 439-446

Research output: Contribution to journalArticleAcademicpeer-review

CD45RA, a specific marker for leukaemia stem cell sub-populations in acute myeloid leukaemia

Kersten, B., Valkering, M., Wouters, R., van Amerongen, R., Hanekamp, D., Kwidama, Z., Valk, P., Ossenkoppele, G., Zeijlemaker, W., Kaspers, G., Cloos, J. & Schuurhuis, G. J., Apr 2016, In : British Journal of Haematology. 173, 2, p. 219-235

Research output: Contribution to journalArticleAcademicpeer-review

Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors

Franke, N. E., Kaspers, G. L., Assaraf, Y. G., van Meerloo, J., Niewerth, D., Kessler, F. L., Poddighe, P. J., Kole, J., Smeets, S. J., Ylstra, B., Bi, C., Chng, W. J., Horton, T. M., Menezes, R. X., Musters, R., Zweegman, S., Jansen, G. & Cloos, J., 15 Nov 2016, In : Oncotarget. 7, 46, p. 74779-74796

Research output: Contribution to journalArticleAcademicpeer-review

Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance

Wojtuszkiewicz, A., Raz, S., Stark, M., Assaraf, Y. G., Jansen, G., Peters, G. J., Sonneveld, E., Kaspers, G. J. L. & Cloos, J., 1 Apr 2016, In : International Journal of Cancer. 138, 7, p. 1645-1656

Research output: Contribution to journalArticleAcademicpeer-review

Leukemia cells teach eachother not to self-destruct

Jimenez, CR., Wojtuszkiewicz, AM. & Cloos, J., May 2016, 5 ed. ASBMB Today.

Research output: Book/ReportReportProfessional

MicroRNA-106b similar to 25 cluster is upregulated in relapsed MLL-rearranged pediatric acute myeloid leukemia

Verboon, L. J., Obulkasim, A., de Rooij, J. D. E., Katsman-Kuipers, J. E., Sonneveld, E., Baruchel, A., Trka, J., Reinhardt, D., Pieters, R., Cloos, J., Kaspers, G. J. L., Klusmann, J-H., Zwaan, C. M., Fornerod, M. & van den Heuvel-Eibrink, M. M., 26 Jul 2016, In : Oncotarget. 7, 30, p. 48412-48422

Research output: Contribution to journalArticleAcademicpeer-review

miR expression profiling at diagnosis predicts relapse in pediatric precursor B-cell acute lymphoblastic leukemia

Avigad, S., Verly, I. R. N., Lebel, A., Kordi, O., Shichrur, K., Ohali, A., Hameiri-Grossman, M., Kaspers, G. J. L., Cloos, J., Fronkova, E., Trka, J., Luria, D., Kodman, Y., Mirsky, H., Gaash, D., Jeison, M., Avrahami, G., Elitzur, S., Gilad, G., Stark, B. & 1 others, Yaniv, I., Apr 2016, In : Genes, Chromosomes and Cancer. 55, 4, p. 328-339

Research output: Contribution to journalArticleAcademicpeer-review

Peripheral blood minimal residual disease may replace bone marrow minimal residual disease as an immunophenotypic biomarker for impending relapse in acute myeloid leukemia

Zeijlemaker, W., Kelder, A., Oussoren-Brockhoff, Y. J. M., Scholten, W., Snel, A. N., Veldhuizen, D., Cloos, J., Ossenkoppele, G. J. & Schuurhuis, G. J., Mar 2016, In : Leukemia. 30, 3, p. 708-715

Research output: Contribution to journalArticleAcademicpeer-review

Proteasome subunit expression analysis and chemosensitivity in relapsed paediatric acute leukaemia patients receiving bortezomib-containing chemotherapy

Niewerth, D., Kaspers, G. J. L., Jansen, G., van Meerloo, J., Zweegman, S., Jenkins, G., Whitlock, J. A., Hunger, S. P., Lu, X., Alonzo, T. A., de Ven, P. M. V., Horton, T. M. & Cloos, J., 6 Sep 2016, In : Journal of hematology & oncology. 9

Research output: Contribution to journalArticleAcademicpeer-review