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Personal profile

Research interests

Our research aims to explain how metabolic reprogramming regulates macrophage subsets in different settings, focusing on cancer and cardiovascular disease. By unravelling key questions in macrophage immunometabolism, our overall goal is to demonstrate whether and how targeting macrophage metabolism could be used for future therapy.

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Research Output 2008 2019

Let's Enter the Wonderful World of Immunometabolites

de Goede, K. E., Harber, K. J. & van den Bossche, J., 2019, In : TRENDS IN ENDOCRINOLOGY AND METABOLISM.

Research output: Contribution to journalArticleAcademicpeer-review

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment?

Van den Bossche, J. & van der Windt, G. J. W., 2 Oct 2018, In : Cell Metabolism. 28, 4, p. 538-540 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Macrophage Immunometabolism: Where Are We (Going)?

Van den Bossche, J., O'Neill, L. A. & Menon, D., Jun 2017, In : Trends in Immunology. 38, 6, p. 395-406 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

van den Bossche, J., Baardman, J., Otto, N. A., van der Velden, S., Neele, A. E., van den Berg, S. M., Luque-Martin, R., Chen, H-J., Boshuizen, M. C. S., Ahmed, M., Hoeksema, M. A., de Vos, A. F. & de Winther, M. P. J., 2016, In : Cell Reports. 17, 3, p. 684-696 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Activities 2011 2018

  • 7 Publication Peer-review
  • 3 Invited talk
  • 1 Organising a conference, workshop, ...
  • 1 Oral presentation

Frontiers in Immunology (Journal)

Jan Van den Bossche (Reviewer)
2018 → …

Activity: Publication peer-review and editorial workPublication Peer-review

M&M; macrophages and mitochondria

Jan Van den Bossche (Speaker)
2018

Activity: Talk or presentationInvited talk

Immunobiology (Journal)

Jan Van den Bossche (Reviewer)
2018 → …

Activity: Publication peer-review and editorial workPublication Peer-review

Metabolic and Functional plasticity of macrophage subsets

Jan Van den Bossche (Speaker)
2018

Activity: Talk or presentationInvited talk

Hypercholesterolemia affects macrophage metabolism and function

Jan Van den Bossche (Speaker)
2018

Activity: Talk or presentationOral presentation

Press / Media

Vet voedsel verandert immuuncellen

Jan Van den Bossche

04/12/2018

1 media contribution

Press/Media: Interview

Verrassende ontdekking in afweercellen vol cholesterol

Jan Van den Bossche

03/12/2018

1 media contribution

Press/Media: Public Engagement Activities

Cholesterol in immuuncellen minder slecht dan gedacht?

Jan Van den Bossche

20/11/2018

1 media contribution

Press/Media: Research

Macrofagen: van Pacman tot klusjesman

Jan Van den Bossche

09/10/2017

1 media contribution

Press/Media: Interview