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Research Output 2008 2019

  • 30 Article
  • 7 Review article
  • 2 Meeting Abstract
  • 2 Comment/Letter to the editor
2019

Going -omics to identify novel therapeutic targets for cardiovascular disease

Harber, K. J., Verberk, S. G. S. & van den Bossche, J., 2019, In : EBioMedicine. 41, p. 7-8

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

Let's Enter the Wonderful World of Immunometabolites

de Goede, K. E., Harber, K. J. & van den Bossche, J., 2019, In : TRENDS IN ENDOCRINOLOGY AND METABOLISM.

Research output: Contribution to journalArticleAcademicpeer-review

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

van Beek, A. A., van den Bossche, J., Mastroberardino, P. G., de Winther, M. P. J. & Leenen, P. J. M., 2019, In : Trends in Immunology. 40, 2, p. 113-127

Research output: Contribution to journalReview articleAcademicpeer-review

2018

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment?

Van den Bossche, J. & van der Windt, G. J. W., 2 Oct 2018, In : Cell Metabolism. 28, 4, p. 538-540 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement

van Dam, A. D., van Beek, L., Pronk, A. C. M., van den Berg, S. M., Van den Bossche, J., de Winther, M. P. J., Koning, F., van Kooten, C., Rensen, P. C. N., Boon, M. R., Verbeek, J. S., van Dijk, K. W. & van Harmelen, V., Feb 2018, In : International Journal of Obesity. 42, 2, p. 260-269 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Metabolic regulation of macrophages in tissues

van den Bossche, J. & Saraber, D. L., 2018, In : Cellular Immunology. 330, p. 54-59 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Myeloid Kdm6b deficiency results in advanced atherosclerosis

Neele, A. E., Gijbels, M. J. J., van der Velden, S., Hoeksema, M. A., Boshuizen, M. C. S., Prange, K. H. M., Chen, H-J., Van den Bossche, J., van Roomen, C. P. P. A., Shami, A., Levels, J. H. M., Kroon, J., Lucas, T., Dimmeler, S., Lutgens, E. & de Winther, M. P. J., Aug 2018, In : Atherosclerosis. 275, p. 156-165 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

Koenis, D. S., Medzikovic, L., van Loenen, P. B., van Weeghel, M., Huveneers, S., Vos, M., Evers-van Gogh, I. J., Van den Bossche, J., Speijer, D., Kim, Y., Wessels, L., Zelcer, N., Zwart, W., Kalkhoven, E. & de Vries, C. J., 21 Aug 2018, In : Cell Reports. 24, 8, p. 2127-2140.e7

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

CD70 limits atherosclerosis and promotes macrophage function

Winkels, H., Meiler, S., Smeets, E., Lievens, D., Engel, D., Spitz, C., Bürger, C., Rinne, P., Beckers, L., Dandl, A., Reim, S., Ahmadsei, M., Van den Bossche, J., Holdt, L. M., Megens, R. T. A., Schmitt, M. M., de Winther, M., Biessen, E. A., Borst, J., Faussner, A. & 3 othersWeber, C., Lutgens, E. & Gerdes, N., 2017, In : Thrombosis and Haemostasis. 117, 1, p. 164-175 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Epigenetic mechanisms of macrophage activation in type 2 diabetes

Ahmed, M., de Winther, M. P. J. & van den Bossche, J., 2017, In : Immunobiology. 222, 10, p. 937-943 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils

van den Berg, S. M., van Dam, A. D., Kusters, P. J. H., Beckers, L., den Toom, M., van der Velden, S., Van den Bossche, J., van Die, I., Boon, M. R., Rensen, P. C. N., Lutgens, E. & de Winther, M. P. J., Oct 2017, In : Molecular Endocrinology. 59, 3, p. 245-255 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

High miR-124-3p expression identifies smoking individuals susceptible to atherosclerosis

de Ronde, M. W. J., Kok, M. G. M., Moerland, P. D., Van den Bossche, J., Neele, A. E., Halliani, A., van der Made, I., de Winther, M. P. J., Meijers, J. C. M., Creemers, E. E. & Pinto-Sietsma, S-J., Aug 2017, In : Atherosclerosis. 263, p. 377-384 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypercholesterolemia Induces Pro-Inflammatory Changes in Monocytes Which Are Reversed by PCSK9 Antibody Treatment

Neele, A. E., Moens, S. J. B., Kroon, J., van der Valk, F. M., Van den Bossche, J., Hoeksema, M. A., Hoogeveen, R. M., Schnitzler, J. G., Baccara-Dinet, M. T., Manvelian, G., Stroes, E. S. & de Winther, M. P., May 2017, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 37

Research output: Contribution to journalMeeting AbstractAcademic

Macrophage Immunometabolism: Where Are We (Going)?

Van den Bossche, J., O'Neill, L. A. & Menon, D., Jun 2017, In : Trends in Immunology. 38, 6, p. 395-406 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells

Neele, A. E., Prange, K. H. M., Hoeksema, M. A., van der Velden, S., Lucas, T., Dimmeler, S., Lutgens, E., van den Bossche, J. & de Winther, M. P. J., 2017, In : Epigenomics. 9, 4, p. 383-391 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia

Bernelot Moens, S. J., Neele, A. E., Kroon, J., Van Der Valk, F. M., Van Den Bossche, J., Hoeksema, M. A., Hoogeveen, R. M., Schnitzler, J. G., Baccara-Dinet, M. T., Manvelian, G., De Winther, M. P. J. & Stroes, E. S. G., 2017, In : European Heart Journal. 38, 20, p. 1584-1593 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Epigenetic Enzyme Kdm6b Controls the Pro-Fibrotic Transcriptome Signature of Foam Cells

Neele, A. E., Prange, K. H., Hoeksema, M. A., van der Velden, S., Lucas, T., Dimmeler, S., Lutgens, E., Van den Bossche, J. & de Winther, M. P., May 2017, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 37

Research output: Contribution to journalMeeting AbstractAcademic

2016

Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms

Boshuizen, M. C. S., Hoeksema, M. A., Neele, A. E., van der Velden, S., Hamers, A. A. J., Van den Bossche, J., Lutgens, E. & de Winther, M. P. J., 1 Jan 2016, In : Cytokine. p. 220-226 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Liposomal prednisolone promotes macrophage lipotoxicity in experimental atherosclerosis

van der Valk, F. M., Schulte, D. M., Meiler, S., Tang, J., Zheng, K. H., van den Bossche, J., Seijkens, T., Laudes, M., de Winther, M., Lutgens, E., Alaarg, A., Metselaar, J. M., Dallinga-Thie, G. M., Mulder, W. J. M., Stroes, E. S. G. & Hamers, A. A. J., 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 6, p. 1463-1470 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

van den Bossche, J., Baardman, J., Otto, N. A., van der Velden, S., Neele, A. E., van den Berg, S. M., Luque-Martin, R., Chen, H-J., Boshuizen, M. C. S., Ahmed, M., Hoeksema, M. A., de Vos, A. F. & de Winther, M. P. J., 2016, In : Cell Reports. 17, 3, p. 684-696 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Myeloid interferon-γ receptor deficiency does not affect atherosclerosis in LDLR-/- mice

Boshuizen, M. C. S., Neele, A. E., Gijbels, M. J. J., van der Velden, S., Hoeksema, M. A., Forman, R. A., Muller, W., Van den Bossche, J. & de Winther, M. P. J., 1 Mar 2016, In : Atherosclerosis. 246, p. 325-333 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans

van der Valk, F. M., Bekkering, S., Kroon, J., Yeang, C., Van den Bossche, J., van Buul, J. D., Ravandi, A., Nederveen, A. J., Verberne, H. J., Scipione, C., Nieuwdorp, M., Joosten, L. A. B., Netea, M. G., Koschinsky, M. L., Witztum, J. L., Tsimikas, S., Riksen, N. P. & Stroes, E. S. G., 23 Aug 2016, In : Circulation. 134, 8, p. 611-24 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015

E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo

Van Den Bossche, J., Laoui, D., Naessens, T., Smits, H. H., Hokke, C. H., Stijlemans, B., Grooten, J., De Baetselier, P. & Van Ginderachter, J. A., 31 Jul 2015, In : Scientific Reports. 5, 12599.

Research output: Contribution to journalArticleAcademicpeer-review

Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis

Neele, A. E., Van Den Bossche, J., Hoeksema, M. A. & De Winther, M. P. J., 15 Sep 2015, In : European Journal of Pharmacology. 763, p. 79-89 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

IFN-γ priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment

Hoeksema, M. A., Scicluna, B. P., Boshuizen, M. C. S., Van Der Velden, S., Neele, A. E., Van Den Bossche, J., Matlung, H. L., Van Den Berg, T. K., Goossens, P. & De Winther, M. P. J., 1 Jan 2015, In : Journal of Immunology. 194, 8, p. 3909-3916 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Metabolic characterization of polarized M1 and M2 bone marrow-derived macrophages using real-time extracellular flux analysis

Van den Bossche, J., Baardman, J. & de Winther, M. P. J., 28 Nov 2015, In : Journal of Visualized Experiments. 2015, 105, e53424.

Research output: Contribution to journalArticleAcademicpeer-review

Metabolic-epigenetic crosstalk in macrophage activation

Baardman, J., Licht, I., De Winther, M. P. J. & Van Den Bossche, J., 1 Oct 2015, In : Epigenomics. 7, 7, p. 1155-1164 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2014

Inhibiting epigenetic enzymes to improve atherogenic macrophage functions

Van Den Bossche, J., Neele, A. E., Hoeksema, M. A., De Heij, F., Boshuizen, M. C. S., Van Der Velden, S., De Boer, V. C., Reedquist, K. A. & De Winther, M. P. J., 12 Dec 2014, In : Biochemical and Biophysical Research Communications. 455, 3-4, p. 396-402 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Macrophage polarization: the epigenetic point of view

Van Den Bossche, J., Neele, A. E., Hoeksema, M. A. & De Winther, M. P. J., 1 Jan 2014, In : Current Opinion in Lipidology. 25, 5, p. 367-373 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Targeting macrophage histone deacetylase 3 stabilizes atherosclerotic lesions

Hoeksema, M. A., Gijbels, M. J. J., van den Bossche, J., van der Velden, S., Sijm, A., Neele, A. E., Seijkens, T., Stöger, J. L., Meiler, S., Boshuizen, M. C. S., Dallinga-Thie, G. M., Levels, J. H. M., Boon, L., Mullican, S. E., Spann, N. J., Cleutjens, J. P., Glass, C. K., Lazar, M. A., de Vries, C. J. M., Biessen, E. A. L. & 3 othersDaemen, M. J. A. P., Lutgens, E. & de Winther, M. P. J., 1 Jan 2014, In : Embo Molecular Medicine. 6, 9, p. 1124-1132 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013

BMP7 Activates Brown Adipose Tissue and Reduces Diet-Induced Obesity Only at Subthermoneutrality

Boon, M. R., van den Berg, S. A. A., Wang, Y., van den Bossche, J., Karkampouna, S., Bauwens, M., De Saint-Hubert, M., van der Horst, G., Vukicevic, S., de Winther, M. P. J., Havekes, L. M., Jukema, J. W., Tamsma, J. T., van der Pluijm, G., van Dijk, K. W. & Rensen, P. C. N., 16 Sep 2013, In : PLoS ONE. 8, 9, e74083.

Research output: Contribution to journalArticleAcademicpeer-review

E-cadherin: From epithelial glue to immunological regulator

Van den Bossche, J. & Van Ginderachter, J. A., 1 Jan 2013, In : European Journal of Immunology. 43, 1, p. 34-37 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

2012

Claudin-1, Claudin-2 and Claudin-11 Genes Differentially Associate with Distinct Types of Anti-inflammatory Macrophages In vitro and with Parasite- and Tumour-elicited Macrophages In vivo

van den Bossche, J., Laoui, D., Morias, Y., Movahedi, K., Raes, G., de Baetselier, P. & van Ginderachter, J. A., 1 Jun 2012, In : Scandinavian Journal of Immunology. 75, 6, p. 588-598 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pivotal advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes

van den Bossche, J., Lamers, W. H., Koehler, E. S., Geuns, J. M. C., Alhonen, L., Uimari, A., Pirnes-Karhu, S., van Overmeire, E., Morias, Y., Brys, L., Vereecke, L., de Baetselier, P. & van Ginderachter, J. A., 1 May 2012, In : Journal of Leukocyte Biology. 91, 5, p. 685-699 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs

Van Den Bossche, J., Malissen, B., Mantovani, A., De Baetselier, P. & Van Ginderachter, J. A., 16 Feb 2012, In : Blood. 119, 7, p. 1623-1633 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The CD20 homolog Ms4a8a integrates pro- and anti-inflammatory signals in novel M2-like macrophages and is expressed in parasite infection

Schmieder, A., Schledzewski, K., Michel, J., Schönhaar, K., Morias, Y., Bosschaerts, T., Van den Bossche, J., Dorny, P., Sauer, A., Sticht, C., Géraud, C., Waibler, Z., Beschin, A. & Goerdt, S., 1 Nov 2012, In : European Journal of Immunology. 42, 11, p. 2971-2982 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2011

Mononuclear phagocyte heterogeneity in cancer: Different subsets and activation states reaching out at the tumor site

Laoui, D., Van Overmeire, E., Movahedi, K., Van den Bossche, J., Schouppe, E., Mommer, C., Nikolaou, A., Morias, Y., De Baetselier, P. & Van Ginderachter, J. A., 1 Nov 2011, In : Immunobiology. 216, 11, p. 1192-1202 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Tumor-associated macrophages in breast cancer: Distinct subsets, distinct functions

Laoui, D., Movahedi, K., van Overmeire, E., van den Bossche, J., Schouppe, E., Mommer, C., Nikolaou, A., Morias, Y., de Baetselier, P. & van Ginderachter, J. A., 6 Dec 2011, In : International Journal of Developmental Biology. 55, 7-9, p. 861-867 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2009

Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes

Van Den Bossche, J., Bogaert, P., Van Hengel, J., Guérin, C. J., Berx, G., Movahedi, K., Van Den Bergh, R., Pereira-Fernandes, A., Geuns, J. M. C., Pircher, H., Dorny, P., Grooten, J., De Baetselier, P. & Van Ginderachter, J. A., 19 Nov 2009, In : Blood. 114, 21, p. 4664-4674 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2008

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell suppressive activity

Movahedi, K., Guilliams, M., Van Den Bossche, J., Van Den Bergh, R., Gysemans, C., Beschin, A., De Baetselier, P. & Van Ginderachter, J. A., 15 Apr 2008, In : Blood. 111, 8, p. 4233-4244 12 p.

Research output: Contribution to journalArticleAcademicpeer-review