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Personal profile

Research interests

During my PhD training I investigated the role of inflammation in Alzheimer’s disease and especially the mechanism on how nonsteroidal anti-inflammatory drugs (NSAIDs) could lower the risk of developing Alzheimer’s disease. I was one of first to discover that the enzyme cyclooxygenase 1, a primary target of NSAIDs, is expressed in microglia in the human brain. As postdoc researcher I was involved in several projects investigating the molecular mechanism of neurodegeneration in Alzheimer’s disease. During this period, I got interested in regulation of protein folding in neurodegenerative diseases. Using post mortem brain tissue, I was the first to show that the unfolded protein response (UPR) is activated in Alzheimer’s disease. In following studies, I was able to show that the UPR is activated in early stages of Alzheimer’s disease and Parkinson’s disease and show the connection between UPR activation and the accumulation of tau and alpha-synuclein in the human brain. Publications that resulted from these studies are currently recognized as key papers subscribing the role of the UPR in neurodegeneration. Currently I am leading several research projects on protein misfolding and neuroinflammation, as well as on the identification of new biomarkers and drug targets for neurodegenerative disease.

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Research Output 1998 2019

Characterization of brainstem TDP-43 distribution in FTD cases with ALS features

Scarioni, M., Gami-Patel, P., Timar, Y. S., Rozemuller, A. J., Hoozemans, J. J., Aronica, E., Raaphorst, J., Pijnenburg, Y. A. & Dijkstra, A. A., Jul 2019, In : European Journal of Neurology. 26, p. 436-436

Research output: Contribution to journalMeeting AbstractAcademic

EIF2AK3 variants in Dutch patients with Alzheimer's disease

Wong, T. H., van der Lee, S. J., van Rooij, J. G. J., Meeter, L. H. H., Frick, P., Melhem, S., Seelaar, H., Ikram, M. A., Rozemuller, A. J., Holstege, H., Hulsman, M., Uitterlinden, A., Neumann, M., Hoozemans, J. J. M., van Duijn, C. M., Rademakers, R. & van Swieten, J. C., 1 Jan 2019, In : Neurobiology of Aging. 73, p. 229.e11-229.e18

Research output: Contribution to journalArticleAcademicpeer-review

Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology

Wiersma, V. I., van Ziel, A. M., Vazquez-Sanchez, S., Nölle, A., Berenjeno-Correa, E., Bonaterra-Pastra, A., Clavaguera, F., Tolnay, M., Musters, R. J. P., van Weering, J. R. T., Verhage, M., Hoozemans, J. J. M. & Scheper, W., 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticleAcademicpeer-review

Imaging of Aβ-deposits in ex-vivo Alzheimer's disease brain tissue using Raman spectroscopy (Conference Presentation)

Lochocki, B., Morrema, T. H. J., den Haan, J., Ariese, F., Bouwman, F. H., Hoozemans, J. J. & de Boer, J. F., 4 Mar 2019.

Research output: Contribution to conferencePaperAcademic

Activities 2014 2017

  • 4 Oral presentation
  • 2 Hosting an academic visitor
  • 2 Membership of board
  • 1 Editorial work

Characterization of abdominal adipose tissue deposits in aortic pathology.

JP Meekel (Speaker), N Bogunovic (Speaker), JJM Hoozemans (Speaker), TG van Schaik (Speaker), RJ Lelij (Speaker), W Wisselink (Speaker), JD Blankensteijn (Speaker), KK Yeung (Speaker)
10 Nov 2017

Activity: Talk or presentationOral presentation

Translational Neuroscience Network Conference 2017 (Event)

Jeroen Hoozemans (Chair), MM Schoonheim (Chair), MMM Wilhelmus (Chair), P Scheltens (Chair), AB Brussaard (Chair)
12 Oct 2017

Activity: MembershipMembership of board

Unfolded protein response activation in C9orf72 FTD cases

Jeroen Hoozemans (Speaker)
2 Mar 2017

Activity: Talk or presentationOral presentation

UNFOLDED PROTEIN RESPONSE ACTIVATION IN C9ORF72 FRONTOTEMPORAL DEMENTIA CASES

Jeroen Hoozemans (Speaker)
1 Apr 2017

Activity: Talk or presentationOral presentation

Claudio Hetz

Jeroen Hoozemans (Host)
12 Jan 2017

Activity: Hosting a visitorHosting an academic visitor