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Personal profile

Research interests

During my PhD training I investigated the role of inflammation in Alzheimer’s disease and especially the mechanism on how nonsteroidal anti-inflammatory drugs (NSAIDs) could lower the risk of developing Alzheimer’s disease. I was one of first to discover that the enzyme cyclooxygenase 1, a primary target of NSAIDs, is expressed in microglia in the human brain. As postdoc researcher I was involved in several projects investigating the molecular mechanism of neurodegeneration in Alzheimer’s disease. During this period, I got interested in regulation of protein folding in neurodegenerative diseases. Using post mortem brain tissue, I was the first to show that the unfolded protein response (UPR) is activated in Alzheimer’s disease. In following studies, I was able to show that the UPR is activated in early stages of Alzheimer’s disease and Parkinson’s disease and show the connection between UPR activation and the accumulation of tau and alpha-synuclein in the human brain. Publications that resulted from these studies are currently recognized as key papers subscribing the role of the UPR in neurodegeneration. Currently I am leading several research projects on protein misfolding and neuroinflammation, as well as on the identification of new biomarkers and drug targets for neurodegenerative disease.

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Research Output 1998 2019

EIF2AK3 variants in Dutch patients with Alzheimer's disease

Wong, T. H., van der Lee, S. J., van Rooij, J. G. J., Meeter, L. H. H., Frick, P., Melhem, S., Seelaar, H., Ikram, M. A., Rozemuller, A. J., Holstege, H., Hulsman, M., Uitterlinden, A., Neumann, M., Hoozemans, J. J. M., van Duijn, C. M., Rademakers, R. & van Swieten, J. C., 1 Jan 2019, In : Neurobiology of Aging. 73, p. 229.e11-229.e18

Research output: Contribution to journalArticleAcademicpeer-review

Imaging of Aβ-deposits in ex-vivo Alzheimer's disease brain tissue using Raman spectroscopy (Conference Presentation)

Lochocki, B., Morrema, T. H. J., den Haan, J., Ariese, F., Bouwman, F. H., Hoozemans, J. J. & de Boer, J. F., 4 Mar 2019.

Research output: Contribution to conferencePaperAcademic

Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology

Li, X., Koudstaal, W., Fletcher, L., Costa, M., van Winsen, M., Siregar, B., Inganäs, H., Kim, J., Keogh, E., Macedo, J., Holland, T., Perry, S., Bard, F., Hoozemans, J. J., Goudsmit, J., Apetri, A. & Pascual, G., 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticleAcademicpeer-review

Von Economo neurons are part of a larger neuronal population that are selectively vulnerable in C9orf72 frontotemporal dementia

Netherlands Brain Bank, 2019, In : Neuropathology and Applied Neurobiology.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

A common antigenic motif recognized by naturally occurring human V H 5-51/V L 4-1 anti-tau antibodies with distinct functionalities

Apetri, A., Crespo, R., Juraszek, J., Pascual, G., Janson, R., Zhu, X., Zhang, H., Keogh, E., Holland, T., Wadia, J., Verveen, H., Siregar, B., Mrosek, M., Taggenbrock, R., Ameijde, J., Inganäs, H., van Winsen, M., Koldijk, M. H., Zuijdgeest, D., Borgers, M. & 13 othersDockx, K., Stoop, E. J. M., Yu, W., Brinkman-van der Linden, E. C., Ummenthum, K., van Kolen, K., Mercken, M., Steinbacher, S., de Marco, D., Hoozemans, J. J., Wilson, I. A., Koudstaal, W. & Goudsmit, J., 2018, In : Acta Neuropathologica Communinications. 6, 1, p. 43 43.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Activities 2014 2017

  • 4 Oral presentation
  • 2 Hosting an academic visitor
  • 2 Membership of board
  • 1 Editorial work

Unfolded protein response activation in C9orf72 FTD cases

Jeroen Hoozemans (Speaker)
2 Mar 2017

Activity: Talk or presentationOral presentation

Reorganisatie van de aortawand door periaortaal vetweefsel in atherosclerotische en aneurysmatische aorta.

JP Meekel (Speaker), TG van Schaik (Speaker), JJM Hoozemans (Speaker), RJ Lelij (Speaker), W Wisselink (Speaker), JD Blankensteijn (Speaker), KK Yeung (Speaker)
11 May 201712 May 2017

Activity: Talk or presentationOral presentation

Dietmar Rudolf Thal

Jeroen Hoozemans (Host)
11 Oct 2017

Activity: Hosting a visitorHosting an academic visitor

Translational Neuroscience Network Conference 2017 (Event)

Jeroen Hoozemans (Chair), MM Schoonheim (Chair), MMM Wilhelmus (Chair), P Scheltens (Chair), AB Brussaard (Chair)
12 Oct 2017

Activity: MembershipMembership of board

Claudio Hetz

Jeroen Hoozemans (Host)
12 Jan 2017

Activity: Hosting a visitorHosting an academic visitor