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Personal profile

Research interests

During my PhD training I investigated the role of inflammation in Alzheimer’s disease and especially the mechanism on how nonsteroidal anti-inflammatory drugs (NSAIDs) could lower the risk of developing Alzheimer’s disease. I was one of first to discover that the enzyme cyclooxygenase 1, a primary target of NSAIDs, is expressed in microglia in the human brain. As postdoc researcher I was involved in several projects investigating the molecular mechanism of neurodegeneration in Alzheimer’s disease. During this period, I got interested in regulation of protein folding in neurodegenerative diseases. Using post mortem brain tissue, I was the first to show that the unfolded protein response (UPR) is activated in Alzheimer’s disease. In following studies, I was able to show that the UPR is activated in early stages of Alzheimer’s disease and Parkinson’s disease and show the connection between UPR activation and the accumulation of tau and alpha-synuclein in the human brain. Publications that resulted from these studies are currently recognized as key papers subscribing the role of the UPR in neurodegeneration. Currently I am leading several research projects on protein misfolding and neuroinflammation, as well as on the identification of new biomarkers and drug targets for neurodegenerative disease.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1998 2019

EIF2AK3 variants in Dutch patients with Alzheimer's disease

Wong, T. H., van der Lee, S. J., van Rooij, J. G. J., Meeter, L. H. H., Frick, P., Melhem, S., Seelaar, H., Ikram, M. A., Rozemuller, A. J., Holstege, H., Hulsman, M., Uitterlinden, A., Neumann, M., Hoozemans, J. J. M., van Duijn, C. M., Rademakers, R. & van Swieten, J. C., 1 Jan 2019, In : Neurobiology of Aging. 73, p. 229.e11-229.e18

Research output: Contribution to journalArticleAcademicpeer-review

A common antigenic motif recognized by naturally occurring human V5-51/V4-1 anti-tau antibodies with distinct functionalities

Apetri, A. , Crespo, R. , Juraszek, J. , Pascual, G. , Janson, R. , Zhu, X. , Zhang, H. , Keogh, E. , Holland, T. , Wadia, J. , Verveen, H. , Siregar, B. , Mrosek, M. , Taggenbrock, R. , Ameijde, J. , Inganäs, H. , van Winsen, M. , Koldijk, M. H. , Zuijdgeest, D. , Borgers, M. & 13 others Dockx, K., Stoop, E. J. M., Yu, W., Brinkman-van der Linden, E. C., Ummenthum, K., van Kolen, K., Mercken, M., Steinbacher, S., de Marco, D., Hoozemans, J. J., Wilson, I. A., Koudstaal, W. & Goudsmit, J., 31 May 2018, In : Acta Neuropathologica Communinications. 6, 1, p. 43

Research output: Contribution to journalArticleAcademicpeer-review

A Laser Microdissection-Liquid Chromatography-Tandem Mass Spectrometry Workflow for Post-mortem Analysis of Brain Tissue

Hondius, D. C., Hoozemans, J. J. M., Rozemuller, A. J. M., Li, K. W. & Smit, A. B., 2018, In : Methods in Molecular Biology. 1723, p. 371-383 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Amyloid-beta and phosphorylated tau in post-mortem Alzheimer's disease retinas

den Haan, J., Morrema, T. H. J., Verbraak, F. D., de Boer, J. F., Scheltens, P., Rozemuller, A. J., Bergen, A. A. B., Bouwman, F. H. & Hoozemans, J. J., 2018, In : Acta Neuropathologica Communinications. 6, 1, p. 147

Research output: Contribution to journalArticleAcademicpeer-review

Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities

Apetri, A. C. , Crespo, R. , Juraszek, J. , Pascual, G. , Janson, R. , Zhu, X. , Keogh, E. , Zhang, H. , Holland, T. , Wadia, J. , Verveen, H. , Siregar, B. , Mrosek, M. , Taggenbrock, R. , van Ameijde, J. , Inganas, H. , van Winsen, M. , Koldijk, M. , Zuijdgeest, D. , Borgers, M. & 13 others Dockx, K., Stoop, E., Yu, W., Brinkman-van der Linden, E. C., Ummenthum, K., van Kolen, K., Mercken, M., Steinbacher, S., de Marco, D., Hoozemans, J. J., Wilson, I. A., Koudstaal, W. & Goudsmit, J., 2018, In : Biorxiv.

Research output: Contribution to journalArticleAcademicpeer-review

Activities 2014 2017

  • 4 Oral presentation
  • 2 Hosting an academic visitor
  • 2 Membership of board
  • 1 Editorial work

Stichting Alzheimer Nederland (External organisation)

Hoozemans, J. (Member)
1 Jan 2017 → …

Activity: MembershipMembership of board

Dietmar Rudolf Thal

Hoozemans, J. (Host)
11 Oct 2017

Activity: Hosting a visitorHosting an academic visitor

Translational Neuroscience Network Conference 2017 (Event)

Hoozemans, J. (Chair), Schoonheim, M. (Chair), Wilhelmus, M. (Chair), Scheltens, P. (Chair), Brussaard, A. (Chair)
12 Oct 2017

Activity: MembershipMembership of board

Characterization of abdominal adipose tissue deposits in aortic pathology.

JP Meekel (Speaker), Bogunovic, N. (Speaker), Hoozemans, J. (Speaker), van Schaik, T. G. (Speaker), Lelij, R. (Speaker), Wisselink, W. (Speaker), Blankensteijn, J. (Speaker), Yeung, K. K. (Speaker)
10 Nov 2017

Activity: Talk or presentationOral presentation

Reorganisatie van de aortawand door periaortaal vetweefsel in atherosclerotische en aneurysmatische aorta.

JP Meekel (Speaker), van Schaik, T. G. (Speaker), Hoozemans, J. (Speaker), Lelij, R. (Speaker), Wisselink, W. (Speaker), Blankensteijn, J. (Speaker), Yeung, K. K. (Speaker)
11 May 201712 May 2017

Activity: Talk or presentationOral presentation