19982020

Research output per year

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Personal profile

Research interests

During my PhD training I investigated the role of inflammation in Alzheimer’s disease and especially the mechanism on how nonsteroidal anti-inflammatory drugs (NSAIDs) could lower the risk of developing Alzheimer’s disease. I was one of first to discover that the enzyme cyclooxygenase 1, a primary target of NSAIDs, is expressed in microglia in the human brain. As postdoc researcher I was involved in several projects investigating the molecular mechanism of neurodegeneration in Alzheimer’s disease. During this period, I got interested in regulation of protein folding in neurodegenerative diseases. Using post mortem brain tissue, I was the first to show that the unfolded protein response (UPR) is activated in Alzheimer’s disease. In following studies, I was able to show that the UPR is activated in early stages of Alzheimer’s disease and Parkinson’s disease and show the connection between UPR activation and the accumulation of tau and alpha-synuclein in the human brain. Publications that resulted from these studies are currently recognized as key papers subscribing the role of the UPR in neurodegeneration. Currently I am leading several research projects on protein misfolding and neuroinflammation, as well as on the identification of new biomarkers and drug targets for neurodegenerative disease.

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Research Output

Neuropathology of Fragile-X associated neuropsychiatric disorders (FXAND)

Dijkstra, A. A., Haify, S., Verwey, N. A., Prins, N. D., Severijnen, L. W., Rozemuller, A. J. M., den Dunnen, W. F. A., Willemsen, R., Hukema, R. K. & Hoozemans, J. J. M., Mar 2020, In : Neuropathology and Applied Neurobiology. 46, p. 44-45

Research output: Contribution to journalMeeting AbstractAcademic

The coarse-grained A beta plaque; a 'new' kid on the block in early-onset Alzheimer's disease, showing a strong association with both inflammatory and vascular changes

Boon, B. D. C., Bulk, M., Jonker, A. J., Morrema, T. H. J., van den Berg, E., Popovic, M., Walter, J., Kumar, S., Natte, R., van der Weerd, L., Bouwman, F. H., van de Berg, W. D. J., Hoozemans, J. J. M. & Rozemuller, A. J. M., Mar 2020, In : Neuropathology and Applied Neurobiology. 46, p. 39-40

Research output: Contribution to journalMeeting AbstractAcademic

The search for a unique Raman signature of amyloid-beta plaques in human brain tissue from Alzheimer's disease patients

Lochocki, B., Morrema, T. H. J., Ariese, F., Hoozemans, J. J. M. & de Boer, J. F., 2 Mar 2020, In : Analyst. 145, 5, p. 1724-1736 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Activities

  • 4 Oral presentation
  • 2 Hosting an academic visitor
  • 2 Membership of board
  • 1 Editorial work

Dietmar Rudolf Thal

Jeroen Hoozemans (Host)
11 Oct 2017

Activity: Hosting a visitorHosting an academic visitor

UNFOLDED PROTEIN RESPONSE ACTIVATION IN C9ORF72 FRONTOTEMPORAL DEMENTIA CASES

Jeroen Hoozemans (Speaker)
1 Apr 2017

Activity: Talk or presentationOral presentation

Reorganisatie van de aortawand door periaortaal vetweefsel in atherosclerotische en aneurysmatische aorta.

JP Meekel (Speaker), TG van Schaik (Speaker), JJM Hoozemans (Speaker), RJ Lelij (Speaker), W Wisselink (Speaker), JD Blankensteijn (Speaker), KK Yeung (Speaker)
11 May 201712 May 2017

Activity: Talk or presentationOral presentation

Unfolded protein response activation in C9orf72 FTD cases

Jeroen Hoozemans (Speaker)
2 Mar 2017

Activity: Talk or presentationOral presentation

Characterization of abdominal adipose tissue deposits in aortic pathology.

JP Meekel (Speaker), N Bogunovic (Speaker), JJM Hoozemans (Speaker), TG van Schaik (Speaker), RJ Lelij (Speaker), W Wisselink (Speaker), JD Blankensteijn (Speaker), KK Yeung (Speaker)
10 Nov 2017

Activity: Talk or presentationOral presentation