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Research Output 1998 2019

A beta(1-42) induces mild endoplasmic reticulum stress in an aggregation state-dependent manner

Chafekar, S. M., Hoozemans, J. J. M., Zwart, R., Baas, F. & Scheper, W., Dec 2007, In : Antioxidants and Redox Signaling. 9, 12, p. 2245-2254

Research output: Contribution to journalArticleAcademicpeer-review

A common antigenic motif recognized by naturally occurring human V H 5-51/V L 4-1 anti-tau antibodies with distinct functionalities

Apetri, A., Crespo, R., Juraszek, J., Pascual, G., Janson, R., Zhu, X., Zhang, H., Keogh, E., Holland, T., Wadia, J., Verveen, H., Siregar, B., Mrosek, M., Taggenbrock, R., Ameijde, J., Inganäs, H., van Winsen, M., Koldijk, M. H., Zuijdgeest, D., Borgers, M. & 13 othersDockx, K., Stoop, E. J. M., Yu, W., Brinkman-van der Linden, E. C., Ummenthum, K., van Kolen, K., Mercken, M., Steinbacher, S., de Marco, D., Hoozemans, J. J., Wilson, I. A., Koudstaal, W. & Goudsmit, J., 2018, In : Acta Neuropathologica Communinications. 6, 1, p. 43 43.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q

Veerhuis, R., Boshuizen, RS., Morbin, M., Mazzoleni, G., Hoozemans, JJM., Langedijk, JPM., Tagliavini, F., Langeveld, JPM. & Eikelenboom, P., 2005, In : Neurobiology of Disease. 19, 1-2, p. 273-282

Research output: Contribution to journalArticleAcademicpeer-review

Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology

Wiersma, V. I., van Hecke, W., Scheper, W., van Osch, M. A. J., Hermsen, W. J. M., Rozemuller, A. J. M. & Hoozemans, J. J. M., 28 Oct 2016, In : Acta Neuropathologica Communinications. 4, 113.

Research output: Contribution to journalArticleAcademicpeer-review

Activation of the unfolded protein response in Parkinson's disease

Hoozemans, J. J. M., van Haastert, E. S., Eikelenboom, P., de Vos, R. A. I., Rozemuller, J. M. & Scheper, W., 16 Mar 2007, In : Biochemical and Biophysical Research Communications. 354, 3, p. 707-11 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Activation of the Unfolded Protein Response Is an Early Event in Alzheimer's and Parkinson's Disease

Hoozemans, J. J. M., van Haastert, E. S., Nijholt, D. A. T., Rozemuller, J. M. & Scheper, W., 2012, In : Neurodegenerative Diseases. 10, 1-4, p. 212-215

Research output: Contribution to journalArticleAcademicpeer-review

Activation of the unfolded protein response is not a common feature in human prion disease

Hoozemans, J. J. M., Wiersma, V. I., van Hecke, W., Scheper, W. & Rozemuller, J. M., Mar 2016, In : Neuropathology and Applied Neurobiology. 42, p. 29-30

Research output: Contribution to journalMeeting AbstractOther research output

Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E-2

Veerhuis, R., Hoozemans, JJM., Janssen, I., Boshuizen, RS., Langeveld, JPM. & Eikelenboom, P., 25 Jan 2002, In : Brain Research. 925, 2, p. 195-203

Research output: Contribution to journalArticleAcademicpeer-review

A Laser Microdissection-Liquid Chromatography-Tandem Mass Spectrometry Workflow for Post-mortem Analysis of Brain Tissue

Hondius, D. C., Hoozemans, J. J. M., Rozemuller, A. J. M., Li, K. W. & Smit, A. B., 2018, In : Methods in Molecular Biology. 1723, p. 371-383 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Alpha-Synuclein Induces the Unfolded Protein Response in Parkinson's Disease SNCA Triplication iPSC-Derived Neurons

Heman-Ackah, S. M., Manzano, R., Hoozemans, J. J. M., Scheper, W., Flynn, R., Haerty, W., Cowley, S. A., Bassett, A. R. & Wood, M. J. A., 1 Jan 2017, In : Human Molecular Genetics. 26, 22, p. 4441-4450 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy

de Wit, N. M., Snkhchyan, H., den Hoedt, S., Wattimena, D., de Vos, R., Mulder, M. T., Walter, J., Martinez-Martinez, P., Hoozemans, J. J., Rozemuller, A. J. & de Vries, H. E., 2017, In : Journal of Alzheimer's Disease. 60, 3, p. 795-807 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Always around, never the same: Pathways of amyloid beta induced neurodegeneration throughout the pathogenic cascade of Alzheimer's disease

Hoozemans, J. J. M., Chafekar, S. M., Baas, F., Eikelenboom, P. & Scheper, W., 1 Jan 2010, In : Frontiers in Medicinal Chemistry. 5, 1, p. 1-14 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Always around, never the same: pathways of amyloid beta induced neurodegeneration throughout the pathogenic cascade of Alzheimer's disease

Hoozemans, J. J. M., Chafekar, S. M., Baas, F., Eikelenboom, P. & Scheper, W., 2006, In : Current Medicinal Chemistry. 13, 22, p. 2599-605 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Alzheimer's Disease and Adult Neurogenesis: Are endogenous stem cells part of the solution?

Marlat, M. W., Hoozemans, J. J. M., Veerhuis, R. & Lucassen, P. J., 2009, In : US Neurology. 5, 1, p. 12-14

Research output: Contribution to journalArticleAcademic

Amyloid-beta and phosphorylated tau in post-mortem Alzheimer's disease retinas

den Haan, J., Morrema, T. H. J., Verbraak, F. D., de Boer, J. F., Scheltens, P., Rozemuller, A. J., Bergen, A. A. B., Bouwman, F. H. & Hoozemans, J. J., 2018, In : Acta Neuropathologica Communinications. 6, 1, p. 147

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes

Hüll, M., Müksch, B., Akundi, R. S., Waschbisch, A., Hoozemans, J. J. M., Veerhuis, R. & Fiebich, B. L., Jun 2006, In : Neurochemistry International. 48, 8, p. 663-72 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Amyloid beta plaque-associated proteins C1q and SAP enhance the A beta(1-42) peptide-induced cytokine secretion by adult human microglia in vitro

Veerhuis, R., Van Breemen, MJ., Hoozemans, JJM., Morbin, M., Ouladhadj, J., Tagliavini, F. & Eikelenboom, P., Feb 2003, In : Acta Neuropathologica. 105, 2, p. 135-144

Research output: Contribution to journalArticleAcademicpeer-review

Amyloid beta plaque-associated proteins C1q and SAP enhance the A beta 1-42 peptide-induced cytokine secretion by adult human microglia in vitro

Veerhuis, R., van Breemen, MJ., Hoozemans, JJM., Gerritsen, WH., Janssen, I., Ouladhadj, J. & Eikelenboom, P., 2002, In : Neurobiology of Aging. 23, 1, p. S12-S12

Research output: Contribution to journalArticleAcademicpeer-review

A New PERKspective on Neurodegeneration

Scheper, W. & Hoozemans, J. J. M., 2013, In : Science Translational Medicine. 5, 206, p. 206fs37

Research output: Contribution to journalArticleAcademicpeer-review

ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy

Carrano, A., Snkhchyan, H., Kooij, G., van der Pol, S., van Horssen, J., Veerhuis, R., Hoozemans, J. J. M., Rozemuller, A. J. M. & de Vries, H. E., 2014, In : Neurobiology of Aging. 35, 3, p. 565-575

Research output: Contribution to journalArticleAcademicpeer-review

26 Downloads (Pure)

Breaking Barriers: Blood-brain barrier alterations in capillary cerebral amyloid angiopathy and Alzheimer's disease

Carrano, A., 2013

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease

del Campo, M., Hoozemans, J. J. M., Dekkers, L. L., Rozemuller, A. J. M., Korth, C., Muller-Schiffmann, A., Scheltens, P., Blankenstein, M. A., Jimenez, C. R., Veerhuis, R. & Teunissen, C. E., 2014, In : Neurobiology of Aging. 35, 7, p. 1596-1604

Research output: Contribution to journalArticleAcademicpeer-review

BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells.

Del Campo Milan, M., Oliveira, C. R., Scheper, W., Zwart, R., Korth, C., Muller-Schiffmann, A., Kostallas, G., Biverstal, H., Presto, J., Johansson, J., Hoozemans, J. J., Pereira, C. F. & Teunissen, C. E., 2015, In : Cellular and Molecular Life Sciences. 72, 8, p. 1599-1611

Research output: Contribution to journalArticleAcademicpeer-review

Characteristics of Dyshoric Capillary Cerebral Amyloid Angiopathy

Richard, E., Carrano, A., Hoozemans, J. J. M., van Horssen, J., van Haastert, E. S., Eurelings, L. S., de Vries, H. E., Thal, D. R., Eikelenboom, P., van Gool, W. A. & Rozemuller, A. J. M., 2010, In : Journal of Neuropathology and Experimental Neurology. 69, 11, p. 1158-1167

Research output: Contribution to journalArticleAcademicpeer-review

21 Downloads (Pure)

Cholinergic imbalance in the multiple sclerosis hippocampus

Kooi, E-J., Prins, M., Bajic, N., Beliën, J. A. M., Gerritsen, W. H., van Horssen, J., Aronica, E., van Dam, A-M., Hoozemans, J. J. M., Francis, P. T., van der Valk, P. & Geurts, J. J. G., Sep 2011, In : Acta Neuropathologica. 122, 3, p. 313-322 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Co-localization of cyclo-oxygenase 2 with cyclin D1 and cyclin E in pyramidal neurons in Alzheimer's disease temporal cortex

Hoozemans, JJM., Veerhuis, R., Bruckner, MK., Arendt, T., Rozemuller, AJM. & Eikelenboom, P., 2002, In : Neurobiology of Aging. 23, 1, p. S222-S222

Research output: Contribution to journalArticleAcademicpeer-review

Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities

Apetri, A. C., Crespo, R., Juraszek, J., Pascual, G., Janson, R., Zhu, X., Keogh, E., Zhang, H., Holland, T., Wadia, J., Verveen, H., Siregar, B., Mrosek, M., Taggenbrock, R., van Ameijde, J., Inganas, H., van Winsen, M., Koldijk, M., Zuijdgeest, D., Borgers, M. & 13 othersDockx, K., Stoop, E., Yu, W., Brinkman-van der Linden, E. C., Ummenthum, K., van Kolen, K., Mercken, M., Steinbacher, S., de Marco, D., Hoozemans, J. J., Wilson, I. A., Koudstaal, W. & Goudsmit, J., 2018, In : Biorxiv.

Research output: Contribution to journalArticleAcademicpeer-review

Complement c1-inhibitor expression in Alzheimer's disease

Veerhuis, R., Janssen, I., Hoozemans, JJM., De Groot, CJA., Hack, CE. & Eikelenboom, P., Sep 1998, In : Acta Neuropathologica. 96, 3, p. 287-296

Research output: Contribution to journalArticleAcademicpeer-review

Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease

Chatterjee, M., Del Campo, M., Morrema, T. H. J., de Waal, M., van der Flier, W. M., Hoozemans, J. J. M. & Teunissen, C. E., 1 Jun 2018, In : Alzheimer's Research & Therapy. 10, 1, p. 52

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain

Hoozemans, JJM., Rozemuller, AJM., Janssen, I., De Groot, CJA., Veerhuis, R. & Eikelenboom, P., Jan 2001, In : Acta Neuropathologica. 101, 1, p. 2-8

Research output: Contribution to journalArticleAcademicpeer-review

Diagnosing frontotemporal dementia: clinico-pathological correlations in the Dutch population

Scarioni, M., Gami-Patel, P., van Swieten, J. C., Rozemuller, A., Dols, A., Hoozemans, J. J., Pijnenburg, Y. A. & Dijkstra, A. A., Jun 2018, In : European Journal of Neurology. 25, p. 478-478

Research output: Contribution to journalMeeting AbstractAcademic

Disturbed Ca2+ Homeostasis Increases Glutaminyl Cyclase Expression; Connecting Two Early Pathogenic Events in Alzheimer's Disease In Vitro

de Kimpe, L., Bennis, A., Zwart, R., van Haastert, E. S., Hoozemans, J. J. M. & Scheper, W., 2012, In : PLoS ONE. 7, 9, p. e44674 e44674.

Research output: Contribution to journalArticleAcademicpeer-review

DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid

Copani, A., Hoozemans, J. J. M., Caraci, F., Calafiore, M., Van Haastert, E. S., Veerhuis, R., Rozemuller, A. J. M., Aronica, E., Sortino, M. A. & Nicoletti, F., 25 Oct 2006, In : Journal of Neuroscience. 26, 43, p. 10949-10957

Research output: Contribution to journalArticleAcademicpeer-review

DNA polymerase-β is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with β-amyloid

Copani, A., Hoozemans, J. J. M., Caraci, F., Calafiore, M., Van Haastert, E. S., Veerhuis, R., Rozemuller, A. J. M., Aronica, E., Sortino, M. A. & Nicoletti, F., 25 Oct 2006, In : Journal of Neuroscience. 26, 43, p. 10949-10957 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Editorial

Hoozemans, J. J. M., 1 Jun 2005, In : Current Drug Targets: CNS and Neurological Disorders. 4, 3, p. 221-222 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

EIF2AK3 variants in Dutch patients with Alzheimer's disease

Wong, T. H., van der Lee, S. J., van Rooij, J. G. J., Meeter, L. H. H., Frick, P., Melhem, S., Seelaar, H., Ikram, M. A., Rozemuller, A. J., Holstege, H., Hulsman, M., Uitterlinden, A., Neumann, M., Hoozemans, J. J. M., van Duijn, C. M., Rademakers, R. & van Swieten, J. C., 1 Jan 2019, In : Neurobiology of Aging. 73, p. 229.e11-229.e18

Research output: Contribution to journalArticleAcademicpeer-review

Endoplasmic reticulum: The unfolded protein response is tangled in neurodegeneration

Hoozemans, J. J. M. & Scheper, W., 2012, In : International Journal of Biochemistry & Cell Biology. 44, 8, p. 1295-1298

Research output: Contribution to journalArticleAcademicpeer-review

Endoplasmic reticulum protein quality control in neurodegenerative disease: the good, the bad and the therapy

Scheper, W. & Hoozemans, J. J. M., 2009, In : Current Medicinal Chemistry. 16, 5, p. 615-26 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Endoplasmic Reticulum Protein Quality Control in Neurodegenerative Disease: The Good, the Bad and the Therapy

Scheper, W. & Hoozemans, J. J. M., 2009, In : Current Medicinal Chemistry. 16, 5, p. 615-626

Research output: Contribution to journalArticleAcademicpeer-review

Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease

Nijholt, D. A. T., Graaf, T. R., van Haastert, E. S., Oliveira, A., Berkers, C. R., Zwart, R., Ovaa, H., Baas, F., Hoozemans, J. J. M. & Scheper, R. J., 2011, In : Cell Death and Differentiation. 18, 6, p. 1071-1081

Research output: Contribution to journalArticleAcademicpeer-review

Endoplasmic Reticulum Stress in Neurodegeneration

Hoozemans, J. J. M. & Scheper, W., 2009, Protein Folding and Misfolding: Neurodegenerative Diseases. Ovádi, J. & Orosz, F. (eds.). Dordrecht: Springer Netherlands, p. 111-132 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review