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Research Output 1998 2019

2008

Increased expression of the oligopeptidase THOP1 is a neuroprotective response to A beta toxicity

Pollio, G., Hoozemans, J. J. M., Andersen, C. A., Roncarati, R., Rosi, M. C., van Haastert, E. S., Seredenina, T., Diamanti, D., Gotta, S., Fiorentini, A., Magnoni, L., Raggiaschi, R., Rozemuller, A. J. M., Casamenti, F., Caricasole, A. & Terstappen, G. C., 2008, In : Neurobiology of Disease. 31, 1, p. 145-158

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation Related Factors: Role in Alzheimer’s Disease and Use as Biomarkers

Hoozemans, JJM., Veerhuis, R., Mulder, SD., Verwey, NA., Mulder, C., Hack, C. E., Blankenstein, MA. & Eikelenboom, P., 1 Oct 2008, Biomarkers for Early Diagnosis of Alzheimer's Disease. 2008, 4th quarter: NOVA Science publishers, Inc., p. 157-210 53 p. Chapter 7

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implications

Eikelenboom, P., Veerhuis, R., Familian, A., Hoozemans, J. J. M., van Gool, W. A. & Rozemuller, A. J. M., 2008, In : Neurodegenerative Diseases. 5, 3-4, p. 190-193

Research output: Contribution to journalArticleAcademicpeer-review

2007

A beta(1-42) induces mild endoplasmic reticulum stress in an aggregation state-dependent manner

Chafekar, S. M., Hoozemans, J. J. M., Zwart, R., Baas, F. & Scheper, W., Dec 2007, In : Antioxidants and Redox Signaling. 9, 12, p. 2245-2254

Research output: Contribution to journalArticleAcademicpeer-review

Activation of the unfolded protein response in Parkinson's disease

Hoozemans, J. J. M., van Haastert, E. S., Eikelenboom, P., de Vos, R. A. I., Rozemuller, J. M. & Scheper, W., 16 Mar 2007, In : Biochemical and Biophysical Research Communications. 354, 3, p. 707-11 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microglia activation in sepsis: a case-control study

Lemstra, A. W., in't Woud, J. C. M. G., Hoozemans, J. J. M., van Haastert, E. S., Rozemuller, A. J. M., Eikelenboom, P. & van Gool, W. A., 15 Jan 2007, In : Journal of Neuroinflammation. 4

Research output: Contribution to journalArticleAcademicpeer-review

Pin1 levels are downregulated during ER stress in human neuroblastoma cells

Kap, Y. S., Hoozemans, J. J. M., Bodewes, A. J., Zwart, R., Meijer, O. C., Baas, F. & Scheper, W., Jan 2007, In : Neurogenetics. 8, 1, p. 21-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pontocerebellar hypoplasia type 2: a neuropathological update

Barth, P. G., Aronica, E., de Vries, L. S., Nikkels, P. G. J., Scheper, W., Hoozemans, J. J., Poll-The, B-T. & Troost, D., Oct 2007, In : Acta Neuropathologica. 114, 4, p. 373-386

Research output: Contribution to journalArticleAcademicpeer-review

Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress

Scheper, W., Hoozemans, J. J. M., Hoogenraad, C. C., Rozemuller, A. J. M., Eikelenboom, P. & Baas, F., Oct 2007, In : Neuropathology and Applied Neurobiology. 33, 5, p. 523-32 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The involvement of aβ in the neuroinflammatory response

Eikelenboom, P., Van Gool, W. A., Rozemuller, A. J. M., Scheper, W., Veerhuis, R. & Hoozemans, J. J. M., 1 Dec 2007, Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. Springer London, p. 52-82 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death

Copani, A., Caraci, F., Hoozemans, J. J. M., Calafiore, M., Sortino, M. A. & Nicoletti, F., Apr 2007, In : Biochimica et Biophysica Acta. Reviews on Cancer. 1772, 4, p. 409-12 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

2006

Always around, never the same: pathways of amyloid beta induced neurodegeneration throughout the pathogenic cascade of Alzheimer's disease

Hoozemans, J. J. M., Chafekar, S. M., Baas, F., Eikelenboom, P. & Scheper, W., 2006, In : Current Medicinal Chemistry. 13, 22, p. 2599-605 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes

Hüll, M., Müksch, B., Akundi, R. S., Waschbisch, A., Hoozemans, J. J. M., Veerhuis, R. & Fiebich, B. L., Jun 2006, In : Neurochemistry International. 48, 8, p. 663-72 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid

Copani, A., Hoozemans, J. J. M., Caraci, F., Calafiore, M., Van Haastert, E. S., Veerhuis, R., Rozemuller, A. J. M., Aronica, E., Sortino, M. A. & Nicoletti, F., 25 Oct 2006, In : Journal of Neuroscience. 26, 43, p. 10949-10957

Research output: Contribution to journalArticleAcademicpeer-review

DNA polymerase-β is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with β-amyloid

Copani, A., Hoozemans, J. J. M., Caraci, F., Calafiore, M., Van Haastert, E. S., Veerhuis, R., Rozemuller, A. J. M., Aronica, E., Sortino, M. A. & Nicoletti, F., 25 Oct 2006, In : Journal of Neuroscience. 26, 43, p. 10949-10957 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB

Waschbisch, A., Fiebich, B. L., Akundi, R. S., Schmitz, M. L., Hoozemans, J. J. M., Candelario-Jalil, E., Virtainen, N., Veerhuis, R., Slawik, H., Yrjänheikki, J. & Hüll, M., Feb 2006, In : Journal of Neurochemistry. 96, 3, p. 680-93 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

The significance of neuroinflammation in understanding Alzheimer's disease

Eikelenboom, P., Veerhuis, R., Scheper, W., Rozemuller, A. J. M., van Gool, W. A. & Hoozemans, J. J. M., Nov 2006, In : Journal of Neural Transmission. 113, 11, p. 1685-95 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2005

Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q

Veerhuis, R., Boshuizen, RS., Morbin, M., Mazzoleni, G., Hoozemans, JJM., Langedijk, JPM., Tagliavini, F., Langeveld, JPM. & Eikelenboom, P., 2005, In : Neurobiology of Disease. 19, 1-2, p. 273-282

Research output: Contribution to journalArticleAcademicpeer-review

Editorial

Hoozemans, J. J. M., 1 Jun 2005, In : Current Drug Targets: CNS and Neurological Disorders. 4, 3, p. 221-222 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs

Hoozemans, J. J. M. & O'Banion, M. K., 1 Jun 2005, In : Current Drug Targets: CNS and Neurological Disorders. 4, 3, p. 307-315 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The unfolded protein response is activated in Alzheimer's disease

Hoozemans, JJM., Veerhuis, R., Van Haastert, ES., Rozemuller, JM., Baas, F., Eikelenboom, P. & Scheper, W., Aug 2005, In : Acta Neuropathologica. 110, 2, p. 165-172

Research output: Contribution to journalArticleAcademicpeer-review

2004
2003

Amyloid beta plaque-associated proteins C1q and SAP enhance the A beta(1-42) peptide-induced cytokine secretion by adult human microglia in vitro

Veerhuis, R., Van Breemen, MJ., Hoozemans, JJM., Morbin, M., Ouladhadj, J., Tagliavini, F. & Eikelenboom, P., Feb 2003, In : Acta Neuropathologica. 105, 2, p. 135-144

Research output: Contribution to journalArticleAcademicpeer-review

Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease

Hoozemans, JJM., Veerhuis, R., Rozemuller, AJM. & Eikelenboom, P., Aug 2003, In : Current Drug Targets. 4, 6, p. 461-468

Research output: Contribution to journalArticleAcademicpeer-review

2002

Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E-2

Veerhuis, R., Hoozemans, JJM., Janssen, I., Boshuizen, RS., Langeveld, JPM. & Eikelenboom, P., 25 Jan 2002, In : Brain Research. 925, 2, p. 195-203

Research output: Contribution to journalArticleAcademicpeer-review

Amyloid beta plaque-associated proteins C1q and SAP enhance the A beta 1-42 peptide-induced cytokine secretion by adult human microglia in vitro

Veerhuis, R., van Breemen, MJ., Hoozemans, JJM., Gerritsen, WH., Janssen, I., Ouladhadj, J. & Eikelenboom, P., 2002, In : Neurobiology of Aging. 23, 1, p. S12-S12

Research output: Contribution to journalArticleAcademicpeer-review

Co-localization of cyclo-oxygenase 2 with cyclin D1 and cyclin E in pyramidal neurons in Alzheimer's disease temporal cortex

Hoozemans, JJM., Veerhuis, R., Bruckner, MK., Arendt, T., Rozemuller, AJM. & Eikelenboom, P., 2002, In : Neurobiology of Aging. 23, 1, p. S222-S222

Research output: Contribution to journalArticleAcademicpeer-review

Neuroinflammation in Alzheimer's disease and prion disease

Eikelenboom, P., Bate, C., Van Gool, WA., Hoozemans, JJM., Rozemuller, JM., Veerhuis, R. & Williams, A., Nov 2002, In : GLIA. 40, 2, p. 232-239

Research output: Contribution to journalArticleAcademicpeer-review

The pathological cascade of Alzheimer's disease: The role of inflammation and its therapeutic implications

Hoozemans, JJM., Veerhuis, R., Rozemuller, AJM. & Eikelenboom, P., Jun 2002, In : Drugs of Today. 38, 6, p. 429-443

Research output: Contribution to journalArticleAcademicpeer-review

The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E2 secretion by cultured human adult microglia: Implications for Alzheimer's disease

Hoozemans, J. J. M., Veerhuis, R., Janssen, I., Van Elk, E. J., Rozemuller, A. J. M. & Eikelenboom, P., 4 Oct 2002, In : Brain Research. 951, 2, p. 218-226 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E-2 secretion by cultured human adult microglia: Implications for Alzheimer's disease

Hoozemans, JJM., Veerhuis, R., Janssen, I., van Elk, EJ., Rozemuller, AJM. & Eikelenboom, P., 4 Oct 2002, In : Brain Research. 951, 2, p. 218-226

Research output: Contribution to journalArticleAcademicpeer-review

2001

Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain

Hoozemans, JJM., Rozemuller, AJM., Janssen, I., De Groot, CJA., Veerhuis, R. & Eikelenboom, P., Jan 2001, In : Acta Neuropathologica. 101, 1, p. 2-8

Research output: Contribution to journalArticleAcademicpeer-review

Establishment of microglial cell cultures derived from postmortem human adult brain tissue: Immunophenotypical and functional characterization

De Groot, CJA., Hulshof, S., Hoozemans, JJM. & Veerhuis, R., 1 Jul 2001, In : MICROSCOPY RESEARCH AND TECHNIQUE. 54, 1, p. 34-39

Research output: Contribution to journalArticleAcademicpeer-review

Immunological aspects of Alzheimer's disease - Therapeutic implications

Hoozemans, JJM., Rozemuller, AJM., Veerhuis, R. & Eikelenboom, P., 2001, In : BIODRUGS. 15, 5, p. 325-337

Research output: Contribution to journalArticleAcademicpeer-review

2000

Neuroinflammation and Alzheimer disease: Clinical and therapeutic implications

Eikelenboom, P., Rozemuller, AJM., Hoozemans, JJM., Veerhuis, R. & Van Gool, WA., 2000, In : Alzheimer Disease and Associated Disorders. 14, p. S54-S61

Research output: Contribution to journalArticleAcademicpeer-review

1998

Complement c1-inhibitor expression in Alzheimer's disease

Veerhuis, R., Janssen, I., Hoozemans, JJM., De Groot, CJA., Hack, CE. & Eikelenboom, P., Sep 1998, In : Acta Neuropathologica. 96, 3, p. 287-296

Research output: Contribution to journalArticleAcademicpeer-review