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Research Output 1998 2019

2007

A beta(1-42) induces mild endoplasmic reticulum stress in an aggregation state-dependent manner

Chafekar, S. M., Hoozemans, J. J. M., Zwart, R., Baas, F. & Scheper, W., Dec 2007, In : Antioxidants and Redox Signaling. 9, 12, p. 2245-2254

Research output: Contribution to journalArticleAcademicpeer-review

Activation of the unfolded protein response in Parkinson's disease

Hoozemans, J. J. M., van Haastert, E. S., Eikelenboom, P., de Vos, R. A. I., Rozemuller, J. M. & Scheper, W., 16 Mar 2007, In : Biochemical and Biophysical Research Communications. 354, 3, p. 707-11 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microglia activation in sepsis: a case-control study

Lemstra, A. W., in't Woud, J. C. M. G., Hoozemans, J. J. M., van Haastert, E. S., Rozemuller, A. J. M., Eikelenboom, P. & van Gool, W. A., 15 Jan 2007, In : Journal of Neuroinflammation. 4

Research output: Contribution to journalArticleAcademicpeer-review

Pin1 levels are downregulated during ER stress in human neuroblastoma cells

Kap, Y. S., Hoozemans, J. J. M., Bodewes, A. J., Zwart, R., Meijer, O. C., Baas, F. & Scheper, W., Jan 2007, In : Neurogenetics. 8, 1, p. 21-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pontocerebellar hypoplasia type 2: a neuropathological update

Barth, P. G., Aronica, E., de Vries, L. S., Nikkels, P. G. J., Scheper, W., Hoozemans, J. J., Poll-The, B-T. & Troost, D., Oct 2007, In : Acta Neuropathologica. 114, 4, p. 373-386

Research output: Contribution to journalArticleAcademicpeer-review

Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress

Scheper, W., Hoozemans, J. J. M., Hoogenraad, C. C., Rozemuller, A. J. M., Eikelenboom, P. & Baas, F., Oct 2007, In : Neuropathology and Applied Neurobiology. 33, 5, p. 523-32 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The involvement of aβ in the neuroinflammatory response

Eikelenboom, P., Van Gool, W. A., Rozemuller, A. J. M., Scheper, W., Veerhuis, R. & Hoozemans, J. J. M., 1 Dec 2007, Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. Springer London, p. 52-82 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death

Copani, A., Caraci, F., Hoozemans, J. J. M., Calafiore, M., Sortino, M. A. & Nicoletti, F., Apr 2007, In : Biochimica et Biophysica Acta. Reviews on Cancer. 1772, 4, p. 409-12 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

2006

Always around, never the same: pathways of amyloid beta induced neurodegeneration throughout the pathogenic cascade of Alzheimer's disease

Hoozemans, J. J. M., Chafekar, S. M., Baas, F., Eikelenboom, P. & Scheper, W., 2006, In : Current Medicinal Chemistry. 13, 22, p. 2599-605 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes

Hüll, M., Müksch, B., Akundi, R. S., Waschbisch, A., Hoozemans, J. J. M., Veerhuis, R. & Fiebich, B. L., Jun 2006, In : Neurochemistry International. 48, 8, p. 663-72 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid

Copani, A., Hoozemans, J. J. M., Caraci, F., Calafiore, M., Van Haastert, E. S., Veerhuis, R., Rozemuller, A. J. M., Aronica, E., Sortino, M. A. & Nicoletti, F., 25 Oct 2006, In : Journal of Neuroscience. 26, 43, p. 10949-10957

Research output: Contribution to journalArticleAcademicpeer-review

DNA polymerase-β is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with β-amyloid

Copani, A., Hoozemans, J. J. M., Caraci, F., Calafiore, M., Van Haastert, E. S., Veerhuis, R., Rozemuller, A. J. M., Aronica, E., Sortino, M. A. & Nicoletti, F., 25 Oct 2006, In : Journal of Neuroscience. 26, 43, p. 10949-10957 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB

Waschbisch, A., Fiebich, B. L., Akundi, R. S., Schmitz, M. L., Hoozemans, J. J. M., Candelario-Jalil, E., Virtainen, N., Veerhuis, R., Slawik, H., Yrjänheikki, J. & Hüll, M., Feb 2006, In : Journal of Neurochemistry. 96, 3, p. 680-93 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

The significance of neuroinflammation in understanding Alzheimer's disease

Eikelenboom, P., Veerhuis, R., Scheper, W., Rozemuller, A. J. M., van Gool, W. A. & Hoozemans, J. J. M., Nov 2006, In : Journal of Neural Transmission. 113, 11, p. 1685-95 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2005

Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q

Veerhuis, R., Boshuizen, RS., Morbin, M., Mazzoleni, G., Hoozemans, JJM., Langedijk, JPM., Tagliavini, F., Langeveld, JPM. & Eikelenboom, P., 2005, In : Neurobiology of Disease. 19, 1-2, p. 273-282

Research output: Contribution to journalArticleAcademicpeer-review

Editorial

Hoozemans, J. J. M., 1 Jun 2005, In : Current Drug Targets: CNS and Neurological Disorders. 4, 3, p. 221-222 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs

Hoozemans, J. J. M. & O'Banion, M. K., 1 Jun 2005, In : Current Drug Targets: CNS and Neurological Disorders. 4, 3, p. 307-315 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The unfolded protein response is activated in Alzheimer's disease

Hoozemans, JJM., Veerhuis, R., Van Haastert, ES., Rozemuller, JM., Baas, F., Eikelenboom, P. & Scheper, W., Aug 2005, In : Acta Neuropathologica. 110, 2, p. 165-172

Research output: Contribution to journalArticleAcademicpeer-review

2004
2003

Amyloid beta plaque-associated proteins C1q and SAP enhance the A beta(1-42) peptide-induced cytokine secretion by adult human microglia in vitro

Veerhuis, R., Van Breemen, MJ., Hoozemans, JJM., Morbin, M., Ouladhadj, J., Tagliavini, F. & Eikelenboom, P., Feb 2003, In : Acta Neuropathologica. 105, 2, p. 135-144

Research output: Contribution to journalArticleAcademicpeer-review

Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease

Hoozemans, JJM., Veerhuis, R., Rozemuller, AJM. & Eikelenboom, P., Aug 2003, In : Current Drug Targets. 4, 6, p. 461-468

Research output: Contribution to journalArticleAcademicpeer-review

2002

Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E-2

Veerhuis, R., Hoozemans, JJM., Janssen, I., Boshuizen, RS., Langeveld, JPM. & Eikelenboom, P., 25 Jan 2002, In : Brain Research. 925, 2, p. 195-203

Research output: Contribution to journalArticleAcademicpeer-review

Amyloid beta plaque-associated proteins C1q and SAP enhance the A beta 1-42 peptide-induced cytokine secretion by adult human microglia in vitro

Veerhuis, R., van Breemen, MJ., Hoozemans, JJM., Gerritsen, WH., Janssen, I., Ouladhadj, J. & Eikelenboom, P., 2002, In : Neurobiology of Aging. 23, 1, p. S12-S12

Research output: Contribution to journalArticleAcademicpeer-review

Co-localization of cyclo-oxygenase 2 with cyclin D1 and cyclin E in pyramidal neurons in Alzheimer's disease temporal cortex

Hoozemans, JJM., Veerhuis, R., Bruckner, MK., Arendt, T., Rozemuller, AJM. & Eikelenboom, P., 2002, In : Neurobiology of Aging. 23, 1, p. S222-S222

Research output: Contribution to journalArticleAcademicpeer-review

Neuroinflammation in Alzheimer's disease and prion disease

Eikelenboom, P., Bate, C., Van Gool, WA., Hoozemans, JJM., Rozemuller, JM., Veerhuis, R. & Williams, A., Nov 2002, In : GLIA. 40, 2, p. 232-239

Research output: Contribution to journalArticleAcademicpeer-review

The pathological cascade of Alzheimer's disease: The role of inflammation and its therapeutic implications

Hoozemans, JJM., Veerhuis, R., Rozemuller, AJM. & Eikelenboom, P., Jun 2002, In : Drugs of Today. 38, 6, p. 429-443

Research output: Contribution to journalArticleAcademicpeer-review

The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E2 secretion by cultured human adult microglia: Implications for Alzheimer's disease

Hoozemans, J. J. M., Veerhuis, R., Janssen, I., Van Elk, E. J., Rozemuller, A. J. M. & Eikelenboom, P., 4 Oct 2002, In : Brain Research. 951, 2, p. 218-226 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E-2 secretion by cultured human adult microglia: Implications for Alzheimer's disease

Hoozemans, JJM., Veerhuis, R., Janssen, I., van Elk, EJ., Rozemuller, AJM. & Eikelenboom, P., 4 Oct 2002, In : Brain Research. 951, 2, p. 218-226

Research output: Contribution to journalArticleAcademicpeer-review

2001

Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain

Hoozemans, JJM., Rozemuller, AJM., Janssen, I., De Groot, CJA., Veerhuis, R. & Eikelenboom, P., Jan 2001, In : Acta Neuropathologica. 101, 1, p. 2-8

Research output: Contribution to journalArticleAcademicpeer-review

Establishment of microglial cell cultures derived from postmortem human adult brain tissue: Immunophenotypical and functional characterization

De Groot, CJA., Hulshof, S., Hoozemans, JJM. & Veerhuis, R., 1 Jul 2001, In : MICROSCOPY RESEARCH AND TECHNIQUE. 54, 1, p. 34-39

Research output: Contribution to journalArticleAcademicpeer-review

Immunological aspects of Alzheimer's disease - Therapeutic implications

Hoozemans, JJM., Rozemuller, AJM., Veerhuis, R. & Eikelenboom, P., 2001, In : BIODRUGS. 15, 5, p. 325-337

Research output: Contribution to journalArticleAcademicpeer-review

2000

Neuroinflammation and Alzheimer disease: Clinical and therapeutic implications

Eikelenboom, P., Rozemuller, AJM., Hoozemans, JJM., Veerhuis, R. & Van Gool, WA., 2000, In : Alzheimer Disease and Associated Disorders. 14, p. S54-S61

Research output: Contribution to journalArticleAcademicpeer-review

1998

Complement c1-inhibitor expression in Alzheimer's disease

Veerhuis, R., Janssen, I., Hoozemans, JJM., De Groot, CJA., Hack, CE. & Eikelenboom, P., Sep 1998, In : Acta Neuropathologica. 96, 3, p. 287-296

Research output: Contribution to journalArticleAcademicpeer-review