Joep Killestein

PROF.DR., (Principal Investigator)

20012019
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Research Output 2001 2019

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Article

Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis

Leurs, C. E., Lopes Pinheiro, M. A., Wierts, L., den Hoedt, S., Mulder, M. T., Eijlers, A. J. C., Schoonheim, M. M., Balk, L. J., Uitdehaag, B. M. J., Killestein, J. & de Vries, H. E., 1 Feb 2019, In : Multiple Sclerosis and Related Disorders. 28, p. 44-49 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gray matter networks and cognitive impairment in multiple sclerosis

Rimkus, C. M., Schoonheim, M. M., Steenwijk, M. D., Vrenken, H., Eijlers, A. J., Killestein, J., Wattjes, M. P., Leite, C. C., Barkhof, F. & Tijms, B. M., 1 Mar 2019, In : Multiple Sclerosis. 25, 3, p. 382-391

Research output: Contribution to journalArticleAcademicpeer-review

Infratentorial and spinal cord lesions: Cumulative predictors of long-term disability?

Dekker, I., Sombekke, M. H., Balk, L. J., Moraal, B., Geurts, J. J. G., Barkhof, F., Uitdehaag, B. M. J., Killestein, J. & Wattjes, M. P., 1 Jan 2019, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study

Leurs, C. E., Twaalfhoven, H. A. M., Lissenberg-Witte, B. I., van Pesch, V., Dujmovic, I., Drulovic, J., Castellazzi, M., Bellini, T., Pugliatti, M., Kuhle, J., Villar, L. M., Alvarez-Cermeño, J. C., Alvarez-Lafuente, R., Hegen, H., Deisenhammer, F., Walchhofer, L. M., Thouvenot, E., Comabella, M., Montalban, X., Vécsei, L. & 19 othersRajda, C., Galimberti, D., Scarpini, E., Altintas, A., Rejdak, K., Frederiksen, J. L., Pihl-Jensen, G., Jensen, P. E. H., Khalil, M., Voortman, M. M., Fazekas, F., Saiz, A., la Puma, D., Vercammen, M., Vanopdenbosch, L., Uitdehaag, B. M. J., Killestein, J., Bridel, C. & Teunissen, C., 2019, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pharmacodynamic assessment of cell-bound natalizumab on PBMC samples stored in liquid nitrogen

ten Brinke, A., Claessen, I., van Kempen, Z. L. E., Killestein, J. & Rispens, T., 2019, In : Journal of Immunological Methods. 473

Research output: Contribution to journalArticleAcademicpeer-review

Plasma proteome in multiple sclerosis disease progression

Malekzadeh, A., Leurs, C., van Wieringen, W., Steenwijk, M. D., Schoonheim, M. M., Amann, M., Naegelin, Y., Kuhle, J., Killestein, J. & Teunissen, C. E., 2019, In : Annals of Clinical and Translational Neurology. 6, 9, p. 1582-1594

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Randomized trial of daily high-dose vitamin D3 in patients with RRMS receiving subcutaneous interferon β-1a

SOLAR Study Group, 12 Nov 2019, In : Neurology. 93, 20, p. e1906-e1916

Research output: Contribution to journalArticleAcademicpeer-review

The natalizumab wearing-off effect: End of natalizumab cycle, recurrence of MS symptoms

van Kempen, Z. L. E., Doesburg, D., Dekker, I., Lissenberg-Witte, B. I., de Vries, A., Claessen, I. A., Brinke, A. T., Rispens, T. & Killestein, J., 22 Oct 2019, In : Neurology. 93, 17, p. e1579-e1586

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Acute syphilitic meningitis in an HIV-infected patient

Wagemakers, A., Hepp, D., Killestein, J., Peferoen, L. & Ang, W., 2018, In : IDCases. 13, e00423.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Asymptomatic spinal cord lesions do not predict the time to disability in patients with early multiple sclerosis.

Dekker, I., Klieverik-Sombekke, MH., Witte, BI., Geurts, JJG., Barkhof, F., Uitdehaag, BMJ., Killestein, J. & Wattjes, MP., 1 Apr 2018, In : Multiple Sclerosis. 24, 4, p. 481-490

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

Leurs, C. E., Podlesniy, P., Trullas, R., Balk, L., Steenwijk, M. D., Malekzadeh, A., Piehl, F., Uitdehaag, B. M., Killestein, J., van Horssen, J. & Teunissen, C. E., 1 Apr 2018, In : Multiple Sclerosis. 24, 4, p. 472-480 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Deep gray matter volume loss drives disability worsening in multiple sclerosis

Eshaghi, A., Prados, F., Brownlee, W. J., Altmann, D. R., Tur, C., Cardoso, M. J., De Angelis, F., van de Pavert, S. H., Cawley, N., De Stefano, N., Stromillo, M. L., Battaglini, M., Ruggieri, S., Gasperini, C., Filippi, M., Rocca, M. A., Rovira, A., Sastre-Garriga, J., Vrenken, H., Leurs, C. E. & 11 othersKillestein, J., Pirpamer, L., Enzinger, C., Ourselin, S., Wheeler-Kingshott, C. A. M. G., Chard, D., Thompson, A. J., Alexander, D. C., Barkhof, F., Ciccarelli, O. & MAGNIMS Study Group, 1 Feb 2018, In : Annals of Neurology. 83, 2, p. 210-222 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects on Spasticity and Neuropathic Pain of an Oral Formulation of δ9-Tetrahydrocannabinol in Patients With Progressive Multiple Sclerosis

van Amerongen, G., Kanhai, K., Baakman, A. C., Heuberger, J., Klaassen, E., Beumer, T. L., Strijers, R. L. M., Killestein, J., van Gerven, J., Cohen, A. & Groeneveld, G. J., 1 Sep 2018, In : Clinical Therapeutics. 40, 9, p. 1467-1482 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

gMS-Classifier1 does not predict disability progression in multiple sclerosis

van Rossum, J. A., Killestein, J., Villar, L. M., Riskind, P. N., Freedman, M. S. & Teunissen, C., 2018, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Imaging of meningeal inflammation should become part of the routine MRI protocol – No

Wattjes, M. P. & Killestein, J., 2018, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticleAcademicpeer-review

Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome: A MAGNIMS multicentre study

Hagens, M. H., Burggraaff, J., Kilsdonk, I. D., Ruggieri, S., Collorone, S., Cortese, R., Cawley, N., Sbardella, E., Andelova, M., Amann, M., Lieb, J. M., Pantano, P., Lissenberg-Witte, B. I., Killestein, J., Oreja-Guevara, C., Wuerfel, J., Ciccarelli, O., Gasperini, C., Lukas, C., Rovira, A. & 3 othersBarkhof, F., Wattjes, M. P. & MAGNIMS Study Group, Mar 2018, In : Multiple Sclerosis. 25, 3, p. 352-360

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Inflammatory natalizumab-associated PML: baseline characteristics, lesion evolution and relation with PML-IRIS

Wattjes, M. P., Wijburg, M. T., Eijk, J. V., Frequin, S., Uitdehaag, B. M. J., Barkhof, F., Warnke, C., Killestein, J. & the Dutch-Belgian Natalizumab-Associated PML Study Group, May 2018, In : Journal of Neurology, Neurosurgery and Psychiatry. 89, 5, p. 535-541

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Information processing speed in multiple sclerosis: Relevance of default mode network dynamics

van Geest, Q., Douw, L., van ‘t Klooster, S., Leurs, C. E., Genova, H. M., Wylie, G. R., Steenwijk, M. D., Killestein, J., Geurts, J. J. G. & Hulst, H. E., 2018, In : NeuroImage: Clinical. 19, p. 507-515

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Switching natalizumab to fingolimod within 6 weeks reduces recurrence of disease activity in MS patients

Leurs, C. E., van Kempen, Z. LE., Dekker, I., Balk, L. J., Wattjes, M. P., Rispens, T., Uitdehaag, B. M. & Killestein, J., Oct 2018, In : Multiple Sclerosis. 24, 11, p. 1453-1460

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The majority of natalizumab-treated MS patients have high natalizumab concentrations at time of re-dosing

van Kempen, Z. LE., Leurs, C. E., Witte, B. I., de Vries, A., Wattjes, M. P., Rispens, T. & Killestein, J., May 2018, In : Multiple Sclerosis. 24, 6, p. 805-810

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The plasma peptides of ovarian cancer

Dufresne, J., Bowden, P., Thavarajah, T., Florentinus-Mefailoski, A., Chen, Z. Z., Tucholska, M., Norzin, T., Ho, M. T., Phan, M., Mohamed, N., Ravandi, A., Stanton, E., Slutsky, A. S., Dos Santos, C. C., Romaschin, A., Marshall, J. C., Addison, C., Malone, S., Heyland, D., Scheltens, P. & 5 othersKillestein, J., Teunissen, C. E., Diamandis, E. P., Michael Siu, K. W. & Marshall, J. G., 2018, In : Clinical Proteomics. 15, 1, 41.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The plasma peptidome 03 Chemical Sciences 0301 Analytical Chemistry

Dufresne, J., Bowden, P., Thavarajah, T., Florentinus-Mefailoski, A., Chen, Z. Z., Tucholska, M., Norzin, T., Ho, M. T., Phan, M., Mohamed, N., Ravandi, A., Stanton, E., Slutsky, A. S., Dos Santos, C. C., Romaschin, A., Marshall, J. C., Addison, C., Malone, S., Heyland, D., Scheltens, P. & 5 othersKillestein, J., Teunissen, C., Diamandis, E. P., Siu, K. W. M. & Marshall, J. G., 1 Dec 2018, In : Clinical Proteomics. 15, 1, 39.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Three-Tesla MRI does not improve the diagnosis of multiple sclerosis: A multicenter study

MAGNIMS Study Group, 17 Jul 2018, In : Neurology. p. e249-e257 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

An observational study of alemtuzumab following fingolimod for multiple sclerosis

Willis, M., Pearson, O., Illes, Z., Sejbaek, T., Nielsen, C., Duddy, M., Petheram, K., Van Munster, C., Killestein, J., Malmeström, C., Tallantyre, E. & Robertson, N., 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 2, e320.

Research output: Contribution to journalArticleAcademicpeer-review

Application of the CSF JCV antibody index to early natalizumabassociated progressive multifocal leukoencephalopathy

Warnke, C., Wijburg, M. T., Hartung, H. P., Killestein, J., Adams, O. & Wattjes, M. P., 1 Dec 2017, In : Journal of Neurology, Neurosurgery and Psychiatry. 88, 12, p. 1092-1094 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of multiplex platforms for cytokine assessments and their potential use for biomarker profiling in multiple sclerosis

Malekzadeh, A., Twaalfhoven, H. A. M., Wijnstok, N. J., Killestein, J., Blankenstein, M. A. & Teunissen, C. E., 1 Mar 2017, In : Cytokine Plus. 91, p. 145-152 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

John Cunningham virus conversion in relation to natalizumab concentration in multiple sclerosis patients

van Kempen, Z. L. E., Leurs, C. E., de Vries, A., Vennegoor, A., Rispens, T., Wattjes, M. P. & Killestein, J., 1 Sep 2017, In : European Journal of Neurology. 24, 9, p. 1196-1199 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Monocyte-derived tissue transglutaminase in multiple sclerosis patients: reflecting an anti-inflammatory status and function of the cells?

Sestito, C., Brevé, J. J. P., van Eggermond, M. C. J. A., Killestein, J., Teunissen, C. E., van Rossum, J., Wilhelmus, M. M. M., Drukarch, B., van den Elsen, P. J. & van Dam, A-M., 21 Dec 2017, In : Journal of Neuroinflammation. 14, 1, p. 257

Research output: Contribution to journalArticleAcademicpeer-review

Neutralizing capacity of monoclonal and polyclonal anti-natalizumab antibodies: The immune response to antibody therapeutics preferentially targets the antigen-binding site

van Schie, K. A., Kruithof, S., van Schouwenburg, P. A., Vennegoor, A., Killestein, J., Wolbink, G. & Rispens, T., 1 Mar 2017, In : Journal of Allergy and Clinical Immunology. 139, 3, p. 1035-1037.e6

Research output: Contribution to journalArticleAcademicpeer-review

Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS

Bruinsma, I. B., van Dijk, M., Bridel, C., van de Lisdonk, T., Haverkort, S. Q., Runia, T. F., Steinman, L., Hintzen, R. Q., Killestein, J., Verbeek, M. M., Teunissen, C. E. & de Jong, B. A., 4 Dec 2017, In : Journal of Neuroinflammation. 14, 1, 235.

Research output: Contribution to journalArticleAcademicpeer-review

Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets

Best, M. G., Sol, N., In ‘t Veld, S. G. J. G., Vancura, A., Muller, M., Niemeijer, A. L. N., Fejes, A. V., Tjon Kon Fat, L. A., Huis In ‘t Veld, A. E., Leurs, C., Le Large, T. Y., Meijer, L. L., Kooi, I. E., Rustenburg, F., Schellen, P., Verschueren, H., Post, E., Wedekind, L. E., Bracht, J., Esenkbrink, M. & 33 othersWils, L., Favaro, F., Schoonhoven, J. D., Tannous, J., Meijers-Heijboer, H., Kazemier, G., Giovannetti, E., Reijneveld, J. C., Idema, S., Killestein, J., Heger, M., de Jager, S. C., Urbanus, R. T., Hoefer, I. E., Pasterkamp, G., Mannhalter, C., Gomez-Arroyo, J., Bogaard, H. J., Noske, D. P., Vandertop, W. P., van den Broek, D., Ylstra, B., Nilsson, R. J. A., Wesseling, P., Karachaliou, N., Rosell, R., Lee-Lewandrowski, E., Lewandrowski, K. B., Tannous, B. A., de Langen, A. J., Smit, E. F., van den Heuvel, M. M. & Wurdinger, T., 14 Aug 2017, In : Cancer Cell. 32, 2, p. 238-252.e9

Research output: Contribution to journalArticleAcademicpeer-review

2016

Concomitant granule cell neuronopathy in patients with natalizumab-associated PML

Wijburg, M. T., Siepman, D., van Eijk, J. J. J., Killestein, J. & Wattjes, M. P., Apr 2016, In : Journal of Neurology. 263, 4, p. 649-656

Research output: Contribution to journalArticleAcademicpeer-review