Joke den Haan

DR., (Principal Investigator)

1992 …2019
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Research Output 1992 2019

  • 50 Article
  • 5 Research VU University Amsterdam, graduation VU University Amsterdam
  • 4 Review article
  • 1 Chapter
2019

Activation of CD8⁺ T Cell Responses after Melanoma Antigen Targeting to CD169⁺ Antigen Presenting Cells in Mice and Humans

van Dinther, D., Lopez Venegas, M., Veninga, H., Olesek, K., Hoogterp, L., Revet, M., Ambrosini, M., Kalay, H., Stöckl, J., van Kooyk, Y. & den Haan, J. M. M., 5 Feb 2019, In : Cancers. 11, 2, 183.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Bacterial inclusion bodies function as vehicles for dendritic cell-mediated T cell responses

Schetters, S. T. T., Jong, W. S. P., Kruijssen, L. J. W., Saparoea, H. B. V. D. B. V., Engels, S., Unger, W. W. J., Houben, D., den Haan, J. M. M., Luirink, J. & Kooyk, Y. V., 8 Oct 2019, In : Cellular Immunology.

Research output: Contribution to journalArticleAcademicpeer-review

CD62L Is a Functional and Phenotypic Marker for Circulating Innate Lymphoid Cell Precursors

Bar-Ephraim, Y. E., Koning, J. J., Burniol Ruiz, E., Konijn, T., Mourits, V. P., Lakeman, K. A., Boon, L., Bögels, M., van Maanen, J. P., Den Haan, J. M. M., van Egmond, M., Bouma, G., Reijmers, R. M. & Mebius, R. E., 1 Jan 2019, In : Journal of Immunology. 202, 1, p. 171-182 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Interplay of CD169+ macrophages and dendritic cells: a game of give and take to induce anti-tumor T cell immunity

van Dinther, D., 2019, 205 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access

Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8 + T cells

Schetters, S. T. T., Jong, W. S. P., Horrevorts, S. K., Kruijssen, L. J. W., Engels, S., Stolk, D., Daleke-Schermerhorn, M. H., Garcia-Vallejo, J., Houben, D., Unger, W. W. J., den Haan, J. M. M., Luirink, J. & van Kooyk, Y., 1 Jun 2019, In : Acta Biomaterialia. 91, p. 248-257 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Tissue-specific expression of IgG receptors by human macrophages ex vivo

Bruggeman, C. W., Houtzager, J., Dierdorp, B., Kers, J., Pals, S. T., Lutter, R., van Gulik, T., den Haan, J. M. M., van den Berg, T. K., van Bruggen, R. & Kuijpers, T. W., 1 Jan 2019, In : PLoS ONE. 14, 10, e0223264.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System

Grabowska, J., Lopez-Venegas, M. A., Affandi, A. J. & den Haan, J. M. M., 2018, In : Frontiers in Immunology. 9, p. 2472

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Comparison of Protein and Peptide Targeting for the Development of a CD169-Based Vaccination Strategy Against Melanoma

van Dinther, D., Veninga, H., Revet, M., Hoogterp, L., Olesek, K., Grabowska, J., Borg, E. G. F., Kalay, H., van Kooyk, Y. & den Haan, J. M. M., 2018, In : Frontiers in Immunology. 9, p. 1997

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude

Nadafi, R., Koning, J. J., Veninga, H., Stachtea, X. N., Konijn, T., Zwiers, A., Malmström, A., den Haan, J. M. M., Mebius, R. E., Maccarana, M. & Reijmers, R. M., 2018, In : Frontiers in Immunology. 9, p. 206

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice

Lai, J. D., Cartier, D., Hartholt, R. B., Swystun, L. L., van Velzen, A. S., den Haan, J. M. M., Hough, C., Voorberg, J. & Lillicrap, D., Mar 2018, In : Journal of Thrombosis and Haemostasis. 16, 3, p. 533-545 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming

van Dinther, D., Veninga, H., Iborra, S., Borg, E. G. F., Hoogterp, L., Olesek, K., Beijer, M. R., Schetters, S. T. T., Kalay, H., Garcia-Vallejo, J. J., Franken, K. L., Cham, L. B., Lang, K. S., van Kooyk, Y., Sancho, D., Crocker, P. R. & den Haan, J. M. M., 6 Feb 2018, In : Cell Reports. 22, 6, p. 1484-1495 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mouse DC-SIGN/CD209a as Target for Antigen Delivery and Adaptive Immunity

Schetters, S. T. T., Kruijssen, L. J. W., Crommentuijn, M. H. W., Kalay, H., Ochando, J., den Haan, J. M. M., Garcia-Vallejo, J. J. & van Kooyk, Y., 7 May 2018, In : Frontiers in Immunology. 9, p. 990

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-γ receptors

Nagelkerke, S. Q., Bruggeman, C. W., den Haan, J. M. M., Mul, E. P. J., van den Berg, T. K., van Bruggen, R. & Kuijpers, T. W., 2018, In : BLOOD ADVANCES. 2, 8, p. 941-953 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation

Bar-Ephraim, Y. E., Cornelissen, F., Papazian, N., Konijn, T., Hoogenboezem, R. M., Sanders, M. A., Westerman, B. A., Gönültas, M., Kwekkeboom, J., Den Haan, J. M. M., Reijmers, R. M., Mebius, R. E. & Cupedo, T., 17 Oct 2017, In : Cell Reports. 21, 3, p. 823-833 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone

Habbeddine, M., Verthuy, C., Rastoin, O., Chasson, L., Bebien, M., Bajenoff, M., Adriouch, S., den Haan, J. M. M., Penninger, J. M. & Lawrence, T., 28 Nov 2017, In : Cell Reports. 21, 9, p. 2515-2527 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells

Haeberlein, S., Obieglo, K., Ozir-Fazalalikhan, A., Chayé, M. A. M., Veninga, H., van der Vlugt, L. E. P. M., Voskamp, A., Boon, L., den Haan, J. M. M., Westerhof, L. B., Wilbers, R. H. P., Schots, A., Schramm, G., Hokke, C. H. & Smits, H. H., 1 Jul 2017, In : PLoS Pathogens. 13, 7, e1006539.

Research output: Contribution to journalArticleAcademicpeer-review

Targeting C-type lectin receptors: A high-carbohydrate diet for dendritic cells to improve cancer vaccines

van Dinther, D., Stolk, D. A., van de Ven, R., van Kooyk, Y., de Gruij, T. D. & den Haan, J. M. M., 1 Oct 2017, In : Journal of Leukocyte Biology. 102, 4, p. 1017-1034 18 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

Perdicchio, M., Ilarregui, J. M., Verstege, M. I., Cornelissen, L. A. M., Schetters, S. T. T., Engels, S., Ambrosini, M., Kalay, H., Veninga, H., den Haan, JMM., van Berkel, L. A., Samsom, J. N., Crocker, P. R., Sparwasser, T., Berod, L., Garcia-Vallejo, J. J., van Kooyk, Y. & Unger, W. W. J., 22 Mar 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. 3329-3334

Research output: Contribution to journalArticleAcademicpeer-review

The spleen

Kraal, G. & den Haan, J., 2016, In Encyclopedia of Immunobiology. Ratcliffe, M. J. H. (ed.). Academic Press, p. 407-412

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2015

Antigen targeting reveals splenic CD169(+) macrophages as promoters of germinal center B-cell responses

Veninga, H., Borg, E. G. F., Vreeman, K., Taylor, P. R., Kalay, H., van Kooyk, Y., Kraal, G., Martinez-Pomares, L. & den Haan, J. M. M., 2015, In : European Journal of Immunology. 45, 3, p. 747-757

Research output: Contribution to journalArticleAcademicpeer-review

Cholinergic receptor activation on epithelia protects against cytokine-induced barrier dysfunction

Dhawan, S., Hiemstra, I. H., Verseijden, C., Hilbers, F. W., te Velde, AA., Willemsen, L. E. M., Stap, J., den Haan, J. M. M. & de Jonge, W. J., 2015, In : Acta Physiologica. 213, 4, p. 846-859

Research output: Contribution to journalArticleAcademicpeer-review

Intestinal epithelial cell transported TLR2 ligand stimulates Ly6C(+) monocyte differentiation in a G-CSF dependent manner

Hiemstra, I. H., Vrijland, K., Hogenboom, M. M., Bouma, G., Kraal, G. & den Haan, J. M. M., 2015, In : Immunobiology. 220, 11, p. 1255-1265

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin A metabolism and mucosal immune function are distinct between BALB/c and C57BL/6 mice

Goverse, G., Olivier, B. J., Molenaar, R., Knippenberg, M., Greuter, M., Konijn, T., Cook, E. C. L., Beijer, M. R., Fedor, D. M., den Haan, J. M. M., Napoli, J. L., Bouma, G. & Mebius, R. E., 2015, In : European Journal of Immunology. 45, 1, p. 89-100

Research output: Contribution to journalArticleAcademicpeer-review

2014
27 Downloads (Pure)

Dendritic cells and macrophages in the spleen: Development, function, and collaboration

Beijer, M. R., 2014

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

Excreted/secreted Trichuris suis products reduce barrier function and suppress inflammatory cytokine production of intestinal epithelial cells

Hiemstra, I. H., Klaver, E. J., Vrijland, K., Kringel, H., Andreasen, A., Bouma, G., Kraal, G., van Die, I. & den Haan, J. M. M., 2014, In : Molecular Immunology. 60, 1, p. 1-7

Research output: Contribution to journalArticleAcademicpeer-review

Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

Baptista, A. P., Roozendaal, R., Reijmers, R. M., Koning, J. J., Unger, W. W. J., Greuter, M. J., Keuning, ED., Molenaar, R., Goverse, G., Sneeboer, M. M. S., den Haan, J. M. M., Boes, M. & Mebius, R. E., 2014, In : eLife. 3, e04433.

Research output: Contribution to journalArticleAcademicpeer-review

The activation of the adaptive immune system: Cross-talk between antigen-presenting cells, T cells and B cells

den Haan, J. M. M., Arens, R. & van Zelm, M. C., 2014, In : Immunology Letters. 162, 2, p. 103-112

Research output: Contribution to journalArticleAcademicpeer-review

The identification and developmental requirements of colonic CD169+macrophages

Hiemstra, I. H., Beijer, M. R., Veninga, H., Vrijland, K., Borg, E. G. F., Olivier, B. J., Mebius, R. E., Kraal, G. & den Haan, J. M. M., 2014, In : Immunology. 142, 2, p. 269-278

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin A and dendritic cell differentiation

Beijer, M. R., Kraal, G. & den Haan, J. M. M., 2014, In : Immunology. 142, 1, p. 39-45

Research output: Contribution to journalArticleAcademicpeer-review

2013

A crucial role for retinoic acid in the development of Notch-dependent murine splenic CD8(-)CD4(-) and CD4(+) dendritic cells

Beijer, M. R., Molenaar, R., Goverse, G., Mebius, R. E., Kraal, G. & den Haan, J. M. M., 2013, In : European Journal of Immunology. 43, 6, p. 1608-1616

Research output: Contribution to journalArticleAcademicpeer-review

Macrophage heterogeneity in lymphoid tissues

den Haan, J. M. M. & Martinez-Pomares, L., 2013, In : Seminars in immunopathology. 35, 5, p. 541-552

Research output: Contribution to journalArticleAcademicpeer-review

248 Downloads (Pure)

Microbial control of the mucosal barrier function: Implications for local and systemic immune homeostasis

Hiemstra, I. H., 2013

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File
2012

Innate Immune Functions of Macrophage Subpopulations in the Spleen

den Haan, J. M. M. & Kraal, G., 2012, In : Journal of innate immunity. 4, 5-6, p. 437-445

Research output: Contribution to journalArticleAcademicpeer-review

Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses

Hiemstra, I. H., Bouma, G., Geerts, D., Kraal, G. & den Haan, J. M. M., 2012, In : Molecular Immunology. 52, 3-4, p. 264-272

Research output: Contribution to journalArticleAcademicpeer-review

44 Downloads (Pure)

Stromal cells of the mouse spleen

den Haan, J. M. M., Mebius, R. E. & Kraal, G., 2012, In : Frontiers in Immunology: Molecular Innate Immunity. 3, 201.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2011

Delivery route, MyD88 signaling and cross-priming events determine the anti-tumor efficacy of an adenovirus based melanoma vaccine.

Hangalapura, B. N., Oosterhoff, D., Gupta, T., de Groot, J., Wijnands, P. G. J. T. B., van Beusechem, V. W., den Haan, J., Tuting, T., van den Eertwegh, A. J. M., Curiel, D. T., Scheper, R. J. & de Gruijl, T. D., 2011, In : Vaccine. 29, 12, p. 2313-2321

Research output: Contribution to journalArticleAcademicpeer-review

Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis

Schwandt, T., Schumak, B., Gielen, G. H., Jungerkes, F., Schmidbauer, P., Klocke, K., Staratschek-Jox, A., van Rooijen, N., Kraal, G., Ludwig-Portugall, I., Franken, L., Wehner, S., Kalff, J. C., Weber, O., Kirschning, C., Coch, C., Kalinke, U., Wenzel, J., Kurts, C., Zawatzky, R. & 7 othersHolzmann, B., Layland, L., Schultze, J. L., Burgdorf, S., den Haan, J. M. M., Knolle, P. A. & Limmer, A., 2011, In : EMBO Journal. 31, 1, p. 201-213

Research output: Contribution to journalArticleAcademicpeer-review

2010

Different mechanisms regulate CD4(+) T cell independent induction of oral and nasal tolerance of CD8(+) T cells

van den Berg, H., Greuter, M. J., Kraal, G. & den Haan, J. M. M., 2010, In : Immunobiology. 215, 2, p. 163-171

Research output: Contribution to journalArticleAcademicpeer-review

Effective collaboration between marginal metallophilic macrophages and CD8(+) dendritic cells in the generation of cytotoxic T cells

Backer, R. A., Schwandt, T., Greuter, M. J., Oosting, M., Jungerkes, F., Tuting, T., Boon, L., O'Toole, T., Kraal, G., Limmer, A. & den Haan, J. M. M., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 216-221

Research output: Contribution to journalArticleAcademicpeer-review

27 Downloads (Pure)

The balancing mucosal immune system: unraveling mechanisms involved in oral tolerance and IBD

van den Berg, H., 2010

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File
2009
55 Downloads (Pure)

Function and homeostasis of murine splenic dendritic cell subsets

Backer, R. A., 2009, S.I.: s.n..

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File
44 Downloads (Pure)

P-Glycoprotein Acts as an Immunomodulator during Neuroinflammation

Kooij, G., Backer, R., Koning, J. J., Reijerkerk, A., van Horssen, J., van der Pol, S. M. A., Drexhage, J., Schinkel, A., Dijkstra, C. D., den Haan, J. M. M., Geijtenbeek, T. B. H. & de Vries, H. E., 2009, In : PLoS ONE. 4, 12, p. e8212 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation

Singh, S. K., Stephani, J., Schaefer, M., Kalay, H., Garcia Vallejo, J. J., den Haan, J. M. M., Saeland, E., Sparwasser, T. & van Kooyk, Y., 2009, In : Molecular Immunology. 47, 2-3, p. 164-174

Research output: Contribution to journalArticleAcademicpeer-review

2008

CD8- dendritic cells preferentially cross-present Saccharomyces cerevisiae antigens

Backer, R. A., van Leeuwen, F. E., Kraal, G. & den Haan, J. M. M., 2008, In : European Journal of Immunology. 38, 2, p. 370-380

Research output: Contribution to journalArticleAcademicpeer-review

2007

Cutting edge: Lipopolysaccharide induces IL-10-producing regulatory CD4+ T cells that suppress the CD8+ T cell response

den Haan, J. M. M., Kraal, G. & Bevan, M. J., 1 May 2007, In : Journal of Immunology. 178, 9, p. 5429-33 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2002

Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo

den Haan, J. M. M. & Bevan, M. J., 16 Sep 2002, In : Journal of Experimental Medicine. 196, 6, p. 817-27 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

General T-cell receptor antagonists to immunomodulate HLA-A2-restricted minor histocompatibility antigen HA-1-specific T-cell responses

Den Haan, J. M. M., Mutis, T., Blokland, E., Ijzerman, A. P. & Goulmy, E., 1 Feb 2002, In : Blood. 99, 3, p. 985-992 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Identification of a novel HLA-B60-restricted T cell epitope of the minor histocompatibility antigen HA-1 locus

Mommaas, B., Kamp, J., Drijfhout, J. W., Beekman, N., Ossendorp, F., Van Veelen, P., Den Haan, J., Goulmy, E. & Mutis, T., 15 Sep 2002, In : Journal of Immunology. 169, 6, p. 3131-3136 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2001

Antigen presentation to CD8+ T cells: cross-priming in infectious diseases

den Haan, J. M. & Bevan, M. J., Aug 2001, In : Current Opinion in Immunology. 13, 4, p. 437-41 5 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2000

A novel helper role for CD4 T cells

den Haan, J. M. & Bevan, M. J., 21 Nov 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 24, p. 12950-2 3 p.

Research output: Contribution to journalReview articleAcademicpeer-review