Jolanda van der Velden

PROF.DR., (Principal Investigator)

1992 …2020

Research output per year

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Research Output

2020

Heterozygous loss of Rbm24 in the adult mouse heart increases sarcomere slack length but does not affect function

de Groot, N. E., van den Hoogenhof, M. M. G., Najafi, A., van der Made, I., van der Velden, J., Beqqali, A., Pinto, Y. M. & Creemers, E. E., 6 May 2020, In : Scientific Reports. 10, 1, 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Cardiac Disorders and Pathophysiology of Sarcomeric Proteins

van der Velden, J. & Stienen, G. J. M., 1 Jan 2019, In : Physiological Reviews. 99, 1, p. 381-426 46 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin

Juni, R. P., Kuster, D. W. D., Goebel, M., Helmes, M., Musters, R. J. P., van der Velden, J., Koolwijk, P., Paulus, W. J. & van Hinsbergh, V. W. M., 1 Sep 2019, In : JACC: Basic to Translational Science. 4, 5, p. 575-591

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle

Stam, K., Cai, Z., van der Velde, N., van Duin, R., Lam, E., van der Velden, J., Hirsch, A., Duncker, D. J. & Merkus, D., 1 Sep 2019, In : Journal of Physiology. 597, 17, p. 4465-4480

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction

Miranda-Silva, D., Wüst, R. C. I., Conceição, G., Gonçalves-Rodrigues, P., Gonçalves, N. D., Gonçalves, A., Kuster, D. W. D., Leite-Moreira, A. F., van der Velden, J., de Sousa Beleza, J. M., Magalhães, J., Stienen, G. J. M. & Falcão-Pires, I., 2019, In : Acta Physiologica. e13378.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

End-diastolic force pre-activates cardiomyocytes and determines contractile force: role of titin and calcium

Najafi, A., van de Locht, M., Schuldt, M., Schönleitner, P., van Willigenburg, M., Bollen, I., Goebel, M., Ottenheijm, C. A. C., van der Velden, J., Helmes, M. & Kuster, D. W. D., 1 Sep 2019, In : Journal of Physiology. 597, 17, p. 4521-4531

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Extracellular SPARC increases cardiomyocyte contraction during health and disease

Deckx, S., Johnson, D. M., Rienks, M., Carai, P., van Deel, E., van der Velden, J., Sipido, K. R., Heymans, S. & Papageorgiou, A-P., 1 Apr 2019, In : PLoS ONE. 14, 4, e0209534.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Extra energy for hearts with a genetic defect: ENERGY trial

van Driel, B. O., van Rossum, A. C., Michels, M., Huurman, R. & van der Velden, J., 2019, In : Netherlands Heart Journal. 27, 4, p. 200-205 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Five-year prognostic significance of global longitudinal strain in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes

van Velzen, H. G., Schinkel, A. F. L., van Grootel, R. W. J., van Slegtenhorst, M. A., van der Velden, J., Strachinaru, M. & Michels, M., 2019, In : Netherlands Heart Journal. 27, 3, p. 117-126 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypertrofische cardiomyopathie

Translated title of the contribution: Hypertrophic cardiomyopathyvan Driel, B., Asselbergs, F. W., de Boer, R. A., van Rossum, A. C., van Tintelen, J. P., van der Velden, J. & Michels, M., 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 8, D2790.

Research output: Contribution to journalArticleProfessional

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits

Wijnker, P. J. M., Sequeira, V., Kuster, D. W. D. & van der Velden, J., 1 Aug 2019, In : Antioxidants and Redox Signaling. 31, 4, p. 318-358

Research output: Contribution to journalReview articleAcademicpeer-review

Hypertrophic Cardiomyopathy - Need for Gene-Specific Treatment?

van Driel, B. & van der Velden, J., 1 Aug 2019, In : JAMA cardiology. 4, 8, p. 831-832

Research output: Contribution to journalComment/Letter to the editorAcademic

Increasing sensitivity—a common-sense approach?

Michels, M., Asselbergs, F. W. & van der Velden, J., 1 Jun 2019, In : Netherlands Heart Journal. 27, 6, p. 287-288

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

Integrative Functional Annotation of 52 Genetic Loci Influencing Myocardial Mass Identifies Candidate Regulatory Variants and Target Genes

Hemerich, D., Pei, J., Harakalova, M., van Setten, J., Boymans, S., Boukens, B. J., Efimov, I. R., Michels, M., van der Velden, J., Vink, A., Cheng, C., van der Harst, P., Moore, J. H., Mokry, M., Tragante, V. & Asselbergs, F. W., 1 Feb 2019, In : Circulation. Genomic and precision medicine. 12, 2, p. 76-83 8 p., e002328.

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial adaptation after surgical therapy differs for aortic valve stenosis and hypertrophic obstructive cardiomyopathy

Parbhudayal, R. Y., Güçlü, A., Zweerink, A., Biesbroek, P. S., Croisille, P., Clarysse, P., Michels, M., Stooker, W., Vonk, A. B. A., van der Ven, P. M., van Rossum, A. C., van der Velden, J. & Nijveldt, R., 1 Jun 2019, In : International Journal of Cardiovascular Imaging. 35, 6, p. 1089-1100 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

Dorsch, L. M., Schuldt, M., dos Remedios, C. G., Schinkel, A. F. L., de Jong, P. L., Michels, M., Kuster, D. W. D., Brundel, B. J. J. M. & van der Velden, J., 18 Jul 2019, In : Cells. 8, 7, 741.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Right ventricular oxygen delivery as a determinant of right ventricular functional reserve during exercise in juvenile swine with chronic pulmonary hypertension

Cai, Z., van Duin, R. W. B., Stam, K., Uitterdijk, A., van der Velden, J., Vonk Noordegraaf, A., Duncker, D. J. & Merkus, D., 1 Jan 2019, In : American Journal of Physiology. Heart and Circulatory Physiology. 317, 4, p. H840-H850

Research output: Contribution to journalArticleAcademicpeer-review

Sex differences in hypertrophic cardiomyopathy: new insights

van Driel, B., Nijenkamp, L., Huurman, R., Michels, M. & van der Velden, J., 2019, In : Current opinion in cardiology. 34, 3, p. 254-259

Research output: Contribution to journalArticleAcademicpeer-review

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

Piroddi, N., Witjas-Paalberends, E. R., Ferrara, C., Ferrantini, C., Vitale, G., Scellini, B., Wijnker, P. J. M., Sequiera, V., Dooijes, D., Dos Remedios, C., Schlossarek, S., Leung, M. C., Messer, A., Ward, D. G., Biggeri, A., Tesi, C., Carrier, L., Redwood, C. S., Marston, S. B., van der Velden, J. & 1 others, Poggesi, C., 7 Jan 2019, In : The Journal of general physiology. 151, 1, p. 18-29 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Untying the knot: protein quality control in inherited cardiomyopathies

Dorsch, L. M., Schuldt, M., Knežević, D., Wiersma, M., Kuster, D. W. D., van der Velden, J. & Brundel, B. J. J. M., 1 May 2019, In : Pflugers Archiv European Journal of Physiology. 471, 5, p. 795-806 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

Boosting small heat shock proteins lowers cardiomyocyte passive stiffness in experimental heart failure with preserved ejection fraction

Waddingham, M. T., Dal Canto, E., Bos, D. D. S. G., Sequeria, V., Van Heerebeek, L., Kuster, D. W. D., De Man, F. S., Van Der Velden, J., Handoko, M. L., Eringa, E. C. & Paulus, W. J., May 2018, In : European Journal of Heart Failure. 20, p. 24-24

Research output: Contribution to journalMeeting AbstractAcademic

Burst-like transcription of mutant and wildtype MYH7-alleles as possible origin of cell-to-cell contractile imbalance in Hypertrophic Cardiomyopathy

Montag, J., Kowalski, K., Makul, M., Ernstberger, P., Radocaj, A., Beck, J., Becker, E., Tripathi, S., Keyser, B., Mühlfeld, C., Wissel, K., Pich, A., van der Velden, J., dos Remedios, C. G., Perrot, A., Francino, A., Navarro-López, F., Brenner, B. & Kraft, T., 9 Apr 2018, In : Frontiers in Physiology. 9, APR, 359.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cardiovascular Function of Modern Pigs Does not Comply with Allometric Scaling Laws

Van Essen, G. J., Hekkert, M. T. L., Sorop, O., Heinonen, I., Van Der Velden, J., Merkus, D. & Duncker, D. J., 1 Aug 2018, In : Scientific Reports. 8, 1, 792.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Complex roads from genotype to phenotype in dilated cardiomyopathy: Scientific update from theworking group of myocardial function of the European Society of Cardiology

Bondue, A., Arbustini, E., Bianco, A., Ciccarelli, M., Dawson, D., de Rosa, M., Hamdani, N., Hilfiker-Kleiner, D., Meder, B., Leite-Moreira, A. F., Thum, T., Tocchetti, C. G., Varricchi, G., van der Velden, J., Walsh, R. & Heymans, S., 2018, In : Cardiovascular Research. 114, 10, p. 1287-1303

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Contribution of impaired parasympathetic activity to right ventricular dysfunction and pulmonary vascular remodeling in pulmonary arterial hypertension

Da Silva Gonçalves Bós, D., Van Der Bruggen, C. E. E., Kurakula, K., Sun, X. Q., Casali, K. R., Casali, A. G., Rol, N., Szulcek, R., Dos Remedios, C., Guignabert, C., Tu, L., Dorfmüller, P., Humbert, M., Wijnker, P. J. M., Kuster, D. W. D., Van Der Velden, J., Goumans, M. J., Bogaard, H. J., Vonk-Noordegraaf, A., De Man, F. S. & 1 others, Handoko, M. L., 1 Jan 2018, In : Circulation. 137, 9, p. 910-924 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease (Biophysical Reviews, (2017), 9, 4, (431-441), 10.1007/s12551-017-0305-3)

dos Remedios, C. G., Lal, S. P., Li, A., McNamara, J., Keogh, A., Macdonald, P. S., Cooke, R., Ehler, E., Knöll, R., Marston, S. B., Stelzer, J., Granzier, H., Bezzina, C., van Dijk, S., De Man, F. S., Stienen, G. J. M., Odeberg, J., Pontén, F., Linke, W. A. & van der Velden, J., 1 Jun 2018, In : Biophysical Reviews. 10, 3, 1 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

High Fibroblast Growth Factor 23 concentrations in experimental renal failure impair calcium handling in cardiomyocytes

Verkaik, M., Oranje, M., Abdurrachim, D., Goebel, M., Gam, Z., Prompers, J. J., Helmes, M., ter Wee, P. M., van der Velden, J., Kuster, D. W., Vervloet, M. G., Eringa, E. C. & the NIGRAM consortium, 1 Apr 2018, In : Physiological Reports. 6, 7, e13591.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

van der Velden, J., Tocchetti, C. G., Varricchi, G., Bianco, A., Sequeira, V., Hilfiker-Kleiner, D., Hamdani, N., Leite-Moreira, A. F., Mayr, M., Falcao-Pires, I., Thum, T., Dawson, D. K., Balligand, J-L. & Heymans, S., 1 Aug 2018, In : Cardiovascular Research. 114, 10, p. 1273-1280

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Molecular autopsy

van Driel, B., Michels, M. & van der Velden, J., 2018, In : Netherlands Heart Journal. 26, 10, p. 471-472

Research output: Contribution to journalComment/Letter to the editorAcademic

Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening

Sorop, O., Heinonen, I., Van Kranenburg, M., Van De Wouw, J., De Beer, V. J., Nguyen, I. T. N., Octavia, Y., Van Duin, R. W. B., Stam, K., Van Geuns, R. J., Wielopolski, P. A., Krestin, G. P., Van Den Meiracker, A. H., Verjans, R., Van Bilsen, M., Danser, A. H. J., Paulus, W. J., Cheng, C., Linke, W. A., Joles, J. A. & 4 others, Verhaar, M. C., Van Der Velden, J., Merkus, D. & Duncker, D. J., 1 Jan 2018, In : Cardiovascular Research. 114, 7, p. 954-964 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials

MRC CHORUS study investigators, 2018, In : The Lancet Oncology. 19, 12, p. 1680-1687

Research output: Contribution to journalArticleAcademicpeer-review

Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation

Deckx, S., Heggermont, W., Carai, P., Rienks, M., Dresselaers, T., Himmelreich, U., van Leeuwen, R., Lommen, W., van der Velden, J., Gonzalez, A., Diez, J., Papageorgiou, A. P. & Heymans, S., 1 Mar 2018, In : Matrix Biology. 66, p. 110-124 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy

Nijenkamp, L. L. A. M., Bollen, I. A. E., van Velzen, H. G., Regan, J. A., van Slegtenhorst, M., Niessen, H. W. M., Schinkel, A. F. L., Krueger, M., Poggesi, C., Ho, C. Y., Kuster, D. W. D., Michels, M. & van der Velden, J., Jun 2018, In : Circulation. Heart failure. 11, 6, e004133.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC

Frantz, S., Falcao-Pires, I., Balligand, J. L., Bauersachs, J., Brutsaert, D., Ciccarelli, M., Dawson, D., de Windt, L. J., Giacca, M., Hamdani, N., Hilfiker-Kleiner, D., Hirsch, E., Leite-Moreira, A., Mayr, M., Thum, T., Tocchetti, C. G., van der Velden, J., Varricchi, G. & Heymans, S., 1 Mar 2018, In : European Journal of Heart Failure. 20, 3, p. 445-459 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Variable cardiac myosin binding protein-C expression in the myofilaments due to MYBPC3 mutations in hypertrophic cardiomyopathy

Parbhudayal, R. Y., Garra, A. R., Götte, M. J. W., Michels, M., Pei, J., Harakalova, M., Asselbergs, F. W., van Rossum, A. C., van der Velden, J. & Kuster, D. W. D., Oct 2018, In : Journal of Molecular and Cellular Cardiology. 123, p. 59-63 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice

Singh, S. R., Zech, A. T. L., Geertz, B., Reischmann-Düsener, S., Osinska, H., Prondzynski, M., Krämer, E., Meng, Q., Redwood, C., van der Velden, J., Robbins, J., Schlossarek, S. & Carrier, L., 1 Oct 2017, In : Circulation. Heart failure. 10, 10, e004140.

Research output: Contribution to journalArticleAcademicpeer-review

Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome

Lynch, T. L., Kuster, D. W. D., Gonzalez, B., Balasubramanian, N., Nair, N., Day, S., Calvino, J. E., Tan, Y., Liebetrau, C., Troidl, C., Hamm, C. W., Güçlü, A., McDonough, B., Marian, A. J., van der Velden, J., Seidman, C. E., Huggins, G. S. & Sadayappan, S., 1 Apr 2017, In : JACC: Basic to Translational Science. 2, 2, p. 122-131 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy

Bollen, I. A. E., van der Meulen, M., de Goede, K., Kuster, D. W. D., Dalinghaus, M. & van der Velden, J., 22 Dec 2017, In : Frontiers in Physiology. 8, 01103.

Research output: Contribution to journalArticleAcademicpeer-review

Clinical Characteristics and Long-Term Outcome of Hypertrophic Cardiomyopathy in Individuals With a MYBPC3 (Myosin-Binding Protein C) Founder Mutation

van Velzen, H. G., Schinkel, A. F. L., Oldenburg, R. A., van Slegtenhorst, M. A., Frohn-Mulder, I. M. E., van der Velden, J. & Michels, M., Aug 2017, In : Circulation-cardiovascular genetics. 10, 4, e001660.

Research output: Contribution to journalArticleAcademicpeer-review

Distinguish mutation-specific pathogenic effects from secondary disease remodelling: an essential but often overlooked concept

Bollen, I. A. E. & van der Velden, J., 1 Aug 2017, In : Cardiovascular Research. 113, 10, p. 1087-1088

Research output: Contribution to journalEditorialAcademicpeer-review

Genotype-specific pathogenic effects in human dilated cardiomyopathy

Bollen, I. A. E., Schuldt, M., Harakalova, M., Vink, A., Asselbergs, F. W., Pinto, J. R., Krueger, M., Kuster, D. W. D. & van der Velden, J., 15 Jul 2017, In : Journal of Physiology - London. 595, 14, p. 4677-4693

Research output: Contribution to journalArticleAcademicpeer-review

Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy

Montag, J., Syring, M., Rose, J., Weber, A. L., Ernstberger, P., Mayer, A. K., Becker, E., Keyser, B., Dos Remedios, C., Perrot, A., van der Velden, J., Francino, A., Navarro-Lopez, F., Ho, C. Y., Brenner, B. & Kraft, T., 30 Nov 2017, In : Journal of Muscle Research and Cell Motility. p. 1-12 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

In vitro model to study the effects of matrix stiffening on Ca2+ handling and myofilament function in isolated adult rat cardiomyocytes

van Deel, E. D., Najafi, A., Fontoura, D., Valent, E., Goebel, M., Kardux, K., Falcao-Pires, I. & van der Velden, J., 15 Jul 2017, In : Journal of Physiology - London. 595, 14, p. 4597-4610

Research output: Contribution to journalArticleAcademicpeer-review

Lamin A/C-Related Cardiac Disease Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation

Hoorntje, E. T., Bollen, I. A., Barge-Schaapveld, D. Q., van Tienen, F. H. J., te Meerman, G. J., Jansweijer, J. A., van Essen, A. J., Volders, P. G., Constantinescu, A. A., van den Akker, P. C., van Spaendonck-Zwarts, K. Y., Oldenburg, R. A., Marcelis, C. L., van der Smagt, J. J., Hennekam, E. A., Vink, A., Bootsma, M., Aten, E., Wilde, A. A. M., van den Wijngaard, A. & 5 others, Broers, J. L., Jongbloed, J. D., van der Velden, J., van den Berg, M. P. & van Tintelen, J. P., Aug 2017, In : Circulation-cardiovascular genetics. 10, 4, e001631.

Research output: Contribution to journalArticleAcademicpeer-review

Life-long tailoring of management for patients with hypertrophic cardiomyopathy: Awareness and decision-making in changing scenarios

Michels, M., Olivotto, I., Asselbergs, F. W. & van der Velden, J., 1 Mar 2017, In : Netherlands Heart Journal. 25, 3, p. 186-199 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

McNamara, J. W., Li, A., Lal, S., Bos, J. M., Harris, S. P., van der Velden, J., Ackerman, M. J., Cooke, R. & dos Remedios, C. G., 28 Jun 2017, In : PLoS ONE. 12, 6, e0180064.

Research output: Contribution to journalArticleAcademicpeer-review

Myofilament Remodeling and Function Is More Impaired in Peripartum Cardiomyopathy Compared with Dilated Cardiomyopathy and Ischemic Heart Disease

Bollen, I. A. E., Ehler, E., Fleischanderl, K., Bouwman, F., Kempers, L., Ricke-Hoch, M., Hilfiker-Kleiner, D., dos Remedios, C. G., Krüger, M., Vink, A., Asselbergs, F. W., van Spaendonck-Zwarts, K. Y., Pinto, Y. M., Kuster, D. W. D. & van der Velden, J., 1 Dec 2017, In : American Journal of Pathology. 187, 12, p. 2645-2658 14 p.

Research output: Contribution to journalArticleAcademicpeer-review