1992 …2019
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Research Output 1992 2019

2019

Cardiac Disorders and Pathophysiology of Sarcomeric Proteins

van der Velden, J. & Stienen, G. J. M., 1 Jan 2019, In : Physiological Reviews. 99, 1, p. 381-426 46 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Open Access

Extra energy for hearts with a genetic defect: ENERGY trial

van Driel, B. O., van Rossum, A. C., Michels, M., Huurman, R. & van der Velden, J., 2019, In : Netherlands Heart Journal. 27, 4, p. 200-205

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Five-year prognostic significance of global longitudinal strain in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes

van Velzen, H. G., Schinkel, A. F. L., van Grootel, R. W. J., van Slegtenhorst, M. A., van der Velden, J., Strachinaru, M. & Michels, M., 2019, In : Netherlands Heart Journal. 27, 3, p. 117-126

Research output: Contribution to journalArticleAcademicpeer-review

Hypertrofische cardiomyopathie

van Driel, B., Asselbergs, F. W., de Boer, R. A., van Rossum, A. C., van Tintelen, J. P., van der Velden, J. & Michels, M., 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 8, D2790.

Research output: Contribution to journalArticleProfessional

Integrative Functional Annotation of 52 Genetic Loci Influencing Myocardial Mass Identifies Candidate Regulatory Variants and Target Genes

Hemerich, D., Pei, J., Harakalova, M., van Setten, J., Boymans, S., Boukens, B. J., Efimov, I. R., Michels, M., van der Velden, J., Vink, A., Cheng, C., van der Harst, P., Moore, J. H., Mokry, M., Tragante, V. & Asselbergs, F. W., 25 Jan 2019, In : Circulation. Genomic and precision medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial adaptation after surgical therapy differs for aortic valve stenosis and hypertrophic obstructive cardiomyopathy

Parbhudayal, R. Y., Güçlü, A., Zweerink, A., Biesbroek, P. S., Croisille, P., Clarysse, P., Michels, M., Stooker, W., Vonk, A. B. A., van der Ven, P. M., van Rossum, A. C., van der Velden, J. & Nijveldt, R., 2019, In : International Journal of Cardiovascular Imaging.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sex differences in hypertrophic cardiomyopathy: new insights

van Driel, B., Nijenkamp, L., Huurman, R., Michels, M. & van der Velden, J., 2019, In : Current opinion in cardiology. 34, 3, p. 254-259

Research output: Contribution to journalArticleAcademicpeer-review

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

Piroddi, N., Witjas-Paalberends, E. R., Ferrara, C., Ferrantini, C., Vitale, G., Scellini, B., Wijnker, P. J. M., Sequiera, V., Dooijes, D., Dos Remedios, C., Schlossarek, S., Leung, M. C., Messer, A., Ward, D. G., Biggeri, A., Tesi, C., Carrier, L., Redwood, C. S., Marston, S. B., van der Velden, J. & 1 othersPoggesi, C., 7 Jan 2019, In : The Journal of general physiology. 151, 1, p. 18-29 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Untying the knot: protein quality control in inherited cardiomyopathies

Dorsch, L. M., Schuldt, M., Knežević, D., Wiersma, M., Kuster, D. W. D., van der Velden, J. & Brundel, B. J. J. M., 1 May 2019, In : Pflugers Archiv European Journal of Physiology. 471, 5, p. 795-806

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Boosting small heat shock proteins lowers cardiomyocyte passive stiffness in experimental heart failure with preserved ejection fraction

Waddingham, M. T., Dal Canto, E., Bos, D. D. S. G., Sequeria, V., Van Heerebeek, L., Kuster, D. W. D., De Man, F. S., Van Der Velden, J., Handoko, M. L., Eringa, E. C. & Paulus, W. J., May 2018, In : European Journal of Heart Failure. 20, p. 24-24

Research output: Contribution to journalMeeting AbstractAcademic

Burst-like transcription of mutant and wildtype MYH7-alleles as possible origin of cell-to-cell contractile imbalance in Hypertrophic Cardiomyopathy

Montag, J., Kowalski, K., Makul, M., Ernstberger, P., Radocaj, A., Beck, J., Becker, E., Tripathi, S., Keyser, B., Mühlfeld, C., Wissel, K., Pich, A., van der Velden, J., dos Remedios, C. G., Perrot, A., Francino, A., Navarro-López, F., Brenner, B. & Kraft, T., 9 Apr 2018, In : Frontiers in Physiology. 9, APR, 359.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cardiac remodeling and genotype-specific pathogenic effects in dilated cardiomyopathy

Bollen, A. E., 2018, 234 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Cardiovascular Function of Modern Pigs Does not Comply with Allometric Scaling Laws

Van Essen, G. J., Hekkert, M. T. L., Sorop, O., Heinonen, I., Van Der Velden, J., Merkus, D. & Duncker, D. J., 1 Aug 2018, In : Scientific Reports. 8, 1, 792.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Complex roads from genotype to phenotype in dilated cardiomyopathy: Scientific update from theworking group of myocardial function of the European Society of Cardiology

Bondue, A., Arbustini, E., Bianco, A., Ciccarelli, M., Dawson, D., de Rosa, M., Hamdani, N., Hilfiker-Kleiner, D., Meder, B., Leite-Moreira, A. F., Thum, T., Tocchetti, C. G., Varricchi, G., van der Velden, J., Walsh, R. & Heymans, S., 2018, In : Cardiovascular Research. 114, 10, p. 1287-1303

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Contribution of impaired parasympathetic activity to right ventricular dysfunction and pulmonary vascular remodeling in pulmonary arterial hypertension

Da Silva Gonçalves Bós, D., Van Der Bruggen, C. E. E., Kurakula, K., Sun, X. Q., Casali, K. R., Casali, A. G., Rol, N., Szulcek, R., Dos Remedios, C., Guignabert, C., Tu, L., Dorfmüller, P., Humbert, M., Wijnker, P. J. M., Kuster, D. W. D., Van Der Velden, J., Goumans, M. J., Bogaard, H. J., Vonk-Noordegraaf, A., De Man, F. S. & 1 othersHandoko, M. L., 1 Jan 2018, In : Circulation. 137, 9, p. 910-924 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease (Biophysical Reviews, (2017), 9, 4, (431-441), 10.1007/s12551-017-0305-3)

dos Remedios, C. G., Lal, S. P., Li, A., McNamara, J., Keogh, A., Macdonald, P. S., Cooke, R., Ehler, E., Knöll, R., Marston, S. B., Stelzer, J., Granzier, H., Bezzina, C., van Dijk, S., De Man, F. S., Stienen, G. J. M., Odeberg, J., Pontén, F., Linke, W. A. & van der Velden, J., 1 Jun 2018, In : Biophysical Reviews. 10, 3, 1 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Disease modifiers in hypertrophic cardiomyopathy: Interaction between calcium, titin and beta-adrenergic receptor stimulation

Najafi, A., 2018, 198 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

High Fibroblast Growth Factor 23 concentrations in experimental renal failure impair calcium handling in cardiomyocytes

the NIGRAM consortium, Verkaik, M., Oranje, M., Abdurrachim, D., Goebel, M., Gam, Z., Prompers, J. J., Helmes, M., ter Wee, P. M., van der Velden, J., Kuster, D. W., Vervloet, M. G. & Eringa, E. C., 1 Apr 2018, In : Physiological Reports. 6, 7, e13591.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits

Wijnker, P. J. M., Sequeira, V., Kuster, D. W. D. & van der Velden, J., 11 Apr 2018, In : Antioxidants and Redox Signaling.

Research output: Contribution to journalReview articleAcademicpeer-review

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

van der Velden, J., Tocchetti, C. G., Varricchi, G., Bianco, A., Sequeira, V., Hilfiker-Kleiner, D., Hamdani, N., Leite-Moreira, A. F., Mayr, M., Falcao-Pires, I., Thum, T., Dawson, D. K., Balligand, J-L. & Heymans, S., 1 Aug 2018, In : Cardiovascular Research. 114, 10, p. 1273-1280

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Molecular autopsy

van Driel, B., Michels, M. & van der Velden, J., 2018, In : Netherlands Heart Journal. 26, 10, p. 471-472

Research output: Contribution to journalComment/Letter to the editorAcademic

Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening

Sorop, O., Heinonen, I., Van Kranenburg, M., Van De Wouw, J., De Beer, V. J., Nguyen, I. T. N., Octavia, Y., Van Duin, R. W. B., Stam, K., Van Geuns, R. J., Wielopolski, P. A., Krestin, G. P., Van Den Meiracker, A. H., Verjans, R., Van Bilsen, M., Danser, A. H. J., Paulus, W. J., Cheng, C., Linke, W. A., Joles, J. A. & 4 othersVerhaar, M. C., Van Der Velden, J., Merkus, D. & Duncker, D. J., 1 Jan 2018, In : Cardiovascular Research. 114, 7, p. 954-964 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials

MRC CHORUS study investigators, 2018, In : The Lancet Oncology. 19, 12, p. 1680-1687

Research output: Contribution to journalArticleAcademicpeer-review

Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation

Deckx, S., Heggermont, W., Carai, P., Rienks, M., Dresselaers, T., Himmelreich, U., van Leeuwen, R., Lommen, W., van der Velden, J., Gonzalez, A., Diez, J., Papageorgiou, A. P. & Heymans, S., 1 Mar 2018, In : Matrix Biology. 66, p. 110-124 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy

Nijenkamp, L. L. A. M., Bollen, I. A. E., van Velzen, H. G., Regan, J. A., van Slegtenhorst, M., Niessen, H. W. M., Schinkel, A. F. L., Krueger, M., Poggesi, C., Ho, C. Y., Kuster, D. W. D., Michels, M. & van der Velden, J., Jun 2018, In : Circulation. Heart failure. 11, 6, e004133.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC

Frantz, S., Falcao-Pires, I., Balligand, J. L., Bauersachs, J., Brutsaert, D., Ciccarelli, M., Dawson, D., de Windt, L. J., Giacca, M., Hamdani, N., Hilfiker-Kleiner, D., Hirsch, E., Leite-Moreira, A., Mayr, M., Thum, T., Tocchetti, C. G., van der Velden, J., Varricchi, G. & Heymans, S., 1 Mar 2018, In : European Journal of Heart Failure. 20, 3, p. 445-459 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Variable cardiac myosin binding protein-C expression in the myofilaments due to MYBPC3 mutations in hypertrophic cardiomyopathy

Parbhudayal, R. Y., Garra, A. R., Götte, M. J. W., Michels, M., Pei, J., Harakalova, M., Asselbergs, F. W., van Rossum, A. C., van der Velden, J. & Kuster, D. W. D., Oct 2018, In : Journal of Molecular and Cellular Cardiology. 123, p. 59-63 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice

Singh, S. R., Zech, A. T. L., Geertz, B., Reischmann-Düsener, S., Osinska, H., Prondzynski, M., Krämer, E., Meng, Q., Redwood, C., van der Velden, J., Robbins, J., Schlossarek, S. & Carrier, L., 1 Oct 2017, In : Circulation. Heart failure. 10, 10, e004140.

Research output: Contribution to journalArticleAcademicpeer-review

Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome

Lynch, T. L., Kuster, D. W. D., Gonzalez, B., Balasubramanian, N., Nair, N., Day, S., Calvino, J. E., Tan, Y., Liebetrau, C., Troidl, C., Hamm, C. W., Güçlü, A., McDonough, B., Marian, A. J., van der Velden, J., Seidman, C. E., Huggins, G. S. & Sadayappan, S., 1 Apr 2017, In : JACC: Basic to Translational Science. 2, 2, p. 122-131 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy

Bollen, I. A. E., van der Meulen, M., de Goede, K., Kuster, D. W. D., Dalinghaus, M. & van der Velden, J., 22 Dec 2017, In : Frontiers in Physiology. 8, 01103.

Research output: Contribution to journalArticleAcademicpeer-review

Clinical Characteristics and Long-Term Outcome of Hypertrophic Cardiomyopathy in Individuals With a MYBPC3 (Myosin-Binding Protein C) Founder Mutation

van Velzen, H. G., Schinkel, A. F. L., Oldenburg, R. A., van Slegtenhorst, M. A., Frohn-Mulder, I. M. E., van der Velden, J. & Michels, M., Aug 2017, In : Circulation-cardiovascular genetics. 10, 4, e001660.

Research output: Contribution to journalArticleAcademicpeer-review

Distinguish mutation-specific pathogenic effects from secondary disease remodelling: an essential but often overlooked concept

Bollen, I. A. E. & van der Velden, J., 1 Aug 2017, In : Cardiovascular Research. 113, 10, p. 1087-1088

Research output: Contribution to journalEditorialAcademicpeer-review

Genotype-specific pathogenic effects in human dilated cardiomyopathy

Bollen, I. A. E., Schuldt, M., Harakalova, M., Vink, A., Asselbergs, F. W., Pinto, J. R., Krueger, M., Kuster, D. W. D. & van der Velden, J., 15 Jul 2017, In : Journal of Physiology - London. 595, 14, p. 4677-4693

Research output: Contribution to journalArticleAcademicpeer-review

Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy

Montag, J., Syring, M., Rose, J., Weber, A. L., Ernstberger, P., Mayer, A. K., Becker, E., Keyser, B., Dos Remedios, C., Perrot, A., van der Velden, J., Francino, A., Navarro-Lopez, F., Ho, C. Y., Brenner, B. & Kraft, T., 30 Nov 2017, In : Journal of Muscle Research and Cell Motility. p. 1-12 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

In vitro model to study the effects of matrix stiffening on Ca2+ handling and myofilament function in isolated adult rat cardiomyocytes

van Deel, E. D., Najafi, A., Fontoura, D., Valent, E., Goebel, M., Kardux, K., Falcao-Pires, I. & van der Velden, J., 15 Jul 2017, In : Journal of Physiology - London. 595, 14, p. 4597-4610

Research output: Contribution to journalArticleAcademicpeer-review

Lamin A/C-Related Cardiac Disease Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation

Hoorntje, E. T., Bollen, I. A., Barge-Schaapveld, D. Q., van Tienen, F. H. J., te Meerman, G. J., Jansweijer, J. A., van Essen, A. J., Volders, P. G., Constantinescu, A. A., van den Akker, P. C., van Spaendonck-Zwarts, K. Y., Oldenburg, R. A., Marcelis, C. L., van der Smagt, J. J., Hennekam, E. A., Vink, A., Bootsma, M., Aten, E., Wilde, A. A. M., van den Wijngaard, A. & 5 othersBroers, J. L., Jongbloed, J. D., van der Velden, J., van den Berg, M. P. & van Tintelen, J. P., Aug 2017, In : Circulation-cardiovascular genetics. 10, 4, e001631.

Research output: Contribution to journalArticleAcademicpeer-review

Life-long tailoring of management for patients with hypertrophic cardiomyopathy: Awareness and decision-making in changing scenarios

Michels, M., Olivotto, I., Asselbergs, F. W. & van der Velden, J., 1 Mar 2017, In : Netherlands Heart Journal. 25, 3, p. 186-199 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

McNamara, J. W., Li, A., Lal, S., Bos, J. M., Harris, S. P., van der Velden, J., Ackerman, M. J., Cooke, R. & dos Remedios, C. G., 28 Jun 2017, In : PLoS ONE. 12, 6, e0180064.

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial O2 utilization and energetics of the left ventricle in hypertrophic cardiomyopathy: Proof for gene-specific and disease-stage specific cardiac changes

Güçlü, A., 2017, 145 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access

Myofilament Remodeling and Function Is More Impaired in Peripartum Cardiomyopathy Compared with Dilated Cardiomyopathy and Ischemic Heart Disease

Bollen, I. A. E., Ehler, E., Fleischanderl, K., Bouwman, F., Kempers, L., Ricke-Hoch, M., Hilfiker-Kleiner, D., dos Remedios, C. G., Krüger, M., Vink, A., Asselbergs, F. W., van Spaendonck-Zwarts, K. Y., Pinto, Y. M., Kuster, D. W. D. & van der Velden, J., 1 Dec 2017, In : American Journal of Pathology. 187, 12, p. 2645-2658 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Rapid frequency-dependent changes in free mitochondrial calcium concentration in rat cardiac myocytes

Wust, R. C. I., Helmes, M., Martin, J. L., van der Wardt, T. J. T., Musters, R. J. P., van der Velden, J. & Stienen, G. J. M., 15 Mar 2017, In : Journal of Physiology - London. 595, 6, p. 2001-2019

Research output: Contribution to journalArticleAcademicpeer-review

RV pressure overload: from hypertrophy to failure

van der Bruggen, C. E. E., Tedford, R. J., Handoko, M. L., van der Velden, J. & de Man, F. S., 1 Oct 2017, In : Cardiovascular Research. 113, 12, p. 1423-1432

Research output: Contribution to journalArticleAcademicpeer-review

Targeting High Oxygen Consumption to Prevent Cardiac Dysfunction in Patients With Aortic Valve Stenosis

van der Velden, J., Oct 2017, In : Circulation.Cardiovascular Imaging. 10, e007015.

Research output: Contribution to journalEditorialAcademicpeer-review

The contribution of mutations in MYH7 to the onset of cardiomyopathy

Bollen, I. A. E. & van der Velden, J., 1 Dec 2017, In : Netherlands Heart Journal. 25, 12, p. 653-654 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

The Frank–Starling Law: a jigsaw of titin proportions

Sequeira, V. & van der Velden, J., 1 Jun 2017, In : Biophysical Reviews. 9, 3, p. 259-267 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

THE IMPACT OF GRADE IN ENDOMETRIOID ENDOMETRIAL CANCER INVADING CERVICAL STROMA AFTER HYSTERECTOMY AND BSO.

van Lonkhuijzen, L., Mom, C., Charles, R., Fons, G., Buist, M., Tjiong, M., Kenter, G. & van der Velden, J., Nov 2017, In : International Journal of Gynecological Cancer. 27, p. 476-476

Research output: Contribution to journalMeeting AbstractAcademic

The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease

dos Remedios, C. G., Lal, S. P., Li, A., McNamara, J., Keogh, A., Macdonald, P. S., Cooke, R., Ehler, E., Knöll, R., Marston, S. B., Stelzer, J., Granzier, H., Bezzina, C., van Dijk, S., De Man, F., Stienen, G. J. M., Odeberg, J., Pontén, F., Linke, W. & van der Velden, J., 1 Aug 2017, In : Biophysical Reviews. 9, 4, p. 431-441 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart

Van Eldik, W., Den Adel, B., Monshouwer-Kloots, J., Salvatori, D., Maas, S., Van Der Made, I., Creemers, E. E., Frank, D., Frey, N., Boontje, N., Van Der Velden, J., Steendijk, P., Mummery, C., Passier, R. & Beqqali, A., 1 Dec 2017, In : PLoS ONE. 12, 12, e0189139.

Research output: Contribution to journalArticleAcademicpeer-review