1992 …2019
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Research Output 1992 2019

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Article
2019

Extra energy for hearts with a genetic defect: ENERGY trial

van Driel, B. O., van Rossum, A. C., Michels, M., Huurman, R. & van der Velden, J., 2019, In : Netherlands Heart Journal. 27, 4, p. 200-205

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Five-year prognostic significance of global longitudinal strain in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes

van Velzen, H. G., Schinkel, A. F. L., van Grootel, R. W. J., van Slegtenhorst, M. A., van der Velden, J., Strachinaru, M. & Michels, M., 2019, In : Netherlands Heart Journal. 27, 3, p. 117-126

Research output: Contribution to journalArticleAcademicpeer-review

Hypertrofische cardiomyopathie

van Driel, B., Asselbergs, F. W., de Boer, R. A., van Rossum, A. C., van Tintelen, J. P., van der Velden, J. & Michels, M., 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 8, D2790.

Research output: Contribution to journalArticleProfessional

Integrative Functional Annotation of 52 Genetic Loci Influencing Myocardial Mass Identifies Candidate Regulatory Variants and Target Genes

Hemerich, D., Pei, J., Harakalova, M., van Setten, J., Boymans, S., Boukens, B. J., Efimov, I. R., Michels, M., van der Velden, J., Vink, A., Cheng, C., van der Harst, P., Moore, J. H., Mokry, M., Tragante, V. & Asselbergs, F. W., 25 Jan 2019, In : Circulation. Genomic and precision medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial adaptation after surgical therapy differs for aortic valve stenosis and hypertrophic obstructive cardiomyopathy

Parbhudayal, R. Y., Güçlü, A., Zweerink, A., Biesbroek, P. S., Croisille, P., Clarysse, P., Michels, M., Stooker, W., Vonk, A. B. A., van der Ven, P. M., van Rossum, A. C., van der Velden, J. & Nijveldt, R., 2019, In : International Journal of Cardiovascular Imaging.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sex differences in hypertrophic cardiomyopathy: new insights

van Driel, B., Nijenkamp, L., Huurman, R., Michels, M. & van der Velden, J., 2019, In : Current opinion in cardiology. 34, 3, p. 254-259

Research output: Contribution to journalArticleAcademicpeer-review

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

Piroddi, N., Witjas-Paalberends, E. R., Ferrara, C., Ferrantini, C., Vitale, G., Scellini, B., Wijnker, P. J. M., Sequiera, V., Dooijes, D., Dos Remedios, C., Schlossarek, S., Leung, M. C., Messer, A., Ward, D. G., Biggeri, A., Tesi, C., Carrier, L., Redwood, C. S., Marston, S. B., van der Velden, J. & 1 othersPoggesi, C., 7 Jan 2019, In : The Journal of general physiology. 151, 1, p. 18-29 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Untying the knot: protein quality control in inherited cardiomyopathies

Dorsch, L. M., Schuldt, M., Knežević, D., Wiersma, M., Kuster, D. W. D., van der Velden, J. & Brundel, B. J. J. M., 1 May 2019, In : Pflugers Archiv European Journal of Physiology. 471, 5, p. 795-806

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Burst-like transcription of mutant and wildtype MYH7-alleles as possible origin of cell-to-cell contractile imbalance in Hypertrophic Cardiomyopathy

Montag, J., Kowalski, K., Makul, M., Ernstberger, P., Radocaj, A., Beck, J., Becker, E., Tripathi, S., Keyser, B., Mühlfeld, C., Wissel, K., Pich, A., van der Velden, J., dos Remedios, C. G., Perrot, A., Francino, A., Navarro-López, F., Brenner, B. & Kraft, T., 9 Apr 2018, In : Frontiers in Physiology. 9, APR, 359.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cardiovascular Function of Modern Pigs Does not Comply with Allometric Scaling Laws

Van Essen, G. J., Hekkert, M. T. L., Sorop, O., Heinonen, I., Van Der Velden, J., Merkus, D. & Duncker, D. J., 1 Aug 2018, In : Scientific Reports. 8, 1, 792.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Contribution of impaired parasympathetic activity to right ventricular dysfunction and pulmonary vascular remodeling in pulmonary arterial hypertension

Da Silva Gonçalves Bós, D., Van Der Bruggen, C. E. E., Kurakula, K., Sun, X. Q., Casali, K. R., Casali, A. G., Rol, N., Szulcek, R., Dos Remedios, C., Guignabert, C., Tu, L., Dorfmüller, P., Humbert, M., Wijnker, P. J. M., Kuster, D. W. D., Van Der Velden, J., Goumans, M. J., Bogaard, H. J., Vonk-Noordegraaf, A., De Man, F. S. & 1 othersHandoko, M. L., 1 Jan 2018, In : Circulation. 137, 9, p. 910-924 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

High Fibroblast Growth Factor 23 concentrations in experimental renal failure impair calcium handling in cardiomyocytes

the NIGRAM consortium, Verkaik, M., Oranje, M., Abdurrachim, D., Goebel, M., Gam, Z., Prompers, J. J., Helmes, M., ter Wee, P. M., van der Velden, J., Kuster, D. W., Vervloet, M. G. & Eringa, E. C., 1 Apr 2018, In : Physiological Reports. 6, 7, e13591.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening

Sorop, O., Heinonen, I., Van Kranenburg, M., Van De Wouw, J., De Beer, V. J., Nguyen, I. T. N., Octavia, Y., Van Duin, R. W. B., Stam, K., Van Geuns, R. J., Wielopolski, P. A., Krestin, G. P., Van Den Meiracker, A. H., Verjans, R., Van Bilsen, M., Danser, A. H. J., Paulus, W. J., Cheng, C., Linke, W. A., Joles, J. A. & 4 othersVerhaar, M. C., Van Der Velden, J., Merkus, D. & Duncker, D. J., 1 Jan 2018, In : Cardiovascular Research. 114, 7, p. 954-964 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials

MRC CHORUS study investigators, 2018, In : The Lancet Oncology. 19, 12, p. 1680-1687

Research output: Contribution to journalArticleAcademicpeer-review

Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation

Deckx, S., Heggermont, W., Carai, P., Rienks, M., Dresselaers, T., Himmelreich, U., van Leeuwen, R., Lommen, W., van der Velden, J., Gonzalez, A., Diez, J., Papageorgiou, A. P. & Heymans, S., 1 Mar 2018, In : Matrix Biology. 66, p. 110-124 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy

Nijenkamp, L. L. A. M., Bollen, I. A. E., van Velzen, H. G., Regan, J. A., van Slegtenhorst, M., Niessen, H. W. M., Schinkel, A. F. L., Krueger, M., Poggesi, C., Ho, C. Y., Kuster, D. W. D., Michels, M. & van der Velden, J., Jun 2018, In : Circulation. Heart failure. 11, 6, e004133.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Variable cardiac myosin binding protein-C expression in the myofilaments due to MYBPC3 mutations in hypertrophic cardiomyopathy

Parbhudayal, R. Y., Garra, A. R., Götte, M. J. W., Michels, M., Pei, J., Harakalova, M., Asselbergs, F. W., van Rossum, A. C., van der Velden, J. & Kuster, D. W. D., Oct 2018, In : Journal of Molecular and Cellular Cardiology. 123, p. 59-63 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice

Singh, S. R., Zech, A. T. L., Geertz, B., Reischmann-Düsener, S., Osinska, H., Prondzynski, M., Krämer, E., Meng, Q., Redwood, C., van der Velden, J., Robbins, J., Schlossarek, S. & Carrier, L., 1 Oct 2017, In : Circulation. Heart failure. 10, 10, e004140.

Research output: Contribution to journalArticleAcademicpeer-review

Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome

Lynch, T. L., Kuster, D. W. D., Gonzalez, B., Balasubramanian, N., Nair, N., Day, S., Calvino, J. E., Tan, Y., Liebetrau, C., Troidl, C., Hamm, C. W., Güçlü, A., McDonough, B., Marian, A. J., van der Velden, J., Seidman, C. E., Huggins, G. S. & Sadayappan, S., 1 Apr 2017, In : JACC: Basic to Translational Science. 2, 2, p. 122-131 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy

Bollen, I. A. E., van der Meulen, M., de Goede, K., Kuster, D. W. D., Dalinghaus, M. & van der Velden, J., 22 Dec 2017, In : Frontiers in Physiology. 8, 01103.

Research output: Contribution to journalArticleAcademicpeer-review

Clinical Characteristics and Long-Term Outcome of Hypertrophic Cardiomyopathy in Individuals With a MYBPC3 (Myosin-Binding Protein C) Founder Mutation

van Velzen, H. G., Schinkel, A. F. L., Oldenburg, R. A., van Slegtenhorst, M. A., Frohn-Mulder, I. M. E., van der Velden, J. & Michels, M., Aug 2017, In : Circulation-cardiovascular genetics. 10, 4, e001660.

Research output: Contribution to journalArticleAcademicpeer-review

Genotype-specific pathogenic effects in human dilated cardiomyopathy

Bollen, I. A. E., Schuldt, M., Harakalova, M., Vink, A., Asselbergs, F. W., Pinto, J. R., Krueger, M., Kuster, D. W. D. & van der Velden, J., 15 Jul 2017, In : Journal of Physiology - London. 595, 14, p. 4677-4693

Research output: Contribution to journalArticleAcademicpeer-review

Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy

Montag, J., Syring, M., Rose, J., Weber, A. L., Ernstberger, P., Mayer, A. K., Becker, E., Keyser, B., Dos Remedios, C., Perrot, A., van der Velden, J., Francino, A., Navarro-Lopez, F., Ho, C. Y., Brenner, B. & Kraft, T., 30 Nov 2017, In : Journal of Muscle Research and Cell Motility. p. 1-12 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

In vitro model to study the effects of matrix stiffening on Ca2+ handling and myofilament function in isolated adult rat cardiomyocytes

van Deel, E. D., Najafi, A., Fontoura, D., Valent, E., Goebel, M., Kardux, K., Falcao-Pires, I. & van der Velden, J., 15 Jul 2017, In : Journal of Physiology - London. 595, 14, p. 4597-4610

Research output: Contribution to journalArticleAcademicpeer-review

Lamin A/C-Related Cardiac Disease Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation

Hoorntje, E. T., Bollen, I. A., Barge-Schaapveld, D. Q., van Tienen, F. H. J., te Meerman, G. J., Jansweijer, J. A., van Essen, A. J., Volders, P. G., Constantinescu, A. A., van den Akker, P. C., van Spaendonck-Zwarts, K. Y., Oldenburg, R. A., Marcelis, C. L., van der Smagt, J. J., Hennekam, E. A., Vink, A., Bootsma, M., Aten, E., Wilde, A. A. M., van den Wijngaard, A. & 5 othersBroers, J. L., Jongbloed, J. D., van der Velden, J., van den Berg, M. P. & van Tintelen, J. P., Aug 2017, In : Circulation-cardiovascular genetics. 10, 4, e001631.

Research output: Contribution to journalArticleAcademicpeer-review

Life-long tailoring of management for patients with hypertrophic cardiomyopathy: Awareness and decision-making in changing scenarios

Michels, M., Olivotto, I., Asselbergs, F. W. & van der Velden, J., 1 Mar 2017, In : Netherlands Heart Journal. 25, 3, p. 186-199 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

McNamara, J. W., Li, A., Lal, S., Bos, J. M., Harris, S. P., van der Velden, J., Ackerman, M. J., Cooke, R. & dos Remedios, C. G., 28 Jun 2017, In : PLoS ONE. 12, 6, e0180064.

Research output: Contribution to journalArticleAcademicpeer-review

Myofilament Remodeling and Function Is More Impaired in Peripartum Cardiomyopathy Compared with Dilated Cardiomyopathy and Ischemic Heart Disease

Bollen, I. A. E., Ehler, E., Fleischanderl, K., Bouwman, F., Kempers, L., Ricke-Hoch, M., Hilfiker-Kleiner, D., dos Remedios, C. G., Krüger, M., Vink, A., Asselbergs, F. W., van Spaendonck-Zwarts, K. Y., Pinto, Y. M., Kuster, D. W. D. & van der Velden, J., 1 Dec 2017, In : American Journal of Pathology. 187, 12, p. 2645-2658 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Rapid frequency-dependent changes in free mitochondrial calcium concentration in rat cardiac myocytes

Wust, R. C. I., Helmes, M., Martin, J. L., van der Wardt, T. J. T., Musters, R. J. P., van der Velden, J. & Stienen, G. J. M., 15 Mar 2017, In : Journal of Physiology - London. 595, 6, p. 2001-2019

Research output: Contribution to journalArticleAcademicpeer-review

RV pressure overload: from hypertrophy to failure

van der Bruggen, C. E. E., Tedford, R. J., Handoko, M. L., van der Velden, J. & de Man, F. S., 1 Oct 2017, In : Cardiovascular Research. 113, 12, p. 1423-1432

Research output: Contribution to journalArticleAcademicpeer-review

Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart

Van Eldik, W., Den Adel, B., Monshouwer-Kloots, J., Salvatori, D., Maas, S., Van Der Made, I., Creemers, E. E., Frank, D., Frey, N., Boontje, N., Van Der Velden, J., Steendijk, P., Mummery, C., Passier, R. & Beqqali, A., 1 Dec 2017, In : PLoS ONE. 12, 12, e0189139.

Research output: Contribution to journalArticleAcademicpeer-review

2016

A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism

Beqqali, A., Bollen, I. A. E., Rasmussen, T. B., van den Hoogenhof, M. M., van Deutekom, H. W. M., Schafer, S., Haas, J., Meder, B., Sorensen, K. E., van Oort, R. J., Mogensen, J., Hubner, N., Creemers, E. E., van der Velden, J. & Pinto, Y. M., 1 Oct 2016, In : Cardiovascular Research. 112, 1, p. 452-463

Research output: Contribution to journalArticleAcademicpeer-review

beta-adrenergic receptor signalling and its functional consequences in the diseased heart

Najafi, A., Sequeira Oliveira, V., Kuster, D. W. D. & van der Velden, J., Apr 2016, In : European Journal of Clinical Investigation. 46, 4, p. 362-374

Research output: Contribution to journalArticleAcademicpeer-review

Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension A View on the Right Ventricle

van der Bruggen, C. E., Happe, C. M., Dorfmueller, P., Trip, P., Spruijt, O. A., Rol, N., Hoevenaars, F. P., Houweling, A. C., Girerd, B., Marcus, J. T., Mercier, O., Humbert, M., Handoko, M. L., van der Velden, J., Noordegraaf, A. V., Bogaard, H. J., Goumans, M-J. & de Man, F. S., 3 May 2016, In : Circulation. 133, 18, p. 1747-1760

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of the effects of a truncating and a missense MYBPC3 mutation on contractile parameters of engineered heart tissue

Wijnker, P. J. M., Friedrich, F. W., Dutsch, A., Reischmann, S., Eder, A., Mannhardt, I., Mearini, G., Eschenhagen, T., van der Velden, J. & Carrier, L., Aug 2016, In : Journal of Molecular and Cellular Cardiology. 97, p. 82-92

Research output: Contribution to journalArticleAcademicpeer-review

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3 '-End Formation in the Failing Human Heart

Creemers, E. E., Bawazeer, A., Ugalde, A. P., van Deutekom, H. W. M., van der Made, I., de Groot, N. E., Adriaens, M. E., Cook, S. A., Bezzina, C. R., Hubner, N., van der Velden, J., Elkon, R., Agami, R. & Pinto, Y. M., 5 Feb 2016, In : Circulation Research. 118, 3, p. 433-438

Research output: Contribution to journalArticleAcademicpeer-review

Mimicking the cardiac cycle in intact cardiomyocytes using diastolic and systolic force clamps; measuring power output

Helmes, M., Najafi, A., Palmer, B. M., Breel, E., Rijnveld, N., Iannuzzi, D. & van der Velden, J., 1 Jul 2016, In : Cardiovascular Research. 111, 1, p. 66-73

Research output: Contribution to journalArticleAcademicpeer-review

RBM20 Regulates Circular RNA Production From the Titin Gene

Khan, M. A. F., Reckman, Y. J., Aufiero, S., van den Hoogenhof, M. M. G., van der Made, I., Beqqali, A., Koolbergen, D. R., Rasmussen, T. B., van der Velden, J., Creemers, E. E. & Pinto, Y. M., 14 Oct 2016, In : Circulation Research. 119, 9, p. 996-1003

Research output: Contribution to journalArticleAcademicpeer-review

Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension Relative Contribution of Fibrosis and Myofibril Stiffness

Rain, S., Andersen, S., Najafi, A., Schultz, J. G., Bos, D. D. S. G., Handoko, M. L., Bogaard, H-J., Vonk-Noordegraaf, A., Andersen, A., van der Velden, J., Ottenheijm, C. A. C. & de Man, F. S., Jul 2016, In : Circulation. Heart failure. 9, 7, e002636.

Research output: Contribution to journalArticleAcademicpeer-review

Selective phosphorylation of PKA targets after beta-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model

Najafi, A., Sequeira Oliveira, V., Helmes, M., Bollen, I. A. E., Goebel, M., Regan, J. A., Carrier, L., Kuster, D. W. D. & Van der Velden, J., 15 May 2016, In : Cardiovascular Research. 110, 2, p. 200-214

Research output: Contribution to journalArticleAcademicpeer-review

S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure

Stathopoulou, K., Wittig, I., Heidler, J., Piasecki, A., Richter, F., Diering, S., van der Velden, J., Buck, F., Donzelli, S., Schroder, E., Wijnker, P. J. M., Voigt, N., Dobrev, D., Sadayappan, S., Eschenhagen, T., Carrier, L., Eaton, P. & Cuello, F., May 2016, In : FASEB Journal. 30, 5, p. 1849-1864

Research output: Contribution to journalArticleAcademicpeer-review

Value of Genetic Testing for the Prediction of Long-Term Outcome in Patients With Hypertrophic Cardiomyopathy

van Velzen, H. G., Vriesendorp, P. A., Oldenburg, R. A., van Slegtenhorst, M. A., van der Velden, J., Schinkel, A. F. L. & Michels, M., 15 Sep 2016, In : American Journal of Cardiology. 118, 6, p. 881-887

Research output: Contribution to journalArticleAcademicpeer-review

2015

ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease

Sequeira Oliveira, V., Najafi, A., Wijnker, P. J. M., dos Remedios, C. G., Michels, M., Kuster, D. W. D. & van der Velden, J., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. E7003-E7012

Research output: Contribution to journalArticleAcademicpeer-review

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

Wijnker, P. J. M., Li, Y., Zhang, P., Foster, D. B., dos Remedios, C., van Eyk, J. E., Stienen, G. J. M., Murphy, A. M. & van der Velden, J., 2015, In : Journal of Molecular and Cellular Cardiology. 82, p. 93-103

Research output: Contribution to journalArticleAcademicpeer-review

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene

de Winter, J. M., Joureau, B., Sequeira Oliveira, V., Clarke, N. F., van der Velden, J., Stienen, G. J. M., Granzier, H., Beggs, A. H. & Ottenheijm, C. A. C., 2015, In : Skeletal Muscle. 5, 12.

Research output: Contribution to journalArticleAcademicpeer-review

Historical perspective on heart function: the Frank–Starling Law

Sequeira Oliveira, V. & van der Velden, J., 2015, In : Biophysical Reviews. 7, 4, p. 421-447

Research output: Contribution to journalArticleAcademicpeer-review

Left ventricular outflow tract gradient is associated with reduced capillary density in hypertrophic cardiomyopathy irrespective of genotype

Güçlü, A., Happé, C., Eren, S., Korkmaz, I. H., Niessen, H. W. M., Klein, P., van Slegtenhorst, M., Schinkel, A. F., Michels, M., van Rossum, A. C., Germans, T. & van der Velden, J., Dec 2015, In : European Journal of Clinical Investigation. 45, 12, p. 1252-1259 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation

Lynch, T. L., Sivaguru, M., Velayutham, M., Cardounel, A. J., Michels, M., Barefield, D., Govindan, S., dos Remedios, C., van der Velden, J. & Sadayappan, S., 2015, In : Oxidative medicine and cellular longevity. 2015, 424751.

Research output: Contribution to journalArticleAcademicpeer-review