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Research Output 2003 2019

2019

Clinical and genetic landscape of treatment naive cervical cancer: Alterations in PIK3CA and in epigenetic modulators associated with sub-optimal outcome

Scholl, S., Popovic, M., de la Rochefordiere, A., Girard, E., Dureau, S., Mandic, A., Koprivsek, K., Samet, N., Craina, M., Margan, M., Samuels, S., Zijlmans, H., Kenter, G., Hillemanns, P., Dema, S., Dema, A., Malenkovic, G., Djuran, B., Floquet, A., Garbay, D. & 34 othersGuyon, F., Colombo, P. E., Fabbro, M., Kerr, C., Ngo, C., Lecuru, F., Campo, E. R. D., Coutant, C., Marchal, F., Mesgouez-Nebout, N., Fourchotte, V., Feron, J. G., Morice, P., Deutsch, E., Wimberger, P., Classe, J-M., Gleeson, N., von der Leyen, H., Minsat, M., Dubot, C., Gestraud, P., Kereszt, A., Nagy, I., Balint, B., Berns, E., Jordanova, E., Saint-Jorre, N. D., Savignoni, A., Servant, N., Hupe, P., de Koning, L., Fumoleau, P., Rouzier, R. & Kamal, M., 2019, In : EBioMedicine.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Defining the Tumor Microenvironment of Penile Cancer by Means of the Cancer Immunogram

de Vries, H-M., Ottenhof, S. R., Horenblas, S., van der Heijden, M. S. & Jordanova, E. S., 2019, In : European Urology Focus.

Research output: Contribution to journalReview articleAcademicpeer-review

HLA class II expression on tumor cells and low numbers of tumor-associated macrophages predict clinical outcome in oropharyngeal cancer

Cioni, B., Jordanova, E. S., Hooijberg, E., van der Linden, R., de Menezes, R. X., Tan, K., Willems, S., Elbers, J. B. W., Broeks, A., Bergman, A. M., Zuur, C. L. & de Boer, J. P., 1 Feb 2019, In : Head and Neck. 41, 2, p. 463-478 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses

Santegoets, S. J., Duurland, C. L., Jordanova, E. S., van Ham, J. J., Ehsan, I., van Egmond, S. L., Welters, M. J. P. & van der Burg, S. H., 18 Jan 2019, In : Journal for Immunotherapy of Cancer. 7, 1, p. 14

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access
2018

Cancer immunophenotyping by 7 colour multispectral imaging without tyramide signal amplification

Ijselstein, M., Brouwer, T., Abdulrahman, Z., Reidy, E., Ramalheiro, A., Heeren, AM., Vahrmeijer, A., Jordanova, ES. & de Miranda, N., 7 Sep 2018, In : The Journal of Pathology: Clinical Research.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Digital PCR-Based T-cell Quantification-Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma

de Lange, M. J., Nell, R. J., Lalai, R. N., Versluis, M., Jordanova, E. S., Luyten, G. P. M., Jager, M. J., van der Burg, S. H., Zoutman, W. H., van Hall, T. & van der Velden, P. A., Dec 2018, In : Molecular Cancer Research. 16, 12, p. 1902-1911 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

HLA class I antigen expression in conjunctival melanoma is not associated with PD-L1/PD-1 status

Cao, J., Brouwer, N. J., Jordanova, E. S., Marinkovic, M., Van Duinen, S. G., De Waard, N. E., Ksander, B. R., Mulder, A., Claas, F. H. J., Heemskerk, M. H. M. & Jager, M. J., 1 Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 1005-1015 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Independent validation of the prognostic significance of invasion patterns in endocervical adenocarcinoma: Pattern A predicts excellent survival

Spaans, V. M., Scheunhage, D. A., Barzaghi, B., de Kroon, C. D., Fleuren, G. J., Bosse, T. & Jordanova, E. S., Nov 2018, In : Gynecologic Oncology. 151, 2, p. 196-201 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Indoleamine 2,3-dioxygenase expression pattern in the tumor microenvironment predicts clinical outcome in early stage cervical cancer

Heeren, A. M., van Dijk, I., Berry, D. R. A. I., Khelil, M., Ferns, D., Kole, J., Musters, R. J. P., Thijssen, V. L., Mom, C. H., Kenter, G. G., Bleeker, M. C. G., de Gruijl, T. D. & Jordanova, E. S., 11 Jul 2018, In : Frontiers in Immunology. 9, JUL, 1598.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intratumoral HPV16-specific T cells constitute a type I–oriented tumor microenvironment to improve survival in HPV16-driven oropharyngeal cancer

Welters, M. J. P., Ma, W., Santegoets, S. J. A. M., Goedemans, R., Ehsan, I., Jordanova, E. S., Van Ham, V. J., Van Unen, V., Koning, F., Van Egmond, S. I., Charoentong, P., Trajanoski, Z., Van Der Velden, L. A. & Van Der Burg, S. H., 1 Feb 2018, In : Clinical Cancer Research. 24, 3, p. 634-647 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target

Cao, J., Pontes, K. C., Heijkants, R. C., Brouwer, N. J., Groenewoud, A., Jordanova, E. S., Marinkovic, M., van Duinen, S., Teunisse, A. F., Verdijk, R. M., Snaar-Jagalska, E., Jochemsen, A. G. & Jager, M. J., 1 Aug 2018, In : Journal of Pathology. 245, 4, p. 433-444 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy

Luk, S. J., Steen, D. M. V. D., Hagedoorn, R. S., Jordanova, E. S., Schilham, M. W., Bovée, J. V. MG., Cleven, A. H. G., Falkenburg, J. H. F., Szuhai, K. & Heemskerk, M. H. M., 2 Dec 2018, In : OncoImmunology. 7, 12

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sponge-supported cultures of primary head and neck tumors for an optimized preclinical model

Dohmen, A. J. C., Sanders, J., Canisius, S., Jordanova, E. S., Aalbersberg, E. A., Brekel, M. W. M. V. D., Neefjes, J. & Zuur, C. L., 18 May 2018, In : Oncotarget. 9, 38, p. 25034-25047 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The landscape of somatic mutations in Indonesian cervical cancer is predominated by the PI3K pathway

Spaans, V. M., Nyoman Bayu Mahendra, I., Purwoto, G., Trietsch, M. D., Osse, M., ter Haar, N., Peters, A. A. W., Fleuren, G. J. & Jordanova, E. S., 1 Jan 2018, In : Gynecologic Oncology. 148, 1, p. 189-196 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The prognostic value of immune factors in the tumor microenvironment of penile squamous cell carcinoma

Ottenhof, S. R., Djajadiningrat, R. S., Thygesen, H. H., Jakobs, P. J., Józwiak, K., Heeren, A. M., de Jong, J., Sanders, J., Horenblas, S. & Jordanova, E. S., 11 Jun 2018, In : Frontiers in Immunology. 9, JUN, 1253.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Tissue damage caused by myeloablative, but not non-myeloablative, conditioning before allogeneic stem cell transplantation results in dermal macrophage recruitment without active T-cell interaction

van Balen, P., van der Zouwen, B., Kruisselbrink, A. B., Eefting, M., Szuhai, K., Jordanova, E. S., Falkenburg, J. H. F. & Jedema, I., 27 Feb 2018, In : Frontiers in Immunology. 9, FEB, 331.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Translating immune characteristics of metastatic tumors into therapeutic targets for cervical cancer

Heeren, AM., 2018, 213 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access
File
2017

Autocrine expression of the epidermal growth factor receptor ligand heparin-binding EGF-like growth factor in cervical cancer

Schrevel, M., Osse, E. M., Prins, F. A., Trimbos, J. B. M. Z., Fleuren, G. J., Gorter, A. & Jordanova, E. S., Jun 2017, In : International Journal of Oncology. 50, 6, p. 1947-1954 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression

Baglio, S. R., Lagerweij, T., Pérez-Lanzón, M., Ho, X. D., Léveillé, N., Melo, S. A., Cleton-Jansen, A. M., Jordanova, E. S., Roncuzzi, L., Greco, M., Van Eijndhoven, M. A. J., Grisendi, G., Dominici, M., Bonafede, R., Lougheed, S. M., De Gruijl, T. D., Zini, N., Cervo, S., Steffan, A., Canzonieri, V. & 6 othersMartson, A., Maasalu, K., Köks, S., Wurdinger, T., Baldini, N. & Pegtel, D. M., 15 Jul 2017, In : Clinical Cancer Research. 23, 14, p. 3721-3733 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review

Mehta, A. M., Mooij, M., Branković, I., Ouburg, S., Morré, S. A. & Jordanova, E. S., 2017, In : Journal of Immunology Research. 2017, p. 8913860

Research output: Contribution to journalReview articleAcademicpeer-review

Expression of Programmed Death Ligand 1 in Penile Cancer is of Prognostic Value and Associated with HPV Status

Ottenhof, S. R., Djajadiningrat, R. S., de Jong, J., Thygesen, H. H., Horenblas, S. & Jordanova, E. S., Mar 2017, In : The Journal of Urology. 197, 3, p. 690-696

Research output: Contribution to journalArticleAcademicpeer-review

HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia

Samuels, S., Marijne Heeren, A., Zijlmans, H. J. M. A. A., Welters, M. J. P., van den Berg, J. H., Philips, D., Kvistborg, P., Ehsan, I., Scholl, S. M. E., Nuijen, B., Schumacher, T. N. M., van Beurden, M., Jordanova, E. S., Haanen, J. B. A. G., van der Burg, S. H. & Kenter, G. G., 1 Sep 2017, In : Cancer Immunology, Immunotherapy. 66, 9, p. 1163-1173 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition

Eggink, F. A. A., Van Gool, I. C. B., Leary, A. C., Pollock, P. M. D., Crosbie, E. J. E., Mileshkin, L. F., Jordanova, E. S. B., Adam, J. C., Freeman-Mills, L. H., Church, D. N. H., Creutzberg, C. L. J., De Bruyn, M. A., Nijman, H. W. A. & Bosse, T. B., 2017, In : OncoImmunology. 6, 2

Research output: Contribution to journalArticleAcademicpeer-review

Immunophenotypes in young-onset colorectal cancer

van Herk, M. E., Lee, M., Rytterdahl, M., Kop, M. E., Ramalheiro, A. F., van der Breggen, R., van Wezel, T., Morreau, H., Jordanova, E. S. & de Miranda, N. F., Jul 2017, In : Cancer Research. 77

Research output: Contribution to journalMeeting AbstractAcademic

L1 cell adhesion molecule (L1CAM) is a strong predictor for locoregional recurrences in cervical cancer

Schrevel, M., Corver, W. E., Vegter, M. E., Ter Haar, N. T., Dreef, E. J., Beltman, J. J., Kenter, G., Bosse, T., de Kroon, C. D. & Jordanova, E. S., 20 Oct 2017, In : Oncotarget. 8, 50, p. 87568-87581 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas

Hoekstra, A. S., Hensen, E. F., Jordanova, E. S., Korpershoek, E., van der Horst-Schrivers, A. N. A., Cornelisse, C., Corssmit, E. P. M., Hes, F. J., Jansen, J. C., Kunst, H. P. M., Timmers, H. J. L. M., Bateman, A., Eccles, D., Bovee, J. V. M. G., Devilee, P. & Bayley, J-P., 28 Feb 2017, In : Oncotarget. 8, 9, p. 14525-14536

Research output: Contribution to journalArticleAcademicpeer-review

MICROENVIRONMENT IN TUMOR-DRAINING LYMPH NODES FROM PATIENTS WITH HPV-RELATED VULVAR CANCER

Zijlmans, H., Heeren, M., Samuels, S., Rotman, J., van der Velden, K., Van de Vijver, K., Kenter, G., Jordanova, E., Bleeker, M. & de Gruijl, T., Nov 2017, In : International Journal of Gynecological Cancer. 27, 4, p. 1397-1397 ESGO7-130.

Research output: Contribution to journalMeeting AbstractAcademic

MICROENVIRONMENT IN TUMOR-DRAINING LYMPH NODES FROM PATIENTS WITH HPV-RELATED VULVAR CANCER

Zijlmans, H., Heeren, M., Samuels, S., Rotman, J., van der Velden, K., de Vijver, K. V., Kenter, G., Jordanova, E., Bleeker, M. & de Gruijl, T., Nov 2017, In : International Journal of Gynecological Cancer. 27, p. 499-499

Research output: Contribution to journalMeeting AbstractAcademic

PD-L1/PD-1 expression and tumor-infiltrating lymphocytes in conjunctival melanoma

Cao, J., Brouwer, N. J., Richards, K. E., Marinkovic, M., van Duinen, S., Hurkmans, D., Verdegaal, E. M. E., Jordanova, E. S. & Jager, M. J., 15 Aug 2017, In : Oncotarget. 8, 33, p. 54722-54734 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma

Gezgin, G., Luk, S. J., Cao, J., Dogrusoz, M., van der Steen, D. M., Hagedoorn, R. S., Krijgsman, D., van der Velden, P. A., Field, M. G., Luyten, G. P. M., Szuhai, K., Harbour, J. W., Jordanova, E. S., Heemskerk, M. H. M. & Jager, M. J., Jun 2017, In : Jama ophthalmology. 135, 6, p. 541-549

Research output: Contribution to journalArticleAcademicpeer-review

Rational molecular assessment and innovative drug selection (RAIDs): Paving the way to personalized medicine in cervical cancer

de Koning, L., Ouine, B., Cartier, A., Berns, E. M., Ruigrok-Ritstier, K., Beaufort, C., Balint, B., Kereszt, A., Kenter, G., Samuels, S., Jordanova, E. S., Jeannot, E., von der Leyen, H., Popovic, M., Luscap-Rondof, W., Sibut, V., Kamoun, C., Britto, I., Rincon, C., Hupe, P. & 2 othersKamal, M. & Scholl, S. M., Jul 2017, In : Cancer Research. 77

Research output: Contribution to journalMeeting AbstractAcademic

The role of the immune system in cervical cancer

Samuels, S., 2017, 214 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access
2016

A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17(+) cell frequency

Punt, S., Dronkers, E. A. C., Welters, M. J. P., Goedemans, R., Koljenovic, S., Bloemena, E., Snijders, P. J. F., Gorter, A., van der Burg, S. H., de Jong, R. J. B. & Jordanova, E. S., Apr 2016, In : Cancer Immunology and Immunotherapy. 65, 4, p. 393-403

Research output: Contribution to journalArticleAcademicpeer-review

Expression of coinhibitory receptors on T cells in the microenvironment of usual vulvar intraepithelial neoplasia is related to proinflammatory effector T cells and an increased recurrence-free survival

Van Esch, E. M. G., Van Poelgeest, M. I. E., Kouwenberg, S., Osse, E. M., Trimbos, J. B. M. Z., Fleuren, G. J., Jordanova, E. S. & Van Der Burg, S. H., 1 Jan 2016, In : International Journal of Cancer. 136, 4, p. E95-E106

Research output: Contribution to journalArticleAcademicpeer-review

Expression of PD-L1 and PD-1 in conjunctival melanoma

Cao, J., Richards, K., Jordanova, E. S., Arinkovic, M., Hurkmans, D., van Duinen, S. G., van der Velden, P. A. & Jager, M. J., Sep 2016, In : Investigative Ophthalmology and Visual Science. 57, 12

Research output: Contribution to journalMeeting AbstractAcademic

Human Leukocyte Antigen-DR Expression is Significantly Related to an Increased Disease-Free and Disease-Specific Survival in Patients With Cervical Adenocarcinoma

Samuels, S., Spaans, V. M., Osse, M., Peters, L. A. W., Kenter, G. G., Fleuren, G. J. & Jordanova, E. S., Oct 2016, In : International Journal of Gynecological Cancer. 26, 8, p. 1503-1509 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

PRAME: a potential target for immunotherapy in uveal melanoma

Gezgin, G., Luk, S. J., Cao, J., Dogrusoz, M., Krijgsman, D., van der Velden, P. A., Luyten, G. P. M., Harbour, J. W., Jordanova, E. S., Heemskerk, M. H. M. & Jager, M. J., Sep 2016, In : Investigative Ophthalmology and Visual Science. 57, 12

Research output: Contribution to journalMeeting AbstractAcademic

Precision medicine in cancer: challenges and recommendations from an EU-funded cervical cancer biobanking study

Samuels, S., Balint, B., von der Leyen, H., Hupé, P., de Koning, L., Kamoun, C., Luscap-Rondof, W., Wittkop, U., Bagrintseva, K., Popovic, M., Kereszt, A., Berns, E., Kenter, G. G., Jordanova, E. S., Kamal, M. & Scholl, S., 6 Dec 2016, In : British Journal of Cancer. 115, 12, p. 1575-1583 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prognostic effect of different PD-L1 expression patterns in squamous cell carcinoma and adenocarcinoma of the cervix

Heeren, A. M., Punt, S., Bleeker, M. C. G., Gaarenstroom, K. N., van der Velden, J., Kenter, G. G., de Gruijl, T. D. & Jordanova, E. S., Jul 2016, In : Modern Pathology. 29, 7, p. 753-763

Research output: Contribution to journalArticleAcademicpeer-review

Sensing of latent EBV infection through exosomal transfer of 5'pppRNA

Baglio, S. R., van Eijndhoven, M. A. J., Koppers-Lalic, D., Berenguer, J., Lougheed, S. M., Gibbs, S., Leveille, N., Rinkel, R. N. P. M., Hopmans, E. S., Swaminathan, S., Verkuijlen, S. A. W. M., Scheffer, G. L., van Kuppeveld, F. J. M., de Gruijl, T. D., Bultink, I. E. M., Jordanova, E. S., Hackenberg, M., Piersma, S. R., Knol, J. C., Voskuyl, A. E. & 4 othersWurdinger, T., Jimenez, C. R., Middeldorp, J. M. & Pegtel, D. M., 2 Feb 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 5, p. E587-E596

Research output: Contribution to journalArticleAcademicpeer-review

Targetable genetic features of primary testicular and primary central nervous system lymphomas

Chapuy, B., Roemer, M. G. M., Stewart, C., Tan, Y., Abo, R. P., Zhang, L., Dunford, A. J., Meredith, D. M., Thorner, A. R., Jordanova, E. S., Liu, G., Feuerhake, F., Ducar, M. D., Illerhaus, G., Gusenleitner, D., Linden, E. A., Sun, H. H., Homer, H., Aono, M., Pinkus, G. S. & 11 othersLigon, A. H., Ligon, K. L., Ferry, J. A., Freeman, G. J., van Hummelen, P., Golub, T. R., Getz, G., Rodig, S. J., de Jong, D., Monti, S. & Shipp, M. A., 18 Feb 2016, In : Blood. 127, 7, p. 869-881

Research output: Contribution to journalArticleAcademicpeer-review