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Article

Intratumoral HPV16-specific T cells constitute a type I–oriented tumor microenvironment to improve survival in HPV16-driven oropharyngeal cancer

Welters, M. J. P., Ma, W., Santegoets, S. J. A. M., Goedemans, R., Ehsan, I., Jordanova, E. S., Van Ham, V. J., Van Unen, V., Koning, F., Van Egmond, S. I., Charoentong, P., Trajanoski, Z., Van Der Velden, L. A. & Van Der Burg, S. H., 1 Feb 2018, In : Clinical Cancer Research. 24, 3, p. 634-647 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

L1 cell adhesion molecule (L1CAM) is a strong predictor for locoregional recurrences in cervical cancer

Schrevel, M., Corver, W. E., Vegter, M. E., Ter Haar, N. T., Dreef, E. J., Beltman, J. J., Kenter, G., Bosse, T., de Kroon, C. D. & Jordanova, E. S., 20 Oct 2017, In : Oncotarget. 8, 50, p. 87568-87581 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lack of TNFα mRNA expression in cervical cancer is not associated with loss of heterozygosity at 6p21.3, inactivating mutations or promoter methylation

Kloth, J. N., Gorter, A., Haar, N. T., Corver, W. E., Jordanova, E. S., Kenter, G. G. & Fleuren, G. J., 1 Jan 2008, In : Molecular Immunology. 45, 1, p. 152-159 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas

Hoekstra, A. S., Hensen, E. F., Jordanova, E. S., Korpershoek, E., van der Horst-Schrivers, A. N. A., Cornelisse, C., Corssmit, E. P. M., Hes, F. J., Jansen, J. C., Kunst, H. P. M., Timmers, H. J. L. M., Bateman, A., Eccles, D., Bovee, J. V. M. G., Devilee, P. & Bayley, J-P., 28 Feb 2017, In : Oncotarget. 8, 9, p. 14525-14536

Research output: Contribution to journalArticleAcademicpeer-review

Mechanisms and effects of loss of human leukocyte antigen class II expression in immune-privileged site-associated B-cell lymphoma

Booman, M., Douwes, J., Glas, A. M., Riemersma, S. A., Jordanova, E. S., Kok, K., Rosenwald, A., de Jong, D., Schuuring, E. & Kluin, P. M., 1 May 2006, In : Clinical Cancer Research. 12, 9, p. 2698-705 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

MGL ligand expression is correlated to lower survival and distant metastasis in cervical squamous cell and adenosquamous carcinoma

Sahasrabudhe, N. M., van der Horst, J. C., Spaans, V., Kenter, G., de Kroon, C., Bosse, T., van Vliet, S. J. & Jordanova, E. S., 1 Jan 2019, In : Frontiers in Oncology. 9, JAN, 29.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neoadjuvant cisplatin and paclitaxel modulate tumor-infiltrating T cells in patients with cervical cancer

Heeren, A. M., van Luijk, I. F., Lakeman, J., Pocorni, N., Kole, J., de Menezes, R. X., Kenter, G. G., Bosse, T., de Kroon, C. D. & Jordanova, E. S., 1 Nov 2019, In : Cancer Immunology, Immunotherapy. 68, 11, p. 1759-1767 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Nodal metastasis in cervical cancer occurs in clearly delineated fields of immune suppression in the pelvic lymph catchment area

Heeren, A. M., de Boer, E., Bleeker, M. C. G., Musters, R. J. P., Buist, M. R., Kenter, G. G., de Gruijl, T. D. & Jordanova, E. S., 2015, In : Oncotarget. 6, 32, p. 32484-32493

Research output: Contribution to journalArticleAcademicpeer-review

Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target

Cao, J., Pontes, K. C., Heijkants, R. C., Brouwer, N. J., Groenewoud, A., Jordanova, E. S., Marinkovic, M., van Duinen, S., Teunisse, A. F., Verdijk, R. M., Snaar-Jagalska, E., Jochemsen, A. G. & Jager, M. J., 1 Aug 2018, In : Journal of Pathology. 245, 4, p. 433-444 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Paired distribution of molecular subtypes in bilateral breast carcinomas

Russnes, H. G., Kuligina, E. S., Suspitsin, E. N., Voskresenskiy, D. A., Jordanova, E. S., Cornelisse, C. J., Borresen-Dale, A. L. & Imyanitov, E. N., 1 Jan 2011, In : Cancer genetics. 204, 2, p. 96-102 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

PD-L1/PD-1 expression and tumor-infiltrating lymphocytes in conjunctival melanoma

Cao, J., Brouwer, N. J., Richards, K. E., Marinkovic, M., van Duinen, S., Hurkmans, D., Verdegaal, E. M. E., Jordanova, E. S. & Jager, M. J., 15 Aug 2017, In : Oncotarget. 8, 33, p. 54722-54734 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy

Luk, S. J., Steen, D. M. V. D., Hagedoorn, R. S., Jordanova, E. S., Schilham, M. W., Bovée, J. V. MG., Cleven, A. H. G., Falkenburg, J. H. F., Szuhai, K. & Heemskerk, M. H. M., 2 Dec 2018, In : OncoImmunology. 7, 12

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma

Gezgin, G., Luk, S. J., Cao, J., Dogrusoz, M., van der Steen, D. M., Hagedoorn, R. S., Krijgsman, D., van der Velden, P. A., Field, M. G., Luyten, G. P. M., Szuhai, K., Harbour, J. W., Jordanova, E. S., Heemskerk, M. H. M. & Jager, M. J., Jun 2017, In : Jama ophthalmology. 135, 6, p. 541-549

Research output: Contribution to journalArticleAcademicpeer-review

Precise Classification of Cervical Carcinomas Combined with Somatic Mutation Profiling Contributes to Predicting Disease Outcome

Spaans, V. M., Trietsch, M. D., Peters, A. A. W., Osse, M., ter Haar, N., Fleuren, G. J. & Jordanova, E. S., 2015, In : PLoS ONE. 10, 7, e0133670.

Research output: Contribution to journalArticleAcademicpeer-review

Precision medicine in cancer: challenges and recommendations from an EU-funded cervical cancer biobanking study

Samuels, S., Balint, B., von der Leyen, H., Hupé, P., de Koning, L., Kamoun, C., Luscap-Rondof, W., Wittkop, U., Bagrintseva, K., Popovic, M., Kereszt, A., Berns, E., Kenter, G. G., Jordanova, E. S., Kamal, M. & Scholl, S., 6 Dec 2016, In : British Journal of Cancer. 115, 12, p. 1575-1583 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Presence of human papillomavirus in semen of healthy men is firmly associated with HPV infections of the penile epithelium

Luttmer, R., Dijkstra, M. G., Snijders, P. J. F., Jordanova, E. S., King, A. J., Pronk, D. T. M., Foresta, C., Garolla, A., Hompes, P. G. A., Berkhof, J., Bleeker, M. C. G., Doorbar, J., Heideman, D. A. M. & Meijer, C. J. L. M., 2015, In : Fertility and Sterility. 104, 4, p. 838-844

Research output: Contribution to journalArticleAcademicpeer-review

Prognostic effect of different PD-L1 expression patterns in squamous cell carcinoma and adenocarcinoma of the cervix

Heeren, A. M., Punt, S., Bleeker, M. C. G., Gaarenstroom, K. N., van der Velden, J., Kenter, G. G., de Gruijl, T. D. & Jordanova, E. S., Jul 2016, In : Modern Pathology. 29, 7, p. 753-763

Research output: Contribution to journalArticleAcademicpeer-review

Prognostic Significance of MYC Rearrangement and Translocation Partner in Diffuse Large B-Cell Lymphoma: A Study by the Lunenburg Lymphoma Biomarker Consortium

Rosenwald, A., Bens, S., Advani, R., Barrans, S., Copie-Bergman, C., Elsensohn, M-H., Natkunam, Y., Calaminici, M., Sander, B., Baia, M., Smith, A., Painter, D., Pham, L., Zhao, S., Ziepert, M., Jordanova, E. S., Molina, T. J., Kersten, M. J., Kimby, E., Klapper, W. & 16 others, Raemaekers, J., Schmitz, N., Jardin, F., Stevens, W. B. C., Hoster, E., Hagenbeek, A., Gribben, J. G., Siebert, R., Gascoyne, R. D., Scott, D. W., Gaulard, P., Salles, G., Burton, C., de Jong, D., Sehn, L. H. & Maucort-Boulch, D., 2019, In : Journal of Clinical Oncology. 37, 35, p. 3359-3368

Research output: Contribution to journalArticleAcademicpeer-review

Proper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes

Massink, M. P. G., Kooi, E. I., van Mil, S. E., Jordanova, E. S., Ameziane, N., Dorsman, J. C., van Beek, D. M., van der Voorn, J. P., Sie, D. L. S., Ylstra, B., van Deurzen, C. L. H. M., Martens, J. W., Smid, M., Sieuwerts, A. M., de Weerd, V., Foekens, J. A., van den Ouweland, A. M. W., van Dyk, E., Nederlof, P. M., Waisfisz, Q. & 1 others, Meijers-Heijboer, H., 2015, In : Molecular oncology. 9, 4, p. 877-888

Research output: Contribution to journalArticleAcademicpeer-review

Sensing of latent EBV infection through exosomal transfer of 5'pppRNA

Baglio, S. R., van Eijndhoven, M. A. J., Koppers-Lalic, D., Berenguer, J., Lougheed, S. M., Gibbs, S., Leveille, N., Rinkel, R. N. P. M., Hopmans, E. S., Swaminathan, S., Verkuijlen, S. A. W. M., Scheffer, G. L., van Kuppeveld, F. J. M., de Gruijl, T. D., Bultink, I. E. M., Jordanova, E. S., Hackenberg, M., Piersma, S. R., Knol, J. C., Voskuyl, A. E. & 4 others, Wurdinger, T., Jimenez, C. R., Middeldorp, J. M. & Pegtel, D. M., 2 Feb 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 5, p. E587-E596

Research output: Contribution to journalArticleAcademicpeer-review

Sponge-supported cultures of primary head and neck tumors for an optimized preclinical model

Dohmen, A. J. C., Sanders, J., Canisius, S., Jordanova, E. S., Aalbersberg, E. A., Brekel, M. W. M. V. D., Neefjes, J. & Zuur, C. L., 18 May 2018, In : Oncotarget. 9, 38, p. 25034-25047 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma

Guislain, A., Gadiot, J., Kaiser, A., Jordanova, E. S., Broeks, A., Sanders, J., van Boven, H., de Gruijl, T. D., Haanen, J. B. A. G., Bex, A. & Blank, C. U., 2015, In : Cancer Immunology and Immunotherapy. 64, 10, p. 1241-1250

Research output: Contribution to journalArticleAcademicpeer-review

Targetable genetic features of primary testicular and primary central nervous system lymphomas

Chapuy, B., Roemer, M. G. M., Stewart, C., Tan, Y., Abo, R. P., Zhang, L., Dunford, A. J., Meredith, D. M., Thorner, A. R., Jordanova, E. S., Liu, G., Feuerhake, F., Ducar, M. D., Illerhaus, G., Gusenleitner, D., Linden, E. A., Sun, H. H., Homer, H., Aono, M., Pinkus, G. S. & 11 others, Ligon, A. H., Ligon, K. L., Ferry, J. A., Freeman, G. J., van Hummelen, P., Golub, T. R., Getz, G., Rodig, S. J., de Jong, D., Monti, S. & Shipp, M. A., 18 Feb 2016, In : Blood. 127, 7, p. 869-881

Research output: Contribution to journalArticleAcademicpeer-review

Targeting the MAPK and PI3K pathways in combination with PD1 blockade in melanoma

Deken, M. A., Gadiot, J., Jordanova, E. S., Lacroix, R., van Gool, M., Kroon, P., Pineda, C., Foppen, M. H. G., Scolyer, R., Song, J-Y., Verbrugge, I., Hoeller, C., Dummer, R., Haanen, J. B. A. G., Long, G. V. & Blank, C. U., 2016, In : OncoImmunology. 5, 12

Research output: Contribution to journalArticleAcademicpeer-review

Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses

Santegoets, S. J., Duurland, C. L., Jordanova, E. S., van Ham, J. J., Ehsan, I., van Egmond, S. L., Welters, M. J. P. & van der Burg, S. H., 18 Jan 2019, In : Journal for Immunotherapy of Cancer. 7, 1, p. 14 14.

Research output: Contribution to journalArticleAcademicpeer-review

T-Cell Regulation in Lepromatous Leprosy

Bobosha, K., Wilson, L., van Meijgaarden, K. E., Bekele, Y., Zewdie, M., van der Ploeg-v Schip, J. J., Abebe, M., Hussein, J., Khadge, S., Neupane, K. D., Hagge, D. A., Jordanova, E. S., Aseffa, A., Ottenhoff, T. H. M. & Geluk, A., 2014, In : PLoS Neglected Tropical Diseases. 8, 4, e2773.

Research output: Contribution to journalArticleAcademicpeer-review

The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFκB activation

Tummers, B., Goedemans, R., Pelascini, L. P. L., Jordanova, E. S., van Esch, E. M., Meyers, C., Melief, C. J. M., Boer, J. M. & van der Burg, S. H., 2015, In : Nature Communications. 6, 6537.

Research output: Contribution to journalArticleAcademicpeer-review

The landscape of somatic mutations in Indonesian cervical cancer is predominated by the PI3K pathway

Spaans, V. M., Nyoman Bayu Mahendra, I., Purwoto, G., Trietsch, M. D., Osse, M., ter Haar, N., Peters, A. A. W., Fleuren, G. J. & Jordanova, E. S., 1 Jan 2018, In : Gynecologic Oncology. 148, 1, p. 189-196 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The prognostic value of immune factors in the tumor microenvironment of penile squamous cell carcinoma

Ottenhof, S. R., Djajadiningrat, R. S., Thygesen, H. H., Jakobs, P. J., Józwiak, K., Heeren, A. M., de Jong, J., Sanders, J., Horenblas, S. & Jordanova, E. S., 11 Jun 2018, In : Frontiers in Immunology. 9, JUN, 1253.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Tissue damage caused by myeloablative, but not non-myeloablative, conditioning before allogeneic stem cell transplantation results in dermal macrophage recruitment without active T-cell interaction

van Balen, P., van der Zouwen, B., Kruisselbrink, A. B., Eefting, M., Szuhai, K., Jordanova, E. S., Falkenburg, J. H. F. & Jedema, I., 27 Feb 2018, In : Frontiers in Immunology. 9, FEB, 331.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Treatment failure in patients with HPV 16-induced vulvar intraepithelial neoplasia: understanding different clinical responses to immunotherapy

van Esch, E. M., Welters, M. J., Jordanova, E. S., Trimbos, J., van der Burg, S. H. & van Poelgeest, M. I., 2012, In : Expert Review of Vaccines. 11, 7, p. 821-840

Research output: Contribution to journalArticleAcademicpeer-review

Tumor-infiltrating CD14-positive myeloid cells and CD8-positive T-cells prolong survival in patients with cervical carcinoma

de Vos van Steenwijk, P. J., Ramwadhdoebe, T. H., Goedemans, R., Doorduijn, E. M., van Ham, J. J., Gorter, A., van Hall, T., Kuijjer, M. L., van Poelgeest, M. I., van der Burg, S. H. & Jordanova, E. S., 2013, In : International Journal of Cancer. 133, 12, p. 2884-2894

Research output: Contribution to journalArticleAcademicpeer-review

Vaccine-Induced Tumor Necrosis Factor-Producing T Cells Synergize with Cisplatin to Promote Tumor Cell Death

van der Sluis, T. C., van Duikeren, S., Huppelschoten, S., Jordanova, E. S., Nejad, E. B., Sloots, A., Boon, L., Smit, V. T. H. B., Welters, M. J. P., Ossendorp, F., van de Water, B., Arens, R., van der Burg, S. H. & Melief, C. J. M., 2015, In : Clinical Cancer Research. 21, 4, p. 781-794

Research output: Contribution to journalArticleAcademicpeer-review

Whole-transcriptome analysis of flow-sorted cervical cancer samples reveals that B cell expressed TCL1A is correlated with improved survival

Punt, S., Corver, W. E., van der Zeeuw, S. A. J., Kielbasa, S. M., Osse, E. M., Buermans, H. P. J., de Kroon, C. D., Jordanova, E. S. & Gorter, A., 2015, In : Oncotarget. 6, 36, p. 38681-38694

Research output: Contribution to journalArticleAcademicpeer-review