Laura Han

MSC.

20152019
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Research Output 2015 2019

2019

Accelerating research on biological aging and mental health: Current challenges and future directions

Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon, S. H. & Picard, M., 1 Aug 2019, In : Psychoneuroendocrinology. 106, p. 293-311 19 p.

Research output: Contribution to journalReview articleAcademicpeer-review

A methylation study of long-term depression risk

Clark, S. L., Hattab, M. W., Chan, R. F., Shabalin, A. A., Han, L. K. M., Zhao, M., Smit, J. H., Jansen, R., Milaneschi, Y., Xie, L. Y., van Grootheest, G., Penninx, B. W. J. H., Aberg, K. A. & van den Oord, E. J. C. G., 9 Sep 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group

Han, L. KM., Dinga, R., Hahn, T., Ching, C., Eyler, L., Aftanas, L., Aghajani, M., Aleman, A., Baune, B., Berger, K., Brak, I., Filho, G. B., Carballedo, A., Connolly, C., Couvy-Duchesne, B., Cullen, K., Dannlowski, U., Davey, C., Dima, D., Duran, F. & 126 othersEnneking, V., Filimonova, E., Frenzel, S., Frodl, T., Fu, C., Godlewska, B., Gotlib, I., Grabe, H., Groenewold, N., Grotegerd, D., Gruber, O., Hall, G., Harrison, B., Hatton, S., Hermesdorf, M., Hickie, I., Ho, T., Hosten, N., Jansen, A., Kahler, C., Kircher, T., Klimes-Dougan, B., Kramer, B., Krug, A., Lagopoulos, J., Leenings, R., MacMaster, F., MacQueen, G., McIntosh, A., McLellan, Q., McMahon, K., Medland, S., Mueller, B., Mwangi, B., Osipov, E., Portella, M., Pozzi, E., Reneman, L., Repple, J., Rosa, P., Sacchet, M., Saemann, P., Schnell, K., Schrantee, A., Simulionyte, E., Soares, J., Sommer, J., Stein, D., Steinstrater, O., Strike, L., Thomopoulos, S., Tol, M-J. V., Veer, I., Vermeiren, R., Walter, H., Wee, N. V. D., Werff, S. V. D., Whalley, H., Winter, N., Wittfeld, K., Wright, M., Wu, M-J., Volzke, H., Yang, T., Zannias, V., Zubicaray, G. D., Zunta-Soares, G., Abe, C., Alda, M., Andreassen, O., Boen, E., Bonnin, C., Canales-Rodriguez, E., Cannon, D., Caseras, X., Chaim-Avancini, T., Elvsashagen, T., Favre, P., Foley, S., Fullerton, J., Goikolea, J., Haarman, B., Hajek, T., Henry, C., Houenou, J., Howells, F., Ingvar, M., Kuplicki, R., Lafer, B., Landen, M., Machado-Vieira, R., Malt, U., McDonald, C., Mitchell, P., Nabulsi, L., Otaduy, M., Overs, B., Polosan, M., Pomarol-Clotet, E., Radua, J., Rive, M., Roberts, G., Ruhe, H., Salvador, R., Sarro, S., Satterthwaite, T., Savitz, J., Schene, A., Schofield, P., Serpa, M., Sim, K., Soeiro-de-Souza, M., Sutherland, A., Temmingh, H., Timmons, G., Uhlmann, A., Vieta, E., Wolf, D., Zanetti, M., Jahanshad, N., Thompson, P., Veltman, D., Penninx, B., Marquand, A., Cole, J. & Schmaal, L., 2019, In : Biorxiv. p. 560623

Research output: Contribution to journalArticleAcademic

Methylome-wide association studies for Major Depressive Disorder in blood overlap with methylation results from brain and large-scale GWAS

Aberg, K., Dean, B., Shabalin, A., Zhao, M., Chan, R., Hattab, M., van Grootheest, G., Han, L., Aghajani, M., Milaneschi, Y., Jansen, R., Xie, L., Clark, S., Penninx, B. & van den Oord, E., 2019, In : European Neuropsychopharmacology. 29, p. S807-S808

Research output: Contribution to journalMeeting AbstractAcademic

2018

Accelerated biological aging in major depressive disorder: capturing aging patterns in DNA methylation with machine learning methods

Han, L., Aghajani, M., Clark, S., Hattab, M., Shabalin, A., Zhao, M., Kumar, G., Chan, R., Xie, L., Jansen, R., Milaneschi, Y., Aberg, K., Van den Oord, E. & Penninx, B., Mar 2018, In : European Neuropsychopharmacology. 28, p. S85-S86

Research output: Contribution to journalMeeting AbstractAcademic

Epigenetic aging in major depressive disorder

Han, L. K. M., Aghajani, M., Clark, S. L., Chan, R. F., Hattab, M. W., Shabalin, A. A., Zhao, M., Kumar, G., Xie, L. Y., Jansen, R., Milaneschi, Y., Dean, B., Aberg, K. A., Van Den Oord, E. J. C. G. & Penninx, B. W. J. H., 1 Aug 2018, In : American Journal of Psychiatry. 175, 8, p. 774-782 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression

Tymofiyeva, O., Henje Blom, E., Ho, T. C., Connolly, C. G., Lindqvist, D., Wolkowitz, O. M., Lin, J., LeWinn, K. Z., Sacchet, M. D., Han, L. K. M., Yuan, J. P., Bhandari, S. P., Xu, D. & Yang, T. T., 2018, In : Journal of Affective Disorders. 232, p. 283-290

Research output: Contribution to journalArticleAcademicpeer-review

Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples

Aberg, K. A., Dean, B., Shabalin, A. A., Chan, R. F., Han, L. K. M., Zhao, M., van Grootheest, G., Xie, L. Y., Milaneschi, Y., Clark, S. L., Turecki, G., Penninx, B. W. J. H. & van den Oord, E. J. C. G., 21 Sep 2018, In : Molecular Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Telomere Length, Epigenetic Aging and Depression in the Netherlands Study of Depression and Anxiety (NESDA)

Han, L., Verhoeven, J., Aghajani, M., Clark, S., Hattab, M., Shabalin, A., Zhao, M., Kumar, G., Chan, R., Xie, L. Y., Milaneschi, Y., Jansen, R., Aberg, K., van den Oord, E. & Penninx, B., 1 May 2018, In : Biological Psychiatry. 83, 9, p. S17-S17

Research output: Contribution to journalMeeting AbstractAcademic

2017

Correcting for cell-type effects in DNA methylation studies: Reference-based method outperforms latent variable approaches in empirical studies

Hattab, M. W., Shabalin, A. A., Clark, S. L., Zhao, M., Kumar, G., Chan, R. F., Xie, L. Y., Jansen, R., Han, L. K. M., Magnusson, P. K. E., van Grootheest, G., Hultman, C. M., Penninx, B. W. J. H., Aberg, K. A. & van den Oord, E. J. C. G., 30 Jan 2017, In : Genome Biology. 18, 1, 24.

Research output: Contribution to journalLetterAcademicpeer-review

2016

Large-scale hypoconnectivity between resting-state functional networks in unmedicated adolescent major depressive disorder

Sacchet, M. D., Ho, T. C., Connolly, C. G., Tymofiyeva, O., LeWinn, K. Z., Han, L. K. M., Blom, E. H., Tapert, S. F., Max, J. E., Frank, G. K. W., Paulus, M. P., Simmons, A. N., Gotlib, I. H. & Yang, T. T., 1 Nov 2016, In : Neuropsychopharmacology. 41, 12, p. 2951-2960 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015

Altered insular activation and increased insular functional connectivity during sad and happy face processing in adolescent major depressive disorder

Henje Blom, E., Connolly, C. G., Ho, T. C., LeWinn, K. Z., Mobayed, N., Han, L., Paulus, M. P., Wu, J., Simmons, A. N. & Yang, T. T., 1 Jul 2015, In : Journal of Affective Disorders. 178, p. 215-223 9 p., 7325.

Research output: Contribution to journalArticleAcademicpeer-review

Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder

Henje Blom, E., Han, L. K. M., Connolly, C. G., Ho, T. C., Lin, J., LeWinn, K. Z., Simmons, A. N., Sacchet, M. D., Mobayed, N., Luna, M. E., Paulus, M., Epel, E. S., Blackburn, E. H., Wolkowitz, O. M. & Yang, T. T., 24 Nov 2015, In : Translational Psychiatry. 5, 11, A172.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access