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Research Output 1996 2019

2019

Abdominal functional electrical stimulation to assist ventilator weaning in critical illness: a double-blinded, randomised, sham-controlled pilot study

McCaughey, E. J., Jonkman, A. H., Boswell-Ruys, C. L., McBain, R. A., Bye, E. A., Hudson, A. L., Collins, D. W., Heunks, L. M. A., McLachlan, A. J., Gandevia, S. C. & Butler, J. E., 24 Jul 2019, In : Critical care (London, England). 23, 1, p. 261

Research output: Contribution to journalArticleAcademicpeer-review

Clinical outcome in neurally adjusted ventilatory assist: A review

Nouwen, M. J., Tuinman, P. R. & Heunks, L. M. A., 2019, In : Netherlands Journal of Critical Care. 27, 3, p. 115-119

Research output: Contribution to journalReview articleAcademicpeer-review

Diaphragm-protective mechanical ventilation

Schepens, T., Dres, M., Heunks, L. & Goligher, E. C., 2019, In : Current Opinion in Critical Care. 25, 1, p. 77-85

Research output: Contribution to journalArticleAcademicpeer-review

Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation

Roesthuis, L., van der Hoeven, H., Sinderby, C., Frenzel, T., Ottenheijm, C., Brochard, L., Doorduin, J. & Heunks, L., Oct 2019, In : Intensive Care Medicine. 45, 10, p. 1372-1381 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

ERS statement on chest imaging in acute respiratory failure

Chiumello, D., Sferrazza Papa, G. F., Artigas, A., Bouhemad, B., Grgic, A., Heunks, L., Markstaller, K., Pellegrino, G. M., Pisani, L., Rigau, D., Schultz, M. J., Sotgiu, G., Spieth, P., Zompatori, M. & Navalesi, P., 27 Jun 2019, In : European Respiratory Journal. p. 1900435

Research output: Contribution to journalArticleAcademicpeer-review

European respiratory society international congress 2018: Highlights from Assembly 2 on respiratory intensive care

Fisser, C., Spoletini, G., Soe, A. K., Livesey, A., Schreiber, A., Swingwood, E., Bos, L. D., Dreher, M., Schultz, M. J., Heunks, L. & Scala, R., 2019, In : ERS Monograph. 5, 1, 00198-2018.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Expiratory muscle dysfunction in critically ill patients: towards improved understanding

Shi, Z-H., Jonkman, A., de Vries, H., Jansen, D., Ottenheijm, C., Girbes, A., Spoelstra-de Man, A., Zhou, J-X., Brochard, L. & Heunks, L., 2019, In : Intensive Care Medicine.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Monitoring patient-ventilator breath contribution in critically ill patients during neurally-adjusted ventilatory assist: reliability and improved algorithms

Jonkman, A. H., Jansen, D., Gadgil, S., Keijzer, C., Girbes, A. R. J., Scheffer, G-J., van der Hoeven, J. G., Tuinman, P. R., Spoelstra-de Man, A. M. E., Sinderby, C. S. & Heunks, L. M. A., 30 May 2019, In : Journal of Applied Physiology.

Research output: Contribution to journalArticleAcademicpeer-review

Neuromuscular Electrical Stimulation Applied to the Abdominal Muscles to Assist Ventilator Weaning in Critically Ill Patients: An Assessor Blinded, Randomized, Sham-Controlled Pilot Study

Mclachlan, A. J., McCaughey, E., Jonkman, A., Boswell-Ruys, C., McBain, R., Bye, E., Hudson, A., Gandevia, S. C., Collins, D., Heunks, L. M. A. & Butler, J., 2019, In : American Journal of Respiratory and Critical Care Medicine. 199

Research output: Contribution to journalMeeting AbstractAcademic

Respiratory acidosis during bronchoscopy-guided percutaneous dilatational tracheostomy: Impact of ventilator settings and endotracheal tube size

Karagiannidis, C., Merten, M. L., Heunks, L., Strassmann, S. E., Schäfer, S., Magnet, F. & Windisch, W., 2019, In : BMC Anesthesiology. 19, 1, 147.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Respiratory Muscle Effort during Weaning: Reply

Doorduin, J. & Heunks, L., May 2019, In : Anesthesiology. 130, 5, p. 857-857

Research output: Contribution to journalLetterAcademicpeer-review

Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study

and the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) and the European Society of Intensive Care Medicine (ESICM) Trials Group, 2019, In : Critical Care Medicine. 47, 2, p. 229-238

Research output: Contribution to journalArticleAcademicpeer-review

The impact of ventilator settings and tube size on development of hypercapnic acidosis during bronchoscopy-guided percutaneous dilatational tracheostomy

Karagiannidis, C., Merten, M. L., Strassmann, S., Schaefer, S., Magnet, F. S., Heunks, L. & Windisch, W., May 2019, In : Medizinische Klinik - Intensivmedizin und Notfallmedizin. 114, 4, p. 394-394

Research output: Contribution to journalMeeting AbstractAcademic

The worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) ERS Clinical Research Collaboration

Heunks, L., Bellani, G., Pham, T. I., Brochard, L. & Laffey, J. G., 2019, In : European Respiratory Journal. 53, 3, 1802228.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

Acetylcholine receptor antagonists in acute respiratory distress syndrome: much more than muscle relaxants

Jansen, D., de Vries, H. & Heunks, L. M. A., 22 May 2018, In : Critical Care. 22, 1, p. 132

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessing breathing effort in mechanical ventilation: physiology and clinical implications

de Vries, H., Jonkman, A., Shi, Z-H., Spoelstra-de Man, A. & Heunks, L., Oct 2018, In : Annals of Translational Medicine. 6, 19, p. 387

Research output: Contribution to journalReview articleAcademicpeer-review

Correlation Between Diaphragm Thickening Fraction and Electrical Activity

Dres, M., Madotto, F., Junhasavasdikul, D., Telias, I. G., Grieco, D., Damiani, L. F., Piraino, T., Pham, T., Melo, L., Chen, L., Heunks, L. M., Sinderby, C. A. & Brochard, L. J., 2018, In : American Journal of Respiratory and Critical Care Medicine. 197

Research output: Contribution to journalMeeting AbstractAcademic

Diaphragm Protective Mechanical Ventilation to Improve Outcome in ICU Patients?

Heunks, L. & Ottenheijm, C., 15 Jan 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 1, p. 150-152

Research output: Contribution to journalEditorialAcademicpeer-review

Estimation of the diaphragm neuromuscular efficiency index in mechanically ventilated critically ill patients

Jansen, D., Jonkman, A. H., Roesthuis, L., Gadgil, S., van der Hoeven, J. G., Scheffer, G-J. J., Girbes, A., Doorduin, J., Sinderby, C. S. & Heunks, L. M. A., 27 Sep 2018, In : Critical Care. 22, 1, 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Glottic patency during noninvasive ventilation in patients with chronic obstructive pulmonary disease

Oppersma, E., Doorduin, J., Gooskens, P. J., Roesthuis, L. H., van der Heijden, E. H. F. M., van der Hoeven, J. G., Veltink, P. H. & Heunks, L. M. A., 2018, In : Respiratory physiology & neurobiology. 259, p. 53-57

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Highlights in acute respiratory failure

Scala, R. & Heunks, L., 31 Mar 2018, In : European respiratory review : an official journal of the European Respiratory Society. 27, 147

Research output: Contribution to journalArticleAcademicpeer-review

Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers

Lindqvist, J., van den Berg, M., van der Pijl, R., Hooijman, P. E., Beishuizen, A., Elshof, J., de Waard, M., Girbes, A., Spoelstra-de Man, A., Shi, Z-H., van den Brom, C., Bogaards, S., Shen, S., Strom, J., Granzier, H., Kole, J., Musters, R. J. P., Paul, M. A., Heunks, L. M. A. & Ottenheijm, C. A. C., 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 4, p. 472-485 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prevalence of Reverse Triggering Assessed by Electrical Activity of the Diaphragm in the First 48 Hours of Mechanical Ventilation

Damiani, F., Junhasavasdikul, D., Dres, M., Piraino, T., Artigas, R. M., Chen, L., Soliman, I., Rauseo, M., Rittayamai, N., Grieco, D., Pham, T., Telias, I. G., Melo, L., Friedrich, J. O., Every, H., Greco, P., Smith, O. M., Sandhu, G., Gu, J., Sinderby, C. A. & 2 othersHeunks, L. M. & Brochard, L. J., 2018, In : American Journal of Respiratory and Critical Care Medicine. 197

Research output: Contribution to journalMeeting AbstractAcademic

Research collaboration critical care in the Netherlands: RCCCNet

RCCCNet executive committee, 2018, In : Netherlands Journal of Critical Care. 26, 4, p. 161-162

Research output: Contribution to journalComment/Letter to the editorAcademic

Respiratory muscle effort during expiration in successful and failed weaning from mechanical ventilation

Doorduin, J., Roesthuis, L. H., Jansen, D., van der Hoeven, J. G., van Hees, H. W. H. & Heunks, L. M. A., 2018, In : Anesthesiology. 129, 3, p. 490-501

Research output: Contribution to journalArticleAcademicpeer-review

The effect of metabolic alkalosis on the ventilatory response in healthy subjects

Oppersma, E., Doorduin, J., van der Hoeven, J. G., Veltink, P. H., van Hees, H. W. H. & Heunks, L. M. A., 2018, In : Respiratory physiology & neurobiology. 249, p. 47-53

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ultrasound imaging of the diaphragm: facts and future. A guide for the bedside clinician

Haaksma, M. E., Atmowihardjo, L., Heunks, L., Spoelstra-de Man, A. & Tuinman, P. R., Mar 2018, In : Netherlands Journal of Critical Care. 26, 2, p. 58-63

Research output: Contribution to journalReview articleAcademicpeer-review

Using ultrasound of heart, lungs and diaphragm to predict weaning success: A prospective observational study

Haaksma, M. E., Smit, J., Hilderink, B., Atmowihardjo, L., Lim, E., Jonkman, A., Heunks, L., Girbes, A. & Tuinman, P. R., 2018, In : Intensive Care Medicine Experimental. 6

Research output: Contribution to journalArticleAcademicpeer-review

2017

Assembly 2: Respiratory intensive care

Scala, R., Heunks, L., Gregoretti, C., Schultz, M. J., Dreher, M. & Winck, J., 1 Jun 2017, In : Breathe. 13, 2, p. 147-148 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Compliance and statistics: Discussion on “Severe hypercapnia and outcomes of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome”

Elbers, P. W. G., Heunks, L., Peñuelas, O., Muriel, A., Nin, N. & Esteban, A., 1 May 2017, In : Intensive Care Medicine. 43, 5, p. 724-725 2 p.

Research output: Contribution to journalLetterAcademicpeer-review

Critical illness-associated diaphragm weakness

Dres, M., Goligher, E. C., Heunks, L. M. A. & Brochard, L. J., 1 Oct 2017, In : Intensive Care Medicine. 43, 10, p. 1441-1452 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill

van den Berg, M., Hooijman, P. E., Beishuizen, A., de Waard, M. C., Paul, M. A., Hartemink, K. J., van Hees, H. W. H., Lawlor, M. W., Brocca, L., Bottinelli, R., Pellegrino, M. A., Stienen, G. J. M., Heunks, L. M. A., Wüst, R. C. I. & Ottenheijm, C. A., 15 Dec 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 12, p. 1544-1558 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Efficacy of ventilator waveform observation for detection of patient-ventilator asynchrony during NIV: A multicentre study

Longhini, F., Colombo, D., Pisani, L., Idone, F., Chun, P., Doorduin, J., Ling, L., Alemani, M., Bruni, A., Zhaochen, J., Tao, Y., Lu, W., Garofalo, E., Carenzo, L., Maggiore, S. M., Qiu, H., Heunks, L., Antonelli, M., Nava, S. & Navalesi, P., 1 Oct 2017, In : ERS Monograph. 3, 4, 00075-2017.

Research output: Contribution to journalArticleAcademicpeer-review

Functional assessment of the diaphragm by speckle tracking ultrasound during inspiratory loading

Oppersma, E., Hatam, N., Doorduin, J., Van Der Hoeven, J. G., Marx, G., Goetzenich, A., Fritsch, S., Heunks, L. M. A. & Bruells, C. S., 1 Nov 2017, In : Journal of Applied Physiology. 123, 5, p. 1063-1070 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study

Laffey, J. G., Madotto, F., Bellani, G., Pham, T., Fan, E., Brochard, L., Amin, P., Arabi, Y., Bajwa, E. K., Bruhn, A., Cerny, V., Clarkson, K., Heunks, L., Kurahashi, K., Laake, J. H., Lorente, J. A., McNamee, L., Nin, N., Palo, J. E., Piquilloud, L. & 10 othersQiu, H., Jiménez, J. I. S., Esteban, A., McAuley, D. F., van Haren, F., Ranieri, M., Rubenfeld, G., Wrigge, H., Slutsky, A. S. & Pesenti, A., 1 Aug 2017, In : The Lancet Respiratory Medicine. 5, 8, p. 627-638 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Novel insights in ICU-acquired respiratory muscle dysfunction: Implications for clinical care

Jonkman, A. H., Jansen, D. & Heunks, L. M. A., 21 Mar 2017, In : Critical Care. 21, 1, 64.

Research output: Contribution to journalReview articleAcademicpeer-review

Partial Neuromuscular Blockade during Partial Ventilatory Support in Sedated Patients with High Tidal Volumes

Doorduin, J., Nollet, J. L., Roesthuis, L. H., van Hees, H. W. H., Brochard, L. J., Sinderby, C. A., van der Hoeven, J. G. & Heunks, L. M. A., 15 Apr 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 8, p. 1033-1042 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary emergencies.

Heunks, LMA., Demoule, A. & Windisch, W., 2017, European Respiratory Monograph.

Research output: Book/ReportBook editingProfessional

The role of calpains in ventilator-induced diaphragm atrophy

Zhu, X., van Hees, H. W. H., Heunks, L., Wang, F., Shao, L., Huang, J., Shi, L. & Ma, S., Dec 2017, In : Intensive Care Medicine Experimental. 5, 1, 14.

Research output: Contribution to journalArticleAcademicpeer-review

Ultrasound to assess diaphragmatic function in the critically ill-a critical perspective

Haaksma, M., Tuinman, P. R. & Heunks, L., 1 Mar 2017, In : Annals of Translational Medicine. 5, 5, 114.

Research output: Contribution to journalArticleAcademicpeer-review

Update in critical care 2016

Dos Santos, C., Heunks, L. & Wunsch, H., 1 Jul 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 1, p. 11-17 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

β 2 -Adrenoceptor agonists reduce the decline of rat diaphragm twitch force during severe hypoxia

van der Heijden, H. F. M., Heunks, L. M. A., Folgering, H., van Herwaarden, C. L. A. & Dekhuijzen, P. N. R., 23 Dec 2017, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 276, 3, p. L474-L480

Research output: Contribution to journalArticleAcademicpeer-review

2016

An immunocompromised patient with fever and pulmonary infiltrates

van Haaften, L., Ten Oever, J., Snoeren, M. & Heunks, L., 1 Jan 2016, In : Netherlands Journal of Critical Care. 24, 1, p. 18-24 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Appropriate positioning of the NAVA catheter

Schellekens, W. J. M. & Heunks, L. M. A., 1 Apr 2016, In : Intensive Care Medicine. 42, 4, p. 1-2 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Assessment of dead-space ventilation in patients with acute respiratory distress syndrome: a prospective observational study

Doorduin, J., Nollet, J. L., Vugts, M. P. A. J., Roesthuis, L. H., Akankan, F., van der Hoeven, J. G., van Hees, H. W. H. & Heunks, L. M. A., 2016, In : Critical Care. 20, 1, 121.

Research output: Contribution to journalArticleAcademicpeer-review

Comparison Between Neurally Adjusted Ventilatory Assist and Pressure Support Ventilation Levels in Terms of Respiratory Effort

Carteaux, G., Cordoba-Izquierdo, A., Lyazidi, A., Heunks, L., Thille, A. W. & Brochard, L., Mar 2016, In : Critical Care Medicine. 44, 3, p. 503-511

Research output: Contribution to journalArticleAcademicpeer-review