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Research Output 1996 2019

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2019

Diaphragm-protective mechanical ventilation

Schepens, T., Dres, M., Heunks, L. & Goligher, E. C., 2019, In : Current Opinion in Critical Care. 25, 1, p. 77-85

Research output: Contribution to journalArticleAcademicpeer-review

European Respiratory Society International Congress 2018: highlights from Assembly 2 on respiratory intensive care

Fisser, C., Spoletini, G., Soe, A. K., Livesey, A., Schreiber, A., Swingwood, E., Bos, L. D., Dreher, M., Schultz, M. J., Heunks, L. & Scala, R., 4 Mar 2019, In : ERJ Open Research. 5, 1, p. 00198-2018 1821 p.

Research output: Contribution to journalArticleAcademicpeer-review

Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study

and the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) and the European Society of Intensive Care Medicine (ESICM) Trials Group, 2019, In : Critical Care Medicine. 47, 2, p. 229-238

Research output: Contribution to journalArticleAcademicpeer-review

2018

Acetylcholine receptor antagonists in acute respiratory distress syndrome: much more than muscle relaxants

Jansen, D., de Vries, H. & Heunks, L. M. A., 22 May 2018, In : Critical Care. 22, 1, p. 132

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Estimation of the diaphragm neuromuscular efficiency index in mechanically ventilated critically ill patients

Jansen, D., Jonkman, A. H., Roesthuis, L., Gadgil, S., van der Hoeven, J. G., Scheffer, G-J. J., Girbes, A., Doorduin, J., Sinderby, C. S. & Heunks, L. M. A., 27 Sep 2018, In : Critical Care. 22, 1, 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Glottic patency during noninvasive ventilation in patients with chronic obstructive pulmonary disease

Oppersma, E., Doorduin, J., Gooskens, P. J., Roesthuis, L. H., van der Heijden, E. H. F. M., van der Hoeven, J. G., Veltink, P. H. & Heunks, L. M. A., 2018, In : Respiratory physiology & neurobiology. 259, p. 53-57

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Highlights in acute respiratory failure

Scala, R. & Heunks, L., 31 Mar 2018, In : European respiratory review : an official journal of the European Respiratory Society. 27, 147

Research output: Contribution to journalArticleAcademicpeer-review

Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers

Lindqvist, J., van den Berg, M., van der Pijl, R., Hooijman, P. E., Beishuizen, A., Elshof, J., de Waard, M., Girbes, A., Spoelstra-de Man, A., Shi, Z-H., van den Brom, C., Bogaards, S., Shen, S., Strom, J., Granzier, H., Kole, J., Musters, R. J. P., Paul, M. A., Heunks, L. M. A. & Ottenheijm, C. A. C., 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 4, p. 472-485 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Respiratory muscle effort during expiration in successful and failed weaning from mechanical ventilation

Doorduin, J., Roesthuis, L. H., Jansen, D., van der Hoeven, J. G., van Hees, H. W. H. & Heunks, L. M. A., 2018, In : Anesthesiology. 129, 3, p. 490-501

Research output: Contribution to journalArticleAcademicpeer-review

The effect of metabolic alkalosis on the ventilatory response in healthy subjects

Oppersma, E., Doorduin, J., van der Hoeven, J. G., Veltink, P. H., van Hees, H. W. H. & Heunks, L. M. A., 2018, In : Respiratory physiology & neurobiology. 249, p. 47-53

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Using ultrasound of heart, lungs and diaphragm to predict weaning success: A prospective observational study

Haaksma, M. E., Smit, J., Hilderink, B., Atmowihardjo, L., Lim, E., Jonkman, A., Heunks, L., Girbes, A. & Tuinman, P. R., 2018, In : Intensive Care Medicine Experimental. 6

Research output: Contribution to journalArticleAcademicpeer-review

2017

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill

van den Berg, M., Hooijman, P. E., Beishuizen, A., de Waard, M. C., Paul, M. A., Hartemink, K. J., van Hees, H. W. H., Lawlor, M. W., Brocca, L., Bottinelli, R., Pellegrino, M. A., Stienen, G. J. M., Heunks, L. M. A., Wüst, R. C. I. & Ottenheijm, C. A., 15 Dec 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 12, p. 1544-1558 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Efficacy of ventilator waveform observation for detection of patient-ventilator asynchrony during NIV: A multicentre study

Longhini, F., Colombo, D., Pisani, L., Idone, F., Chun, P., Doorduin, J., Ling, L., Alemani, M., Bruni, A., Zhaochen, J., Tao, Y., Lu, W., Garofalo, E., Carenzo, L., Maggiore, S. M., Qiu, H., Heunks, L., Antonelli, M., Nava, S. & Navalesi, P., 1 Oct 2017, In : ERS Monograph. 3, 4, 00075-2017.

Research output: Contribution to journalArticleAcademicpeer-review

Functional assessment of the diaphragm by speckle tracking ultrasound during inspiratory loading

Oppersma, E., Hatam, N., Doorduin, J., Van Der Hoeven, J. G., Marx, G., Goetzenich, A., Fritsch, S., Heunks, L. M. A. & Bruells, C. S., 1 Nov 2017, In : Journal of Applied Physiology. 123, 5, p. 1063-1070 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study

Laffey, J. G., Madotto, F., Bellani, G., Pham, T., Fan, E., Brochard, L., Amin, P., Arabi, Y., Bajwa, E. K., Bruhn, A., Cerny, V., Clarkson, K., Heunks, L., Kurahashi, K., Laake, J. H., Lorente, J. A., McNamee, L., Nin, N., Palo, J. E., Piquilloud, L. & 10 othersQiu, H., Jiménez, J. I. S., Esteban, A., McAuley, D. F., van Haren, F., Ranieri, M., Rubenfeld, G., Wrigge, H., Slutsky, A. S. & Pesenti, A., 1 Aug 2017, In : The Lancet Respiratory Medicine. 5, 8, p. 627-638 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Partial Neuromuscular Blockade during Partial Ventilatory Support in Sedated Patients with High Tidal Volumes

Doorduin, J., Nollet, J. L., Roesthuis, L. H., van Hees, H. W. H., Brochard, L. J., Sinderby, C. A., van der Hoeven, J. G. & Heunks, L. M. A., 15 Apr 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 8, p. 1033-1042 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The role of calpains in ventilator-induced diaphragm atrophy

Zhu, X., van Hees, H. W. H., Heunks, L., Wang, F., Shao, L., Huang, J., Shi, L. & Ma, S., Dec 2017, In : Intensive Care Medicine Experimental. 5, 1, 14.

Research output: Contribution to journalArticleAcademicpeer-review

Ultrasound to assess diaphragmatic function in the critically ill-a critical perspective

Haaksma, M., Tuinman, P. R. & Heunks, L., 1 Mar 2017, In : Annals of Translational Medicine. 5, 5, 114.

Research output: Contribution to journalArticleAcademicpeer-review

Update in critical care 2016

Dos Santos, C., Heunks, L. & Wunsch, H., 1 Jul 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 1, p. 11-17 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

β 2 -Adrenoceptor agonists reduce the decline of rat diaphragm twitch force during severe hypoxia

van der Heijden, H. F. M., Heunks, L. M. A., Folgering, H., van Herwaarden, C. L. A. & Dekhuijzen, P. N. R., 23 Dec 2017, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 276, 3, p. L474-L480

Research output: Contribution to journalArticleAcademicpeer-review

2016

An immunocompromised patient with fever and pulmonary infiltrates

van Haaften, L., Ten Oever, J., Snoeren, M. & Heunks, L., 1 Jan 2016, In : Netherlands Journal of Critical Care. 24, 1, p. 18-24 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Appropriate positioning of the NAVA catheter

Schellekens, W. J. M. & Heunks, L. M. A., 1 Apr 2016, In : Intensive Care Medicine. 42, 4, p. 1-2 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Assessment of dead-space ventilation in patients with acute respiratory distress syndrome: a prospective observational study

Doorduin, J., Nollet, J. L., Vugts, M. P. A. J., Roesthuis, L. H., Akankan, F., van der Hoeven, J. G., van Hees, H. W. H. & Heunks, L. M. A., 2016, In : Critical Care. 20, 1, 121.

Research output: Contribution to journalArticleAcademicpeer-review

Comparison Between Neurally Adjusted Ventilatory Assist and Pressure Support Ventilation Levels in Terms of Respiratory Effort

Carteaux, G., Cordoba-Izquierdo, A., Lyazidi, A., Heunks, L., Thille, A. W. & Brochard, L., Mar 2016, In : Critical Care Medicine. 44, 3, p. 503-511

Research output: Contribution to journalArticleAcademicpeer-review

Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper

Farmakis, D., Alvarez, J., Gal, T. B., Brito, D., Fedele, F., Fonseca, C., Gordon, A. C., Gotsman, I., Grossini, E., Guarracino, F., Harjola, V-P., Hellman, Y., Heunks, L., Ivancan, V., Karavidas, A., Kivikko, M., Lomivorotov, V., Longrois, D., Masip, J., Metra, M. & 15 othersMorelli, A., Nikolaou, M., Papp, Z., Parkhomenko, A., Poelzl, G., Pollesello, P., Ravn, H. B., Rex, S., Riha, H., Ricksten, S-E., Schwinger, R. H. G., Vrtovec, B., Yilmaz, M. B., Zielinska, M. & Parissis, J., 1 Nov 2016, In : International Journal of Cardiology. 222, p. 303-12 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

New type of wasted effort during neurally adjusted ventilatory assist: A case report

Doorduin, J., Roesthuis, L. H., van der Hoeven, J. G. & Heunks, L. M. A., 1 Jul 2016, In : Netherlands Journal of Critical Care. 24, 4, p. 18-19 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study

Laffey, J. G., Bellani, G., Pham, T., Fan, E., Madotto, F., Bajwa, E. K., Brochard, L., Clarkson, K., Esteban, A., Gattinoni, L., van Haren, F., Heunks, L. M., Kurahashi, K., Laake, J. H., Larsson, A., McAuley, D. F., McNamee, L., Nin, N., Qiu, H., Ranieri, M. & 5 othersRubenfeld, G. D., Thompson, B. T., Wrigge, H., Slutsky, A. S. & Pesenti, A., Dec 2016, In : Intensive Care Medicine. 42, 12, p. 1865-1876

Research output: Contribution to journalArticleAcademicpeer-review

Strategies to optimize respiratory muscle function in ICU patients

Schellekens, W-J. M., van Hees, H. W. H., Doorduin, J., Roesthuis, L. H., Scheffer, G. J., van der Hoeven, J. G. & Heunks, L. M. A., 19 Apr 2016, In : Critical Care. 20, 1, 103.

Research output: Contribution to journalArticleAcademicpeer-review

The differential diagnosis for failure to wean from mechanical ventilation

Doorduin, J., van der Hoeven, J. G. & Heunks, L. M. A., Apr 2016, In : Current Opinion in Anaesthesiology. 29, 2, p. 150-157 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Assisted Ventilation in Patients with Acute Respiratory Distress Syndrome: Lung-distending Pressure and Patient-Ventilator Interaction

Doorduin, J., Sinderby, C. A., Beck, J., Van Der Hoeven, J. G. & Heunks, L. M. A., 20 Jul 2015, In : Anesthesiology. 123, 1, p. 181-190 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of experimental human endotoxemia on diaphragm function

Doorduin, J., Leentjens, J., Kox, M., Van Hees, H. W. H., Van Der Hoeven, J. G., Pickkers, P. & Heunks, L. M. A., 1 Jan 2015, In : Shock. 44, 4, p. 316-322 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Levosimendan affects oxidative and inflammatory pathways in the diaphragm of ventilated endotoxemic mice

Schellekens, W. J. M., van Hees, H. W. H., Linkels, M., Dekhuijzen, P. N. R., Scheffer, G. J., van der Hoeven, J. G. & Heunks, L. M. A., 14 Dec 2015, In : Critical Care. 19, 1, 69.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Automated patient-ventilator interaction analysis during neurally adjusted non-invasive ventilation and pressure support ventilation in chronic obstructive pulmonary disease

Doorduin, J., Sinderby, C. A., Beck, J., van der Hoeven, J. G. & Heunks, L. M. A., 1 Jan 2014, In : Critical Care. 18, 5, 550.

Research output: Contribution to journalArticleAcademicpeer-review

Hypercapnia attenuates ventilator-induced diaphragm atrophy and modulates dysfunction

Schellekens, W. J. M., van Hees, H. W. H., Kox, M., Linkels, M., Acuña, G. L. A., Dekhuijzen, PN. N. R., Scheffer, G. J., van der Hoeven, J. G. & Heunks, L. M. A., 9 Feb 2014, In : Critical Care. 18, 1, R28.

Research output: Contribution to journalArticleAcademicpeer-review

Resveratrol attenuates NF-κB-binding activity but not cytokine production in mechanically ventilated mice

Van Der Wal, S. E. I., Vaneker, M., Kox, M., Braak, G., Van Hees, H. W. H., Van Den Brink, I. A., Van De Pol, F. M., Heunks, L. M., Van Der Hoeven, J. G., Joosten, L. A. B., Vissers, K. C. P. & Scheffer, G. J., 1 Jan 2014, In : Acta Anaesthesiologica Scandinavica. 58, 4, p. 487-494 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Difficult weaning: Principles and practice of a structured diagnostic approach

Doorduin, J., Haans, A. J. C., van der Hoeven, J. G. & Heunks, L. M. A., 1 Oct 2013, In : Netherlands Journal of Critical Care. 17, 4, p. 11-15 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Dysfonction diaphragmatique induite par la ventilation mécanique: Physiopathologie et stratégies thérapeutiques d'avenir

Georges, M., Sigala, DI., Vassilakopoulos, T. & Heunks, L., 1 Dec 2013, In : Revue des Maladies Respiratoires Actualites. 5, 7, p. 659-664 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Extracorporele CO2-verwijdering: nieuwe toepassingen?

Intven, F. A., Van Der Hoeven, J. G. & Heunks, L. M. A., 24 Apr 2013, In : Nederlands Tijdschrift voor Geneeskunde. 157, 13, A5300.

Research output: Contribution to journalArticleAcademicpeer-review

Monitoring of the respiratory muscles in the critically Ill

Doorduin, J., Van Hees, H. W. H., Van Der Hoeven, J. G. & Heunks, L. M. A., 1 Jan 2013, In : American Journal of Respiratory and Critical Care Medicine. 187, 1, p. 20-27 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Time course of diaphragm function recovery after controlled mechanical ventilation in rats

Thomas, D., Maes, K., Agten, A., Heunks, L., Dekhuijzen, R., Decramer, M., Van Hees, H. & Gayan-Ramirez, G., 15 Sep 2013, In : Journal of Applied Physiology. 115, 6, p. 775-784 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2012

Necrotising myositis: Significance of early diagnosis, radical surgery and aggressive antibiotic therapy

Nassikovker, P., Holla, M., van der Hoeven, J. G. & Heunks, L. M. A., 1 Aug 2012, In : Netherlands Journal of Critical Care. 16, 4, p. 141-144 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

The calcium sensitizer levosimendan improves human diaphragm function

Doorduin, J., Sinderby, C. A., Beck, J., Stegeman, D. F., Van Hees, H. W. H., Van Der Hoeven, J. G. & Heunks, L. M. A., 1 Jan 2012, In : American Journal of Respiratory and Critical Care Medicine. 185, 1, p. 90-95 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Toll-like receptor 4 signaling in ventilator-induced diaphragm atrophy

Schellekens, W. J. M., Van Hees, H. W. H., Vaneker, M., Linkels, M., Dekhuijzen, P. N. R., Scheffer, G. J., Van Der Hoeven, J. G. & Heunks, L. M. A., 1 Aug 2012, In : Anesthesiology. 117, 2, p. 329-338 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2011

Levosimendan improves calcium sensitivity of diaphragm muscle fibres from a rat model of heart failure

Van Hees, H. W. H., Andrade Acuña, G. L., Linkels, M., Dekhuijzen, P. N. R. & Heunks, L. M. A., 1 Feb 2011, In : British Journal of Pharmacology. 162, 3, p. 566-573 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Plasma from septic shock patients induces loss of muscle protein.

van Hees, H. W. H., Schellekens, W. J. M., Linkels, M., Leenders, F., Zoll, J., Donders, R., Dekhuijzen, P. N. R., van der Hoeven, J. G. & Heunks, L. M. A., 1 Dec 2011, In : Critical care (London, England). 15, 5

Research output: Contribution to journalArticleAcademicpeer-review

Titin-based mechanosensing and signaling: role in diaphragm atrophy during unloading?

Ottenheijm, C. A. C., van Hees, H. W. H., Heunks, L. M. A. & Granzier, H., 2011, In : American Journal of Physiology. Lung Cellular and Molecular Physiology. 300, 2, p. L161-L166

Research output: Contribution to journalArticleAcademicpeer-review

2010

Non-invasive mechanical ventilation for diagnostic bronchoscopy using a new face mask: An observational feasibility study

Heunks, L. M. A., De Bruin, C. J. R., Van Der Hoeven, J. G. & Van Der Heijden, H. F. M., 1 Jan 2010, In : Intensive Care Medicine. 36, 1, p. 143-147 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Trachea rupture in tenascin-xdeficient type ehlers-danlos syndrome

Besselink-Lobanova, A., Maandag, N. J. G., Voermans, N. C., Van Der Heijden, H. F. M., Van Der Hoeven, J. G. & Heunks, L. M. A., 1 Jan 2010, In : Anesthesiology. 113, 3, p. 746-749 4 p.

Research output: Contribution to journalArticleAcademicpeer-review