Research output per year
Research output per year
Personal profile
Research interests
Curriculum Vitae
1991-1992: Research fellow at Harvard University, Boston, U.S.A. Department of Biochemistry, Boston at the laboratory of Prof. Dr. J. Strominger (Supervision Prof. E.A. Macintyre)
1992: Master Medical Biology, VU University, Amsterdam, The Netherlands.
1993-1998: Doctorate: PhD at the Netherlands Cancer Institute, Department of Immunology, Amsterdam, The Netherlands at the laboratory of Prof. Dr. J. Borst.Thesis defense at 01-09-1998 at Utrecht University (Promoter: Prof. R. Bernards).
1998-1999: Post-doctoral research fellow the Netherlands Cancer Institute (Prof. Dr. J. Borst)
1999-2005: Post-doctoral research fellow at the laboratory of Prof. Dr. H. Clevers, Hubrecht Institute, Laboratory of developmental biology and stem cell research, Utrecht, The Netherlands.
2005-2008: Post-doctoral research fellow at the laboratory of Prof. Dr. R. Bernards, Department of carcinogenesis, Netherlands Cancer Institute, Amsterdam, The Netherlands.
May 2008-May 2008 till present: Principle Investigator, Assistant Professor and head of the molecular diagnostic team at the department of Hematology, Head Prof. Dr. S. Zweegman. Vice-Head: Prof. Dr. G.J. Ossenkoppele. VU University Medical Center, The Netherlands.
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Bimodal expression of potential drug target CLL-1 (CLEC12A) on CD34+ blasts of AML patients
Ngai, L. L., Ma, C. Y., Maguire, O., Do, A. D., Robert, A., Logan, A. C., Griffiths, E. A., Nemeth, M. J., Green, C., Pourmohamad, T., van Kuijk, B. J., Snel, A. N., Kwidama, Z. W., Venniker-Punt, B., Cooper, J., Manz, M. G., Gjertsen, B. T., Smit, L., Ossenkoppele, G. J., Janssen, J. J. W. M. & 2 others, , Sep 2021, In: European Journal of Haematology. 107, 3, p. 343-353 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Distinct bone marrow immunophenotypic features define the splicing factor 3B subunit 1 (SF3B1)-mutant myelodysplastic syndromes subtype
Duetz, C., Westers, T. M., in ’t Hout, F. E. M., Cremers, E. M. P., Alhan, C., Venniker-Punt, B., Visser-Wisselaar, H. A., Chitu, D. A., de Graaf, A. O., Smit, L., Jansen, J. H. & van de Loosdrecht, A. A., May 2021, In: British Journal of Haematology. 193, 4, p. 798-803 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Escape From Treatment; the Different Faces of Leukemic Stem Cells and Therapy Resistance in Acute Myeloid Leukemia
van Gils, N., Denkers, F. & Smit, L., 3 May 2021, In: Frontiers in Oncology. 11, p. 659253 659253.Research output: Contribution to journal › Review article › Academic › peer-review
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The Novel Oral BET-CBP/p300 Dual Inhibitor NEO2734 Is Highly Effective in Eradicating Acute Myeloid Leukemia Blasts and Stem/Progenitor Cells
van Gils, N., Martiañez Canales, T., Vermue, E., Rutten, A., Denkers, F., van der Deure, T., Ossenkoppele, G. J., Giles, F. & Smit, L., 8 Jul 2021, In: HemaSphere. 5, 8, p. e610 0000610.Research output: Contribution to journal › Article › Academic › peer-review
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IGFBP7 activates retinoid acid-induced responses in acute myeloid leukemia stem and progenitor cells
van Gils, N., Verhagen, H. J. M. P., Rutten, A., Menezes, R. X., Tsui, M-L., Vermue, E., Dekens, E., Brocco, F., Denkers, F., Kessler, F. L., Ossenkoppele, G. J., Janssen, J. J. W. M. & Smit, L., 22 Dec 2020, In: Blood. 4, 24, p. 6368-6383 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Prizes
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Single Cell Epigenomics Scientific Challenge
Smit, Linda (Recipient), 29 May 2020
Prize: Honorary award