Research Output per year
Personal profile
Research interests
Curriculum Vitae
1991-1992: Research fellow at Harvard University, Boston, U.S.A. Department of Biochemistry, Boston at the laboratory of Prof. Dr. J. Strominger (Supervision Prof. E.A. Macintyre)
1992: Master Medical Biology, VU University, Amsterdam, The Netherlands.
1993-1998: Doctorate: PhD at the Netherlands Cancer Institute, Department of Immunology, Amsterdam, The Netherlands at the laboratory of Prof. Dr. J. Borst.Thesis defense at 01-09-1998 at Utrecht University (Promoter: Prof. R. Bernards).
1998-1999: Post-doctoral research fellow the Netherlands Cancer Institute (Prof. Dr. J. Borst)
1999-2005: Post-doctoral research fellow at the laboratory of Prof. Dr. H. Clevers, Hubrecht Institute, Laboratory of developmental biology and stem cell research, Utrecht, The Netherlands.
2005-2008: Post-doctoral research fellow at the laboratory of Prof. Dr. R. Bernards, Department of carcinogenesis, Netherlands Cancer Institute, Amsterdam, The Netherlands.
May 2008-May 2008 till present: Principle Investigator, Assistant Professor and head of the molecular diagnostic team at the department of Hematology, Head Prof. Dr. S. Zweegman. Vice-Head: Prof. Dr. G.J. Ossenkoppele. VU University Medical Center, The Netherlands.
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Research Output 2013 2019
CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia
Naik, J., Themeli, M., de Jong-Korlaar, R., Ruiter, R. W. J., Poddighe, P. J., Yuan, H., de Bruijn, J. D., Ossenkoppele, G. J., Zweegman, S., Smit, L., Mutis, T., Martens, A. C. M., van de Donk, N. W. C. J. & Groen, R. W. J., 2019, In : Haematologica. 104, 3, p. e100-e103Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open Access
Abstract 1114: IGFBP7 reduces acute myeloid leukemia stem cell survival without affecting normal hematopoiesis
Cil, M., Vermue, E., Zweegman, S., Smit, M., Schuurhuis, G. J., Klootwijk, L. L. D. V., Menezes, R. X., Tsui, M-L., Smit, L., Rutten, A., Gils, N. V., Brocco, F., Roemer, M. G., Ossenkoppele, G. J., Verhagen, H. J., Rhenen, A. V., Janssen, J. J., Denkers, F. & Heukelom, S., 17 Aug 2018, In : Cancer Research. 78, 13 Supplement, p. 1114-1114 1 p.Research output: Contribution to journal › Article › Academic › peer-review
IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis
Verhagen, H. J. M. P., van Gils, N., Martiañez, T., van Rhenen, A., Rutten, A., Denkers, F., de Leeuw, D. C., Smit, M. A., Tsui, M-L., de Vos Klootwijk, L. L. E., Menezes, R. X., Çil, M., Roemer, M. G. M., Vermue, E., Heukelom, S., Zweegman, S., Janssen, J. J. W. M., Ossenkoppele, G. J., Schuurhuis, G. J. & Smit, L., 11 Dec 2018, In : Cell Reports. 25, 11, p. 3021-3035.e5Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Insulin-like Growth Factor Binding Protein 7 Activates the Retinoid Acid Differentiation Pathway in Acute Myeloid Leukemia Cells
Van Gils, N., Verhagen, H. J. M. P., Rutten, A., Menezes, R. X., Tsui, M-L., Dekens, E., Denkers, F., Vermue, E., Janssen, J. J. W. M., Ossenkoppele, G. J. & Smit, L., 21 Nov 2018, In : Blood. 132, Suppl 1Research output: Contribution to journal › Meeting Abstract › Academic
Target identification to selectively eradicate acute myeloid leukemia stem cells
Verhagen, H. J. M. P., 2018, 206 p.Research output: Thesis › Research VU University Amsterdam, graduation VU University Amsterdam › Academic