Linda Smit

, (Principal Investigator)


Research output per year

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Personal profile

Research interests

Curriculum Vitae

1991-1992: Research fellow at Harvard University, Boston, U.S.A. Department of Biochemistry, Boston at the laboratory of Prof. Dr. J. Strominger (Supervision Prof. E.A. Macintyre)

1992:  Master Medical Biology, VU University, Amsterdam, The Netherlands.

1993-1998Doctorate: PhD at the Netherlands Cancer Institute, Department of Immunology, Amsterdam, The Netherlands at the laboratory of Prof. Dr. J. Borst.Thesis defense at 01-09-1998 at Utrecht University (Promoter: Prof. R. Bernards).

1998-1999Post-doctoral research fellow the Netherlands Cancer Institute (Prof. Dr. J. Borst)

1999-2005Post-doctoral research fellow at the laboratory of Prof. Dr. H. Clevers, Hubrecht Institute, Laboratory of developmental biology and stem cell research, Utrecht, The Netherlands.

2005-2008Post-doctoral research fellow at the laboratory of Prof. Dr. R. Bernards, Department of carcinogenesis, Netherlands Cancer Institute, Amsterdam, The Netherlands.

May 2008-May 2008 till present: Principle Investigator, Assistant Professor and head of the molecular diagnostic team at the department of Hematology, Head Prof. Dr. S. Zweegman. Vice-Head: Prof. Dr. G.J. Ossenkoppele. VU University Medical Center, The Netherlands.

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Research Output

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin

Qiao, X., van der Zanden, S. Y., Wander, D. P. A., Borràs, D. M., Song, J. Y., Li, X., van Duikeren, S., van Gils, N., Rutten, A., van Herwaarden, T., van Tellingen, O., Giacomelli, E., Bellin, M., Orlova, V., Tertoolen, L. G. J., Gerhardt, S., Akkermans, J. J., Bakker, J. M., Zuur, C. L., Pang, B. & 7 others, Smits, A. M., Mummery, C. L., Smit, L., Arens, R., Li, J., Overkleeft, H. S. & Neefjes, J., 30 Jun 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 26, p. 15182-15192 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia

Naik, J., Themeli, M., de Jong-Korlaar, R., Ruiter, R. W. J., Poddighe, P. J., Yuan, H., de Bruijn, J. D., Ossenkoppele, G. J., Zweegman, S., Smit, L., Mutis, T., Martens, A. C. M., van de Donk, N. W. C. J. & Groen, R. W. J., 28 Feb 2019, In : Haematologica. 104, 3, p. e100-e103

Research output: Contribution to journalLetterAcademicpeer-review

Open Access

Abstract 1114: IGFBP7 reduces acute myeloid leukemia stem cell survival without affecting normal hematopoiesis

Cil, M., Vermue, E., Zweegman, S., Smit, M., Schuurhuis, G. J., Klootwijk, L. L. D. V., Menezes, R. X., Tsui, M-L., Smit, L., Rutten, A., Gils, N. V., Brocco, F., Roemer, M. G., Ossenkoppele, G. J., Verhagen, H. J., Rhenen, A. V., Janssen, J. J., Denkers, F. & Heukelom, S., 17 Aug 2018, In : Cancer Research. 78, 13 Supplement, p. 1114-1114 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis

Verhagen, H. J. M. P., van Gils, N., Martiañez, T., van Rhenen, A., Rutten, A., Denkers, F., de Leeuw, D. C., Smit, M. A., Tsui, M-L., de Vos Klootwijk, L. L. E., Menezes, R. X., Çil, M., Roemer, M. G. M., Vermue, E., Heukelom, S., Zweegman, S., Janssen, J. J. W. M., Ossenkoppele, G. J., Schuurhuis, G. J. & Smit, L., 11 Dec 2018, In : Cell Reports. 25, 11, p. 3021-3035.e5

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Insulin-like Growth Factor Binding Protein 7 Activates the Retinoid Acid Differentiation Pathway in Acute Myeloid Leukemia Cells

Van Gils, N., Verhagen, H. J. M. P., Rutten, A., Menezes, R. X., Tsui, M-L., Dekens, E., Denkers, F., Vermue, E., Janssen, J. J. W. M., Ossenkoppele, G. J. & Smit, L., 21 Nov 2018, In : Blood. 132, Suppl 1

Research output: Contribution to journalMeeting AbstractAcademic