Loek van Heerebeek

DRS.

20022020

Research output per year

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Research Output

2020

A randomised comparison of the effect of haemodynamic monitoring with CardioMEMS in addition to standard care on quality of life and hospitalisations in patients with chronic heart failure: Design and rationale of the MONITOR HF multicentre randomised clinical trial

Brugts, J. J., Veenis, J. F., Radhoe, S. P., Linssen, G. C. M., van Gent, M., Borleffs, C. J. W., van Ramshorst, J., van Pol, P., Tukkie, R., Spee, R. F., Emans, M. E., Kok, W., van Halm, V., Handoko, L., Beeres, S. L. M. A., Post, M. C., Boersma, E., Lenzen, M. J., Manintveld, O. C., Koffijberg, H. & 10 others, van Baal, P., Versteegh, M., Smilde, T. D., van Heerebeek, L., Rienstra, M., Mosterd, A., Delnoy, P. P. H., Asselbergs, F. W., Brunner-la Rocca, H. P. & de Boer, R. A., 1 Jan 2020, In : Netherlands Heart Journal. 28, 1, p. 16-26 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure)

Stienen, S., Ferreira, J. P., Kobayashi, M., Preud'homme, G., Dobre, D., Machu, J-L., Duarte, K., Bresso, E., Devignes, M-D., López, N., Girerd, N., Aakhus, S., Ambrosio, G., Brunner-La Rocca, H-P., Fontes-Carvalho, R., Fraser, A. G., van Heerebeek, L., Heymans, S., de Keulenaer, G., Marino, P. & 8 others, McDonald, K., Mebazaa, A., Papp, Z., Raddino, R., Tschöpe, C., Paulus, W. J., Zannad, F. & Rossignol, P., 16 Feb 2020, In : Biomarkers. 25, 2, p. 1-11 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Outpatient treatment of worsening heart failure with intravenous and subcutaneous diuretics: a systematic review of the literature

Wierda, E., Dickhoff, C., Handoko, M. L., Oosterom, L., Kok, W. E., de Rover, Y., de Mol, B. A. J. M., van Heerebeek, L. & Schroeder-Tanka, J. M., 1 Jan 2020, (Accepted/In press) In : ESC Heart Failure. 7, 3, 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

Boosting small heat shock proteins lowers cardiomyocyte passive stiffness in experimental heart failure with preserved ejection fraction

Waddingham, M. T., Dal Canto, E., Bos, D. D. S. G., Sequeria, V., Van Heerebeek, L., Kuster, D. W. D., De Man, F. S., Van Der Velden, J., Handoko, M. L., Eringa, E. C. & Paulus, W. J., May 2018, In : European Journal of Heart Failure. 20, p. 24-24

Research output: Contribution to journalMeeting AbstractAcademic

2017

Heart failure with preserved ejection fraction: a nephrologist-directed primer

Afsar, B., Rossignol, P., van Heerebeek, L., Paulus, W. J., Damman, K., Heymans, S., van Empel, V., Sag, A., Maisel, A. & Kanbay, M., 1 Nov 2017, In : Heart Failure Reviews. 22, 6, p. 765-773 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Phosphodiesterase-5 inhibition in heart failure with preserved ejection fraction: trading therapy for prevention

Guazzi, M., van Heerebeek, L. & Paulus, W. J., Mar 2017, In : European Journal of Heart Failure. 19, 3, p. 337-339

Research output: Contribution to journalEditorialAcademicpeer-review

2016

Connecting heart failure with preserved ejection fraction and renal dysfunction: the role of endothelial dysfunction and inflammation

Ter Maaten, J. M., Damman, K., Verhaar, M. C., Paulus, W. J., Duncker, D. J., Cheng, C., van Heerebeek, L., Hillege, H. L., Lam, C. S. P., Navis, G. & Voors, A. A., Jun 2016, In : European Journal of Heart Failure. 18, 6, p. 588-98 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinct Endothelial Cell Responses in the Heart and Kidney Microvasculature Characterize the Progression of Heart Failure With Preserved Ejection Fraction in the Obese ZSF1 Rat With Cardiorenal Metabolic Syndrome

van Dijk, C. G. M., Oosterhuis, N. R., Xu, Y. J., Brandt, M., Paulus, W. J., van Heerebeek, L., Duncker, D. J., Verhaar, M. C., Fontoura, D., Lourenco, A. P., Leite-Moreira, A. F., Falcao-Pires, I., Joles, J. A. & Cheng, C., Apr 2016, In : Circulation. Heart failure. 9, 4, e002760.

Research output: Contribution to journalArticleAcademicpeer-review

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction A Multiorgan Roadmap

Shah, S. J., Kitzman, D. W., Borlaug, B. A., van Heerebeek, L., Zile, M. R., Kass, D. A. & Paulus, W. J., 5 Jul 2016, In : Circulation. 134, 1, p. 73-90

Research output: Contribution to journalArticleAcademicpeer-review

Understanding heart failure with preserved ejection fraction: where are we today?

van Heerebeek, L. & Paulus, W. J., Apr 2016, In : Netherlands Heart Journal. 24, 4, p. 227-236

Research output: Contribution to journalArticleAcademicpeer-review

2015

Ancient Gunpowder and Novel Insights Team Up Against Heart Failure With Preserved Ejection Fraction

Paulus, W. J. & van Heerebeek, L., 2015, In : Journal of the American College of Cardiology. 66, 15, p. 1683-1686

Research output: Contribution to journalArticleAcademicpeer-review

2014

Diastolic heart failure: putting the puzzle together!

van Heerebeek, L., 2014, In : Netherlands Heart Journal. 22, 5, p. 249-250

Research output: Contribution to journalArticleAcademicpeer-review

2013

Diastolic Heart Failure: Putting the Puzzle together!

van Heerebeek, L., 2013

Research output: ThesisResearch VU University Amsterdam, graduation VU University Amsterdam

File
511 Downloads (Pure)
2012

Low myocardial protein kinase G activity in heart failure with preserved ejection fraction

van Heerebeek, L., Hamdani, N., Falcao-Pires, I., Leite-Moreira, A. F., Begieneman, M. P. V., Bronzwaer, J. G. F., van der Velden, J., Stienen, G. J. M., Laarman, G. J., Somsen, A. T., Verheugt, F. W. A., Niessen, H. W. M. & Paulus, W. J., 14 Aug 2012, In : Circulation. 126, 7, p. 830-839 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
65 Downloads (Pure)

Molecular and cellular basis for diastolic dysfunction

van Heerebeek, L., Franssen, C. P. M., Hamdani, N., Verheugt, F. W. A., Somsen, G. A. & Paulus, W. J., 2012, In : Current Heart Failure Reports. 9, 4, p. 293-302

Research output: Contribution to journalArticleAcademicpeer-review

2011

Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness

Falcão-Pires, I., Hamdani, N., Borbely, A., Gavina, C., Schalkwijk, C. G., van der Velden, J., van Heerebeek, L., Stienen, G. J. M., Niessen, H. W. M., Leite-Moreira, A. F. & Paulus, W. J., 6 Sep 2011, In : Circulation. 124, 10, p. 1151-1159 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
71 Downloads (Pure)
2009

Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction

Hamdani, N., Paulus, W. J., van Heerebeek, L., Borbely, A., Boontje, N., Zuidwijk, M. J., Bronzwaer, J. G. F., Simonides, W. S., Niessen, H. W. M., Stienen, G. J. M. & van der Velden, J., 2009, In : European Heart Journal. 30, 15, p. 1863-1872

Research output: Contribution to journalArticleAcademicpeer-review

Hypophosphorylation of the stiff N2B Titin isoform raises cardiomyocyte resting tension in failing human myocardium

Borbely, A., Falcão-Pires, I., van Heerebeek, L., Hamdani, N., Edes, I., Gavina, C., Leite-Moreira, A. F., Bronzwaer, J. G. F., Papp, Z., van der Velden, J., Stienen, G. J. M. & Paulus, W. J., 2009, In : Circulation Research. 104, 6, p. 780-786 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
62 Downloads (Pure)

The dialogue between diabetes and diastole

van Heerebeek, L. & Paulus, W. J., 2009, In : European Journal of Heart Failure. 11, 1, p. 3-5

Research output: Contribution to journalArticleAcademicpeer-review

The failing diabetic heart: Focus on diastolic left ventricular dysfunction

van Heerebeek, L., Somsen, A. & Paulus, W. J., 2009, In : Current Diabetes Reports. 9, 1, p. 79-86

Research output: Contribution to journalArticleAcademicpeer-review

Transcriptional and posttranslational modifications of titin implications for diastole

Borbely, A., van Heerebeek, L. & Paulus, W. J., 2009, In : Circulation Research. 104, 1, p. 12-14 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
68 Downloads (Pure)
2008

Circulating white blood cells and platelets amplify oxidative stress in heart failure

Ijsselmuiden, A. J. J., Musters, R. J. P., de Ruiter, G., van Heerebeek, L., Alderse-Baas, F., van Schiftgaarde, M., Leyte, A., Tangelder, G. J., Laarman, G. J. & Paulus, W. J., 2008, In : Nature Clinical Practice Cardiovascular Medicine. 5, 12, p. 811-820

Research output: Contribution to journalArticleAcademic

Diastolic stiffness of the failing diabetic heart: Importance of fibrosis, advanced glycation end products. and myocyte resting tension

Van Heerebeek, L., Hamdani, N., Handoko, M. L., Falcao-Pires, I., Musters, R. J., Borbely, A., Van Velden, J. D., Stienen, G. J. M., Paulus, W. J., Bronzwaer, J. G. F., Diamant, M., Kupreishvili, K., Niessen, H. W. M., Schalkwijk, C. G., Ijsselmuiden, A. J. J. & Laarman, G. J., 10 Jun 2008, In : Circulation. 117, 23, p. e484

Research output: Contribution to journalLetterAcademicpeer-review

Open Access

Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension

van Heerebeek, L., Hamdani, N., Handoko, M. L., Falcao-Pires, I., Musters, R. J., Kupreishvili, K., Ijsselmuiden, A. J. J., Schalkwijk, C. G., Bronzwaer, J. G. F., Diamant, M., Borbély, A., van der Velden, J., Stienen, G. J. M., Laarman, G. J., Niessen, H. W. M. & Paulus, W. J., 1 Jan 2008, In : Circulation. 117, 1, p. 43-51 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Invasive Evaluation of Diastolic Left Ventricular Dysfunction

van Heerebeek, L. & Paulus, W. J., 2008, Diastolic Heart Failure. p. 137-147

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2006

Myocardial structure and function differ in systolic and diastolic heart failure

van Heerebeek, L., Borbély, A., Niessen, H. W. M., Bronzwaer, J. G. F., van der Velden, J., Stienen, G. J. M., Linke, W. A., Laarman, G. J. & Paulus, W. J., 25 Apr 2006, In : Circulation. 113, 16, p. 1966-73 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2002

NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system?

Van Heerebeek, L., Meischl, C., Stooker, W., Meijer, C. J. L. M., Niessen, H. W. M. & Roos, D., Aug 2002, In : Journal of Clinical Pathology. 55, 8, p. 561-8 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review