20012020

Research output per year

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Research Output

2019

A dual-color bioluminescence reporter mouse for simultaneous in vivo imaging of T cell localization and function

Kleinovink, J. W., Mezzanotte, L., Zambito, G., Fransen, M. F., Cruz, L. J., Verbeek, J. S., Chan, A., Ossendorp, F. & Löwik, C., 2019, In : Frontiers in Immunology. 10, JAN, 3097.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

FcγR interaction is not required for effective anti-PD-L1 immunotherapy but can add additional benefit depending on the tumor model

Sow, H. S., Benonisson, H., Breukel, C., Visser, R., Verhagen, O. J. H. M., Bentlage, A. E. H., Brouwers, C., Claassens, J. W. C., Linssen, M. M., Camps, M., van Hall, T., Ossendorp, F., Fransen, M. F., Vidarsson, G. & Verbeek, J. S., 2019, In : International Journal of Cancer. 144, 2, p. 345-354

Research output: Contribution to journalArticleAcademicpeer-review

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

van der Schoot, J. M. S., Fennemann, F. L., Valente, M., Dolen, Y., Hagemans, I. M., Becker, A. M. D., le Gall, C. M., van Dalen, D., Cevirgel, A., van Bruggen, J. A. C., Engelfriet, M., Caval, T., Bentlage, A. E. H., Fransen, M. F., Nederend, M., Leusen, J. H. W., Heck, A. J. R., Vidarsson, G., Figdor, C. G., Verdoes, M. & 1 others, Scheeren, F. A., 2019, In : Science Advances. 5, 8, eaaw1822.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

A restricted role for FcgR in the regulation of adaptive immunity

Fransen, M. F., Benonisson, H., van Maren, W. W., Sow, H. S., Breukel, C., Linssen, M. M., Claassens, J. W. C., Brouwers, C., van der Kaa, J., Camps, M., Kleinovink, J. W., Vonk, K. K., van Heiningen, S., Klar, N., van Beek, L., van Harmelen, V., Daxinger, L., Nandakumar, K. S., Holmdahl, R., Coward, C. & 8 others, Lin, Q., Hirose, S., Salvatori, D., van Hall, T., van Kooten, C., Mastroeni, P., Ossendorp, F. & Verbeek, J. S., 2018, In : Journal of Immunology. 200, 8, p. 2615-2626

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

FcγRI expression on macrophages is required for antibodymediated tumor protection by cytomegalovirus-based vaccines

Benonisson, H., Sow, H. S., Breukel, C., Claassens, J. W. C., Brouwers, C., Linssen, M. M., Redeker, A., Fransen, M. F., van Hall, T., Ossendorp, F., Arens, R. & Verbeek, S., 2018, In : Oncotarget. 9, 50, p. 29392-29402

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

High FcγR expression on intratumoral macrophages enhances tumor-targeting antibody therapy

Benonisson, H., Sow, H. S., Breukel, C., Claassens, J., Brouwers, C., Linssen, M. M., Fransen, M. F., Sluijter, M., Ossendorp, F., van Hall, T. & Verbeek, J. S., 2018, In : Journal of Immunology. 201, 12, p. 3741-3749

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy

Fransen, M. F., Schoonderwoerd, M., Knopf, P., Camps, M. G., Hawinkels, L. J., Kneilling, M., van Hall, T. & Ossendorp, F., 2018, In : JCI Insight. 3, 23

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy

Kleinovink, J. W., Marijt, K. A., Schoonderwoerd, M. J. A., van Hall, T., Ossendorp, F. & Fransen, M. F., 2017, In : OncoImmunology. 6, 4, e1294299.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

PD-L1 immune suppression in cancer: Tumor cells or host cells?

Kleinovink, J. W., van Hall, T., Ossendorp, F. & Fransen, M. F., 2017, In : OncoImmunology. 6, 7, e1325982.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Photodynamic-immune checkpoint therapy eradicates local and distant tumors by CD8+ T cells

Kleinovink, J. W., Fransen, M. F., Löwik, C. W. & Ossendorp, F., 2017, In : Cancer Immunology Research. 5, 10, p. 832-838

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Self-Assembling Peptide Epitopes as Novel Platform for Anticancer Vaccination

Rad-Malekshahi, M., Fransen, M. F., Krawczyk, M., Mansourian, M., Bourajjaj, M., Chen, J., Ossendorp, F., Hennink, W. E., Mastrobattista, E. & Amidi, M., 2017, In : Molecular Pharmaceutics. 14, 5, p. 1482-1493

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Combination of photodynamic therapy and specific immunotherapy efficiently eradicates established tumors

Kleinovink, J. W., van Driel, P. B., Snoeks, T. J., Prokopi, N., Fransen, M. F., Cruz, L. J., Mezzanotte, L., Chan, A., Löwik, C. W. & Ossendorp, F., 2016, In : Clinical Cancer Research. 22, 6, p. 1459-1468

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015

Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: Invivo tracking and evaluation of antigen-specific CD8+ T cell immune response

Rahimian, S., Kleinovink, J. W., Fransen, M. F., Mezzanotte, L., Gold, H., Wisse, P., Overkleeft, H., Amidi, M., Jiskoot, W., Löwik, C. W., Ossendorp, F. & Hennink, W. E., 2015, In : Biomaterials. 37, p. 469-477

Research output: Contribution to journalArticleAcademicpeer-review

Particulate systems based on poly(Lactic-co-glycolic)acid (pLGA) for immunotherapy of cancer

Rahimian, S., Fransen, M. F., Kleinovink, J. W., Amidi, M., Ossendorp, F. & Hennink, W. E., 2015, In : Current pharmaceutical design. 21, 29, p. 4201-4216

Research output: Contribution to journalReview articleAcademicpeer-review

Polymeric microparticles for sustained and local delivery of antiCD40 and antiCTLA-4 in immunotherapy of cancer

Rahimian, S., Fransen, M. F., Kleinovink, J. W., Amidi, M., Ossendorp, F. & Hennink, W. E., 2015, In : Biomaterials. 61, p. 33-40

Research output: Contribution to journalArticleAcademicpeer-review

Polymeric nanoparticles for co-delivery of synthetic long peptide antigen and poly IC as therapeutic cancer vaccine formulation

Rahimian, S., Fransen, M. F., Kleinovink, J. W., Christensen, J. R., Amidi, M., Hennink, W. E. & Ossendorp, F., 2015, In : Journal of Controlled Release. 203, p. 16-22

Research output: Contribution to journalArticleAcademicpeer-review

Reduction-sensitive dextran nanogels aimed for intracellular delivery of antigens

Li, D., Kordalivand, N., Fransen, M. F., Ossendorp, F., Raemdonck, K., Vermonden, T., Hennink, W. E. & van Nostrum, C. F., 2015, In : Advanced Functional Materials. 25, 20, p. 2993-3003

Research output: Contribution to journalArticleAcademicpeer-review

2014

Effectiveness of slow-release systems in CD40 agonistic antibody immunotherapy of cancer

Fransen, M. F., Cordfunke, R. A., Sluijter, M., van Steenbergen, M. J., Drijfhout, J. W., Ossendorp, F., Hennink, W. E. & Melief, C. J. M., 2014, In : Vaccine. 32, 15, p. 1654-1660

Research output: Contribution to journalArticleAcademicpeer-review

IgG-mediated anaphylaxis to a Synthetic long peptide vaccine containing a B cell epitope can be avoided by slow-release formulation

Quakkelaar, E. D., Fransen, M. F., van Maren, W. W. C., Vaneman, J., Loof, N. M., van Heiningen, S. H., Verbeek, J. S., Ossendorp, F. & Melief, C. J. M., 2014, In : Journal of Immunology. 192, 12, p. 5813-5820

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2013

Controlled local delivery of CTLA-4 blocking antibody induces CD8 + T-cell-dependent tumor eradication and decreases risk of toxic side effects

Fransen, M. F., van der Sluis, T. C., Ossendorp, F., Arens, R. & Melief, C. J. M., 2013, In : Clinical Cancer Research. 19, 19, p. 5381-5389

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Local immunomodulation for cancer therapy: Providing treatment where needed

Fransen, M. F., Ossendorp, F., Arens, R. & Melief, C. J. M., 2013, In : OncoImmunology. 2, 11, e26493.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Local targets for immune therapy to cancer: Tumor draining lymph nodes and tumor microenvironment

Fransen, M. F., Arens, R. & Melief, C. J. M., 2013, In : International Journal of Cancer. 132, 9, p. 1971-1976

Research output: Contribution to journalReview articleAcademicpeer-review

2012

Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors

van Duikeren, S., Fransen, M. F., Redeker, A., Wieles, B., Platenburg, G., Krebber, W-J., Ossendorp, F., Melief, C. J. M. & Arens, R., 2012, In : Journal of Immunology. 189, 7, p. 3397-3403

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2011

Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody

Fransen, M. F., Sluijter, M., Morreau, H., Arens, R. & Melief, C. J. M., 2011, In : Clinical Cancer Research. 17, 8, p. 2270-2280

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2010

Separate roles for antigen recognition and lymph node inflammation in CD8+ memory T cell formation

Fransen, M. F., van Stipdonk, M. J., Sluijter, M., Schoenberger, S. P., Melief, C. J. & Offringa, R., 2010, In : Journal of Immunology. 185, 6, p. 3167-3173

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2005

CD4+ T cells are able to promote tumor growth through inhibition of tumor-specific CD8+ T-cell responses in tumor-bearing hosts

den Boer, A. T., van Mierlo, G. J. D., Fransen, M. F., Melief, C. J. M., Offringa, R. & Toes, R. E. M., 2005, In : Cancer Research. 65, 15, p. 6984-6989

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Maintenance of immune tolerance depends on normal tissue homeostasis

Boonman, Z. F. H. M., van Mierlo, G. J. D., Fransen, M. F., de Keizer, R. J. W., Jager, M. J., Melief, C. J. M. & Toes, R. E. M., 2005, In : Journal of Immunology. 175, 7, p. 4247-4254

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2004

Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8+ CTL to cause tumor eradication

van Mierlo, G. J. D., Boonman, Z. F. H. M., Dumortier, H. L. M. H., den Boer, A. T., Fransen, M. F., Nouta, J., van der Voort, E. I. H., Offringa, R., Toes, R. E. M. & Melief, C. J. M., 2004, In : Journal of Immunology. 173, 11, p. 6753-6759

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intraocular Tumor Antigen Drains Specifically to Submandibular Lymph Nodes, Resulting in an Abortive Cytotoxic T Cell Reaction

Boonman, Z. F. H. M., van Mierlo, G. J. D., Fransen, M. F., Franken, K. L. M. C., Offringa, R., Melief, C. J. M., Jager, M. J. & Toes, R. E. M., 2004, In : Journal of Immunology. 172, 3, p. 1567-1574

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Tumoricidal Activity of Memory CD8+ T Cells Is Hampered by Persistent Systemic Antigen, but Full Functional Capacity Is Regained in an Antigen-Free Environment

den Boer, A. T., van Mierlo, G. J. D., Fransen, M. F., Melief, C. J. M., Offringa, R. & Toes, R. E. M., 2004, In : Journal of Immunology. 172, 10, p. 6074-6079

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2002

CD40 stimulation leads to effective therapy of CD40- tumors through induction of strong systemic cytotoxic T lymphocyte immunity

van Mierlo, G. J. D., Boer, A. T. D., Medema, J. P., van der Voort, E. I. H., Fransen, M. F., Offringa, R., Melief, C. J. M. & Toes, R. E. M., 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 8, p. 5561-5566

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In vivo triggering through 4-1BB enables TH-independent priming of CTL in the presence of an intact CD28 costimulatory pathway

Diehl, L., van Mierlo, G. J. D., den Boer, A. T., van der Voort, E., Fransen, M., van Bostelen, L., Krimpenfort, P., Melief, C. J. M., Mittler, R., Toes, R. E. M. & Offringa, R., 2002, In : Journal of Immunology. 168, 8, p. 3755-3762

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2001

Longevity of antigen presentation and activation status of APC are decisive factors in the balance between CTL immunity versus tolerance

den Boer, A. T., Diehl, L., van Mierlo, G. J. D., van der Voort, E. I. H., Fransen, M. F., Krimpenfort, P., Melief, C. J. M., Offringa, R. & Toes, R. E. M., 2001, In : Journal of Immunology. 167, 5, p. 2522-2528

Research output: Contribution to journalArticleAcademicpeer-review