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Research Output 2010 2019

2019
Open Access

Endocriene bijwerkingen van checkpointremmers

Chen, W. J. Y., Krul-Poel, Y. H. M., Roth, C., Labots, M., van den Eertwegh, A. J. M. & Dreijerink, K. M. A., 31 Oct 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163

Research output: Contribution to journalArticleProfessional

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases

Beekhof, R., van Alphen, C., Henneman, A. A., Knol, J. C., Pham, T. V., Rolfs, F., Labots, M., Henneberry, E., le Large, T. Y., de Haas, R. R., Piersma, S. R., Vurchio, V., Bertotti, A., Trusolino, L., Verheul, H. M. & Jimenez, C. R., 1 Apr 2019, In : Molecular Systems Biology. 15, 4, p. e8250 e8250.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pan-cancer whole-genome analyses of metastatic solid tumours

Priestley, P., Baber, J., Lolkema, M. P., Steeghs, N., de Bruijn, E., Shale, C., Duyvesteyn, K., Haidari, S., van Hoeck, A., Onstenk, W., Roepman, P., Voda, M., Bloemendal, H. J., Tjan-Heijnen, V. C. G., van Herpen, C. M. L., Labots, M., Witteveen, P. O., Smit, E. F., Sleijfer, S., Voest, E. E. & 1 othersCuppen, E., 23 Oct 2019, In : Nature. 575, 7781, p. 210-216

Research output: Contribution to journalArticleAcademicpeer-review

Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes

Overbeek, J. A., Kuiper, J. G., van der Heijden, A. A. W. A., Labots, M., Haug, U., Herings, R. M. C. & Nijpels, G., 6 Feb 2019, In : International Journal of Colorectal Disease. 34, 2, p. 269-276 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs

van der Velden, D. L., Hoes, L. R., van der Wijngaart, H., van Berge Henegouwen, J. M., van Werkhoven, E., Roepman, P., Schilsky, R. L., de Leng, W. W. J., Huitema, A. D. R., Nuijen, B., Nederlof, P. M., van Herpen, C. M. L., de Groot, D. J. A., Devriese, L. A., Hoeben, A., de Jonge, M. J. A., Chalabi, M., Smit, E. F., de Langen, A. J., Mehra, N. & 7 othersLabots, M., Kapiteijn, E., Sleijfer, S., Cuppen, E., Verheul, H. M. W., Gelderblom, H. & Voest, E. E., 3 Oct 2019, In : Nature. 574, 7776, p. 127-131 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies

Angus, L., Smid, M., Wilting, S. M., van Riet, J., Van Hoeck, A., Nguyen, L., Nik-Zainal, S., Steenbruggen, T. G., Tjan-Heijnen, V. C. G., Labots, M., van Riel, J. M. G. H., Bloemendal, H. J., Steeghs, N., Lolkema, M. P., Voest, E. E., van de Werken, H. J. G., Jager, A., Cuppen, E., Sleijfer, S. & Martens, J. W. M., 1 Oct 2019, In : Nature Genetics. 51, 10, p. 1450-1458 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018
Open Access

Tumor (phospho)proteomic and genomic profiling to guide selection of targeted therapy in patients with cancer

Labots, M., 2018, 210 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

2017

A phase 1/2 study of intermittent, high dose sunitinib in patients with advanced solid tumors.

Rovithi, M., Labots, M., Richard, Honeywell, Ten Tije, A. J., Ruijter, R., Skardhamar, M., Peters, G. J., Voortman, J. & Verheul, H. M. W., 20 May 2017, In : Journal of Clinical Oncology. 35

Research output: Contribution to journalMeeting AbstractAcademic

Phosphotyrosine-based-phosphoproteomics scaled-down to biopsy level for analysis of individual tumor biology and treatment selection

Labots, M., van der Mijn, J. C., Beekhof, R., Piersma, S. R., de Goeij-de Haas, R. R., Pham, T. V., Knol, J. C., Dekker, H., van Grieken, N. C. T., Verheul, H. M. W. & Jiménez, C. R., 6 Jun 2017, In : Journal of Proteomics. 162, p. 99-107 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Evaluation of a tyrosine kinase peptide microarray for tyrosine kinase inhibitor therapy selection in cancer

Labots, M., Gotink, K. J., Dekker, H., Azijli, K., van der Mijn, J. C., Huijts, C. M., Piersma, S. R., Jiménez, C. R. & Verheul, H. M. W., 16 Dec 2016, In : Experimental & Molecular Medicine. 48, 12, p. e279

Research output: Contribution to journalArticleAcademicpeer-review

2015

Evaluation of different phospho-tyrosine antibodies for label-free phosphoproteomics

van der Mijn, J. C., Labots, M., Piersma, S. R., Pham, T. V., Knol, J. C., Broxterman, H. J., Verheul, H. M. & Jimenez, C. R., 2015, In : Journal of Proteomics. 127, p. 259-263

Research output: Contribution to journalArticleAcademicpeer-review

Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines

Piersma, S. R., Knol, J. C., de Reus, I., Labots, M., Sampadi, B. K., Pham, T. V., Ishihama, Y., Verheul, H. M. W. & Jimenez, C. R., 2015, In : Journal of Proteomics. 127, p. 247-258

Research output: Contribution to journalArticleAcademicpeer-review

Therapeutic Drug Monitoring to Individualize the Dosing of Pazopanib: A Pharmacokinetic Feasibility Study

de Wit, D., van Erp, N. P., Den Hartigh, J., Wolterbeek, R., van Deursen, M., Labots, M., Guchelaar, H. J., Verheul, H. M. & Gelderblom, H., 2015, In : Therapeutic Drug Monitoring. 37, 3, p. 331-338

Research output: Contribution to journalArticleAcademicpeer-review

2014

Genomic landscape of metastatic colorectal cancer

Haan, J. C., Labots, M., Rausch, C., Koopman, M., de Nooy-van Tol, J., Mekenkamp, L. J. M., van de Wiel, M. A., Israeli, D., van Essen, H. F., van Grieken, N. C. T., Voorham, Q. J. M., Bosch, L. J. W., Qu, X., Kabbarah, O., Verheul, H. M. W., Nagtegaal, I. D., Punt, C. J. A., Ylstra, B. & Meijer, G. A., 2014, In : Nature Communications. 5, 5457.

Research output: Contribution to journalArticleAcademicpeer-review

High-dose, intermittent sunitinib as an alternative treatment strategy

Rovithi, M., de Haas, R. R., Honeywell, R. J., Voortman, J., Griffioen, A. W., Labots, M., Luik, A. M., Peters, G. J., Broxterman, H. J. & Verheul, H. M. W., 1 Oct 2014, In : Cancer Research. 74, 19

Research output: Contribution to journalMeeting AbstractAcademic

High-level copy number gains of established and potential drug target genes in gastric cancer as a lead for treatment development and selection

Labots, M., Buffart, T. E., Haan, J. C., van Grieken, N. C. T., Tijssen, M., van de Velde, C. J. H., Grabsch, H. I., Ylstra, B., Carvalho, B., Fijneman, R. J. A., Verheul, H. M. W. & Meijer, G. A., 2014, In : Cellular Oncology. 37, 1, p. 41-52

Research output: Contribution to journalArticleAcademicpeer-review

Mass Spectrometry-Based Serum and Plasma Peptidome Profiling for Prediction of Treatment Outcome in Patients With Solid Malignancies

Labots, M., Schutte, L. M., van der Mun, J. C., Pham, T. V., Jimenez, C. R. & Verheul, H. M. W., 2014, In : The Oncologist. 19, 10, p. 1028-1039

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Mechanisms and Modulation of Key Pathways Underlying the Synergistic Interaction of Sorafenib with Erlotinib in Non-Small-Cell-Lung Cancer (NSCLC) Cells

Giovannetti, E., Labots, M., Dekker, H., Galvani, E., Lind, J. S. W., Sciarrillo, R., Honeywell, R. J., Smit, E. F., Verheul, H. M. & Peters, G. J., 2013, In : Current Pharmaceutical Design. 19, 5, p. 927-939

Research output: Contribution to journalArticleAcademicpeer-review

2011

Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance

Gotink, K. J., Broxterman, H. J., Labots, M., de Haas, R. R., Dekker, H., Honeywell, R. J., Rudek, M. A., Beerepoot, L. V., Musters, R. J. P., Jansen, G., Griffioen, A. W., Assaraf, Y. G., Pili, R., Peters, G. J. & Verheul, H. M. W., 2011, In : Clinical Cancer Research. 17, 23, p. 7337-7346

Research output: Contribution to journalArticleAcademicpeer-review

2010

Jonge vrouwen met hypertensie: denk aan 'de pil'.

Labots, M., Kooter, J., Serné, E. & Smulders, Y., 1 Dec 2010, In : Nederlands Tijdschrift voor Geneeskunde. 154, 22

Research output: Contribution to journalArticleAcademicpeer-review

Jonge vrouwen met hypertensie: Denk aan 'de pil'

Labots, M., Kooter, J., Serné, E. & Smulders, Y., 5 Jun 2010, In : Nederlands Tijdschrift voor Geneeskunde. 154, 22, p. 1057-1060 4 p.

Research output: Contribution to journalLetterAcademicpeer-review

Jonge vrouwen met hypertensie: denk aan 'de pil'

Labots, M., Kooter, A. J., Serné, E. H. & Smulders, Y. M., 2010, In : Nederlands Tijdschrift voor Geneeskunde. 154, A1789.

Research output: Contribution to journalArticleProfessional

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