Marike van der Leeden

DR., (Principal Investigator)


Research output per year

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Personal profile

Research interests

The general objective of my research line is to provide a contribution to rehabilitation and allied health care by means of the development, scientific foundation and implementation of interventions aimed at improving the functioning of people with a complex health status / complex care demand.
I am mainly involved in research concerning rehabilitation in patients with musculoskeletal disorders (osteoarthritis, rheumatoid arthritis, and chronic widespread pain), and patients with cancer (with a focus on peri-operative care). These patients often have other diseases in addition to their index disease, which may lead to multiple problems in daily life and a complex health care demand.

The themes addressed in my research line are: (1) lifestyle interventions in healthcare (with a focus on exercise), (2) self-management, behavioral change and the role of technology and (3) supporting clinical reasoning of health professionals in case of a complex health status / a complex care demand.
I have extensive experience in setting up, conducting and supervising clinical trials, cohort studies and systematic literature reviews. More recently, I am also involved in implementation research.

I value close cooperation and exchange of expertise between practitioners and researchers. Implementation of research in clinical practice has my full attention, as also expressed by my contribution to (development of) graduate and post-graduate educational programs in higher education and by supervising Bachelor and Master students in ongoing studies.


Rehabilitation Medicine, Human Movement Sciences, Physiotherapy

External positions

Senior researcher, Amsterdam Rehabilitation Research Center/Reade

1 Jan 2010 → …

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

In-Hospital Mobilization, Physical Fitness, and Physical Functioning After Lung Cancer Surgery

van der Leeden, M., Balland, C., Geleijn, E., Huijsmans, R. J., Dekker, J., Paul, M. A., Dickhoff, C. & Stuiver, M. M., 2019, In : Annals of Thoracic Surgery. 107, 6, p. 1639-1646

Research output: Contribution to journalArticleAcademicpeer-review

Efficacy of Tailored Exercise Therapy on Physical Functioning in Patients With Knee Osteoarthritis and Comorbidity: A Randomized Controlled Trial

de Rooij, M., van der Leeden, M., Cheung, J., van der Esch, M., Häkkinen, A., Haverkamp, D., Roorda, L. D., Twisk, J., Vollebregt, J., Lems, W. F. & Dekker, J., 1 Jun 2017, In : Arthritis Care and Research. 69, 6, p. 807-816 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Structured clinical reasoning for exercise prescription in patients with comorbidity

van der Leeden, M., Stuiver, M. M., Huijsmans, R., Geleijn, E., de Rooij, M. & Dekker, J., 2018, In : Disability and Rehabilitation. 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Three trajectories of activity limitations in early symptomatic knee osteoarthritis: a 5-year follow-up study

Holla, J. F. M., van der Leeden, M., Heijmans, M. W., Roorda, L. D., Bierma-Zeinstra, S. M. A., Boers, M., Lems, W. F., Steultjens, M. P. M. & Dekker, J., 2014, In : Annals of the Rheumatic Diseases. 73, 7, p. 1369-1375

Research output: Contribution to journalArticleAcademicpeer-review

Exercise in People With Comorbidity or Multimorbidity

Dekker, J., Buurman, B. M. & van der Leeden, M., 1 Sep 2019, In : Health Psychology. 38, 9, p. 822-830 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access


Arthritis Research UK Primary Care Centre, Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom.

Marike van der Leeden (Visiting researcher), Martin van der Esch (Visiting researcher) & WF Lems (Visiting researcher)

15 Jan 201916 Jan 2019

Activity: Visiting an external institutionVisiting an external academic institution

Tailoring exercise therapy to comorbidity in patients with knee osteoarthritis

Marike van der Leeden (Speaker)

13 May 2019

Activity: Talk or presentationInvited talk

International Conference on Physical Therapy in Oncology

Marike van der Leeden (Participant)

5 Jun 2018

Activity: Participating in or organising an eventOrganising a conference, workshop, ...


Appointed Principal Investigator

van der Leeden, Marike (Recipient), 1 Sep 2019

Prize: Other distinction