Research Output per year
Personal profile
Research interests
My research line focuses on providing a better understanding of clinical progression in multiple sclerosis (MS). MS is actually a network disorder, as the progressive formation of white matter lesions leads to a disconnection of axonal bundles and hence a disruption of the brain network, in turn leading to extensive neurodegeneration of network hubs like the thalamus. As such, my main focus is on understanding how alterations to (functional and structural) brain networks relate to complex symptoms such as cognitive dysfunction, how networks change during progression, and which patterns are predictive of decline. Apart from such a mechanistic approach to study the brain, my aim is also to provide the neuro(radio)logist advanced imaging markers that can be used in clinic, such as atrophy of the thalamus. In addition to MS, I also investigate similar network-focused mechanisms of progression in Parkinson's disease, as well as psychiatric disorders such as the effects of childhood trauma and stress.
Key words: Clinical progression, multiple sclerosis, brain network, connectivity, functional MRI, magnetoencephalography, diffusion tensor imaging, atrophy, cognition, Parkinson's disease.
Specialisation
I am mainly specialized in network neuroscience in multiple sclerosis (MS), using advanced imaging methods to study clinical progression. Imaging tools I use to study brain networks and connectivity are based on functional MRI, magnetoencephalography, diffusion tensor imaging and atrophy measures. Apart from MS, I also study these same aspects in Parkinson disease.
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output
Network collapse and cognitive impairment in multiple sclerosis
Schoonheim, M. M., Meijer, K. A. & Geurts, J. J. G., 2015, In : Frontiers in Neurology. 6, 82.Research output: Contribution to journal › Article › Academic › peer-review
Thalamus structure and function determine severity of cognitive impairment in multiple sclerosis
Schoonheim, M. M., Hulst, H. E., Brandt, R. B., Strik, M., Wink, A. M., Uitdehaag, B. M. J., Barkhof, F. & Geurts, J. J. G., 24 Feb 2015, In : Neurology. 84, 8, p. 776-83 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Reduced Network Dynamics on Functional MRI Signals Cognitive Impairment in Multiple Sclerosis
Eijlers, A. J. C., Wink, A. M., Meijer, K. A., Douw, L., Geurts, J. J. G. & Schoonheim, M. M., 1 Jan 2019, In : Radiology. 292, 2, p. 449-457 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Staging of cortical and deep grey matter functional connectivity changes in multiple sclerosis
Meijer, K. A., Eijlers, A. J. C., Geurts, J. J. G. & Schoonheim, M. M., 1 Feb 2018, In : Journal of Neurology, Neurosurgery and Psychiatry. 89, 2, p. 205-210 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Explaining the heterogeneity of functional connectivity findings in multiple sclerosis: An empirically informed modeling study
Tewarie, P., Steenwijk, M. D., Brookes, M. J., Uitdehaag, B. M. J., Geurts, J. J. G., Stam, C. J. & Schoonheim, M. M., 21 Jun 2018, In : Human Brain Mapping. 39, 6, p. 2541-2548Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Activities
Cognitive impairment and the network collapse in multiple sclerosis
Menno Schoonheim (Speaker)16 Jan 2020
Activity: Talk or presentation › Invited talk
Een netwerkperspectief op klinische progressie bij MS
Menno Schoonheim (Speaker)16 Jan 2020
Activity: Talk or presentation › Invited talk
Functional imaging
Menno Schoonheim (Speaker)23 Jun 2020
Activity: Talk or presentation › Invited talk
MRI-pathological correlation in Multiple Sclerosis
Menno Schoonheim (Speaker)28 Jan 2020
Activity: Talk or presentation › Invited talk
Long-range connections and cognition in MS
Menno Schoonheim (Speaker)12 Nov 2020
Activity: Talk or presentation › Invited talk
Press / Media
Een verstoorde hersenfunctie komt vaker voor bij mensen die harder achteruit gaan
01/11/2019
1 Media contribution
Press/Media: Public Engagement Activities
MS bestuderen als netwerkziekte
18/04/2019
1 Media contribution
Press/Media: Public Engagement Activities
‘Een verstoorde hersenfunctie komt vaker voor bij mensen die harder achteruit gaan’
02/03/2019
1 Media contribution
Press/Media: Public Engagement Activities
Nationale MS dag: Nieuwe ontwikkelingen in neurowetenschappen
18/11/2018
1 Media contribution
Press/Media: Public Engagement Activities
Prizes
Best presentation of a young scientific investigator
Menno Schoonheim (Recipient), 22 Oct 2011
Prize: Honorary award
Radiology: Editor's recognition award for reviewing with special distinction
Menno Schoonheim (Recipient), 1 Dec 2018
Prize: Honorary award
File
Radiology: Editor's recognition award for reviewing with special distinction
Menno Schoonheim (Recipient), 1 Dec 2019
Prize: Honorary award