Projects per year
Personal profile
Research interests
My research line focuses on providing a better understanding of clinical progression in multiple sclerosis (MS). MS is actually a network disorder, as the progressive formation of white matter lesions leads to a disconnection of axonal bundles and hence a disruption of the brain network, in turn leading to extensive neurodegeneration of network hubs like the thalamus. As such, my main focus is on understanding how alterations to (functional and structural) brain networks relate to complex symptoms such as cognitive dysfunction, how networks change during progression, and which patterns are predictive of decline. Apart from such a mechanistic approach to study the brain, my aim is also to provide the neuro(radio)logist advanced imaging markers that can be used in clinic, such as atrophy of the thalamus. In addition to MS, I also investigate similar network-focused mechanisms of progression in Parkinson's disease, as well as psychiatric disorders such as the effects of childhood trauma and stress.
Key words: Clinical progression, multiple sclerosis, brain network, connectivity, functional MRI, magnetoencephalography, diffusion tensor imaging, atrophy, cognition, Parkinson's disease.
Specialisation
I am mainly specialized in network neuroscience in multiple sclerosis (MS), using advanced imaging methods to study clinical progression. Imaging tools I use to study brain networks and connectivity are based on functional MRI, magnetoencephalography, diffusion tensor imaging and atrophy measures. Apart from MS, I also study these same aspects in Parkinson disease.
Network
Projects
- 2 Active
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REACT: Brain dynamics in childhood trauma-related depression
Pasteuning, J., Sep, M., Schoonheim, M. & Vinkers, C.
01/01/2022 → …
Project: Research
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RESET: REStoring mood in Early life Trauma
Linsen, F., Gathier, A., Broeder, C., Sep, M., Verhoeven, J., Schoonheim, M., van Oppen, P., Penninx, B. & Vinkers, C.
01/01/2020 → …
Project: Research
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Network collapse and cognitive impairment in multiple sclerosis
Schoonheim, M. M., Meijer, K. A. & Geurts, J. J. G., 2015, In: Frontiers in Neurology. 6, 82.Research output: Contribution to journal › Article › Academic › peer-review
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Thalamus structure and function determine severity of cognitive impairment in multiple sclerosis
Schoonheim, M. M., Hulst, H. E., Brandt, R. B., Strik, M., Wink, A. M., Uitdehaag, B. M. J., Barkhof, F. & Geurts, J. J. G., 24 Feb 2015, In: Neurology. 84, 8, p. 776-83 8 p.Research output: Contribution to journal › Article › Academic › peer-review
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Reduced Network Dynamics on Functional MRI Signals Cognitive Impairment in Multiple Sclerosis
Eijlers, A. J. C., Wink, A. M., Meijer, K. A., Douw, L., Geurts, J. J. G. & Schoonheim, M. M., 1 Jan 2019, In: Radiology. 292, 2, p. 449-457 9 p.Research output: Contribution to journal › Article › Academic › peer-review
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Staging of cortical and deep grey matter functional connectivity changes in multiple sclerosis
Meijer, K. A., Eijlers, A. J. C., Geurts, J. J. G. & Schoonheim, M. M., 1 Feb 2018, In: Journal of Neurology, Neurosurgery and Psychiatry. 89, 2, p. 205-210 6 p.Research output: Contribution to journal › Article › Academic › peer-review
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Explaining the heterogeneity of functional connectivity findings in multiple sclerosis: An empirically informed modeling study
Tewarie, P., Steenwijk, M. D., Brookes, M. J., Uitdehaag, B. M. J., Geurts, J. J. G., Stam, C. J. & Schoonheim, M. M., 21 Jun 2018, In: Human Brain Mapping. 39, 6, p. 2541-2548Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Activities
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Pathology of grey matter in multiple sclerosis
Menno Schoonheim (Speaker)
7 Jul 2021Activity: Talk or presentation › Invited talk
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MRI-pathological correlation in Multiple Sclerosis
Menno Schoonheim (Speaker)
28 Jan 2020Activity: Talk or presentation › Invited talk
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Translational Neuroscience Network (TN2)
Menno Schoonheim (Organiser), Jeroen Hoozemans (Organiser), Micha Wilhelmus (Organiser), Matthijs C. Brouwer (Organiser), Hugo Vrenken (Organiser) & Arjen Brussaard (Organiser)
20 Nov 2020Activity: Participating in or organising an event › Organising a conference, workshop, ...
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MRI & Cognitive Decline
Menno Schoonheim (Speaker)
4 Dec 2020Activity: Talk or presentation › Invited talk
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Cognitive impairment and the network collapse in multiple sclerosis
Menno Schoonheim (Speaker)
16 Jan 2020Activity: Talk or presentation › Invited talk
Press / Media
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Een verstoorde hersenfunctie komt vaker voor bij mensen die harder achteruit gaan
01/11/2019
1 Media contribution
Press/Media: Public Engagement Activities
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MS bestuderen als netwerkziekte
18/04/2019
1 Media contribution
Press/Media: Public Engagement Activities
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‘Een verstoorde hersenfunctie komt vaker voor bij mensen die harder achteruit gaan’
02/03/2019
1 Media contribution
Press/Media: Public Engagement Activities
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Nationale MS dag: Nieuwe ontwikkelingen in neurowetenschappen
18/11/2018
1 Media contribution
Press/Media: Public Engagement Activities
Prizes
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Best presentation of a young scientific investigator
Schoonheim, Menno (Recipient), 22 Oct 2011
Prize: Honorary award
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Radiology: Editor's recognition award for reviewing with special distinction
Schoonheim, Menno (Recipient), 1 Dec 2019
Prize: Honorary award
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Radiology: Editor's recognition award for reviewing with special distinction
Schoonheim, Menno (Recipient), 1 Dec 2018
Prize: Honorary award
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