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Personal profile

Research interests

My research line focuses on providing a better understanding of clinical progression in multiple sclerosis (MS). MS is actually a network disorder, as the progressive formation of white matter lesions leads to a disconnection of axonal bundles and hence a disruption of the brain network, in turn leading to extensive neurodegeneration of network hubs like the thalamus. As such, my main focus is on understanding how alterations to (functional and structural) brain networks relate to complex symptoms such as cognitive dysfunction, how networks change during progression, and which patterns are predictive of decline. Apart from such a mechanistic approach to study the brain, my aim is also to provide the neuro(radio)logist advanced imaging markers that can be used in clinic, such as atrophy of the thalamus. In addition to MS, I also investigate similar network-focused mechanisms of progression in Parkinson's disease, as well as psychiatric disorders such as the effects of childhood trauma and stress.

Key words: Clinical progression, multiple sclerosis, brain network, connectivity, functional MRI, magnetoencephalography, diffusion tensor imaging, atrophy, cognition, Parkinson's disease.

Specialisation

I am mainly specialized in network neuroscience in multiple sclerosis (MS), using advanced imaging methods to study clinical progression. Imaging tools I use to study brain networks and connectivity are based on functional MRI, magnetoencephalography, diffusion tensor imaging and atrophy measures. Apart from MS, I also study these same aspects in Parkinson disease.

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Research Output

Network collapse and cognitive impairment in multiple sclerosis

Schoonheim, M. M., Meijer, K. A. & Geurts, J. J. G., 2015, In : Frontiers in Neurology. 6, 82.

Research output: Contribution to journalArticleAcademicpeer-review

Thalamus structure and function determine severity of cognitive impairment in multiple sclerosis

Schoonheim, M. M., Hulst, H. E., Brandt, R. B., Strik, M., Wink, A. M., Uitdehaag, B. M. J., Barkhof, F. & Geurts, J. J. G., 24 Feb 2015, In : Neurology. 84, 8, p. 776-83 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Reduced Network Dynamics on Functional MRI Signals Cognitive Impairment in Multiple Sclerosis

Eijlers, A. J. C., Wink, A. M., Meijer, K. A., Douw, L., Geurts, J. J. G. & Schoonheim, M. M., 1 Jan 2019, In : Radiology. 292, 2, p. 449-457 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Staging of cortical and deep grey matter functional connectivity changes in multiple sclerosis

Meijer, K. A., Eijlers, A. J. C., Geurts, J. J. G. & Schoonheim, M. M., 1 Feb 2018, In : Journal of Neurology, Neurosurgery and Psychiatry. 89, 2, p. 205-210 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Activities

Cognitive impairment and the network collapse in multiple sclerosis

Menno Schoonheim (Speaker)
16 Jan 2020

Activity: Talk or presentationInvited talk

Een netwerkperspectief op klinische progressie bij MS

Menno Schoonheim (Speaker)
16 Jan 2020

Activity: Talk or presentationInvited talk

Functional imaging

Menno Schoonheim (Speaker)
23 Jun 2020

Activity: Talk or presentationInvited talk

MRI-pathological correlation in Multiple Sclerosis

Menno Schoonheim (Speaker)
28 Jan 2020

Activity: Talk or presentationInvited talk

Long-range connections and cognition in MS

Menno Schoonheim (Speaker)
12 Nov 2020

Activity: Talk or presentationInvited talk

Press / Media

Een verstoorde hersenfunctie komt vaker voor bij mensen die harder achteruit gaan

Menno Schoonheim

01/11/2019

1 Media contribution

Press/Media: Public Engagement Activities

Natalizumab

Menno Schoonheim

01/07/2019

1 Media contribution

Press/Media: Interview

MS bestuderen als netwerkziekte

Menno Schoonheim

18/04/2019

1 Media contribution

Press/Media: Public Engagement Activities

‘Een verstoorde hersenfunctie komt vaker voor bij mensen die harder achteruit gaan’

Menno Schoonheim

02/03/2019

1 Media contribution

Press/Media: Public Engagement Activities

Nationale MS dag: Nieuwe ontwikkelingen in neurowetenschappen

MM Schoonheim

18/11/2018

1 Media contribution

Press/Media: Public Engagement Activities