Micha Wilhelmus

DR.

20022019
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Research Output 2002 2019

  • 49 Article
  • 3 Review article
  • 2 Research VU University Amsterdam, graduation VU University Amsterdam
  • 1 Book
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Article
2018
Open Access

Correction: Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis

Chrobok, N. L., Bol, J. G. J. M., Jongenelen, C. A., Brevé, J. J. P., El Alaoui, S., Fidalgo-Lopez, J., Fournet, G., Joseph, B., Wilhelmus, M. M. M., Drukarch, B. & van Dam, A-M., 2018, In : PLoS ONE. 13, 12, p. e0209522

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Development of fluorine-18 labeled peptidic PET tracers for imaging active tissue transglutaminase

van der Wildt, B., Wilhelmus, M. M. M., Kooijman, E. J. M., Jongenelen, C. A. M., Schuit, R. C., Büchold, C., Pasternack, R., Lammertsma, A. A., Drukarch, B. & Windhorst, A. D., 1 Jan 2017, In : Nuclear Medicine and Biology. 44, p. 90-104 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of a single, oral 60 mg caffeine dose on attention in healthy adult subjects

Wilhelmus, M. M. M., Hay, J. L., Zuiker, R. G. J. A., Okkerse, P., Perdrieu, C., Sauser, J., Beaumont, M., Schmitt, J., Van Gerven, J. M. A. & Silber, B. Y., 1 Feb 2017, In : Journal of Psychopharmacology. 31, 2, p. 222-232 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats

Bedussi, B., Naessens, D. M. P., de Vos-Geelen, J., Olde Engberink, R., Wilhelmus, M. M. M., Richard, E., Ten Hove, M., Vanbavel, E. & Bakker, E. N. T. P., 1 Dec 2017, In : Scientific Reports. 7, 1, 744.

Research output: Contribution to journalArticleAcademicpeer-review

Monocyte behaviour and tissue transglutaminase expression during experimental autoimmune encephalomyelitis in transgenic CX3CR1gfp/gfp mice

Chrobok, N. L., Jaouen, A., Fenrich, K. K., Bol, J. G. J. M., Wilhelmus, M. M. M., Drukarch, B., Debarbieux, F. & van Dam, A. M., 1 Mar 2017, In : Amino Acids. 49, 3, p. 643-658 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Monocyte-derived tissue transglutaminase in multiple sclerosis patients: reflecting an anti-inflammatory status and function of the cells?

Sestito, C., Brevé, J. J. P., van Eggermond, M. C. J. A., Killestein, J., Teunissen, C. E., van Rossum, J., Wilhelmus, M. M. M., Drukarch, B., van den Elsen, P. J. & van Dam, A-M., 21 Dec 2017, In : Journal of Neuroinflammation. 14, 1, p. 257

Research output: Contribution to journalArticleAcademicpeer-review

2016

Catalytically active tissue transglutaminase colocalises with Aβ pathology in Alzheimer's disease mouse models

Wilhelmus, M. M. M., De Jager, M., Smit, A. B., Van Der Loo, R. J. & Drukarch, B., 3 Feb 2016, In : Scientific Reports. 6, 20569.

Research output: Contribution to journalArticleAcademicpeer-review

Development of carbon-11 labeled acryl amides for selective PET imaging of active tissue transglutaminase

van der Wildt, B., Wilhelmus, M. M. M., Bijkerk, J., Haveman, L. Y. F., Kooijman, E. J. M., Schuit, R. C., Bol, J. G. J. M., Jongenelen, C. A. M., Lammertsma, A. A., Drukarch, B. & Windhorst, A. D., Apr 2016, In : Nuclear Medicine and Biology. 43, 4, p. 232-242

Research output: Contribution to journalArticleAcademicpeer-review

2015

Eiwitvouwing

van 't Hoog, A. & Wilhelmus, M. M. M., 2015, In : Chemische Feitelijkheden. 77, 314.

Research output: Contribution to journalArticleProfessional

Tissue Transglutaminase contributes to experimental multiple sclerosis pathogenesis and clinical outcome by promoting macrophage migration

van Strien, M. E., de Vries, H. E., Chrobok, N. L., Bol, J. G. J. M., Breve, J. J. P., van der Pol, S. M. P., Kooij, G., van Buul, J. D., Karpuj, M., Steinman, L., Wilhelmus, M. M., Sestito, C., Drukarch, B. & Van Dam, A-M., Nov 2015, In : Brain Behavior and Immunity. 50, p. 141-154 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Interplay Between Age, Cerebral Small Vessel Disease, Parenchymal Amyloid-beta, and Tau Pathology: Longitudinal Studies in Hypertensive Stroke-Prone Rats

Schreiber, S., Drukarch, B., Garz, C., Niklass, S., Stanaszek, L., Kropf, S., Bueche, C., Held, F., Vielhaber, S., Attems, J., Reymann, K. G., Heinze, H. J., Carare, R. O. & Wilhelmus, M. M. M., 2014, In : Journal of Alzheimer's Disease. 42, Suppl. 3, p. S205-S215

Research output: Contribution to journalArticleAcademicpeer-review

Tissue Transglutaminase in Alzheimer's Disease: Involvement in Pathogenesis and its Potential as a Therapeutic Target

Wilhelmus, M. M. M., Jager, M., Bakker, E. N. T. P. & Drukarch, B., 2014, In : Journal of Alzheimer's Disease. 42, Suppl. 3, p. S289-S303

Research output: Contribution to journalArticleAcademicpeer-review

Tissue transglutaminase is a biochemical marker for Alzheimer's disease

Wilhelmus, M. M. M. & Drukarch, B., 2014, In : Neurobiology of Aging. 35, 4, p. E3-E4

Research output: Contribution to journalArticleAcademicpeer-review

Tissue transglutaminase colocalizes with extracellular matrix proteins in cerebral amyloid angiopathy

de Jager, A. M., van der Wildt, B., Schul, E., Bol, J. G. J. M., van Duinen, S. G., Drukarch, B. & Wilhelmus, M. M. M., 2013, In : Neurobiology of Aging. 34, 4, p. 1159-1169

Research output: Contribution to journalArticleAcademicpeer-review

2012

Het bloedvat jong houden. Dat is wat we willen

Wilhelmus, M. M. M., 2012, In : Alzheimer Actueel. 2012, 3, p. 3-4

Research output: Contribution to journalArticleProfessional

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

Wilhelmus, M. M. M., Nijland, P. G., Drukarch, B., de Vries, H. E. & van Horssen, J., 2012, In : Free Radical Biology and Medicine. 53, 4, p. 983-992

Research output: Contribution to journalArticleAcademicpeer-review

Tissue Transglutaminase: A Novel Therapeutic Target in Cerebral Amyloid Angiopathy

Wilhelmus, M. M. M., Jager, M. & Drukarch, B., 2012, In : Neurodegenerative Diseases. 10, 1-4, p. 317-319

Research output: Contribution to journalArticleAcademicpeer-review

Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies

Wilhelmus, M. M. M., de Jager, A. M., Rozemuller, J. M., Breve, J. J. P., Bol, J. G. J. M., Eckert, R. L. & Drukarch, B., 2012, In : Journal of Pathology. 226, 1, p. 132-142

Research output: Contribution to journalArticleAcademicpeer-review

Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease

Verhaar, R., Jongenelen, C. A. M., Gerard, M., Baekelandt, V., Van Dam, A-M., Wilhelmus, M. M. M. & Drukarch, B., Jun 2011, In : Neurochemistry International. 58, 7, p. 785-793 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hyperactief enzym lijkt Alzheimer te veroorzaken

Wilhelmus, M. M. M., 2011, In : Hersen Magazine. 9, p. 6-7

Research output: Contribution to journalArticlePopular

Novel role of transglutaminase 1 in corpora amylacea formation?

Wilhelmus, M. M. M., Verhaar, R., Bol, J. G. J. M., van Dam, A-M., Hoozemans, J. J. M., Rozemuller, A. J. M. & Drukarch, B., 2011, In : Neurobiology of Aging. 32, 5, p. 845-856 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Presence of Tissue Transglutaminase in Granular Endoplasmic Reticulum is Characteristic of Melanized Neurons in Parkinson's Disease Brain

Wilhelmus, M. M., Verhaar, R., Andringa, G., Bol, J. G. J. M., Cras, P., Shan, L., Hoozemans, J. J. & Drukarch, B., 2011, In : Brain Pathology. 21, 2, p. 130-139 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2010

Apolipoprotein E protects cultured pericytes and astrocytes from D-A beta(1-40)-mediated cell death

Bruinsma, I. B., Wilhelmus, M. M. M., Kox, M., Veerhuis, R., de Waal, R. M. W. & Verbeek, M. M., 2010, In : Brain Research. 1315, p. 169-180

Research output: Contribution to journalArticleAcademicpeer-review

Tissue Transglutaminase Locates to ER in Parkinson's Disease: A Novel Mechanism Linking Neuronal Stress to Protein Aggregation?

Wilhelmus, M., Verhaar, R., Bol, J., Jongenelen, C., Andringa, G., Cras, P., Hoozemans, J. & Drukarch, B., 15 Sep 2010, In : Movement Disorders. 25, p. S630-S630

Research output: Contribution to journalArticleAcademicpeer-review

2009

Amyloid beta induces cellular relocalization and production of agrin and glypican-1

Timmer, N. M., van Horssen, J., Otte-Holler, I., Wilhelmus, M. M. M., David, G., Beers, J., de Waal, R. M. W. & Verbeek, M. M., 2009, In : Brain Research. 1260, p. 38-46

Research output: Contribution to journalArticleAcademicpeer-review

Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesions

Witte, M. E., Bol, J. G. J. M., Gerritsen, W. H., van der Valk, P., Drukarch, B., van Horssen, J. & Wilhelmus, M. M. M., 2009, In : Neurobiology of Disease. 36, 3, p. 445-452

Research output: Contribution to journalArticleAcademicpeer-review

Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion

Wilhelmus, M. M. M., Boelens, W. C., Kox, M., Maat-Schieman, M. L. C., Veerhuis, R., de Waal, R. M. W. & Verbeek, M. M., 2009, In : Neurobiology of Aging. 30, 2, p. 229-240

Research output: Contribution to journalArticleAcademicpeer-review

2008

Tissue transglutaminase modulates alpha-synuclein oligomerization

Segers-Nolten, I. M. J., Wilhelmus, M. M. M., Veldhuis, G., van Rooijen, B. D., Drukarch, B. & Subramaniam, V., 2008, In : Protein Science. 17, 8, p. 1395-1402

Research output: Contribution to journalArticleAcademicpeer-review

2007

Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells

Wilhelmus, M. M. M., Otte-Höller, I., van Triel, J. J. J., Veerhuis, R., Maat-Schieman, M. L. C., Bu, G., de Waal, R. M. W. & Verbeek, M. M., Dec 2007, In : The American Journal of Pathology. 171, 6, p. 1989-99 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2006

Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity

Wilhelmus, M. M. M., Boelens, W. C., Otte-Höller, I., Kamps, B., Kusters, B., Maat-Schieman, M. L. C., de Waal, R. M. W. & Verbeek, M. M., Feb 2006, In : Acta Neuropathologica. 111, 2, p. 139-49 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity

Wilhelmus, M. M. M., Boelens, W. C., Otte-Höller, I., Kamps, B., de Waal, R. M. W. & Verbeek, M. M., 17 May 2006, In : Brain Research. 1089, 1, p. 67-78 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains

Wilhelmus, M. M. M., Otte-Höller, I., Wesseling, P., de Waal, R. M. W., Boelens, W. C. & Verbeek, M. M., Apr 2006, In : Neuropathology and Applied Neurobiology. 32, 2, p. 119-30 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2005

Apolipoprotein E genotype regulates amyloid-beta cytotoxicity

Wilhelmus, M. M. M., Otte-Höller, I., Davis, J., Van Nostrand, W. E., de Waal, R. M. W. & Verbeek, M. M., 6 Apr 2005, In : Journal of Neuroscience. 25, 14, p. 3621-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2002

Collagen XVIII: a novel heparan sulfate proteoglycan associated with vascular amyloid depositions and senile plaques in Alzheimer's disease brains

van Horssen, J., Wilhelmus, M. M. M., Heljasvaara, R., Pihlajaniemi, T., Wesseling, P., de Waal, R. M. W. & Verbeek, M. M., Oct 2002, In : Brain Pathology. 12, 4, p. 456-62 7 p.

Research output: Contribution to journalArticleAcademicpeer-review