20012019

Research output per year

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Personal profile

Research interests

My lab studies the role of synaptic genes in health and disease. We focus specifically on genes that regulate neurotransmitter release, a key determinant of information processing in the brain. Defects in these genes are associated with SNAREopathies, a special class of brain disorders, which include epilepsy and neurodevelopmental disorders such as autism spectrum disorder, intellectual disability, and schizophrenia. For several years we have been studying cellular phenotypes of these genes in mouse models, using single-cell patch-clamp electrophysiology, to assess synaptic function with high resolution. Recently, we have been using human stem-cell derived neurons to employ the same techniques to measure synaptic (dis)function in nerve cells of patients.  To speed up this type of analyses, we are developing brain-on-chip approaches in collaboration with Twente University. In our research we closely collaborate with clinical geneticists, paediatricians, and medical statisticians to link genetic defects, to cellular phenotypes and behaviour in the same patients. With this approach we  aim at contributing to initiatives towards personalized medicine.   

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Research Output

Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner

Huson, V., van Boven, M. A., Stuefer, A., Verhage, M. & Cornelisse, L. N., 1 Dec 2019, In : Scientific Reports. 9, 1, p. 11341

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy

Kovačević, J., Maroteaux, G., Schut, D., Loos, M., Dubey, M., Pitsch, J., Remmelink, E., Koopmans, B., Crowley, J., Cornelisse, L. N., Sullivan, P. F., Schoch, S., Toonen, R. F., Stiedl, O. & Verhage, M., 2018, In : Brain. 141, 5, p. 1350-1374

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.

Schotten, S., Meijer, M., Walter, A. M., Huson, V. W. J., Mamer, L., Kalogreades, L., Veer, M. T., Ruiter, M., Brose, N., Rosenmund, C., Sorensen, J. B., Verhage, M. & Cornelisse, L. N., 2015, In : eLife. 4, e05531.

Research output: Contribution to journalArticleAcademicpeer-review

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

Meijer, M., Rehbach, K., Brunner, J. W., Classen, J. A., Lammertse, H. C. A., van Linge, L. A., Schut, D., Krutenko, T., Hebisch, M., Cornelisse, L. N., Sullivan, P. F., Peitz, M., Toonen, R. F., Brüstle, O. & Verhage, M., 14 May 2019, In : Cell Reports. 27, 7, p. 2199-2211.e6

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., Hussain, N. K., Imig, C., de Jong, A. P. H., Jung, H., Kohansalnodehi, M., Kramarz, B., Lipstein, N., Lovering, R. C., MacGillavry, H., Mariano, V. & 53 others, Mi, H., Ninov, M., Osumi-Sutherland, D., Pielot, R., Smalla, K-H., Tang, H., Tashman, K., Toonen, R. F. G., Verpelli, C., Reig-Viader, R., Watanabe, K., van Weering, J., Achsel, T., Ashrafi, G., Asi, N., Brown, T. C., de Camilli, P., Feuermann, M., Foulger, R. E., Gaudet, P., Joglekar, A., Kanellopoulos, A., Malenka, R., Nicoll, R. A., Pulido, C., de Juan-Sanz, J., Sheng, M., Südhof, T. C., Tilgner, H. U., Bagni, C., Bayés, À., Biederer, T., Brose, N., Chua, J. J. E., Dieterich, D. C., Gundelfinger, E. D., Hoogenraad, C., Huganir, R. L., Jahn, R., Kaeser, P. S., Kim, E., Kreutz, M. R., McPherson, P. S., Neale, B. M., O'Connor, V., Posthuma, D., Ryan, T. A., Sala, C., Feng, G., Hyman, S. E., Thomas, P. D., Smit, A. B. & Verhage, M., 17 Jul 2019, In : Neuron. 103, 2, p. 217-234.e4

Research output: Contribution to journalArticleAcademicpeer-review