Niels van Royen

PROF.DR.

20102019
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Research Output 2010 2019

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2019

ACRA Perfusion Study

van Leeuwen, M. A. H., van der Heijden, D. J., Hollander, M. R., Mulder, M. J., van de Ven, P. M., Ritt, M. J. P. F., Kiemeneij, F., van Mieghem, N. M. & van Royen, N., 2019, In : Circulation. Cardiovascular interventions. 12, 4, p. e007641

Research output: Contribution to journalArticleAcademicpeer-review

Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment

Sen, S., Ahmad, Y., Dehbi, H-M., Howard, J. P., Iglesias, J. F., Al-Lamee, R., Petraco, R., Nijjer, S., Bhindi, R., Lehman, S., Walters, D., Sapontis, J., Janssens, L., Vrints, C. J., Khashaba, A., Laine, M., van Belle, E., Krackhardt, F., Bojara, W., Going, O. & 41 othersHärle, T., Indolfi, C., Niccoli, G., Ribichini, F., Tanaka, N., Yokoi, H., Takashima, H., Kikuta, Y., Erglis, A., Vinhas, H., Silva, P. C., Baptista, S. R. B., Alghamdi, A., Hellig, F., Koo, B-K., Nam, C-W., Shin, E-S., Doh, J-H., Brugaletta, S., Alegria-Barrero, E., Meuwissen, M., Piek, J. J., van Royen, N., Sezer, M., di Mario, C., Gerber, R. T., Malik, I. S., Sharp, A. S. P., Talwar, S., Tang, K., Samady, H., Altman, J., Seto, A. H., Singh, J., Jeremias, A., Matsuo, H., Kharbanda, R. K., Patel, M. R., Serruys, P., Escaned, J. & Davies, J. E., 2019, In : Journal of the American College of Cardiology. 73, 4, p. 444-453

Research output: Contribution to journalArticleAcademicpeer-review

Comprehensive physiological evaluation of epicardial and microvascular coronary domains using vascular conductance and zero flow pressure

van der Hoeven, N. W., de Waard, G. A., Quirós, A., De Hoyos, A., Broyd, C., Nijjer, S. S., van de Hoef, T. P., Petraco, R., Driessen, R. S., Mejía-Rentería, H., Kikuta, Y., Echavarría Pinto, M., van de Ven, P. M., Meuwissen, M., Knaapen, P., Piek, J. J., Davies, J. E., van Royen, N. & Escaned, J., 8 Feb 2019, In : EuroIntervention. 14, 15, p. e1593-e1600

Research output: Contribution to journalArticleAcademicpeer-review

Coronary angiography after cardiac arrest without ST-segment elevation

Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R. M., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., Beishuizen, A., Stoel, M., Camaro, C. & 18 othersvan der Hoeven, H., Henriques, J. P., Vlaar, A. P. J., Vink, M. A., van den Bogaard, B., Heestermans, T. A. C. M., de Ruijter, W., Delnoij, T. S. R., Crijns, H. J. G. M., Jessurun, G. A. J., Oemrawsingh, P. V., Gosselink, M. T. M., Plomp, K., Magro, M., Elbers, P. W. G., van de Ven, P. M., Oudemansvan Straaten, H. M. & van Royen, N., 2019, In : New England Journal of Medicine. 380, 15, p. 1397-1407

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Coronary Microcirculation Downstream Non-Infarct-Related Arteries in the Subacute Phase of Myocardial Infarction: Implications for Physiology-Guided Revascularization

Mejía-Rentería, H., Lee, J. M., van der Hoeven, N. W., Gonzalo, N., Jiménez-Quevedo, P., Nombela-Franco, L., Núñez-Gil, I. J., Salinas, P., del Trigo, M., Cerrato, E., van Royen, N., Knaapen, P., Koo, B-K., Macaya, C., Fernández-Ortiz, A. & Escaned, J., 2019, In : Journal of the American Heart Association. 8, 9, p. e011534

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Diastolic-systolic velocity ratio to detect coronary stenoses under physiological resting conditions: A mechanistic study

de Waard, G. A., Broyd, C. J., Cook, C. M., van der Hoeven, N. W., Petraco, R., Nijjer, S. S., van de Hoef, T. P., Echavarria-Pinto, M., Meuwissen, M., Sen, S., Knaapen, P., Escaned, J., Piek, J. J., van Royen, N. & Davies, J. E., 2019, In : Open Heart. 6, 1, e000968.

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of Microvascular Injury in Revascularized Patients with ST Elevation Myocardial Infarction Treated with Ticagrelor versus Prasugrel: The REDUCE-MVI Trial

van Leeuwen, M. A. H., van der Hoeven, N. W., Janssens, G. N., Everaars, H., Nap, A., Lemkes, J. S., de Waard, G. A., van de Ven, P. M., van Rossum, A. C., ten Cate, T. J. F., Piek, J. J., von Birgelen, C., Escaned, J., Valgimigli, M., Diletti, R., Riksen, N. P., van Mieghem, N. M., Nijveldt, R. & van Royen, N., 2019, In : Circulation. 139, 5, p. 636-646

Research output: Contribution to journalArticleAcademicpeer-review

Paclitaxel-eluting balloon versus everolimus-eluting stent in patients with diabetes mellitus and in-stent restenosis: Insights from the randomized DARE trial

Claessen, B. E., Henriques, J. P. S., Vendrik, J., Boerlage-van Dijk, K., van der Schaaf, R. J., Meuwissen, M., van Royen, N., Gosselink, A. T. M., van Wely, M. H., Dirkali, A., Arkenbout, E. K., Piek, J. J. & Baan, J., 1 Feb 2019, In : Catheterization and Cardiovascular Interventions. 93, 2, p. 216-221 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Temporal Changes in Coronary Hyperemic and Resting Hemodynamic Indices in Nonculprit Vessels of Patients With ST-Segment Elevation Myocardial Infarction

van der Hoeven, N. W., Janssens, G. N., de Waard, G. A., Everaars, H., Broyd, C. J., Beijnink, C. W. H., van de Ven, P. M., Nijveldt, R., Cook, C. M., Petraco, R., Ten Cate, T., von Birgelen, C., Escaned, J., Davies, J. E., van Leeuwen, M. A. H. & van Royen, N., 3 Jul 2019, In : JAMA cardiology.

Research output: Contribution to journalArticleAcademicpeer-review

Therapeutic application of contrast ultrasound in ST elevation myocardial infarction: Role in coronary thrombosis and microvascular obstruction

Slikkerveer, J., Juffermans, L. J., van Royen, N., Appelman, Y., Porter, T. R. & Kamp, O., Feb 2019, In : European heart journal. Acute cardiovascular care. 8, 1, p. 45-53 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The ventricular fibrillation waveform in relation to shock success in early vs. late phases of out-of-hospital resuscitation

Thannhauser, J., Nas, J., van Grunsven, P. M., Meinsma, G., Zwart, H. J., de Boer, M. J., van Royen, N., Bonnes, J. L. & Brouwer, M. A., 2019, In : Resuscitation. 139, p. 99-105

Research output: Contribution to journalArticleAcademicpeer-review

2018

A Randomized Comparison of Paclitaxel-Eluting Balloon Versus Everolimus-Eluting Stent for the Treatment of Any In-Stent Restenosis: The DARE Trial

Baan, J., Claessen, B. E., Dijk, K. B., Vendrik, J., van der Schaaf, R. J., Meuwissen, M., van Royen, N., Gosselink, A. T. M., van Wely, M. H., Dirkali, A., Arkenbout, E. K., de Winter, R. J., Koch, K. T., Sjauw, K. D., Beijk, M. A., Vis, M. M., Wykrzykowska, J. J., Piek, J. J., Tijssen, J. G. P. & Henriques, J. P. S., 2018, In : JACC: Cardiovascular Interventions. 11, 3, p. 287-297

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Doppler Versus Thermodilution-Derived Coronary Microvascular Resistance to Predict Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarction or Stable Angina Pectoris

Williams, R. P., de Waard, G. A., De Silva, K., Lumley, M., Asrress, K., Arri, S., Ellis, H., Mir, A., Clapp, B., Chiribiri, A., Plein, S., Teunissen, P. F., Hollander, M. R., Marber, M., Redwood, S., van Royen, N. & Perera, D., 2 Jan 2018, In : American Journal of Cardiology. 121, 1, p. 1-8

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of Plaque Burden and Morphology on Myocardial Blood Flow and Fractional Flow Reserve

Driessen, R. S., Stuijfzand, W. J., Raijmakers, P. G., Danad, I., Min, J. K., Leipsic, J. A., Ahmadi, A., Narula, J., van de Ven, P. M., Huisman, M. C., Lammertsma, A. A., van Rossum, A. C., van Royen, N. & Knaapen, P., 6 Feb 2018, In : Journal of the American College of Cardiology. 71, 5, p. 499-509 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Ticagrelor, Prasugrel, or Clopidogrel on Endothelial Function and Other Vascular Biomarkers: A Randomized Crossover Study

HI-TECH Investigators, 2018, In : JACC: Cardiovascular Interventions. 11, 16, p. 1576-1586 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Elevated monocyte-specific type I interferon signalling correlates positively with cardiac healing in myocardial infarct patients but interferon alpha application deteriorates myocardial healing in rats

Ter Horst, E. N., Krijnen, P. A. J., Hakimzadeh, N., Robbers, L. F. H. J., Hirsch, A., Nijveldt, R., Lommerse, I., Fontijn, R. D., Meinster, E., Delewi, R., van Royen, N., Zijlstra, F., van Rossum, A. C., van der Schoot, C. E., van der Pouw Kraan, T. C. T. M., Horrevoets, A. J., van der Laan, A. M., Niessen, H. W. M. & Piek, J. J., 12 Nov 2018, In : Basic Research in Cardiology. 114, 1, p. 1

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hyperaemic microvascular resistance predicts clinical outcome and microvascular injury after myocardial infarction

de Waard, G. A., Fahrni, G., de Wit, D., Kitabata, H., Williams, R., Patel, N., Teunissen, P. F., van de Ven, P. M., Umman, S., Knaapen, P., Perera, D., Akasaka, T., Sezer, M., Kharbanda, R. K. & van Royen, N., 1 Jan 2018, In : Heart. 104, 2, p. 127-134 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Impact of sheath size and hemostasis time on radial artery patency after transradial coronary angiography and intervention in Japanese and non-Japanese patients: A substudy from RAP and BEAT (Radial Artery Patency and Bleeding, Efficacy, Adverse evenT) randomized multicenter trial

Aminian, A., Saito, S., Takahashi, A., Bernat, I., Jobe, R. L., Kajiya, T., Gilchrist, I. C., Louvard, Y., Kiemeneij, F., van Royen, N., van Leeuwen, M., Yamazaki, S., Matsukage, T., Iglesias, J. F. & Rao, S. V., 2018, In : Catheterization and Cardiovascular Interventions. 92, 5, p. 844-851

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Influence of Microcirculatory Dysfunction on Angiography-Based Functional Assessment of Coronary Stenoses

Mejía-Rentería, H., Lee, J. M., Lauri, F., van der Hoeven, N. W., de Waard, G. A., Macaya, F., Pérez-Vizcayno, M. J., Gonzalo, N., Jiménez-Quevedo, P., Nombela-Franco, L., Salinas, P., Núñez-Gil, I., del Trigo, M., Goto, S., Lee, H. J., Liontou, C., Fernández-Ortiz, A., Macaya, C., van Royen, N., Koo, B-K. & 1 othersEscaned, J., 2018, In : JACC: Cardiovascular Interventions. 11, 8, p. 741-753

Research output: Contribution to journalArticleAcademicpeer-review

Long-Term Prognostic Implications of Previous Silent Myocardial Infarction in Patients Presenting With Acute Myocardial Infarction

Amier, R. P., Smulders, M. W., van der Flier, W. M., Bekkers, S. C. A. M., Zweerink, A., Allaart, C. P., Demirkiran, A., Roos, S. T., Teunissen, P. F. A., Appelman, Y., van Royen, N., Kim, R. J., van Rossum, A. C. & Nijveldt, R., 1 Dec 2018, In : JACC. Cardiovascular imaging. 11, 12, p. 1773-1781 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

One-year clinical outcome of early administration of intravenous beta-blockers in patients with ST-segment elevation myocardial infarction before primary percutaneous coronary reperfusion

Roolvink, V., Ottervanger, J. P., Ibáñez, B., Dambrink, J. H., Gosselink, M., Kedhi, E., van Royen, N., Lipsic, E., Remkes, W., Piek, J., Fuster, V. & van't Hof, A., 2018, In : EuroIntervention. 14, 6, p. 688-691

Research output: Contribution to journalArticleAcademicpeer-review

Optical coherence tomography substudy of a prospective multicentre randomised post-market trial to assess the safety and effectiveness of the Firehawk cobalt-chromium coronary stent (rapamycin target-eluting) system for the treatment of atherosclerotic lesions: TARGET All Comers

Baumbach, A., Lansky, A. J., Onuma, Y., Asano, T., Johnson, T., Anderson, R., Kiemeneij, F., Zheng, M., van Royen, N., Slagboom, T., Vlachojannis, G., Xu, B., Serruys, P. W. & Wijns, W., 2018, In : EuroIntervention. 14, 10, p. 1121-1128

Research output: Contribution to journalArticleAcademicpeer-review

Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes

Escaned, J., Ryan, N., Mejía-Rentería, H., Cook, C. M., Dehbi, H-M., Alegria-Barrero, E., Alghamdi, A., Al-Lamee, R., Altman, J., Ambrosia, A., Baptista, S. R. B., Bertilsson, M., Bhindi, R., Birgander, M., Bojara, W., Brugaletta, S., Buller, C., Calais, F., Silva, P. C., Carlsson, J. R. & 68 othersChristiansen, E. H., Danielewicz, M., di Mario, C., Doh, J-H., Erglis, A., Erlinge, D., Gerber, R. T., Going, O., Gudmundsdottir, I., Härle, T., Hauer, D., Hellig, F., Indolfi, C., Jakobsen, L., Janssens, L., Jensen, J., Jeremias, A., Kåregren, A., Karlsson, A-C., Kharbanda, R. K., Khashaba, A., Kikuta, Y., Krackhardt, F., Koo, B-K., Koul, S., Laine, M., Lehman, S. J., Lindroos, P., Malik, I. S., Maeng, M., Matsuo, H., Meuwissen, M., Nam, C-W., Niccoli, G., Nijjer, S. S., Olsson, H., Olsson, S-E., Omerovic, E., Panayi, G., Petraco, R., Piek, J. J., Ribichini, F., Samady, H., Samuels, B., Sandhall, L., Sapontis, J., Sen, S., Seto, A. H., Sezer, M., Sharp, A. S. P., Shin, E-S., Singh, J., Takashima, H., Talwar, S., Tanaka, N., Tang, K., van Belle, E., van Royen, N., Varenhorst, C., Vinhas, H., Vrints, C. J., Walters, D., Yokoi, H., Fröbert, O., Patel, M. R., Serruys, P., Davies, J. E. & Götberg, M., 2018, In : JACC: Cardiovascular Interventions. 11, 15, p. 1437-1449

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Strain analysis is superior to wall thickening in discriminating between infarcted myocardium with and without microvascular obstruction

Everaars, H., Robbers, L. F. H. J., Götte, M., Croisille, P., Hirsch, A., Teunissen, P. F. A., van de Ven, P. M., van Royen, N., Zijlstra, F., Piek, J. J., van Rossum, A. C. & Nijveldt, R., 1 Dec 2018, In : European Radiology. 28, 12, p. 5171-5181 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable polymer coronary stent (TARGET All Comers): a multicentre, open-label, randomised non-inferiority trial

TARGET All Comers Investigators, 2018, In : The Lancet. 392, 10153, p. 1117-1126

Research output: Contribution to journalArticleAcademicpeer-review

Timing of revascularization in patients with transient ST-segment elevation myocardial infarction: a randomized clinical trial

Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., van de Ven, P. M., Marques, K. M. J., Nap, A., van Leeuwen, M. A. H., Appelman, Y. E. A., Knaapen, P., Verouden, N. J. W., Allaart, C. P., Brinckman, S. L., Saraber, C. E., Plomp, K. J., Timmer, J. R., Kedhi, E., Hermanides, R. S., Meuwissen, M., Schaap, J., van der Weerdt, A. P. & 3 othersvan Rossum, A. C., Nijveldt, R. & van Royen, N., 26 Oct 2018, In : European Heart Journal. 40, 3, p. 283-291 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Bivalirudin infusion to reduce ventricular infarction: the open-label, randomised Bivalirudin Infusion for Ventricular InfArction Limitation (BIVAL) study

van Geuns, R. J., Sideris, G., Van Royen, N., El Mahmoud, R., Diletti, R., Bal Dit Sollier, C., Garot, J., Van Der Hoeven, N. W., Cortese, B., Ding, L., Lechthaler, I., Deliargyris, E. N., Anthopoulos, P. & Drouet, L., 4 Aug 2017, In : EuroIntervention. 13, 5, p. e540-e548

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of Coronary CT Angiography, SPECT, PET, and Hybrid Imaging for Diagnosis of Ischemic Heart Disease Determined by Fractional Flow Reserve

Danad, I., Raijmakers, P. G., Driessen, R. S., Leipsic, J., Raju, R., Naoum, C., Knuuti, J., Mäki, M., Underwood, R. S., Min, J. K., Elmore, K., Stuijfzand, W. J., van Royen, N., Tulevski, I. I., Somsen, A. G., Huisman, M. C., van Lingen, A. A., Heymans, M. W., van de Ven, P. M., van Kuijk, C. & 3 othersLammertsma, A. A., van Rossum, A. C. & Knaapen, P., 1 Oct 2017, In : JAMA cardiology. 2, 10, p. 1100-1107 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of successful percutaneous coronary intervention of chronic total occlusions on myocardial perfusion and left ventricular function

Stuijfzand, W. J., Biesbroek, P. S., Raijmakers, P. G., Driessen, R. S., Schumacher, S. P., van Diemen, P., van den Berg, J., Nijveldt, R., Lammertsma, A. A., Walsh, S. J., Hanratty, C. G., Spratt, J. C., van Rossum, A. C., Nap, A., van Royen, N. & Knaapen, P., Jun 2017, In : EuroIntervention. 13, 3, p. 345-354

Research output: Contribution to journalArticleAcademicpeer-review

Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance in Angiographically Intermediate Coronary Stenoses An Analysis Using Doppler-Derived Coronary Flow Measurements

Cook, C. M., Jeremias, A., Petraco, R., Sen, S., Nijjer, S., Shun-Shin, M. J., Ahmad, Y., de Waard, G., van de Hoef, T., Echavarria-Pinto, M., van Lavieren, M., Al Lamee, R., Kikuta, Y., Shiono, Y., Buch, A., Meuwissen, M., Danad, I., Knaapen, P., Maehara, A., Koo, B-K. & 8 othersMintz, G. S., Escaned, J., Stone, G. W., Francis, D. P., Mayet, J., Piek, J. J., van Royen, N. & Davies, J. E., 26 Dec 2017, In : JACC Cardiovascular Interventions. 10, 24, p. 2514-2524

Research output: Contribution to journalArticleAcademicpeer-review

Nonculprit Stenosis Evaluation Using Instantaneous Wave-Free Ratio in Patients With ST-Segment Elevation Myocardial Infarction

Thim, T., Götberg, M., Fröbert, O., Nijveldt, R., van Royen, N., Baptista, S. B., Koul, S., Kellerth, T., Bøtker, H. E., Terkelsen, C. J., Christiansen, E. H., Jakobsen, L., Kristensen, S. D. & Maeng, M., 26 Dec 2017, In : JACC: Cardiovascular Interventions. 10, 24, p. 2528-2535 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Non-invasive assessment of the collateral circulation in the hand: Validation of the Nexfin system and relation to clinical outcome after transradial catheterisation

Hollander, M. R., Van Leeuwen, M. A. H., Van Der Heijden, D. J., Keizer, V. M. N., Van De Ven, P. M., IJsselmuiden, S. J. J., Van Mieghem, N. M., Amoroso, G., Ritt, M. J. P. F., Knaapen, P. & Van Royen, N., 1 Feb 2017, In : EuroIntervention. 12, 14, p. 1773-1781 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Predictors of intramyocardial hemorrhage after reperfused ST-segment elevation myocardial infarction

Amier, R. P., Tijssen, R. Y. G., Teunissen, P. F. A., Fernández-Jiménez, R., Pizarro, G., García-Lunar, I., Bastante, T., van de Ven, P. M., Beek, A. M., Smulders, M. W., Bekkers, S. C. A. M., van Royen, N., Ibanez, B. & Nijveldt, R., 1 Aug 2017, In : Journal of the American Heart Association. 6, 8, e005651.

Research output: Contribution to journalArticleAcademicpeer-review