Paul Knaapen

DR., (Principal Investigator)

20032020

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2003

The perfusable tissue index: A marker of myocardial viability

Knaapen, P., Boellaard, R., Götte, M. J. W., van der Weerdt, A. P., Visser, C. A., Lammertsma, A. A. & Visser, F. C., 1 Jan 2003, In : Journal of Nuclear Cardiology. 10, 6, p. 684-691 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2004

Perfusable tissue index as a potential marker of fibrosis in patients with idiopathic dilated cardiomyopathy

Knaapen, P., Boellaard, R., Götte, M. J. W., Dijkmans, P. A., Van Campen, L. M. C., De Cock, C. C., Luurtsema, G., Visser, C. A., Lammertsma, A. A. & Visser, F. C., 1 Aug 2004, In : Journal of Nuclear Medicine. 45, 8, p. 1299-1304 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Postinjection transmission scanning in myocardial 18F-FDG PET studies using both filtered backprojection and iterative reconstruction

Van Der Weerdt, A. P., Boellaard, R., Knaapen, P., Visser, C. A., Lammertsma, A. A. & Visser, F. C., 1 Feb 2004, In : Journal of Nuclear Medicine. 45, 2, p. 169-175 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2005

Delayed contrast enhancement and perfusable tissue index in hypertrophic cardiomyopathy: Comparison between cardiac MRI and PET

Knaapen, P., Van Dockum, W. G., Bondarenko, O., Kok, W. E. M., Götte, M. J. W., Boellaard, R., Beek, A. M., Visser, C. A., Van Rossum, A. C., Lammertsma, A. A. & Visser, F. C., 1 Dec 2005, In : Journal of Nuclear Medicine. 46, 6, p. 923-929 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Measurement of left ventricular volumes and function with O-15-labeled carbon monoxide gated positron emission tomography: Comparison with magnetic resonance imaging

Hofman, H. A., Knaapen, P., Boellaard, R., Bondarenko, O., Götte, M. J. W., van Dockum, W. G., Visser, C. A., van Rossum, A. C., Lammertsma, A. A. & Visser, F. C., 1 Nov 2005, In : Journal of Nuclear Cardiology. 12, 6, p. 639-644 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2006

Does myocardial fibrosis hinder contractile function and perfusion in idiopathic dilated cardiomyopathy? PET and MR imaging study

Knaapen, P., Götte, M. J. W., Paulus, W. J., Zwanenburg, J. J. M., Dijkmans, P. A., Boellaard, R., Marcus, J. T., Twisk, J. W. R., Visser, C. A., Van Rossum, A. C., Lammertsma, A. A. & Visser, F. C., 1 Aug 2006, In : Radiology. 240, 2, p. 380-388 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of basis function and linear least squares methods for generating parametric blood flow images using 15O-water and positron emission tomography

Boellaard, R., Knaapen, P., Rijbroek, A., Luurtsema, G. J. J. & Lammertsma, A. A., 1 Jan 2006, In : Molecular Imaging and Biology. 7, 4, p. 273-285 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Impact of scar on water-perfusable tissue index in chronic ischemic heart disease: Evaluation with PET and contrast-enhanced MRI

Knaapen, P., Bondarenko, O., Beek, A. M., Götte, M. J. W., Boellaard, R., van Weerdt, A. P., Visser, C. A., van Rossum, A. C., Lammertsma, A. A. & Visser, F. C., 1 Jul 2006, In : Molecular Imaging and Biology. 8, 4, p. 245-251 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2007

Hyperaemic microvascular resistance is not increased in viable myocardium after chronic myocardial infarction

Marques, K. M., Knaapen, P., Boellaard, R., Westerhof, N., Lammertsma, A. A., Visser, C. A. & Visser, F. C., 1 Oct 2007, In : European Heart Journal. 28, 19, p. 2320-2325 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microvascular function in viable myocardium after chronic infarction does not influence fractional flow reserve measurements

Marques, K. M., Knaapen, P., Boellaard, R., Lammertsma, A. A., Westerhof, N. & Visser, F. C., 1 Dec 2007, In : Journal of Nuclear Medicine. 48, 12, p. 1987-1992 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2008

Cardiac positron emission tomography: myocardial perfusion and metabolism in clinical practice

Knaapen, P. & Lubberink, J. M., 2008, In : Clinical Research in Cardiology. 97, 11, p. 791-796

Research output: Contribution to journalArticleAcademicpeer-review

Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy

Knaapen, P., Germans, T., Camici, P. G., Rimoldi, O. E., ten Cate, F. J., ten Berg, J. M., Dijkmans, P. A., Boellaard, R., van Dockum, W. G., Gotte, M. J. W., Twisk, J. W. R., van Rossum, A. C., Lammertsma, A. A. & Visser, F. C., 2008, In : American Journal of Physiology. Heart and Circulatory Physiology. 294, 2, p. H986-H993

Research output: Contribution to journalArticleAcademicpeer-review

Mechanical dyssynchrony by 3D echo correlates with acute haemodynamic response to biventricular pacing in heart failure patients

van Dijk, J., Knaapen, P., Rüssel, I. K., Hendriks, T., Allaart, C. P., de Cock, C. C. & Kamp, O., 2008, In : Europace. 10, 1, p. 63-68

Research output: Contribution to journalArticleAcademicpeer-review

Right ventricular dimensions and function in isolated left bundle branch block: is there evidence of biventricular involvement?

van Dijk, J., Knaapen, P., Bekkering, I., Gotte, M. J. W. & Kamp, O., 2008, In : Echocardiography. 25, 5, p. 457-464

Research output: Contribution to journalArticleAcademicpeer-review

Stroke volume measurements with first-pass dynamic positron emission tomography: comparison with cardiovascular magnetic resonance

Knaapen, P., Lubberink, J. M., Rijzewijk, L. J., van der Meer, R. W., Unger, M., Germans, T., Bax, J. J., Smit, J. W. A., Lamb, H. J., van Rossum, A. C., Diamant, M., Visser, F. C. & Lammertsma, A. A., 2008, In : Journal of Nucleair Cardiology. 15, 2, p. 218-224

Research output: Contribution to journalArticleAcademicpeer-review

2009

Coronary microvascular resistance: methods for its quantification in humans

Knaapen, P., Camici, P. G., Marques, K. M. J., Nijveldt, R. J., Bax, J. J., Westerhof, N., Gotte, M. J. W., Jerosch-Herold, M., Schelbert, H. R., Lammertsma, A. A. & van Rossum, A. C., 2009, In : Basic Research in Cardiology. 104, 5, p. 485-498

Research output: Contribution to journalArticleAcademicpeer-review

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Impact of alcohol septal ablation on left anterior descending coronary artery blood flow in hypertrophic obstructive cardiomyopathy

van Dockum, W. G., Knaapen, P., Hofman, M. B. M., Kuijer, J. P. A., ten Cate, F. J., ten Berg, J. M., Beek, A. M., Twisk, J. W. R. & van Rossum, A. C., 2009, In : International Journal of Cardiovascular Imaging. 25, 5, p. 511-518

Research output: Contribution to journalArticleAcademicpeer-review

Infarct size in primary angioplasty without on-site cardiac surgical backup versus transferal to a tertiary center: a single photon emission computed tomography study

Knaapen, P., Mulder, M., van der Zant, F. M., Peels, H. O., Twisk, J. W. R., van Rossum, A. C., Cornel, J. H. & Umans, V. A., 2009, In : European Journal of Nuclear Medicine and Molecular Imaging. 36, 2, p. 237-243

Research output: Contribution to journalArticleAcademicpeer-review

Left ventricular torsion: An expanding role in the analysis of myocardial dysfunction

Russel, I. K., Gotte, M. J. W., Bronzwaer, J. G. F., Knaapen, P., Paulus, W. J. & van Rossum, A. C., 2009, In : JACC Cardiovascular Imaging. 2, 5, p. 648-655

Research output: Contribution to journalArticleAcademicpeer-review

Stroke work or systolic dP/dt(max) to evaluate acute response to cardiac resynchronization therapy: are they interchangeable?

de Roest, G. J., Knaapen, P., Gotte, M. J. W., Hendriks, T., Allaart, C. P., de Cock, C. C. & van Rossum, A. C., 2009, In : European Journal of Heart Failure. 11, 7, p. 706-708

Research output: Contribution to journalArticleAcademicpeer-review

2010

Cardiac PET-CT: advanced hybrid imaging for the detection of coronary artery disease

Knaapen, P., de Haan, S., Hoekstra, O. S., Halbmeijer, R., Appelman, Y. E. A., Groothuis, J. G. J., Comans, E. F. I., Meijerink, M. R., Lammertsma, A. A., Lubberink, J. M., Gotte, M. J. W. & van Rossum, A. C., 2010, In : Netherlands Heart Journal. 18, 2, p. 90-98

Research output: Contribution to journalArticleAcademicpeer-review

Coronary steal: Revealing the diagnosis with quantitative cardiac PET/CT

Heijne, M., Raijmakers, P. G. H. M., Harms, H. J., Lubberink, J. M., Halbmeijer, R., Appelman, Y. E. A. & Knaapen, P., 2010, In : Journal of Nuclear Cardiology. 17, 6, p. 1118-1121

Research output: Contribution to journalArticleAcademicpeer-review

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Determinants of myocardial energetics and efficiency in symptomatic hypertrophic cardiomyopathy

Timmer, S. A. J., Germans, T., Gotte, M. J. W., Rüssel, I. K., Dijkmans, P. A., Lubberink, J. M., ten Berg, J. M., ten Cate, F. J., Lammertsma, A. A., Knaapen, P. & van Rossum, A. C., 2010, In : European Journal of Nuclear Medicine and Molecular Imaging. 37, 4, p. 779-788

Research output: Contribution to journalArticleAcademicpeer-review

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71 Downloads (Pure)

Low-Dose Quantitative Myocardial Blood Flow Imaging Using O-15-Water and PET Without Attenuation Correction

Lubberink, J. M., Harms, H. J., Halbmeijer, R., de Haan, S., Knaapen, P. & Lammertsma, A. A., 2010, In : Journal of Nuclear Medicine. 51, 4, p. 575-580

Research output: Contribution to journalArticleAcademicpeer-review

Magnetic resonance imaging, pacemakers and implantable cardioverter-defibrillators: current situation and clinical perspective

Gotte, M. J. W., Rüssel, I. K., de Roest, G. J., Germans, T., Veldkamp, R. F., Knaapen, P., Allaart, C. P. & van Rossum, A. C., 2010, In : Netherlands Heart Journal. 18, 1, p. 31-37

Research output: Contribution to journalArticleAcademicpeer-review

Potential of [C-11]acetate for measuring myocardial blood flow: Studies in normal subjects and patients with hypertrophic cardiomyopathy

Timmer, S. A. J., Lubberink, J. M., Germans, T., Gotte, M. J. W., ten Berg, J. M., ten Cate, F. J., van Rossum, A. C., Lammertsma, A. A. & Knaapen, P., 2010, In : Journal of Nuclear Cardiology. 17, 2, p. 264-275

Research output: Contribution to journalArticleAcademicpeer-review

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Risk stratification for ventricular arrhythmias in ischaemic cardiomyopathy: the value of non-invasive imaging

de Haan, S., Knaapen, P., Beek, A. M., de Cock, C. C., Lammertsma, A. A., van Rossum, A. C. & Allaart, C. P., 2010, In : Europace. 12, 4, p. 468-474

Research output: Contribution to journalArticleAcademicpeer-review

2011

Automatic generation of absolute myocardial blood flow images using [(15)O]H(2)O and a clinical PET/CT scanner

Harms, H. J., Knaapen, P., de Haan, S., Halbmeijer, R., Lammertsma, A. A. & Lubberink, J. M., 2011, In : European Journal of Nuclear Medicine and Molecular Imaging. 38, 5, p. 930-939

Research output: Contribution to journalArticleAcademicpeer-review

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Carriers of the hypertrophic cardiomyopathy MYBPC3 mutation are characterized by reduced myocardial efficiency in the absence of hypertrophy and microvascular dysfunction

Timmer, S. A. J., Germans, T., Brouwer, W. P., Lubberink, J. M., van der Velden, J., Wilde, A. A. M., Christiaans, I., Lammertsma, A. A., Knaapen, P. & van Rossum, A. C., 2011, In : European Journal of Heart Failure. 13, 12, p. 1283-1289

Research output: Contribution to journalArticleAcademicpeer-review

Effects of alcohol septal ablation on coronary microvascular function and myocardial energetics in hypertrophic obstructive cardiomyopathy

Timmer, S. A. J., Knaapen, P., Germans, T., Dijkmans, P. A., Lubberink, J. M., ten Berg, J. M., ten Cate, F. J., Rüssel, I. K., Gotte, M. J. W., Lammertsma, A. A. & van Rossum, A. C., 2011, In : American Journal of Physiology. Heart and Circulatory Physiology. 301, 1, p. H129-H137

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Pacing Rates on Global and Regional Myocardial Blood Flow

ten Cate, T. J. F., Knaapen, P., Lammertsma, A. A., de Cock, C. C., van Hemel, N. M. & Verzijlbergen, J. F., 2011, In : Pacing and Clinical Electrophysiology. 34, 5, p. 587-592

Research output: Contribution to journalArticleAcademicpeer-review

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62 Downloads (Pure)

Long-term Clinical Outcome and MIBI SPECT Parameters in Percutaneous Coronary Interventions

Mulder, M., van der Zant, F. M., Knaapen, P., Cornel, J. H. & Umans, V. A. W. M., 2011, In : Netherlands Heart Journal. 19, 2, p. 68-72

Research output: Contribution to journalArticleAcademic

Open Access
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60 Downloads (Pure)

Magnetic resonance imaging, pacemakers and implantable cardioverter-defibrillators: current situation and clinical perspective

Gotte, M. J. W., Rüssel, I. K., de Roest, G. J., Germans, T., Veldkamp, R. F., Knaapen, P., Allaart, C. P. & van Rossum, A. C., 2011, In : Netherlands Heart Journal. 19, Supplement, p. 3-9

Research output: Contribution to journalArticleAcademic

Myocardial Oxygen Extraction Fraction Measured Using Bolus Inhalation of (15)O-Oxygen Gas and Dynamic PET

Lubberink, J. M., Wong, Y. Y., Raijmakers, P. G. H. M., Schuit, R. C., Luurtsema, G., Boellaard, R., Knaapen, P., Vonk Noordegraaf, A. & Lammertsma, A. A., 2011, In : Journal of Nuclear Medicine. 52, 1, p. 60-66

Research output: Contribution to journalArticleAcademicpeer-review

Parametric Images of Myocardial Viability Using a Single (15)O-H(2)O PET/CT Scan

Harms, H. J., de Haan, S., Knaapen, P., Allaart, C. P., Lammertsma, A. A. & Lubberink, J. M., 2011, In : Journal of Nuclear Medicine. 52, 5, p. 745-749

Research output: Contribution to journalArticleAcademicpeer-review

Relation of Coronary Microvascular Dysfunction in Hypertrophic Cardiomyopathy to Contractile Dysfunction Independent from Myocardial Injury

Timmer, S. A. J., Germans, T., Gotte, M. J. W., Rüssel, I. K., Lubberink, J. M., ten Berg, J. M., ten Cate, F. J., Lammertsma, A. A., Knaapen, P. & van Rossum, A. C., 2011, In : American Journal of Cardiology. 107, 10, p. 1522-1528

Research output: Contribution to journalArticleAcademicpeer-review

Right Ventricular Energetics in Patients With Hypertrophic Cardiomyopathy and the Effect of Alcohol Septal Ablation

Timmer, S. A. J., Knaapen, P., Germans, T., Lubberink, J. M., Dijkmans, P. A., Vonk Noordegraaf, A., ten Berg, J. M., ten Cate, F. J., Lammertsma, A. A. & van Rossum, A. C., 2011, In : Journal of Cardiac Failure. 17, 10, p. 827-831

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Scar size and characteristics assessed by CMR predict ventricular arrhythmias in ischaemic cardiomyopathy: comparison of previously validated models

de Haan, S., Meijers, T. A., Knaapen, P., Beek, A. M., van Rossum, A. C. & Allaart, C. P., 2011, In : Heart. 97, 23, p. 1951-1956

Research output: Contribution to journalArticleAcademicpeer-review

Supine-exercise-induced oxygen supply to the right myocardium is attenuated in patients with severe idiopathic pulmonary arterial hypertension

Wong, Y. Y., Raijmakers, P. G. H. M., Knaapen, P., Lubberink, J. M., Ruiter, G., Marcus, J. T., Boonstra, A., Lammertsma, A. A., Westerhof, N., van der Laarse, W. J. & Vonk Noordegraaf, A., 2011, In : Heart. 97, 24, p. 2069-2074

Research output: Contribution to journalArticleAcademicpeer-review

2012

Computed tomography to detect acute myocardial infarction

Katinakis, P. A., Knaapen, P., de Gast, M. & Girbes, A. R. J., 1 Feb 2012, In : Netherlands Journal of Critical Care. 16, 1, p. 29-30 2 p.

Research output: Contribution to journalArticleAcademicpeer-review