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Research Output 2000 2019

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2019

Cell Type- and Exposure-Specific Modulation of CD63/CD81-Positive and Tissue Factor-Positive Extracellular Vesicle Release in response to Respiratory Toxicants

Stassen, F. R. M., van Eijck, P. H., Savelkoul, P. H. M., Wouters, E. F. M., Rohde, G. G. U., Briedé, J. J., Reynaert, N. L., de Kok, T. M. & Benedikter, B. J., 2019, In : Oxidative medicine and cellular longevity. 2019, p. 5204218

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles

Benedikter, B. J., Bouwman, F. G., Heinzmann, A. C. A., Vajen, T., Mariman, E. C., Wouters, E. F. M., Savelkoul, P. H. M., Koenen, R. R., Rohde, G. G. U., van Oerle, R., Spronk, H. M. & Stassen, F. R. M., 2019, In : Journal of Extracellular Vesicles. 8, 1, 1585163.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The skin microbiota in patients hospitalized for cellulitis and association with outcome

Cranendonk, D. R., Hugenholtz, F., Prins, J. M., Savelkoul, P. H. M., Budding, A. E., Wiersinga, W. J., Hoepelman, A. I. M., Oosterheert, J. J., van Agtmael, M. A., Branger, J., Brinkman, K., Lauw, F. N., Pijlman, A. H., Sankatsing, S. U. C., Soetekouw, R., Veenstra, J. & de Vries, P. J., 2019, In : Clinical Infectious Diseases. 68, 8, p. 1292-1299

Research output: Contribution to journalArticleAcademicpeer-review

The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study

Koedooder, R., Singer, M., Schoenmakers, S., Savelkoul, P. H. M., Morré, S. A., de Jonge, J. D., Poort, L., Cuypers, W. J. S. S., Beckers, N. G. M., Broekmans, F. J. M., Cohlen, B. J., den Hartog, J. E., Fleischer, K., Lambalk, C. B., Smeenk, J. M. J. S., Budding, A. E. & Laven, J. S. E., 2019, In : Human Reproduction. 34, 6, p. 1042-1054

Research output: Contribution to journalArticleAcademicpeer-review

2018
Open Access

Development of prediction models for upper and lower respiratory and gastrointestinal tract infections using social network parameters in middle-aged and older persons -The Maastricht Study-

BRINKHUES, S., VAN KUIJK, S. M. J., HOEBE, C. J. P. A., SAVELKOUL, P. H. M., KRETZSCHMAR, M. E. E., JANSEN, M. W. J., DE VRIES, N., SEP, S. J. S., DAGNELIE, P. C., SCHAPER, N. C., VERHEY, F. R. J., BOSMA, H., MAES, J., SCHRAM, M. T. & DUKERS-MUIJRERS, N. H. T. M., 1 Apr 2018, In : Epidemiology and Infection. 146, 5, p. 533-543 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of a real-time PCR assay for detection and quantification of bacterial DNA directly in blood of preterm neonates with suspected late-onset sepsis

van den Brand, M., van den Dungen, F. A. M., Bos, M. P., van Weissenbruch, M. M., van Furth, A. M., de Lange, A., Rubenjan, A., Peters, R. P. H. & Savelkoul, P. H. M., 22 Apr 2018, In : Critical Care. 22, 1, 105.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Gut Microbiota and Body Weight in School-Aged Children: The KOALA Birth Cohort Study

Mbakwa, C. A., Hermes, G. D. A., Penders, J., Savelkoul, P. H. M., Thijs, C., Dagnelie, P. C., Mommers, M., Zoetendal, E. G., Smidt, H. & Arts, I. C. W., 2018, In : Obesity. 26, 11, p. 1767-1776

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Safety and immunogenicity of HBAI20 Hepatitis B vaccine in healthy naïve and nonresponding adults

Koc, M., Savelkoul, P. H. M., van Loo, I. H. M., Peeters, A. & Oude Lashof, A. M. L., 2018, In : Journal of Viral Hepatitis. 25, 9, p. 1048-1056

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Social network characteristics are associated with type 2 diabetes complications: The Maastricht study

Brinkhues, S., Dukers-Muijrers, N. H. T. M., Hoebe, C. J. P. A., van der Kallen, C. J. H., Koster, A., Henry, R. M. A., Stehouwer, C. D. A., Savelkoul, P. H. M., Schaper, N. C. & Schram, M. T., 2018, In : Diabetes Care. 41, 8, p. 1654-1662

Research output: Contribution to journalArticleAcademicpeer-review

Social networks in relation to self-reported symptomatic infections in individuals aged 40-75 - the Maastricht study -

Brinkhues, S., Schram, M. T., Hoebe, C. J. P. A., Kretzschmar, M. E. E., Koster, A., Dagnelie, P. C., Sep, S. J. S., van Kuijk, S. M. J., Savelkoul, P. H. M. & Dukers-Muijrers, N. H. T. M., 2018, In : BMC Infectious Diseases. 18, 1, 300.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection

Volgers, C., Grauls, G. E., Hellebrand, P. H. M., Savelkoul, P. H. M. & Stassen, F. R. M., 1 Dec 2017, In : Inflammopharmacology. 25, 6, p. 643-651 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Immunomodulatory role for membrane vesicles released by THP-1 macrophages and respiratory pathogens during macrophage infection

Volgers, C., Benedikter, B. J., Grauls, G. E., Savelkoul, P. H. M. & Stassen, F. R. M., 13 Nov 2017, In : BMC Microbiology. 17, 1, 216.

Research output: Contribution to journalArticleAcademicpeer-review

Interpretation of microbiota-based diagnostics by explaining individual classifier decisions

Eck, A., Zintgraf, L. M., de Groot, E. F. J., de Meij, T. G. J., Cohen, T. S., Savelkoul, P. H. M., Welling, M. & Budding, A. E., 4 Oct 2017, In : BMC Bioinformatics. 18, 1, 441.

Research output: Contribution to journalArticleAcademicpeer-review

Robust microbiota-based diagnostics for inflammatory bowel disease

Eck, A., De Groot, E. F. J., De Meij, T. G. J., Welling, M., Savelkoul, P. H. M. & Budding, A. E., 1 Jun 2017, In : Journal of Clinical Microbiology. 55, 6, p. 1720-1732 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Socially isolated individuals are more prone to have newly diagnosed and prevalent type 2 diabetes mellitus - The Maastricht study - The M

Brinkhues, S., Dukers-Muijrers, N. H. T. M., Hoebe, C. J. P. A., Van Der Kallen, C. J. H., Dagnelie, P. C., Koster, A., Henry, R. M. A., Sep, S. J. S., Schaper, N. C., Stehouwer, C. D. A., Bosma, H., Savelkoul, P. H. M. & Schram, M. T., 19 Dec 2017, In : BMC Public Health. 17, 1, 955.

Research output: Contribution to journalArticleAcademicpeer-review

Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies

Benedikter, B. J., Bouwman, F. G., Vajen, T., Heinzmann, A. C. A., Grauls, G., Mariman, E. C., Wouters, E. F. M., Savelkoul, P. H., Lopez-Iglesias, C., Koenen, R. R., Rohde, G. G. U. & Stassen, F. R. M., 1 Dec 2017, In : Scientific Reports. 7, 1, 15297.

Research output: Contribution to journalArticleAcademicpeer-review

2016

A novel quantitative PCR assay for the detection of Streptococcus pneumoniae using the competence regulator gene target comX

Habets, M. N., Cremers, A. J. H., Bos, M. P., Savelkoul, P., Eleveld, M. J., Meis, J. F., Hermans, P. W. M., Melchers, W. J., de Jonge, M. I. & Diavatopoulos, D. A., Feb 2016, In : Journal of Medical Microbiology. 65, 2, p. 129-36 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

A prospective multicenter evaluation of direct molecular detection of blood stream infection from a clinical perspective

Nieman, A. E., Savelkoul, P. H. M., Beishuizen, A., Henrich, B., Lamik, B., MacKenzie, C. R., Kindgen-Milles, D., Helmers, A., Diaz, C., Sakka, S. G. & Schade, R. P., 30 Jun 2016, In : BMC Infectious Diseases. 16, p. 314

Research output: Contribution to journalArticleAcademicpeer-review

Automated Broad-Range Molecular Detection of Bacteria in Clinical Samples

Budding, A. E., Hoogewerf, M., Vandenbroucke-Grauls, C. M. J. E. & Savelkoul, P. H. M., Apr 2016, In : Journal of Clinical Microbiology. 54, 4, p. 934-43 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Characterization of Microbiota in Children with Chronic Functional Constipation

de Meij, T. G. J., de Groot, E. F. J., Budding, A. E., Kneepkens, C. M. F., Benninga, M. A., van Bodegraven, A. A., Savelkoul, P. H. M. & Eck Hauer, A., 2016, In : PLoS ONE. 11, 10, p. e0164731

Research output: Contribution to journalArticleAcademicpeer-review

Composition and stability of intestinal microbiota of healthy children within a Dutch population

de Meij, T. G. J., Budding, A. E., de Groot, E. F. J., Jansen, F. M., Kneepkens, F., Benninga, M. A., Penders, J., van Bodegraven, A. A. & Savelkoul, P. H. M., Apr 2016, In : FASEB Journal. 30, 4, p. 1512-1522

Research output: Contribution to journalArticleAcademicpeer-review

Detection of the plasmid-mediated colistin-resistance gene mcr-1 in faecal metagenomes of Dutch travellers

von Wintersdorff, C. J. H., Wolffs, P. F. G., van Niekerk, J. M., Beuken, E., van Alphen, L. B., Stobberingh, E. E., Lashof, A. M. L. O., Hoebe, C. J. P. A., Savelkoul, P. H. M. & Penders, J., Dec 2016, In : Journal of Antimicrobial Chemotherapy. 71, 12, p. 3416-3419

Research output: Contribution to journalArticleAcademicpeer-review

Exposure to common respiratory bacteria alters the airway epithelial response to subsequent viral infection

Bellinghausen, C., Gulraiz, F., Heinzmann, A. C. A., Dentener, M. A., Savelkoul, P. H. M., Wouters, E. F. M., Rohde, G. G. U. & Stassen, F. R. M., 3 Jun 2016, In : Respiration Research. 17, 1, p. 68

Research output: Contribution to journalArticleAcademicpeer-review

Inaccurate First-Generation Testosterone Assays Are Influenced by Sex Hormone–Binding Globulin Concentrations

Heijboer, A., Savelkoul, P., Kruit, A., Endert, E. & Blankenstein, MA., Aug 2016, In : the Journal of Applied Laboratory Medicine. 1, 2, p. 194 201 p.

Research output: Contribution to journalArticleAcademicpeer-review

Long-Term Green Tea Supplementation Does Not Change the Human Gut Microbiota

Janssens, P. L. H. R., Penders, J., Hursel, R., Budding, A. E., Savelkoul, P. H. M. & Westerterp-Plantenga, M. S., 2016, In : PLoS ONE. 11, 4, p. e0153134

Research output: Contribution to journalArticleAcademicpeer-review

Prevalence and risk factors for carriage of ESBL-producing Enterobacteriaceae in Amsterdam

Reuland, E. A., Al Naiemi, N., Kaiser, A. M., Heck, M., Kluytmans, J. A. J. W., Savelkoul, P. H. M., Elders, P. J. M. & Vandenbroucke-Grauls, C. M. J. E., Apr 2016, In : Journal of Antimicrobial Chemotherapy. 71, 4, p. 1076-82 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stenotrophomonas maltophilia ventilator-associated pneumonia. A retrospective matched case-control study

Scholte, J. B. J., Zhou, T. L., Bergmans, D. C. J. J., Rohde, G. G. U., Winkens, B., Van Dessel, H. A., Dormans, T. P. J., Linssen, C. F. M., Roekaerts, P. M. H. J., Savelkoul, P. H. M. & van Mook, W. N. K. A., 2016, In : Infectious diseases (London, England). 48, 10, p. 738-43 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Viral-bacterial interactions in the respiratory tract

Bellinghausen, C., Rohde, G. G. U., Savelkoul, P. H. M., Wouters, E. F. M. & Stassen, F. R. M., Dec 2016, In : Journal of General Virology. 97, 12, p. 3089-3102 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Allelic imbalance at the HER2/TOP2A locus in breast cancer

Huijsmans, C. J. J., van den Brule, A. J. C., Rigter, H., Poodt, J., van der Linden, J. C., Savelkoul, P. H. M., Hilbink, M. & Hermans, M. H. A., 2015, In : Diagnostic pathology. 10, 56.

Research output: Contribution to journalArticleAcademicpeer-review

Can the Hydroxyapatite-Coated Skin-Penetrating Abutment for Bone Conduction Hearing Implants Integrate with the Surrounding Skin?

van Hoof, M., Wigren, S., Duimel, H., Savelkoul, P. H. M., Flynn, M. & Stokroos, R. J., 2015, In : Frontiers in surgery. 2, 45.

Research output: Contribution to journalArticleAcademicpeer-review

Diet drives quick changes in the metabolic activity and composition of human gut microbiota in a validated in vitro gut model

Aguirre, M., Eck, A., Koenen, M. E., Savelkoul, P. H. M., Budding, A. E. & Venema, K., 27 Oct 2015, In : Research in Microbiology. 167, 2, p. 114-25 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Dispersion of the HIV-1 Epidemic in Men Who Have Sex with Men in the Netherlands: A Combined Mathematical Model and Phylogenetic Analysis

ATHENA observational cohort, 1 Nov 2015, In : PLoS Medicine. 12, 11, e1001898.

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of an optimal preparation of human standardized fecal inocula for in vitro fermentation studies

Aguirre, M., Eck Hauer, A., Koenen, M. E., Savelkoul, P. H. M., Budding, A. E. & Venema, K., 2015, In : Journal of Microbiological Methods. 117, p. 78-84

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of Approaches to Monitor Staphylococcus aureus Virulence Factor Expression during Human Disease

Rozemeijer, W., Fink, P., Rojas, E., Jones, C. H., Pavliakova, D., Giardina, P., Murphy, E., Liberator, P., Jiang, Q., Girgenti, D., Peters, R. P. H., Savelkoul, P. H. M., Jansen, K. U., Anderson, A. S. & Kluytmans, J., 2015, In : PLoS ONE. 10, 2, e0116945.

Research output: Contribution to journalArticleAcademicpeer-review

Long Term Development of Gut Microbiota Composition in Atopic Children: Impact of Probiotics

Rutten, N. B. M. M., Gorissen, D. M. W., van Eck, A., Niers, L. E. M., Vlieger, A. M., Besseling-van d Vaart, I., Budding, A. E., Savelkoul, P. H. M., van der Ent, C. K. & Rijkers, G. T., 2015, In : PLoS ONE. 10, 9, e0137681.

Research output: Contribution to journalArticleAcademicpeer-review

On the Origin of Species: Factors Shaping the Establishment of Infant's Gut Microbiota

van Best, N., Hornef, M. W., Savelkoul, P. H. M. & Penders, J., 2015, In : Birth defects research part c-embryo today-reviews. 105, 4, p. 240-251

Research output: Contribution to journalArticleAcademicpeer-review

Plasmid-Mediated AmpC: Prevalence in Community-Acquired Isolates in Amsterdam, the Netherlands, and Risk Factors for Carriage

Reuland, E. A., Halaby, T., Hays, J. P., de Jongh, D. M. C., Snetselaar, H. D. R., Keulen, M., Elders, P. J. M., Savelkoul, P. H. M., Vandenbroucke-Grauls, C. M. J. E. & Naiemi, N., 2015, In : PLoS ONE. 10, 1, e0113033.

Research output: Contribution to journalArticleAcademicpeer-review

The Effect of Sampling and Storage on the Fecal Microbiota Composition in Healthy and Diseased Subjects

Tedjo, D. I., Jonkers, D. M., Savelkoul, P. H. M., Masclee, A. A., van Best, N., Pierik, M. J. & Penders, J., 2015, In : PLoS ONE. 10, 5, e0126685.

Research output: Contribution to journalArticleAcademicpeer-review

Tropheryma whipplei, a Potential Commensal Detected in Individuals Undergoing Routine Colonoscopy

Grasman, M. E., Pettersson, A. M., Catsburg, A., Koek, A. G., van Bodegraven, A. A. & Savelkoul, P. H. M., 2015, In : Journal of Clinical Microbiology. 53, 12, p. 3919-3921

Research output: Contribution to journalArticleAcademicpeer-review

2014

Detection and Occurrence of Plasmid-Mediated AmpC in Highly Resistant Gram-Negative Rods

Reuland, E. A., Hays, J. P., de Jongh, D. M. C., Abdelrehim, E., Willemsen, I., Kluijtmans, J. A. J. W., Savelkoul, P. H. M., Vandenbroucke-Grauls, C. M. J. E. & Naiemi, N., 2014, In : PLoS ONE. 9, 3, e91396.

Research output: Contribution to journalArticleAcademicpeer-review

Development of a multiplex real-time PCR assay for the rapid diagnosis of neonatal late onset sepsis

van den Brand, M., Peters, R. P. H., Catsburg, A., Rubenjan, A., Broeke, F. J., van den Dungen, F. A. M., van Weissenbruch, M. M., van Furth, A. M., Koressaar, T., Remm, M., Savelkoul, P. H. M. & Bos, M. P., 2014, In : Journal of Microbiological Methods. 106, p. 8-15

Research output: Contribution to journalArticleAcademicpeer-review

Endotracheal aspirate and bronchoalveolar lavage fluid analysis: interchangeable diagnostic modalities in suspected ventilator-associated pneumonia?

Scholte, J. B., van Dessel, H. A., Linssen, C. F., Bergmans, D. C., Savelkoul, P. H. M., Roekaerts, P. M. & van Mook, W. N., 2014, In : Journal of Clinical Microbiology. 52, 10, p. 3597-3604

Research output: Contribution to journalArticleAcademicpeer-review

Extended-spectrum beta-lactamase producing Klebsiella spp. in chicken meat and humans: a comparison of typing methods

Overdevest, I. T. M. A., van Heck, M., van der Zwaluw, K., Huijsdens, X., van Santen, M., Rijnsburger, M. C., Eustace, A., Xu, L., Hawkey, P., Savelkoul, P. H. M., Vandenbroucke-Grauls, C., Willemsen, I., van de Ven, J., Verhulst, C. & Kluijtmans, J. A. J. W., 2014, In : Clinical Microbiology and Infection. 20, 3, p. 251-255

Research output: Contribution to journalArticleAcademicpeer-review

Fecal Microbial Composition of Ulcerative Colitis and Crohn's Disease Patients in Remission and Subsequent Exacerbation

Wills, E. S., Jonkers, D. M., Savelkoul, P. H. M., Masclee, A. A., Pierik, M. J. & Penders, J., 2014, In : PLoS ONE. 9, 3, e90981.

Research output: Contribution to journalArticleAcademicpeer-review

Fecal microbiome analysis as a diagnostic test for diverticulitis

Daniels, L., Budding, A. E., de Korte, N., van Eck, A., Bogaards, J. A., Stockmann, H. B., Consten, E. C., Savelkoul, P. H. M. & Boermeester, M. A., 2014, In : European Journal of Clinical Microbiology and Infectious Diseases. 33, 11, p. 1927-1936

Research output: Contribution to journalArticleAcademicpeer-review

High Rates of Antimicrobial Drug Resistance Gene Acquisition after International Travel, the Netherlands

von Wintersdorff, C. J., Penders, J., Stobberingh, E. E., lashof, A. M., Hoebe, C. J., Savelkoul, P. H. M. & Wolffs, P. F., 2014, In : Emerging Infectious Diseases. 20, 4, p. 649-657

Research output: Contribution to journalArticleAcademicpeer-review

Prevalence of ESBL-producing Enterobacteriaceae in raw vegetables

Reuland, E. A., Naiemi, N., Raadsen, S. A., Savelkoul, P. H. M., Kluijtmans, J. A. J. W. & Vandenbroucke-Grauls, C. M. J. E., 2014, In : European Journal of Clinical Microbiology and Infectious Diseases. 33, 10, p. 1843-1846

Research output: Contribution to journalArticleAcademicpeer-review