Paul van der Valk

PROF.DR., (Principal Investigator)

1984 …2019
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Research Output 1984 2019

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2019

A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis

Nutma, E., Stephenson, J. A., Gorter, R. P., de Bruin, J., Boucherie, D. M., Donat, C. K., Breur, M., van der Valk, P., Matthews, P. M., Owen, D. R. & Amor, S., 3 Oct 2019, In : Brain : a journal of neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Biochemically Silent Sympathetic Paraganglioma, Pheochromocytoma, or Metastatic Disease in SDHD Mutation Carriers

Dreijerink, K. M. A., Rijken, J. A., Compaijen, C. J., Timmers, H. J. L. M., van der Horst-Schrivers, A. N. A., van Leeuwaarde, R. S., van Dam, P. S., Leemans, C. R., van Dam, E. W. C. M., Dickhoff, C., Dommering, C. J., de Graaf, P., Zwezerijnen, G. J. C., van der Valk, P., Menke-van der Houven van Oordt, C. W., Hensen, E. F., Corssmit, E. P. M. & Eekhoff, E. M. W., Nov 2019, In : The Journal of clinical endocrinology and metabolism. 104, 11, p. 5421-5426

Research output: Contribution to journalArticleAcademicpeer-review

CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions

Prins, H. J., Duijkers, R., van der Valk, P., Schoorl, M., Daniels, J. M. A., van der Werf, T. S. & Boersma, W. G., 2019, In : The European respiratory journal. 53, 5

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Specialisatie versus generalisme in de pathologie

van der Valk, P., 1 Jan 2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 20, D3585.

Research output: Contribution to journalArticleProfessional

2018

9.4T and 17.6T MRI of Retinoblastoma: Ex Vivo evaluation of microstructural anatomy and disease extent compared with histopathology

de Jong, M. C., de Graaf, P., Pouwels, P. J. W., Beenakker, J. W., Jansen, R. W., Geurts, J. J. G., Moll, A. C., Castelijns, J. A., van der Valk, P. & van der Weerd, L., 1 Jun 2018, In : Journal of Magnetic Resonance Imaging. p. 1487-1497 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis

Gorter, R. P., Nutma, E., Jahrei, M-C., de Jonge, J. C., Quinlan, R. A., van der Valk, P., van Noort, J. M., Baron, W. & Amor, S., Nov 2018, In : Clinical and Experimental Immunology. 194, 2, p. 137-152 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MR Imaging Features of Retinoblastoma: Association with Gene Expression Profiles

Jansen, R. W., de Jong, M. C., Kooi, I. E., Sirin, S., Göricke, S., Brisse, H. J., Maeder, P., Galluzzi, P., van der Valk, P., Cloos, J., Eekhout, I., Castelijns, J. A., Moll, A. C., Dorsman, J. C. & de Graaf, P., Aug 2018, In : Radiology. 288, 2, p. 506-515 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Cortical remyelination is heterogeneous in multiple sclerosis

Strijbis, E. M. M., Kooi, E. J., van der Valk, P. & Geurts, J. J. G., 2017, In : Journal of Neuropathology and Experimental Neurology. 76, 5, p. 390-401 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Identification of highly connected hub genes in the protective response program of human macrophages and microglia activated by alpha B-crystallin

Holtman, I. R., Bsibsi, M., Gerritsen, W. H., Boddeke, H. W. G. M., Eggen, B. J. L., van der Valk, P., Kipp, M., van Noort, J. M. & Amor, S., 1 Mar 2017, In : GLIA. 65, 3, p. 460-473 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Neurofilament light as an immune target for pathogenic antibodies

Puentes, F., van der Star, B. J., Boomkamp, S. D., Kipp, M., Boon, L., Bosca, I., Raffel, J., Gnanapavan, S., van der Valk, P., Stephenson, J., Barnett, S. C., Baker, D. & Amor, S., Dec 2017, In : Immunology. 152, 4, p. 580-588 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice

Peferoen, L. A. N., Breur, M., van de Berg, S., Peferoen-Baert, R., Boddeke, E. H. W. G. M., van der Valk, P., Pryce, G., van Noort, J. M., Baker, D. & Amor, S., Oct 2016, In : Immunology. 149, 2, p. 146-156

Research output: Contribution to journalArticleAcademicpeer-review

A Meta-Analysis of Retinoblastoma Copy Numbers Refines the List of Possible Driver Genes Involved in Tumor Progression

Kooi, I. E., Mol, B. M., Massink, M. P. G., de Jong, M. C., de Graaf, P., van der Valk, P., Meijers-Heijboer, H., Kaspers, G. J. L., Moll, A. C., te Riele, H., Cloos, J. & Dorsman, J. C., 26 Apr 2016, In : PLoS ONE. 11, 4

Research output: Contribution to journalArticleAcademicpeer-review

Diagnostic Accuracy of Intraocular Tumor Size Measured with MR Imaging in the Prediction of Postlaminar Optic Nerve Invasion and Massive Choroidal Invasion of Retinoblastoma

De Jong, M. C., van der Meer, F. J. S., Goricke, S. L., Brisse, H. J., Galluzzi, P., Galluzzi, P., Maeder, P., Sirin, S., De Francesco, S., Sastre-Garau, X., Metz, K. A., Cerase, A., Noij, D. P., van der Valk, P., Moll, A. C., Castelijns, J. A. & de Graaf, P., Jun 2016, In : Radiology. 279, 3, p. 817-826

Research output: Contribution to journalArticleAcademicpeer-review

Expression of IL-1 beta in rhesus EAE and MS lesions is mainly induced in the CNS itself

Burm, S. M., Peferoen, L. A. N., Zuiderwijk-Sick, E. A., Haanstra, K. G., 't Hart, B. A., van der Valk, P., Amor, S., Bauer, J. & Bajramovic, J. J., 6 Jun 2016, In : Journal of Neuroinflammation. 13, 138.

Research output: Contribution to journalArticleAcademicpeer-review

From a Suspicious Cystic Pineal Gland to Pineoblastoma in a Patient with Familial Unilateral Retinoblastoma

de Jong, M. C., Moll, A. C., Goericke, S., van der Valk, P., Kors, W. A., Castelijns, J. A. & de Graaf, P., 2 Jan 2016, In : Ophthalmic Genetics. 37, 1, p. 116-118

Research output: Contribution to journalArticleAcademicpeer-review

Lesion Expansion in Experimental Demyelination Animal Models and Multiple Sclerosis Lesions

Grosse-Veldmann, R., Becker, B., Amor, S., van der Valk, P., Beyer, C. & Kipp, M., Sep 2016, In : Molecular Neurobiology. 53, 7, p. 4905-4917

Research output: Contribution to journalArticleAcademicpeer-review

Methylation of IGF2 regulatory regions to diagnose adrenocortical carcinomas

Creemers, S. G., van Koetsveld, P. M., van Kemenade, F. J., Papathomas, T. G., Franssen, G. J. H., Dogan, F., Eekhoff, E. M. W., van der Valk, P., de Herder, W. W., Janssen, J. A. M. J. L., Feelders, R. A. & Hofland, L. J., Sep 2016, In : Endocrine-Related Cancer. 23, 9, p. 727-737

Research output: Contribution to journalArticleAcademicpeer-review

Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease

Ummenthum, K., Peferoen, L. A. N., Finardi, A., Baker, D., Pryce, G., Mantovani, A., Bsibsi, M., Bottazzi, B., Peferoen-Baert, R., van der Valk, P., Garlanda, C., Kipp, M., Furlan, R., van Noort, J. M. & Amor, S., Mar 2016, In : European Journal of Immunology. 46, 3, p. 701-711

Research output: Contribution to journalArticleAcademicpeer-review

2015

Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis

Peferoen, L. A. N., Vogel, D. Y. S., Ummenthum, K., Breur, M., Heijnen, P. D. A. M., Gerritsen, W. H., Peferoen-Baert, R. M. B., van der Valk, P., Dijkstra, C. D. & Amor, S., 2015, In : Journal of Neuropathology and Experimental Neurology. 74, 1, p. 48-63

Research output: Contribution to journalArticleAcademicpeer-review

Assessment of early-stage optic nerve invasion in retinoblastoma using high-resolution 1.5 Tesla MRI with surface coils: a multicentre, prospective accuracy study with histopathological correlation

Brisse, H. J., de Graaf, P., Galluzzi, P., Cosker, K., Maeder, P., Goricke, S., Rodjan, F., de Jong, M. C., Savignoni, A., Aerts, I., Desjardins, L., Moll, A. C., Hadjistilianou, T., Toti, P., van der Valk, P., Castelijns, J. A. & Sastre-Garau, X., 2015, In : European Radiology. 25, 5, p. 1443-1452

Research output: Contribution to journalArticleAcademicpeer-review

Can MS lesion stages be distinguished with MRI? A postmortem MRI and histopathology study

Jonkman, L. E., Lopez Soriano, A., Amor, S., Barkhof, F., van der Valk, P., Vrenken, H. & Geurts, J. J. G., 2015, In : Journal of Neurology. 262, 4, p. 1074-1080

Research output: Contribution to journalArticleAcademicpeer-review

Detection of Calcifications in Retinoblastoma Using Gradient-Echo MR Imaging Sequences: Comparative Study between In Vivo MR Imaging and Ex Vivo High-Resolution CT

Rodjan, F., de Graaf, P., van der Valk, P., Hadjistilianou, T., Cerase, A., Toti, P., de Jong, M. C., Moll, A. C., Castelijns, J. A. & Galluzzi, P., 2015, In : American Journal of Neuroradiology. 36, 2, p. 355-360

Research output: Contribution to journalArticleAcademicpeer-review

Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions

Nijland, P. G., Molenaar, R. J., van der Pol, S. M. A., van der Valk, P., van Noorden, C. J. F., de Vries, H. E. & van Horssen, J., 4 Dec 2015, In : Acta Neuropathologica Communinications. 3, 79.

Research output: Contribution to journalArticleAcademicpeer-review

GM-CSF promotes migration of human monocytes across the blood brain barrier

Vogel, D. Y. S., Kooij, G., Heijnen, P. D. A. M., Breur, M., Peferoen, L. A. N., van der Valk, P., de Vries, H. E., Amor, S. & Dijkstra, C. D., 2015, In : European Journal of Immunology. 45, 6, p. 1808-1819

Research output: Contribution to journalArticleAcademicpeer-review

Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progression

Kooi, E. I., Mol, B. M., Moll, A. C., van der Valk, P., de Jong, M. C., de Graaf, P., van Mil, S. E., Schouten-van Meeteren, A. Y. N., Meijers-Heijboer, H., Kaspers, G. J. L., te Riele, H., Cloos, J. & Dorsman, J. C., 2015, In : EBioMedicine. 2, 7, p. 660-670

Research output: Contribution to journalArticleAcademicpeer-review

Neuronal and Axonal Loss in Normal-Appearing Gray Matter and Subpial Lesions in Multiple Sclerosis

Klaver, R., Popescu, V., Voorn, P., van der Graaf, Y., van der Valk, P., de Vries, H. E., Schenk, G. J. & Geurts, J. J. G., 2015, In : Journal of Neuropathology and Experimental Neurology. 74, 5, p. 453-458

Research output: Contribution to journalArticleAcademicpeer-review

Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter

Peferoen, L. A. N., Gerritsen, W. H., Breur, M., Ummenthum, K. M. D., Peferoen-Baert, R. M. B., van der Valk, P., van Noort, J. M. & Amor, S., 2015, In : Acta Neuropathologica Communinications. 3, 1, 87.

Research output: Contribution to journalArticleAcademicpeer-review

Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin alpha-4-transduced outside-in signalling

Haarmann, A., Nowak, E., Deiss, A., van der Pol, S. M. A., Monoranu, C. M., Kooij, G., Muller, N., van der Valk, P., Stoll, G., de Vries, H. E., Berberich-Siebelt, F. & Buttmann, M., 2015, In : Acta Neuropathologica. 129, 5, p. 639-652

Research output: Contribution to journalArticleAcademicpeer-review

Visual pathway neurodegeneration winged by mitochondrial dysfunction

Petzold, A. F. S., Nijland, P. G., Balk, L. J., Amorini, A. M., Lazzarino, G., Wattjes, M. P., Gasperini, C., van der Valk, P., Tavazzi, B. & van Horssen, J., 2015, In : Annals of Clinical and Translational Neurology. 2, 2, p. 140-150

Research output: Contribution to journalArticleAcademicpeer-review

What drives MRI-measured cortical atrophy in multiple sclerosis?

Popescu, V., Klaver, R., Voorn, P., van der Graaf, Y., Knol, D. L., Twisk, J. W. R., Versteeg, A., Schenk, G. J., van der Valk, P., Barkhof, F., de Vries, H. E., Vrenken, H. & Geurts, J. J. G., 1 Jan 2015, In : Multiple Sclerosis. 21, 10, p. 1280-1290 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis

Mizee, M. R., Nijland, P. G., van der Pol, S. M. A., Drexhage, J. A. R., Hof, B., Mebius, R., van der Valk, P., van Horssen, J., Reijerkerk, A. & de Vries, H. E., 2014, In : Acta Neuropathologica. 128, 5, p. 691-703

Research output: Contribution to journalArticleAcademicpeer-review

Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

Nijland, P. G., Witte, M. E., van het Hof, B., van der Pol, S. M. A., Bauer, J., Lassmann, H., van der Valk, P., de Vries, H. E. & van Horssen, J., 2014, In : Acta Neuropathologica Communinications. 2, p. 170 170.

Research output: Contribution to journalArticleAcademicpeer-review

Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions

Nijland, P. G., Michailidou, I., Witte, M. E., Mizee, M. R., van der Pol, SM., Hof, B., Reijerkerk, A., Pellerin, L., van der Valk, P., de Vries, H. E. & van Horssen, J., 2014, In : GLIA. 62, 7, p. 1125-1141

Research output: Contribution to journalArticleAcademicpeer-review

Childhood Lymphomatoid Granulomatosis: A Report of 2 Cases and Review of the Literature

Tacke, Z. C. A., Eikelenboom, M. J., Vermeulen, R. J., van der Knaap, M. S., Euser, A. M., van der Valk, P. & Kaspers, G. J. L., 2014, In : Journal of Pediatric Hematology / Oncology. 36, 7, p. E416-E422

Research output: Contribution to journalArticleAcademicpeer-review

CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG

Garcia-Vallejo, J. J., Ilarregui, J. M., Kalay, H., Chamorro, S., Koning, N., Unger, W. W. J., Ambrosini, M., Montserrat, V., Fernandes, R. J., Bruijns, S. C. M., van Weering, J. R. T., Paauw, N. J., O'Toole, T. G., van Horssen, J., van der Valk, P., Nazmi, K., Bolscher, J. G., Bajramovic, J., Dijkstra, C. D., 't Hart, B. A. & 1 othersvan Kooyk, Y., 2014, In : Journal of Experimental Medicine. 211, 7, p. 1465-1483

Research output: Contribution to journalArticleAcademicpeer-review

Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-gamma and alpha B-crystallin

Bsibsi, M., Peferoen, L. A. N., Holtman, I. R., Nacken, P. J., Gerritsen, W. H., Witte, M. E., van Horssen, J., Eggen, B. J. L., van der Valk, P., Amor, S. & van Noort, J. M., 2014, In : Acta Neuropathologica. 128, 2, p. 215-229

Research output: Contribution to journalArticleAcademicpeer-review

Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients

Prins, M., Dutta, R., Baselmans, B., Brevé, J. J. P., Bol, J. G. J. M., Deckard, S. A., van der Valk, P., Amor, S., Trapp, B. D., de Vries, H. E., Drukarch, B. & van Dam, A-M., 23 Aug 2014, In : Acta Neuropathologica Communinications. 2, p. 98

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation in neurodegenerative diseases-an update

Amor, S., Peferoen, L. A. N., Vogel, D. Y. S., Breur, M., van der Valk, P., Baker, D. & van Noort, J. M., 2014, In : Immunology. 142, 2, p. 151-166

Research output: Contribution to journalArticleAcademicpeer-review

Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis

Al-Izki, S., Pryce, G., Hankey, D. J. R., Lidster, K., von Kutzleben, S. M., Browne, L., Clutterbuck, L., Posada, C., Chan, A. W. E., Amor, S., Perkins, V., Gerritsen, W. H., Ummenthum, K., Peferoen-Baert, R., van der Valk, P., Montoya, A., Joel, S. P., Garthwaite, J., Giovannoni, G., Selwood, D. L. & 1 othersBaker, D., 2014, In : Brain. 137, p. 92-108

Research output: Contribution to journalArticleAcademicpeer-review

Oligodendrocyte-microglia cross-talk in the central nervous system

Peferoen, L., Kipp, M., van der Valk, P., van Noort, J. M. & Amor, S., 2014, In : Immunology. 141, 3, p. 302-313

Research output: Contribution to journalArticleAcademicpeer-review

Spatial and temporal evolution of distal 10q deletion, a prognostically unfavorable event in diffuse low-grade gliomas

van Thuijl, H. F., Scheinin, I., Sie, D. L. S., Alentorn, A., van Essen, H. F., Cordes, M., Fleischeuer, R., Beute, G., van den Brink, W. A., Meijer, G. A., Havenith, M., Idbaih, A., Hoang-Xuan, K., Mokhtari, K., Verhaak, R. G. W., van der Valk, P., van de Wiel, M. A., Heimans, J. J., Aronica, E., Reijneveld, J. C. & 2 othersWesseling, P. & Ylstra, B., 2014, In : Genome Biology. 15, 9, 471.

Research output: Contribution to journalArticleAcademicpeer-review

The epigenetics of multiple sclerosis and other related disorders

van den Elsen, P. J., van Eggermond, M. C. J. A., Puentes, F., van der Valk, P., Baker, D. & Amor, S., 2014, In : Multiple Sclerosis and Related Disorders. 3, 2, p. 163-175

Research output: Contribution to journalArticleAcademicpeer-review

2013

Alpha-B-crystallin induces an immune-regulatory and antiviral microglial response in preactive multiple sclerosis lesions

Bsibsi, M., Holtman, I. R., Gerritsen, W. H., Eggen, B. J. L., Boddeke, E., van der Valk, P., van Noort, J. M. & Amor, S., 2013, In : Journal of Neuropathology and Experimental Neurology. 72, 10, p. 970-979

Research output: Contribution to journalArticleAcademicpeer-review

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis

Puentes, F., van der Star, B. J., Victor, M., Kipp, M., Beyer, C., Peferoen-Baert, R., Ummenthum, K., Pryce, G., Gerritsen, W. H., Huizinga, R., Reijerkerk, A., van der Valk, P., Baker, D. & Amor, S., 2013, In : Journal of Neuroinflammation. 10, p. 18 18.

Research output: Contribution to journalArticleAcademicpeer-review

Human Endogenous Retrovirus Type W Envelope Protein Inhibits Oligodendroglial Precursor Cell Differentiation

Kremer, D., Schichel, T., Forster, M., Tzekova, N., Bernard, C., van der Valk, P., van Horssen, J., Hartung, H. P., Perron, H. & Kury, P., 2013, In : Annals of Neurology. 74, 5, p. 721-732

Research output: Contribution to journalArticleAcademicpeer-review

Implementation of a multi-institutional diffuse intrinsic pontine glioma autopsy protocol and characterization of a primary cell culture

Caretti, V., Jansen, M. H. A., van Vuurden, D. G., Lagerweij, T., Bugiani, M., Horsman, I., Wessels, H., van der Valk, P., Cloos, J., Noske, D. P., Vandertop, W. P., Wesseling, P., Würdinger, T., Hulleman, E. & Kaspers, G. J. L., 2013, In : Neuropathology and Applied Neurobiology. 39, 4, p. 426-436

Research output: Contribution to journalArticleAcademicpeer-review

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Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

Vogel, D. Y. S., Vereyken, E. J. F., Glim, J. E., Heijnen, D. A. M., Moeton, M., van der Valk, P., Amor, S., Teunissen, C. E., van Horssen, J. & Dijkstra, C. D., 2013, In : Journal of Neuroinflammation. 10, p. 35 35.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons

Singh, S., Metz, I., Amor, S., van der Valk, P., Stadelmann, C. & Bruck, W., 2013, In : Acta Neuropathologica. 125, 4, p. 595-608

Research output: Contribution to journalArticleAcademicpeer-review