Mutation-specific pathology and treatment of hypertrophic cardiomyopathy in patients, mouse models and human engineered heart tissue

Wijnker, P. J. M. & van der Velden, J., 1 Aug 2020, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1866, 8, 165774.

Research output: Contribution to journal › Review article › Academic › peer-review

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

Buikema, J. W., Lee, S., Goodyer, W. R., Maas, R. G., Chirikian, O., Li, G., Miao, Y., Paige, S. L., Lee, D., Wu, H., Paik, D. T., Rhee, S., Tian, L., Galdos, F. X., Puluca, N., Beyersdorf, B., Hu, J., Beck, A., Venkamatran, S., Swami, S. & 17 others, Wijnker, P., Schuldt, M., Dorsch, L. M., van Mil, A., Red-Horse, K., Wu, J. Y., Geisen, C., Hesse, M., Serpooshan, V., Jovinge, S., Fleischmann, B. K., Doevendans, P. A., van der Velden, J., Garcia, K. C., Wu, J. C., Sluijter, J. P. G. & Wu, S. M., 2 Jul 2020, In: Cell Stem Cell. 27, 1, p. 50-63

Research output: Contribution to journal › Article › Academic › peer-review

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits

Wijnker, P. J. M., Sequeira, V., Kuster, D. W. D. & van der Velden, J., 1 Aug 2019, In: Antioxidants and Redox Signaling. 31, 4, p. 318-358

Research output: Contribution to journal › Review article › Academic › peer-review

Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue

Dutsch, A., Wijnker, P. J. M., Schlossarek, S., Friedrich, F. W., Krämer, E., Braren, I., Hirt, M. N., Brenière-Letuffe, D., Rhoden, A., Mannhardt, I., Eschenhagen, T., Carrier, L. & Mearini, G., 2019, In: Scientific Reports. 9, 1, 18152.

Research output: Contribution to journal › Article › Academic › peer-review

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

Piroddi, N., Witjas-Paalberends, E. R., Ferrara, C., Ferrantini, C., Vitale, G., Scellini, B., Wijnker, P. J. M., Sequiera, V., Dooijes, D., Dos Remedios, C., Schlossarek, S., Leung, M. C., Messer, A., Ward, D. G., Biggeri, A., Tesi, C., Carrier, L., Redwood, C. S., Marston, S. B., van der Velden, J. & 1 others, Poggesi, C., 7 Jan 2019, In: The Journal of general physiology. 151, 1, p. 18-29 12 p.

Research output: Contribution to journal › Article › Academic › peer-review