20002019
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Research Output 2000 2019

2019

Bosutinib Protects against Vascular Leakage by Improving Endothelial Cell-Matrix Adhesion

Botros, L., Pronk, M., Juschten, J., Liddle, J., Tuinman, P. R., van Bezu, J., Huveneers, S., Bogaard, H. J., van Hinsbergh, V., Hordijk, P. & Aman, J., 2019, In : Journal of Vascular Research. 56, p. 15-15

Research output: Contribution to journalMeeting AbstractAcademic

FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB

Pronk, M. C. A., Majolée, J., Loregger, A., van Bezu, J. S. M., Zelcer, N., Hordijk, P. L. & Kovačević, I., 1 Mar 2019, In : Molecular Biology of the Cell. 30, 5, p. 607-621 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology

Bogunovic, N., Meekel, J. P., Micha, D., Blankensteijn, J. D., Hordijk, P. L. & Yeung, K. K., 2019, In : Scientific Reports. 9, 1, 6837.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Stabilization of cell-cell junctions by active Vitamin D ameliorates uraemia-induced loss of human endothelial barrier function

Cuenca, M. V., van Bezu, J., Beelen, R. H. J., Vervloet, M. G. & Hordijk, P. L., 2019, In : Nephrology, Dialysis, Transplantation. 34, 2, p. 252-264 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability

Amado-Azevedo, J., de Menezes, R. X., van Nieuw Amerongen, G. P., van Hinsbergh, V. W. M. & Hordijk, P. L., 2018, In : PLoS ONE. 13, 7, e0201231.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Correction: Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor

Smeets, M. W. J., Bierings, R., Meems, H., Mul, F. P. J., Geerts, D., Vlaar, A. P. J., Voorberg, J. & Hordijk, P. L., 21 Mar 2018, In : PLoS ONE. 13, 3, e0194958.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Early-onset preeclampsia predisposes to preclinical diastolic left ventricular dysfunction in the fifth decade of life: An observational study

Bokslag, A., Franssen, C., Alma, L. J., Kovacevic, I., van Kesteren, F., Teunissen, P. W., Kamp, O., Ganzevoort, W., Hordijk, P. L., de Groot, C. J. M. & Paulus, W. J., 2018, In : PLoS ONE. 13, 6, e0198908.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Erythrocytes and von Willebrand Factor in Venous Thrombosis

Smeets, MWJ., 17 May 2018

Research output: ThesisResearch external, graduation externalAcademic

Inflammation-sensitive myosin-x functionally supports leukocyte extravasation by Cdc42-mediated ICAM-1-rich endothelial filopodia formation

Kroon, J., Schaefer, A., van Rijssel, J., Hoogenboezem, M., van Alphen, F., Hordijk, P., Stroes, E. S. G., Strömblad, S., van Rheenen, J. & van Buul, J. D., 2018, In : Journal of Immunology. 200, 5, p. 1790-1801

Research output: Contribution to journalArticleAcademicpeer-review

Regulation of vascular permeability by RhoGTPases: Fiat Lux! (Let there be light!)

Coelho Amado de Azevedo, J. M., 2018, 216 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

RhoGTPases, post-translational modifications and tyrosine kinases in endothelial barrier regulation

Pronk, M. C. A., 2018, 166 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

The covalently immobilized antimicrobial peptide LL37 acts as a VEGF mimic and stimulates endothelial cell proliferation

Szulcek, R., Bollensdorff, C., Hordijk, P. & Gabriel, M., 2018, In : Biochemical and Biophysical Research Communications. 496, 3, p. 887-890

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB

Kovačević, I., Sakaue, T., Majoleé, J., Pronk, M. C., Maekawa, M., Geerts, D., Fernandez-Borja, M., Higashiyama, S. & Hordijk, P. L., 2018, In : Journal of Cell Biology. 217, 3, p. 1015-1032

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The minor histocompatibility antigen 1 (HMHA1)/ArhGAP45 is a RacGAP and a novel regulator of endothelial integrity

Amado-Azevedo, J., Reinhard, N. R., van Bezu, J., van Nieuw Amerongen, G. P., van Hinsbergh, V. W. M. & Hordijk, P. L., 1 Feb 2018, In : Vascular Pharmacology. 101, p. 38-47 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin D attenuates endothelial dysfunction in uremic rats and maintains human endothelial stability

Cuenca, M. V., Ferrantelli, E., Meinster, E., Pouw, S. M., Kovačević, I., de Menezes, R. X., Niessen, H. W., Beelen, R. H. J., Hordijk, P. L. & Vervloet, M. G., 1 Sep 2018, In : Journal of the American Heart Association. 7, 17, e008776.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity

Amado-Azevedo, J., Reinhard, N. R., van Bezu, J., Menezes, R. X., Van Beusechem, V. W., Van Nieuw Amerongen, G. P., Van Hinsbergh, V. W. M. & Hordijk, P. L., 1 Dec 2017, In : Scientific Reports. 7, 1, 10132.

Research output: Contribution to journalArticleAcademicpeer-review

Endothelial CD2AP binds the receptor ICAM-1 to control mechanosignaling, leukocyte adhesion, and the route of leukocyte diapedesis in vitro

Schaefer, A., Van Duijn, T. J., Majolee, J., Burridge, K. & Hordijk, P. L., 15 Jun 2017, In : Journal of Immunology. 198, 12, p. 4823-4836 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Leukocyte trafficking and vascular integrity

Heemskerk, N., 2017

Research output: ThesisResearch VU University Amsterdam, graduation externalAcademic

Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor

Smeets, M. W. J., Bierings, R., Meems, H., Mul, F. P. J., Geerts, D., Vlaar, A. P. J., Voorberg, J. & Hordijk, P. L., 1 Mar 2017, In : PLoS ONE. 12, 3, e0173077.

Research output: Contribution to journalArticleAcademicpeer-review

RhoA, RhoB and RhoC differentially regulate endothelial barrier function

Pronk, M. C. A., van Bezu, J. S. M., van Nieuw Amerongen, G. P., van Hinsbergh, V. W. M. & Hordijk, P. L., 26 Sep 2017, In : Small GTPases. p. 1-19 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Stasis Promotes Erythrocyte Adhesion to von Willebrand Factor

Smeets, M. W. J., Mourik, M. J., Niessen, H. W. M. & Hordijk, P. L., Sep 2017, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 9, p. 1618-1627 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The balance between Gαi-Cdc42/Rac and Gα1/2/13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate

Reinhard, N. R., Mastop, M., Yin, T., Wu, Y., Bosma, E. K., Gadella, T. W. J., Goedhart, J. & Hordijk, P. L., 7 Nov 2017, In : Molecular Biology of the Cell. 28, 23, p. 3371-3382 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

A New Generation of FRET Sensors for Robust Measurement of G alpha(i1), G alpha(i2) and G alpha(i3) Activation Kinetics in Single Cells

van Unen, J., Stumpf, A. D., Schmid, B., Reinhard, N. R., Hordijk, P. L., Hoffmann, C., Gadella, T. W. J. & Goedhart, J., 22 Jan 2016, In : PLoS ONE. 11, 1, e0146789.

Research output: Contribution to journalArticleAcademicpeer-review

Correction: Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction

Hollander, M. R., de Waard, G. A., Konijnenberg, L. S. F., Meijer-van Putten, R. M. E., van den Brom, C. E., Paauw, N., de Vries, H. E., van de Ven, P. M., Aman, J., Van Nieuw Amerongen, G. P., Hordijk, P. L., Niessen, H. W. M., Horrevoets, A. J. G. & Van Royen, N., 2016, In : PLoS ONE. 11, 11, p. e0166809

Research output: Contribution to journalArticleAcademicpeer-review

Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake

Nelson, J. K., Cook, E. C. L., Loregger, A., Hoeksema, M. A., Scheij, S., Kovacevic, I., Hordijk, P. L., Ovaa, H. & Zelcer, N., 26 Feb 2016, In : Journal of Biological Chemistry. 291, 9, p. 4813-4825

Research output: Contribution to journalArticleAcademicpeer-review

Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction

Hollander, M. R., de Waard, G. A., Konijnenberg, L. S. F., Meijer-van Putten, R. M. E., van den Brom, C. E., Paauw, N., de Vries, H. E., van de Ven, P. M., Aman, J., van Nieuw Amerongen, G., Hordijk, P. L., Niessen, H. W. M., Horrevoets, A. J. G. & Van Royen, N., 15 Nov 2016, In : PLoS ONE. 11, 11, e0157233.

Research output: Contribution to journalArticleAcademicpeer-review

Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction

Hollander, M. R., de Waard, G. A., Konijnenberg, L. S. F., Meijer-van Putten, R. M. E., van den Brom, C. E., Paauw, N., de Vries, H. E., van de Ven, P. M., Aman, J., Van Nieuw-Amerongen, G. P., Hordijk, P. L., Niessen, H. W. M., Horrevoets, A. J. G. & Van Royen, N., 2016, In : PLoS ONE. 11, 7, p. e0157233

Research output: Contribution to journalArticleAcademicpeer-review

Generation and distribution of endothelium-derived contractile forces and their impact on vascular permeability

Valent, E. T., 2016

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia

Woodfin, A., Beyrau, M., Voisin, M-B., Ma, B., Whiteford, J. R., Hordijk, P. L., Hogg, N. & Nourshargh, S., 18 Feb 2016, In : Blood. 127, 7, p. 898-907

Research output: Contribution to journalArticleAcademicpeer-review

Intracellular pH steers vascular wall remodelling

Hordijk, P. L., 1 Aug 2016, In : Cardiovascular Research. 111, 3, p. 165-166

Research output: Contribution to journalEditorialAcademicpeer-review

Recent insights into endothelial control of leukocyte extravasation

Hordijk, P. L., Apr 2016, In : Cellular and Molecular Life Sciences. 73, 8, p. 1591-1608

Research output: Contribution to journalArticleAcademicpeer-review

Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells

Reinhard, N. R., van Helden, S. F., Anthony, E. C., Yin, T., Wu, Y. I., Goedhart, J., Gadella, T. W. J. & Hordijk, P. L., 5 May 2016, In : Scientific Reports. 6

Research output: Contribution to journalArticleAcademicpeer-review

The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions

Dorland, Y. L., Malinova, T. S., van Stalborch, A-M. D., Grieve, A. G., van Geemen, D., Jansen, N. S., de Kreuk, B-J., Nawaz, K., Kole, J., Geerts, D., Musters, R. J. P., de Rooij, J., Hordijk, P. L. & Huveneers, S., Jul 2016, In : Nature Communications. 7, 12210.

Research output: Contribution to journalArticleAcademicpeer-review

Traction force dynamics predict gap formation in activated endothelium

Valent, E. T., van Nieuw Amerongen, G., van Hinsbergh, V. W. M. & Hordijk, P. L., 10 Sep 2016, In : Experimental Cell Research. 347, 1, p. 161-170

Research output: Contribution to journalArticleAcademicpeer-review

2015

Between Rho(k) and a hard place: The relation between vessel wall stiffness, endothelial contractility, and cardiovascular disease

Huveneers, S., Daemen, M. J. A. P. & Hordijk, P. L., 1 Jan 2015, In : Circulation Research. 116, 5, p. 895-908 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Cell-stiffness-induced mechanosignaling - a key driver of leukocyte transendothelial migration

Schaefer, A. & Hordijk, P. L., 1 Jan 2015, In : Journal of Cell Science. 128, 13, p. 2221-2230 10 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Plasminogen activator inhibitor-1 controls vascular integrity by regulating VE-cadherin trafficking

Daniel, A. E., Timmerman, I., Kovacevic, I., Hordijk, P. L., Adriaanse, L., Paatero, I., Belting, H. G. & Van Buul, J. D., 1 Dec 2015, In : PLoS ONE. 10, 12, e0145684.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration

Schaefer, A., Riet, J. T., Ritz, K., Hoogenboezem, M., Anthony, E. C., Mul, F. P. J., de Vries, C. J., Daemen, M. J., Figdor, C. G., van Buul, J. D. & Hordijk, P. L., 1 Jan 2014, In : Journal of Cell Science. 127, 20, p. 4470-4482 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

F-actin-anchored focal adhesions distinguish endothelial phenotypes of human arteries and veins

Van Geemen, D., Smeets, M. W. J., Van Stalborch, A. M. D., Woerdeman, L. A. E., Daemen, M. J. A. P., Hordijk, P. L. & Huveneers, S., 1 Jan 2014, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 9, p. 2059-2067 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Toward understanding RhoGTPase specificity: Structure, function and local activation

Schaefer, A., Reinhard, N. R. & Hordijk, P. L., 12 Dec 2014, In : Small GTPases. 5, 2

Research output: Contribution to journalArticleAcademicpeer-review

2013

BIGH3 modulates adhesion and migration of hematopoietic stem and progenitor cells

Klamer, S. E., Kuijk, C. G. M., Hordijk, P. L., Van Der Schoot, C. E., Von Lindern, M., Van Hennik, P. B. & Voermans, C., 1 Sep 2013, In : Cell Adhesion and Migration. 7, 5, p. 434-449 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cytoplasmic targeting of the proto-oncogene SET promotes cell spreading and migration

Lam, B. D., Anthony, E. C. & Hordijk, P. L., 16 Jan 2013, In : FEBS Letters. 587, 2, p. 111-119 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nucleophosmin1 Is a Negative Regulator of the Small GTPase Rac1

Zoughlami, Y., van Stalborgh, A. M., van Hennik, P. B. & Hordijk, P. L., 16 Jul 2013, In : PLoS ONE. 8, 7, e68477.

Research output: Contribution to journalArticleAcademicpeer-review

The Human Minor Histocompatibility Antigen1 Is a RhoGAP

de Kreuk, B. J., Schaefer, A., Anthony, E. C., Tol, S., Fernandez-Borja, M., Geerts, D., Pool, J., Hambach, L., Goulmy, E. & Hordijk, P. L., 23 Sep 2013, In : PLoS ONE. 8, 9, e73962.

Research output: Contribution to journalArticleAcademicpeer-review

The immunosuppressant FTY720 (Fingolimod) induces nuclear exit of the proto-oncogene SET/I2PP2A

Daniël Lam, B., Anthony, E. C. & Hordijk, P. L., 1 Dec 2013, In : Molecular and Cellular Pharmacology. 5, 3, p. 95-107 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Rac1 hyper variable region in targeting and signaling-a tail of many stories

Lam, B. D. & Hordijk, P. L., 1 Jan 2013, In : Small GTPases. 4, 2, p. 78-89

Research output: Contribution to journalArticleAcademicpeer-review

2012

Analysis of nucleo-cytoplasmic shuttling of the proto-oncogene SET/I2PP2A

Daniel Lam, B., Anthony, E. C. & Hordijk, P. L., 1 Jan 2012, In : Cytometry Part A. 81 A, 1, p. 81-89 9 p.

Research output: Contribution to journalArticleAcademicpeer-review