Philip Scheltens

PROF.DR.

20022019
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Research Output 2002 2019

2019

Alzheimer disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal

Alzheimer's Disease Neuroimaging Initiative, 2019, In : Neurology. 92, 23, p. e2699-e2705

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

AMYPAD Diagnostic and Patient Management Study: Rationale and design

Frisoni, G. B., Barkhof, F., Altomare, D., Berkhof, J., Boccardi, M., Canzoneri, E., Collij, L., Drzezga, A., Farrar, G., Garibotto, V., Gismondi, R., Gispert, J-D., Jessen, F., Kivipelto, M., Lopes Alves, I., Molinuevo, J-L., Nordberg, A., Payoux, P., Ritchie, C., Savicheva, I. & 8 othersScheltens, P., Schmidt, M. E., Schott, J., Stephens, A., van Berckel, B., Vellas, B., Walker, Z. & Raffa, N., Mar 2019, In : Alzheimers & Dementia. 15, 3, p. 388-399

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB) & The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessing cognition and daily function in early dementia using the cognitive-functional composite: Findings from the Catch-Cog study cohort

Jutten, R. J., Harrison, J. E., Lee Meeuw Kjoe, P. R., Ingala, S., Vreeswijk, R., van Deelen, R. A. J., de Jong, F. J., Opmeer, E. M., Aleman, A., Ritchie, C. W., Scheltens, P. & Sikkes, S. A. M., 2019, In : Alzheimer's Research and Therapy. 11, 1, 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Associations of AD biomarkers and cognitive performance with nutritional status: The NUDAD project

Doorduijn, A. S., Visser, M., van de Rest, O., Kester, M. I., de Leeuw, F. A., Boesveldt, S., Fieldhouse, J. L. P., van den Heuvel, E. G. H. M., Teunissen, C. E., Scheltens, P., van der Flier, W. M. & de van der Schueren, M. A. E., 2019, In : Nutrients. 11, 5, 1161.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Auditory hallucinations in adults with hearing impairment: a large prevalence study

Linszen, M. M. J., van Zanten, G. A., Teunisse, R. J., Brouwer, R. M., Scheltens, P. & Sommer, I. E., 1 Jan 2019, In : Psychological Medicine. 49, 1, p. 132-139 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Automatically computed rating scales from MRI for patients with cognitive disorders

Alzheimer’s Disease Neuroimaging Initiative, 2019, In : European Radiology.

Research output: Contribution to journalArticleAcademicpeer-review

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

Liebsch, F., Kulic, L., Teunissen, C., Shobo, A., Ulku, I., Engelschalt, V., Hancock, M. A., van der Flier, W. M., Kunach, P., Rosa-Neto, P., Scheltens, P., Poirier, J., Saftig, P., Bateman, R. J., Breitner, J., Hock, C. & Multhaup, G., 2019, In : Nature Communications. 10, 1, 2240.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

Bos, I., Vos, S., Verhey, F., Scheltens, P., Teunissen, C., Engelborghs, S., Sleegers, K., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R. G., Tsolaki, M., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Lleó, A., Johannsen, P., Freund-Levi, Y., Frölich, L. & 12 othersVandenberghe, R., Westwood, S., Dobricic, V., Barkhof, F., Legido-Quigley, C., Bertram, L., Lovestone, S., Streffer, J., Andreasson, U., Blennow, K., Zetterberg, H. & Visser, P. J., 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Data-driven approaches for tau-PET imaging biomarkers in Alzheimer's disease

The Alzheimer's Disease Neuroimaging Initiative, 1 Feb 2019, In : Human Brain Mapping. 40, 2, p. 638-651 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development and usability of ADappt - an online tool to support clinicians, patients and caregivers in the diagnosis of Mild Cognitive Impairment and Alzheimer's disease (Preprint)

van Maurik, I., Visser, L. N. C., Pel-Littel, R. E., van Buchem, M. M., Zwan, M. D., Kunneman, M., Pelkmans, W., Bouwman, F. H., Minkman, M., Schoonenboom, N., Scheltens, P., Smets, E. M. & van der Flier, W. M., 16 Jan 2019, In : JMIR Formative Research.

Research output: Contribution to journalArticleAcademicpeer-review

Driving Difficulties Among Patients with Alzheimer's Disease and Other Neurodegenerative Disorders

Fuermaier, A. B. M., Piersma, D., de Waard, D., Davidse, R. J., de Groot, J., Doumen, M. J. A., Bredewoud, R. A., Claesen, R., Lemstra, A. W., Scheltens, P., Vermeeren, A., Ponds, R., Verhey, F., De Deyn, P. P., Brouwer, W. H. & Tucha, O., 2019, In : Journal of Alzheimer's Disease. 69, 4, p. 1019-1030 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

AIBL Research Group & Alzheimer Disease Neuroimaging Initiative, 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Early Amyloid Pathology: Identical twins two of a kind?

Konijnenberg, E., 25 Jun 2019

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer's disease: Protocol of the BEAT-IT study

Eikelboom, W. S., Singleton, E., van den Berg, E., Coesmans, M., Mattace Raso, F., van Bruchem, R. L., Goudzwaard, J. A., de Jong, F. J., Koopmanschap, M., den Heijer, T., Driesen, J. J. M., Vroegindeweij, L. J. H. M., Thomeer, E. C., Hoogers, S. E., Dijkstra, A. A., Zuidema, S. U., Pijnenburg, Y. A. L., Scheltens, P., van Swieten, J. C., Ossenkoppele, R. & 1 othersPapma, J. M., 2019, In : Alzheimer's Research and Therapy. 11, 1, 48.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

High amyloid burden is associated with fewer specific words during spontaneous speech in individuals with subjective cognitive decline

Verfaillie, S. C. J., Witteman, J., Slot, R. E. R., Pruis, I. J., Vermaat, L. E. W., Prins, N. D., Schiller, N. O., van de Wiel, M., Scheltens, P., van Berckel, B. N. M., van der Flier, W. M. & Sikkes, S. A. M., 2019, In : Neuropsychologia. 131, p. 184-192

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

How Do Different Forms of Vascular Brain Injury Relate to Cognition in a Memory Clinic Population: The TRACE-VCI Study

Boomsma, J. M. F., Exalto, L. G., Barkhof, F., van den Berg, E., de Bresser, J., Heinen, R., Leeuwis, A. E., Prins, N. D., Scheltens, P., Weinstein, H. C., van der Flier, W. M. & Biessels, G. J., 2019, In : Journal of Alzheimer's Disease. 68, 3, p. 1273-1286

Research output: Contribution to journalArticleAcademicpeer-review

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study

TRACE-VCI study group, 25 Apr 2019, In : Journal of Psychiatry and Neuroscience. 44, 4, p. 1-10 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inflammatory biomarkers in Alzheimer's disease plasma

Annex: NIMA–Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer's Disease & NIMA Consortium, 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study

Lleó, A., Alcolea, D., Martínez-Lage, P., Scheltens, P., Parnetti, L., Poirier, J., Simonsen, A. H., Verbeek, M. M., Rosa-Neto, P., Slot, R. E. R., Tainta, M., Izaguirre, A., Reijs, B. L. R., Farotti, L., Tsolaki, M., Vandenbergue, R., Freund-Levi, Y., Verhey, F. R. J., Clarimón, J., Fortea, J. & 8 othersFrolich, L., Santana, I., Molinuevo, J. L., Lehmann, S., Visser, P. J., Teunissen, C. E., Zetterberg, H. & Blennow, K., 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Modeling grey matter atrophy as a function of time, aging or cognitive decline show different anatomical patterns in Alzheimer's disease

Dicks, E., Vermunt, L., van der Flier, W. M., Visser, P. J., Barkhof, F., Scheltens, P., Tijms, B. M. & Alzheimer's Disease Neuroimaging Initiative, 19 Mar 2019, In : NeuroImage: Clinical. 22

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

Kim, M., Snowden, S., Suvitaival, T., Ali, A., Merkler, D. J., Ahmad, T., Westwood, S., Baird, A., Proitsi, P., Nevado-Holgado, A., Hye, A., Bos, I., Vos, S., Vandenberghe, R., Teunissen, C., ten Kate, M., Scheltens, P., Gabel, S., Meersmans, K., Blin, O. & 31 othersRichardson, J., de Roeck, E., Sleegers, K., Bordet, R. G., Rami, L., Kettunen, P., Tsolaki, M., Verhey, F., Sala, I., Lléo, A., Peyratout, G., Tainta, M., Johannsen, P., Freund-Levi, Y., Frölich, L., Dobricic, V., Engelborghs, S., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Popp, J., Martinez-Lage, P., Bertram, L., Barkhof, F., Ashton, N., Blennow, K., Zetterberg, H., Streffer, J., Visser, P. J., Lovestone, S. & Legido-Quigley, C., 2019, In : Alzheimer's and Dementia. 15, 6, p. 817-827

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prognostic value of Alzheimer's biomarkers in mild cognitive impairment: the effect of age at onset

Alzheimer’s Disease Neuroimaging Initiative, 2 Jul 2019, In : Journal of Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Repeat length variations in ATXN1 and AR modify disease expression in Alzheimer's disease

Gardiner, S. L., Harder, A. V. E., Campman, Y. J. M., Trompet, S., Gussekloo, J., van Belzen, M. J., Boogaard, M. W., Roos, R. A. C., Jansen, I. E., Pijnenburg, Y. A. L., Scheltens, P., van der Flier, W. M. & Aziz, N. A., 1 Jan 2019, In : Neurobiology of Aging. 73, p. 230.e9-230.e17

Research output: Contribution to journalArticleAcademicpeer-review

Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group, INSIGHT-preAD study group & SCD-I working group, 1 Mar 2019, In : Alzheimer's and Dementia. 15, 3, p. 465-476 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Testing Episodic Memory in Elderly Subjects: Not as Simple as It Looks

Boelaarts, L., Meyer, S. R. A., Scheltens, P. & de Jonghe, J. F. M., 2019, In : Dementia and Geriatric Cognitive Disorders EXTRA. p. 207-216

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Clinical Phenotype of Vascular Cognitive Impairment in Patients with Type 2 Diabetes Mellitus

Groeneveld, O. N., Moneti, C., Heinen, R., de Bresser, J., Kuijf, H. J., Exalto, L. G., Boomsma, J. M. F., Kappelle, L. J., Barkhof, F., Prins, N. D., Scheltens, P., van der Flier, W. M. & Biessels, G. J., 2019, In : Journal of Alzheimer's Disease. 68, 1, p. 311-322

Research output: Contribution to journalArticleAcademicpeer-review

White Matter Hyperintensities and Hippocampal Atrophy in Relation to Cognition: The 90+ Study

Legdeur, N., Visser, P. J., Woodworth, D. C., Muller, M., Fletcher, E., Maillard, P., Scheltens, P., DeCarli, C., Kawas, C. H. & Corrada, M. M., 2019, In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticleAcademicpeer-review

“Alzheimer's disease” is neither “Alzheimer's clinical syndrome” nor “dementia”

Jagust, W., Jack, C. R., Bennett, D. A., Blennow, K., Haeberlein, S. B., Holtzman, D. M., Jessen, F., Karlawish, J., Liu, E., Molinuevo, J. L., Montine, T., Phelps, C., Rankin, K. P., Rowe, C. C., Scheltens, P., Siemers, E. & Sperling, R., 2019, In : Alzheimer's and Dementia. 15, 1, p. 153-157

Research output: Contribution to journalEditorialAcademicpeer-review

Amsterdam dementia cohort: Performing research to optimize care

Van Der Flier, W. M. & Scheltens, P., 1 Jan 2018, In : Journal of Alzheimer's Disease. 62, 3, p. 1091-1111 21 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Amyloid-beta and phosphorylated tau in post-mortem Alzheimer's disease retinas

den Haan, J., Morrema, T. H. J., Verbraak, F. D., de Boer, J. F., Scheltens, P., Rozemuller, A. J., Bergen, A. A. B., Bouwman, F. H. & Hoozemans, J. J., 2018, In : Acta Neuropathologica Communinications. 6, 1, p. 147

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease

Scheltens, P., Prins, N., Lammertsma, A., Yaqub, M., Gouw, A., Wink, A. M., Chu, H. M., van Berckel, B. N. M. & Alam, J., 1 Apr 2018, In : Annals of Clinical and Translational Neurology. 5, 4, p. 464-473 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy

Chakraborty, A., Kamermans, A., van Het Hof, B., Castricum, K., Aanhane, E., van Horssen, J., Thijssen, V. L., Scheltens, P., Teunissen, C. E., Fontijn, R. D., van der Flier, W. M. & de Vries, H. E., 2018, In : Brain : a journal of neurology. 141, 12, p. 3377-3388 12 p.

Research output: Contribution to journalArticleAcademicpeer-review