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Research Output 2002 2019

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AMYPAD Diagnostic and Patient Management Study: Rationale and design

Frisoni, G. B., Barkhof, F., Altomare, D., Berkhof, J., Boccardi, M., Canzoneri, E., Collij, L., Drzezga, A., Farrar, G., Garibotto, V., Gismondi, R., Gispert, J-D., Jessen, F., Kivipelto, M., Lopes Alves, I., Molinuevo, J-L., Nordberg, A., Payoux, P., Ritchie, C., Savicheva, I. & 8 othersScheltens, P., Schmidt, M. E., Schott, J., Stephens, A., van Berckel, B., Vellas, B., Walker, Z. & Raffa, N., Mar 2019, In : Alzheimers & Dementia. 15, 3, p. 388-399

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Auditory hallucinations in adults with hearing impairment: a large prevalence study

Linszen, M. M. J., van Zanten, G. A., Teunisse, R. J., Brouwer, R. M., Scheltens, P. & Sommer, I. E., 1 Jan 2019, In : Psychological Medicine. 49, 1, p. 132-139 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Automatically computed rating scales from MRI for patients with cognitive disorders

Alzheimer’s Disease Neuroimaging Initiative, 2019, In : European Radiology.

Research output: Contribution to journalArticleAcademicpeer-review

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

Bos, I., Vos, S., Verhey, F., Scheltens, P., Teunissen, C., Engelborghs, S., Sleegers, K., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R. G., Tsolaki, M., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Lleó, A., Johannsen, P., Freund-Levi, Y., Frölich, L. & 12 othersVandenberghe, R., Westwood, S., Dobricic, V., Barkhof, F., Legido-Quigley, C., Bertram, L., Lovestone, S., Streffer, J., Andreasson, U., Blennow, K., Zetterberg, H. & Visser, P. J., 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Data-driven approaches for tau-PET imaging biomarkers in Alzheimer's disease

The Alzheimer's Disease Neuroimaging Initiative, 1 Feb 2019, In : Human Brain Mapping. 40, 2, p. 638-651 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

How Do Different Forms of Vascular Brain Injury Relate to Cognition in a Memory Clinic Population: The TRACE-VCI Study

Boomsma, J. M. F., Exalto, L. G., Barkhof, F., Berg, E. V. D., Bresser, J. D., Heinen, R., Leeuwis, A. E., Prins, N. D., Scheltens, P., Weinstein, H. C., van der Flier, W. M., Biessels, G. J. & behalf of the TRACE-VCI study group, 18 Mar 2019, In : Journal of Alzheimer's Disease.

Research output: Contribution to journalArticleAcademicpeer-review

How Do Different Forms of Vascular Brain Injury Relate to Cognition in a Memory Clinic Population: The TRACE-VCI Study

Boomsma, J. M. F., Exalto, L. G., Barkhof, F., van den Berg, E., de Bresser, J., Heinen, R., Leeuwis, A. E., Prins, N. D., Scheltens, P., Weinstein, H. C., van der Flier, W. M. & Biessels, G. J., 2019, In : Journal of Alzheimer's Disease. 68, 3, p. 1273-1286

Research output: Contribution to journalArticleAcademicpeer-review

Inflammatory biomarkers in Alzheimer's disease plasma

Annex: NIMA–Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer's Disease & NIMA Consortium, 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study

Lleó, A., Alcolea, D., Martínez-Lage, P., Scheltens, P., Parnetti, L., Poirier, J., Simonsen, A. H., Verbeek, M. M., Rosa-Neto, P., Slot, R. E. R., Tainta, M., Izaguirre, A., Reijs, B. L. R., Farotti, L., Tsolaki, M., Vandenbergue, R., Freund-Levi, Y., Verhey, F. R. J., Clarimón, J., Fortea, J. & 8 othersFrolich, L., Santana, I., Molinuevo, J. L., Lehmann, S., Visser, P. J., Teunissen, C. E., Zetterberg, H. & Blennow, K., 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Modeling grey matter atrophy as a function of time, aging or cognitive decline show different anatomical patterns in Alzheimer's disease

Dicks, E., Vermunt, L., van der Flier, W. M., Visser, P. J., Barkhof, F., Scheltens, P., Tijms, B. M. & Alzheimer's Disease Neuroimaging Initiative, 19 Mar 2019, In : NeuroImage: Clinical. 22

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Repeat length variations in ATXN1 and AR modify disease expression in Alzheimer's disease

Gardiner, S. L., Harder, A. V. E., Campman, Y. J. M., Trompet, S., Gussekloo, J., van Belzen, M. J., Boogaard, M. W., Roos, R. A. C., Jansen, I. E., Pijnenburg, Y. A. L., Scheltens, P., van der Flier, W. M. & Aziz, N. A., 1 Jan 2019, In : Neurobiology of Aging. 73, p. 230.e9-230.e17

Research output: Contribution to journalArticleAcademicpeer-review

The Clinical Phenotype of Vascular Cognitive Impairment in Patients with Type 2 Diabetes Mellitus

Groeneveld, O. N., Moneti, C., Heinen, R., de Bresser, J., Kuijf, H. J., Exalto, L. G., Boomsma, J. M. F., Kappelle, L. J., Barkhof, F., Prins, N. D., Scheltens, P., van der Flier, W. M. & Biessels, G. J., 2019, In : Journal of Alzheimer's Disease. 68, 1, p. 311-322

Research output: Contribution to journalArticleAcademicpeer-review

Amyloid-beta and phosphorylated tau in post-mortem Alzheimer's disease retinas

den Haan, J., Morrema, T. H. J., Verbraak, F. D., de Boer, J. F., Scheltens, P., Rozemuller, A. J., Bergen, A. A. B., Bouwman, F. H. & Hoozemans, J. J., 2018, In : Acta Neuropathologica Communinications. 6, 1, p. 147

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease

Scheltens, P., Prins, N., Lammertsma, A., Yaqub, M., Gouw, A., Wink, A. M., Chu, H. M., van Berckel, B. N. M. & Alam, J., 1 Apr 2018, In : Annals of Clinical and Translational Neurology. 5, 4, p. 464-473 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy

Chakraborty, A., Kamermans, A., van Het Hof, B., Castricum, K., Aanhane, E., van Horssen, J., Thijssen, V. L., Scheltens, P., Teunissen, C. E., Fontijn, R. D., van der Flier, W. M. & de Vries, H. E., 2018, In : Brain : a journal of neurology. 141, 12, p. 3377-3388 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

A novel cognitive-functional composite measure to detect changes in early Alzheimer's disease: Test–retest reliability and feasibility

Jutten, R. J., Harrison, J., Lee Meeuw Kjoe, P. R., Opmeer, E. M., Schoonenboom, N. S. M., de Jong, F. J., Ritchie, C. W., Scheltens, P. & Sikkes, S. A. M., 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 153-160

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessing Fitness to Drive in Patients with Different Types of Dementia

Piersma, D., Fuermaier, A. B. M., de Waard, D. I., Davidse, R. J., de Groot, J., Doumen, M. J. A., Bredewoud, R. A., Claesen, R., Lemstra, A. W., Scheltens, P., Vermeeren, A., Ponds, R., Verhey, F., de Deyn, P. P., Brouwer, W. H. & Tucha, O., 2018, In : Alzheimer Disease and Associated Disorders. 32, 1, p. 70-75

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association of Amyloid Positron Emission Tomography With Changes in Diagnosis and Patient Treatment in an Unselected Memory Clinic Cohort: The ABIDE Project

de Wilde, A., van der Flier, W. M., Pelkmans, W., Bouwman, F., Verwer, J., Groot, C., van Buchem, M. M., Zwan, M., Ossenkoppele, R., Yaqub, M., Kunneman, M., Smets, E. M. A., Barkhof, F., Lammertsma, A. A., Stephens, A., van Lier, E., Biessels, G. J., van Berckel, B. N. & Scheltens, P., 1 Sep 2018, In : JAMA Neurology. p. 1062-1070 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Atrophy subtypes in prodromal Alzheimer's disease are associated with cognitive decline

ten Kate, M., Dicks, E., van der Flier, W. M., Teunissen, C. E., Barkhof, F., Scheltens, P., Tijms, B. M. & Alzheimer’s Disease Neuroimaging Initiative, 2018, In : Brain : a journal of neurology. 141, 12, p. 3443-3456 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Brain-Area Specific White Matter Hyperintensities: Associations to Falls in Parkinson's Disease

Ciliz, M., Sartor, J., Lindig, T., Pilotto, A., Schäffer, E., Weiss, M., Scheltens, P., Becker, S., Hobert, M. A., Berg, D., Liepelt-Scarfone, I. & Maetzler, W., 1 Jan 2018, In : Journal of parkinsons disease. 8, 3, p. 455-462 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cerebral White Matter Lesions have Low Impact on Cognitive Function in a Large Elderly Memory Clinic Population

Claus, J. J., Coenen, M., Staekenborg, S. S., Schuur, J., Tielkes, C. E. M., Koster, P. & Scheltens, P., 2018, In : Journal of Alzheimer's Disease. 63, 3, p. 1129-1139

Research output: Contribution to journalArticleAcademicpeer-review

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., Melo van Lent, D., Tynkkynen, J., Fischer, K., Hernesniemi, J., Haller, T., Singh-Manoux, A., Verhoeven, A., Willemsen, G., de Leeuw, F. A., Wagner, H., van Dongen, J., Hertel, J., Budde, K., Willems van Dijk, K. & 28 othersWeinhold, L., Ikram, M. A., Pietzner, M., Perola, M., Wagner, M., Friedrich, N., Slagboom, P. E., Scheltens, P., Yang, Q., Gertzen, R. E., Egert, S., Li, S., Hankemeier, T., van Beijsterveldt, C. E. M., Vasan, R. S., Maier, W., Peeters, C. F. W., Jörgen Grabe, H., Ramirez, A., Seshadri, S., Metspalu, A., Kivimäki, M., Salomaa, V., Demirkan, A., Boomsma, D. I., van der Flier, W. M., Amin, N. & van Duijn, C. M., 1 Jun 2018, In : Alzheimer's and Dementia. 14, 6, p. 707-722 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clinical phenotype, atrophy, and small vessel disease in APOEε2 carriers with Alzheimer disease

Groot, C., Sudre, C. H., Barkhof, F., Teunissen, C. E., van Berckel, B. N. M., Seo, S. W., Ourselin, S., Scheltens, P., Cardoso, M. J., van der Flier, W. M. & Ossenkoppele, R., 13 Nov 2018, In : Neurology. 91, 20, p. e1851-e1859

Research output: Contribution to journalArticleAcademicpeer-review

Computer-assisted prediction of clinical progression in the earliest stages of AD

Rhodius-Meester, H. F. M., Liedes, H., Koikkalainen, J., Wolfsgruber, S., Coll-Padros, N., Kornhuber, J., Peters, O., Jessen, F., Kleineidam, L., Molinuevo, J. L., Rami, L., Teunissen, C. E., Barkhof, F., Sikkes, S. A. M., Wesselman, L. M. P., Slot, R. E. R., Verfaillie, S. C. J., Scheltens, P., Tijms, B. M., Lötjönen, J. & 1 othersvan der Flier, W. M., 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 726-736

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Current state of Alzheimer’s fluid biomarkers

Molinuevo, J. L., Ayton, S., Batrla, R., Bednar, M. M., Bittner, T., Cummings, J., Fagan, A. M., Hampel, H., Mielke, M. M., Mikulskis, A., O’Bryant, S., Scheltens, P., Sevigny, J., Shaw, L. M., Soares, H. D., Tong, G., Trojanowski, J. Q., Zetterberg, H. & Blennow, K., 2018, In : Acta Neuropathologica.

Research output: Contribution to journalArticleAcademicpeer-review

Data-driven differential diagnosis of dementia using multiclass disease state index classifier

Tolonen, A., Rhodius-Meester, H. F. M., Bruun, M., Koikkalainen, J., Barkhof, F., Lemstra, A. W., Koene, T., Scheltens, P., Teunissen, C. E., Tong, T., Guerrero, R., Schuh, A., Ledig, C., Baroni, M., Rueckert, D., Soininen, H., Remes, A. M., Waldemar, G., Hasselbalch, S. G., Mecocci, P. & 2 othersvan der Flier, W. M. & Lötjönen, J., 25 Apr 2018, In : Frontiers in Aging Neuroscience. 10, APR, 111.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Disease-related determinants are associated with mortality in dementia due to Alzheimer's disease

Rhodius-Meester, H. F. M., Liedes, H., Koene, T., Lemstra, A. W., Teunissen, C. E., Barkhof, F., Scheltens, P., Van Gils, M., Lötjönen, J. & Van Der Flier, W. M., 20 Feb 2018, In : Alzheimer's Research and Therapy. 10, 1, 23.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

EEG-based neurophysiological indicators of hallucinations in Alzheimer's disease: Comparison with dementia with Lewy bodies

Dauwan, M., Linszen, M. M. J., Lemstra, A. W., Scheltens, P., Stam, C. J. & Sommer, I. E., Jul 2018, In : Neurobiology of Aging. 67, p. 75-83 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

Vermunt, L., van der Flier, W., Frisoni, G. B., Guessous, I., Kivipelto, M., Marizzoni, M., Martinez-Lage, P., Molinuevo, J. L., Porteous, D., Ritchie, K., Scheltens, P., Ousset, P. J., Ritchie, C. W., Luscan, G. & Visser, P. J., 1 Jun 2018, In : Alzheimer's and Dementia. 14, 6, p. 837-842 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Evaluating combinations of diagnostic tests to discriminate different dementia types

Bruun, M., Rhodius-Meester, H. F. M., Koikkalainen, J., Baroni, M., Gjerum, L., Lemstra, A. W., Barkhof, F., Remes, A. M., Urhemaa, T., Tolonen, A., Rueckert, D., van Gils, M., Frederiksen, K. S., Waldemar, G., Scheltens, P., Mecocci, P., Soininen, H., Lötjönen, J., Hasselbalch, S. G. & van der Flier, W. M., 1 Jan 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 509-518 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Gray matter network disruptions and regional amyloid beta in cognitively normal adults

ten Kate, M., Visser, P. J., Bakardjian, H., Barkhof, F., Sikkes, S. A. M., van der Flier, W. M., Scheltens, P., Hampel, H., Habert, M. O., Dubois, B., Tijms, B. M., Audrain, C., Auffret, A., Bakardjian, H., Baldacci, F., Batrancourt, B., Benakki, I., Benali, H., Bertin, H., Bertrand, A. & 31 othersBoukadida, L., Cacciamani, F., Causse, V., Cavedo, E., Cherif Touil, S., Chiesa, P. A., Colliot, O., Dalla Barba, G., Depaulis, M., Dos Santos, A., Dubois, B., Dubois, M., Epelbaum, S., Fontaine, B., Francisque, H., Gagliardi, G., Genin, A., Genthon, R., Glasman, P., Gombert, F., Habert, M. O., Hampel, H., Hewa, H., Houot, M., Jungalee, N., Kas, A., Kilani, M., La Corte, V., Le Roy, F., Lehericy, S. & INSIGHT-preAD study group, 15 Mar 2018, In : Frontiers in Aging Neuroscience. 10, FEB, 67.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Gray matter network measures are associated with cognitive decline in mild cognitive impairment

Dicks, E., Tijms, B. M., ten Kate, M., Gouw, A. A., Benedictus, M. R., Teunissen, C. E., Barkhof, F., Scheltens, P. & van der Flier, W. M., 1 Jan 2018, In : Neurobiology of Aging. 61, p. 198-206 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease

Scheltens, N. M. E., van der Weijden, K., Adriaanse, S. M., van Assema, D., Oomen, P. P., Krudop, W. A., Lammertsma, A. A., Barkhof, F., Koene, T., Teunissen, C. E., Scheltens, P., van der Flier, W. M., Pijnenburg, Y. A. L., Yaqub, M., Ossenkoppele, R. & van Berckel, B. N. M., 1 Jan 2018, In : NeuroImage: Clinical. 19, p. 625-632 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

International FTD-Genomics Consortium, 2018, In : PLoS Medicine. 15, 1, e1002487.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access