Philip Scheltens

PROF.DR., (Principal Investigator)

19992020
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Research Output 1999 2020

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2020

Comorbid amyloid-β pathology affects clinical and imaging features in VCD

Leijenaar, J. F., Groot, C., Sudre, C. H., Bergeron, D., Leeuwis, A. E., Cardoso, M. J., Carrasco, F. P., Laforce, R., Barkhof, F., van der Flier, W. M., Scheltens, P., Prins, N. D. & Ossenkoppele, R., 1 Feb 2020, In : Alzheimers & Dementia. 16, 2, p. 354-364

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Methylphenidate and galantamine in patients with vascular cognitive impairment-the proof-of-principle study STREAM-VCI

Leijenaar, J. F., Groeneveld, G. J., Klaassen, E. S., Leeuwis, A. E., Scheltens, P., Weinstein, H. C., van Gerven, J. M. A., Barkhof, F., van der Flier, W. M. & Prins, N. D., 2020, In : Alzheimer's Research & Therapy. 12, 1, p. 10

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings

IMI-EPAD collaborators, 2020, In : Alzheimer's Research & Therapy. 12, 1, p. 8

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy

Rhodius-Meester, H. F. M., van Maurik, I. S., Koikkalainen, J., Tolonen, A., Frederiksen, K. S., Hasselbalch, S. G., Soininen, H., Herukka, S-K., Remes, A. M., Teunissen, C. E., Barkhof, F., Pijnenburg, Y. A. L., Scheltens, P., Lötjönen, J. & van der Flier, W. M., 2020, In : PLoS ONE. 15, 1, p. e0226784

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An 123I-FP-CIT SPECT study

van der Zande, J. J., Joling, M., Happach, I. G., Vriend, C., Scheltens, P., Booij, J. & Lemstra, A. W., 2020, In : NeuroImage: Clinical. 25, 102062.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Specific Nutritional Biomarker Profiles in Mild Cognitive Impairment and Subjective Cognitive Decline Are Associated With Clinical Progression: The NUDAD Project

de Leeuw, F. A., van der Flier, W. M., Tijms, B. M., Scheltens, P., Mendes, V. M., Manadas, B., Bierau, J. R., van Wijk, N., van den Heuvel, E. G. H. M., Mohajeri, M. H., Teunissen, C. E. & Kester, M. I., 27 Jan 2020, In : Journal of the American Medical Directors Association.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

ADDED DIAGNOSTIC VALUE OF 18F-FLUTEMETAMOL PET SCANNING IN YOUNG PATIENTS WITH DEMENTIA

Handels, R., Zwan, M. D., Pelkmans, W., Bouwman, F. H., Biessels, G. J., Roks, G., Schoonenboom, N. S. M., Verwey, N. A., Van Berckel, B. N. M., van der Flier, W. M., Verhey, F. R. J. & Scheltens, P., Jul 2019, In : Alzheimers & Dementia. 15, 7, p. P740

Research output: Contribution to journalArticleAcademicpeer-review

Alzheimer disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal

Vermunt, L., van Paasen, A. J. L., Teunissen, C. E., Scheltens, P., Visser, P. J., Tijms, B. M. & Alzheimer's Disease Neuroimaging Initiative, 4 Jun 2019, In : Neurology. 92, 23, p. e2699-e2705

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort

Stamate, D., Kim, M., Proitsi, P., Westwood, S., Baird, A., Nevado-Holgado, A., Hye, A., Bos, I., Vos, S. J. B., Vandenberghe, R., Teunissen, C. E., Kate, M. T., Scheltens, P., Gabel, S., Meersmans, K., Blin, O., Richardson, J., de Roeck, E., Engelborghs, S., Sleegers, K. & 25 othersBordet, R. G., Ramit, L., Kettunen, P., Tsolaki, M., Verhey, F., Alcolea, D., Lléo, A., Peyratout, G., Tainta, M., Johannsen, P., Freund-Levi, Y., Frölich, L., Dobricic, V., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Popp, J., Martinez-Lage, P., Bertram, L., Blennow, K., Zetterberg, H., Streffer, J., Visser, P. J., Lovestone, S. & Legido-Quigley, C., 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 933-938

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

AMYPAD Diagnostic and Patient Management Study: Rationale and design

Frisoni, G. B., Barkhof, F., Altomare, D., Berkhof, J., Boccardi, M., Canzoneri, E., Collij, L., Drzezga, A., Farrar, G., Garibotto, V., Gismondi, R., Gispert, J-D., Jessen, F., Kivipelto, M., Lopes Alves, I., Molinuevo, J-L., Nordberg, A., Payoux, P., Ritchie, C., Savicheva, I. & 8 othersScheltens, P., Schmidt, M. E., Schott, J., Stephens, A., van Berckel, B., Vellas, B., Walker, Z. & Raffa, N., 1 Mar 2019, In : Alzheimers & Dementia. 15, 3, p. 388-399 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

van der Lee, S. J., Conway, O. J., Jansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hernández, I., van Eijk, K. R., Stringa, N., Chen, J. A., Zettergren, A., Andlauer, T. F. M., Diez-Fairen, M., Simon-Sanchez, J., Lleó, A., Zetterberg, H., Nygaard, M., Blauwendraat, C., Savage, J. E., Mengel-From, J. & 37 othersMoreno-Grau, S., Wagner, M., Fortea, J., Keogh, M. J., Blennow, K., Skoog, I., Friese, M. A., Pletnikova, O., Zulaica, M., Lage, C., de Rojas, I., Riedel-Heller, S., Illán-Gala, I., Wei, W., Jeune, B., Hulsman, M., Beker, N., Tesi, N., Collij, L. E., van Berckel, B. N. M., Reinders, M. J. T., van Schoor, N. M., Lemstra, A. W., Pijnenburg, Y. A. L., Scheltens, P., Huisman, M. A., Heutink, P., Posthuma, D., van der Flier, W. M., Holstege, H., DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB) & The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, 1 Aug 2019, In : Acta Neuropathologica. 138, 2, p. 237-250

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Applying the ATN scheme in a memory clinic population: The ABIDE project

Altomare, D., de Wilde, A., Ossenkoppele, R., Pelkmans, W., Bouwman, F., Groot, C., van Maurik, I., Zwan, M., Yaqub, M., Barkhof, F., van Berckel, B. N., Teunissen, C. E., Frisoni, G. B., Scheltens, P. & van der Flier, W. M., 22 Oct 2019, In : Neurology. 93, 17, p. e1635-e1646

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessing cognition and daily function in early dementia using the cognitive-functional composite: Findings from the Catch-Cog study cohort

Jutten, R. J., Harrison, J. E., Lee Meeuw Kjoe, P. R., Ingala, S., Vreeswijk, R., van Deelen, R. A. J., de Jong, F. J., Opmeer, E. M., Aleman, A., Ritchie, C. W., Scheltens, P. & Sikkes, S. A. M., 15 May 2019, In : Alzheimer's Research and Therapy. 11, 1, 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Associations of AD biomarkers and cognitive performance with nutritional status: The NUDAD project

Doorduijn, A. S., Visser, M., van de Rest, O., Kester, M. I., de Leeuw, F. A., Boesveldt, S., Fieldhouse, J. L. P., van den Heuvel, E. G. H. M., Teunissen, C. E., Scheltens, P., van der Flier, W. M. & de van der Schueren, M. A. E., 1 May 2019, In : Nutrients. 11, 5, 1161.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Auditory hallucinations in adults with hearing impairment: a large prevalence study

Linszen, M. M. J., van Zanten, G. A., Teunisse, R. J., Brouwer, R. M., Scheltens, P. & Sommer, I. E., 1 Jan 2019, In : Psychological Medicine. 49, 1, p. 132-139 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Automatically computed rating scales from MRI for patients with cognitive disorders

Koikkalainen, J. R., Rhodius-Meester, H. F. M., Frederiksen, K. S., Bruun, M., Hasselbalch, S. G., Baroni, M., Mecocci, P., Vanninen, R., Remes, A., Soininen, H., van Gils, M., van der Flier, W. M., Scheltens, P., Barkhof, F., Erkinjuntti, T., Lötjönen, J. M. P. & Alzheimer’s Disease Neuroimaging Initiative, 1 Sep 2019, In : European Radiology. 29, 9, p. 4937-4947 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

Liebsch, F., Kulic, L., Teunissen, C., Shobo, A., Ulku, I., Engelschalt, V., Hancock, M. A., van der Flier, W. M., Kunach, P., Rosa-Neto, P., Scheltens, P., Poirier, J., Saftig, P., Bateman, R. J., Breitner, J., Hock, C. & Multhaup, G., 1 Dec 2019, In : Nature Communications. 10, 1, 2240.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study

van Maurik, I. S., Vos, S. J., Bos, I., Bouwman, F. H., Teunissen, C. E., Scheltens, P., Barkhof, F., Frolich, L., Kornhuber, J., Wiltfang, J., Maier, W., Peters, O., Rüther, E., Nobili, F., Frisoni, G. B., Spiru, L., Freund-Levi, Y., Wallin, A. K., Hampel, H., Soininen, H. & 20 othersTsolaki, M., Verhey, F., Kłoszewska, I., Mecocci, P., Vellas, B., Lovestone, S., Galluzzi, S., Herukka, S-K., Santana, I., Baldeiras, I., de Mendonça, A., Silva, D., Chetelat, G., Egret, S., Palmqvist, S., Hansson, O., Visser, P. J., Berkhof, J., van der Flier, W. M. & Alzheimer's Disease Neuroimaging Initiative, 1 Nov 2019, In : Lancet Neurology. 18, 11, p. 1034-1044

Research output: Contribution to journalArticleAcademicpeer-review

Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions

Weaver, N. A., Doeven, T., Barkhof, F., Biesbroek, J. M., Groeneveld, O. N., Kuijf, H. J., Prins, N. D., Scheltens, P., Teunissen, C. E., van der Flier, W. M., Biessels, G. J. & TRACE-VCI study group, 1 Dec 2019, In : Neurobiology of Aging. 84, p. 225-234 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

Bos, I., Vos, S., Verhey, F., Scheltens, P., Teunissen, C., Engelborghs, S., Sleegers, K., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R. G., Tsolaki, M., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Lleó, A., Johannsen, P., Freund-Levi, Y., Frölich, L. & 12 othersVandenberghe, R., Westwood, S., Dobricic, V., Barkhof, F., Legido-Quigley, C., Bertram, L., Lovestone, S., Streffer, J., Andreasson, U., Blennow, K., Zetterberg, H. & Visser, P. J., 1 May 2019, In : Alzheimer's and Dementia. 15, 5, p. 644-654 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cerebrospinal fluid collection: An informative animation video for patients and caregivers

Babapour Mofrad, R., Visser, L. N. C., Fruijtier, A. D., Scheltens, P., Smets, E. E. M. A., van der Flier, W. M. & Teunissen, C. E., 1 Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 435-438 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clinician-patient communication during the diagnostic workup: The ABIDE project

Visser, L. N. C., Kunneman, M., Murugesu, L., van Maurik, I., Zwan, M., Bouwman, F. H., Schuur, J., Wind, H. A., Blaauw, M. S. J., Kragt, J. J., Roks, G., Boelaarts, L., Schipper, A. C., Schooneboom, N., Scheltens, P., van der Flier, W. M. & Smets, E. M. A., 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 520-528

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cognitive and functional progression of dementia in two longitudinal studies

Wang, Y., Haaksma, M. L., Ramakers, I. H. G. B., Verhey, F. R. J., van de Flier, W. M., Scheltens, P., van Maurik, I., Olde Rikkert, M. G. M., Leoutsakos, J-M. S. & Melis, R. J. F., 18 Jul 2019, In : International Journal of Geriatric Psychiatry. 34, 11, p. 1623-1632

Research output: Contribution to journalArticleAcademicpeer-review

Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship

van Loenhoud, A. C., van der Flier, W. M., Wink, A. M., Dicks, E., Groot, C., Twisk, J., Barkhof, F., Scheltens, P., Ossenkoppele, R. & Alzheimer's Disease Neuroimaging Initiative, 23 Jul 2019, In : Neurology. 93, 4, p. e334-e346

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Data-driven approaches for tau-PET imaging biomarkers in Alzheimer's disease

Vogel, J. W., Mattsson, N., Iturria-Medina, Y., Strandberg, O. T., Schöll, M., Dansereau, C., Villeneuve, S., van der Flier, W. M., Scheltens, P., Bellec, P., Evans, A. C., Hansson, O., Ossenkoppele, R. & The Alzheimer's Disease Neuroimaging Initiative, 1 Feb 2019, In : Human Brain Mapping. 40, 2, p. 638-651 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Decision tree supports the interpretation of CSF biomarkers in Alzheimer's disease

Babapour Mofrad, R., Schoonenboom, N. S. M., Tijms, B. M., Scheltens, P., Visser, P. J., van der Flier, W. M. & Teunissen, C. E., 1 Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 1-9 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Determinants of Cross-Sectional and Longitudinal Health-Related Quality of Life in Memory Clinic Patients Without Dementia

Banning, L. C. P., Janssen, E. P. C. J., Hamel, R. E. G., de Vugt, M., Köhler, S., Wolfs, C. A. G., Oosterveld, S. M., Melis, R. J. F., Olde Rikkert, M. G. M., Kessels, R. P. C., Pijnenburg, Y. A. L., Koene, T., van der Flier, W. M., Scheltens, P., Visser, P. J., Verhey, F. R. J., Aalten, P. & Ramakers, I. H. G. B., 1 Jan 2019, In : Journal of Geriatric Psychiatry and Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Development and Usability of ADappt: Web-Based Tool to Support Clinicians, Patients, and Caregivers in the Diagnosis of Mild Cognitive Impairment and Alzheimer Disease

van Maurik, I. S., Visser, L. N., Pel-Littel, R. E., van Buchem, M. M., Zwan, M. D., Kunneman, M., Pelkmans, W., Bouwman, F. H., Minkman, M., Schoonenboom, N., Scheltens, P., Smets, E. M. & van der Flier, W. M., 8 Jul 2019, In : JMIR Formative Research. 21, 3

Research output: Contribution to journalArticleAcademicpeer-review

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Shi, L., Westwood, S., Baird, A. L., Winchester, L., Dobricic, V., Kilpert, F., Hong, S., Franke, A., Hye, A., Ashton, N. J., Morgan, A. R., Bos, I., Vos, S. J. B., Buckley, N. J., Kate, M. T., Scheltens, P., Vandenberghe, R., Gabel, S., Meersmans, K., Engelborghs, S. & 33 othersde Roeck, E. E., Sleegers, K., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R. G., Molinuevo, J. L., Rami, L., Wallin, A., Kettunen, P., Tsolaki, M., Verhey, F., Lleó, A., Alcolea, D., Popp, J., Peyratout, G., Martinez-Lage, P., Tainta, M., Johannsen, P., Teunissen, C. E., Freund-Levi, Y., Frölich, L., Legido-Quigley, C., Barkhof, F., Blennow, K., Zetterberg, H., Baker, S., Morgan, B. P., Streffer, J., Visser, P. J., Bertram, L., Lovestone, S. & Nevado-Holgado, A. J., Nov 2019, In : Alzheimer's and Dementia. 15, 11, p. 1478-1488

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Driving Difficulties Among Patients with Alzheimer's Disease and Other Neurodegenerative Disorders

Fuermaier, A. B. M., Piersma, D., de Waard, D., Davidse, R. J., de Groot, J., Doumen, M. J. A., Bredewoud, R. A., Claesen, R., Lemstra, A. W., Scheltens, P., Vermeeren, A., Ponds, R., Verhey, F., De Deyn, P. P., Brouwer, W. H. & Tucha, O., 1 Jan 2019, In : Journal of Alzheimer's Disease. 69, 4, p. 1019-1030 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

Vermunt, L., Sikkes, S. A. M., van den Hout, A., Handels, R., Bos, I., van der Flier, W. M., Kern, S., Ousset, P-J., Maruff, P., Skoog, I., Verhey, F. R. J., Freund-Levi, Y., Tsolaki, M., Wallin, Å. K., Olde Rikkert, M., Soininen, H., Spiru, L., Zetterberg, H., Blennow, K., Scheltens, P. & 46 othersMuniz-Terrera, G., Visser, P. J., Vellas, B., Reynish, E., Ousset, P. J., Andrieu, S., Burns, A., Pasquier, F., Frisoni, G., Salmon, E., Michel, J. P., Zekry, D. S., Boada, M., Dartigues, J. F., Olde-Rikkert, M. G. M., Rigaud, A. S., Winblad, B., Malick, A., Sinclair, A., Frölich, L., Scheltens, P., Ribera, C., Touchon, J., Robert, P., Salva, A., Waldemar, G., Bullock, R., Tsolaki, M., Rodriguez, G., AIBL Research Group, Alzheimer Disease Neuroimaging Initiative, Spiru, L., Jones, R. W., Stiens, G., Stoppe, G., Eriksdotter-Jonhagen, M., Cherubini, A., Lage, P. M., Gomez-Isla, T., Camus, V., Agüera-Morales, E., Lopez, F., Andrieu, S., Savy, S., Cantet, C. & Coley, N., 1 Jul 2019, In : Alzheimer's and Dementia. 15, 7, p. 888-898 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer's disease: Protocol of the BEAT-IT study

Eikelboom, W. S., Singleton, E., van den Berg, E., Coesmans, M., Mattace Raso, F., van Bruchem, R. L., Goudzwaard, J. A., de Jong, F. J., Koopmanschap, M., den Heijer, T., Driesen, J. J. M., Vroegindeweij, L. J. H. M., Thomeer, E. C., Hoogers, S. E., Dijkstra, A. A., Zuidema, S. U., Pijnenburg, Y. A. L., Scheltens, P., van Swieten, J. C., Ossenkoppele, R. & 1 othersPapma, J. M., 24 May 2019, In : Alzheimer's Research and Therapy. 11, 1, 48.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease

Hijazi, S., Heistek, T. S., Scheltens, P., Neumann, U., Shimshek, D. R., Mansvelder, H. D., Smit, A. B. & van Kesteren, R. E., 20 Aug 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access