Pieter Koolwijk

DR.

20082019
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Research Output 2008 2019

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Article
2019

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin

Juni, R. P., Kuster, D. W. D., Goebel, M., Helmes, M., Musters, R. J. P., van der Velden, J., Koolwijk, P., Paulus, W. J. & van Hinsbergh, V. W. M., 1 Sep 2019, In : JACC: Basic to Translational Science. 4, 5, p. 575-591

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells

Uthman, L., Homayr, A., Juni, R. P., Spin, E. L., Kerindongo, R., Boomsma, M., Hollmann, M. W., Preckel, B., Koolwijk, P., van Hinsbergh, V. W. M., Zuurbier, C. J., Albrecht, M. & Weber, N. C., 2019, In : Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 53, 5, p. 865-886

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

IL-6 counteracts the inhibitory effect of IL-4 on osteogenic differentiation of human adipose stem cells

Bastidas-Coral, A. P., Hogervorst, J. M. A., Forouzanfar, T., Kleverlaan, C. J., Koolwijk, P., Klein-Nulend, J. & Bakker, A. D., 2019, In : Journal of Cellular Physiology. 234, 11, p. 20520-20532

Research output: Contribution to journalArticleAcademicpeer-review

Indoxyl sulfate stimulates angiogenesis by regulating reactive oxygen species production via CYP1B1

Pei, J., Juni, R., Harakalova, M., Duncker, D. J., Asselbergs, F. W., Koolwijk, P., van Hinsbergh, V. W. M., Verhaar, M. C., Mokry, M. & Cheng, C., 2019, In : Toxins. 11, 8, 454.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

Rol, N., de Raaf, M. A., Sun, X. Q., Kuiper, V. P., da Silva Gonçalves Bos, D., Happé, C., Kurakula, K., Dickhoff, C., Thuillet, R., Tu, L., Guignabert, C., Schalij, I., Lodder, K., Pan, X., Herrmann, F. E., van Nieuw Amerongen, G. P., Koolwijk, P., Vonk-Noordegraaf, A., de Man, F. S., Wollin, L. & 3 othersGoumans, M-J., Szulcek, R. & Bogaard, H. J., 2019, In : Cardiovascular Research. 115, 2, p. 432-439

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants

Boas, S. E. M., Carvalho, J., van den Broek, M., Weijers, E. M., Goumans, M-J., Koolwijk, P. & Merks, R. M. H., 2018, In : PLoS Computational Biology. 14, 7, e1006239.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Folinic acid increases protein arginine methylation in human endothelial cells

Esse, R., Teerlink, T., Koolwijk, P., Tavares de Almeida, I., Blom, H. J. & Castro, R., 2018, In : Nutrients. 10, 4, 404.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Gestational diabetes alters microRNA signatures in human feto-placental endothelial cells depending on fetal sex

Strutz, J., Cvitic, S., Hackl, H., Kashofer, K., Appel, H. M., Thüringer, A., Desoye, G., Koolwijk, P. & Hiden, U., 2018, In : Clinical science (London, England : 1979). 132, 22, p. 2437-2449

Research output: Contribution to journalArticleAcademicpeer-review

Hypoxia Impairs Initial Outgrowth of Endothelial Colony Forming Cells and Reduces Their Proliferative and Sprouting Potential

Tasev, D., Dekker-Vroling, L., van Wijhe, M., Broxterman, H. J., Koolwijk, P. & van Hinsbergh, V. W. M., 20 Dec 2018, In : Frontiers in medicine. 5, 356.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Hypoxia decreases osteogenic differentiation potential but enhances vasculogenic differentiation potential of human adipose stem cells on biphasic calcium phosphate scaffolds in fibrin gels

van Esterik, F. A. S., Hogervorst, J. M. A., Koolwijk, P. & Klein-Nulend, J., 2017, In : Journal of Stem Cells. 12, 2, p. 41-52 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro

Nauta, T. D., van den Broek, M., Gibbs, S., van der Pouw-Kraan, T. C. T. M., Oudejans, C. B., van Hinsbergh, V. W. M. & Koolwijk, P., 2017, In : Angiogenesis. 20, 1, p. 39-54

Research output: Contribution to journalArticleAcademicpeer-review

IGF-1 attenuates hypoxia-induced atrophy but inhibits myoglobin expression in C2C12 skeletal muscle myotubes

Peters, E. L., van der Linde, S. M., Vogel, I. S. P., Haroon, M., Offringa, C., de Wit, G. M. J., Koolwijk, P., van der Laarse, W. J. & Jaspers, R. T., 1 Sep 2017, In : International Journal of Molecular Sciences. 18, 9, 1889.

Research output: Contribution to journalArticleAcademicpeer-review

The effects of hyperoxia on microvascular endothelial cell proliferation and production of vaso-active substances

Attaye, I., Smulders, Y. M., de Waard, M. C., Oudemans-van Straaten, H. M., Smit, B., Van Wijhe, M. H., Musters, R. J., Koolwijk, P. & Spoelstra-de Man, A. M. E., Apr 2017, In : Intensive Care Medicine Experimental. 5, 1, 22.

Research output: Contribution to journalArticleAcademicpeer-review

2016

CD34 expression modulates tube-forming capacity and barrier properties of peripheral blood-derived endothelial colony-forming cells (ECFCs)

Tasev, D., Konijnenberg, L. S. F., Amado-Azevedo, J., van Wijhe, M. H., Koolwijk, P. & van Hinsbergh, V. W. M., Jul 2016, In : Angiogenesis. 19, 3, p. 325-338

Research output: Contribution to journalArticleAcademicpeer-review

Correction: HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells

Nauta, T. D., Duyndam, M. C. A., Weijers, E. M., van Hinsbergh, V. W. M. & Koolwijk, P., 23 Sep 2016, In : PLoS ONE. 11, 9, e0163840.

Research output: Contribution to journalArticleAcademicpeer-review

Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering

Monsuur, H. N., Weijers, E. M., Niessen, F. B., Gefen, A., Koolwijk, P., Gibbs, S. & van den Broek, L. J., 30 Nov 2016, In : PLoS ONE. 11, 11, e0167056.

Research output: Contribution to journalArticleAcademicpeer-review

Genome-Wide Identification of Epigenetic Hotspots Potentially Related to Cardiovascular Risk in Adult Women after a Complicated Pregnancy

Oudejans, C., Poutsma, A., Michel, O., Mulders, J., Visser, A., van Dijk, M., Nauta, T., Bokslag, A., Paulus, W., de Haas, A., Koolwijk, P. & de Groot, C. J. M., 12 Feb 2016, In : PLoS ONE. 11, 2, e0148313.

Research output: Contribution to journalArticleAcademicpeer-review

Globular adiponectin controls insulin-mediated vasoreactivity in muscle through AMPK alpha 2

de Boer, M. P., Meijer, R. I., Richter, E. A., van Nieuw Amerongen, G., Sipkema, P., van Poelgeest, E. M., Aman, J., Kokhuis, T. J. A., Koolwijk, P., van Hinsbergh, V. W. M., Smulders, Y. M., Serne, E. H. & Eringa, E. C., Mar 2016, In : Vascular Pharmacology. 78, p. 24-35

Research output: Contribution to journalArticleAcademicpeer-review

HIF-2 alpha Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells

Nauta, T. D., Duyndam, M. C. A., Weijers, E. M., van Hinsbergh, V. M. W. & Koolwijk, P., 4 Aug 2016, In : PLoS ONE. 11, 8, e0163840.

Research output: Contribution to journalArticleAcademicpeer-review

Matrix Remodeling and Osteogenic Differentiation of Human Adipose-Derived Stem Cells Increases with Higher Fibrin Matrix Stiffness

de Jong, T., Weijers, E. M., Bakker, A. D., Koolwijk, P. & Smit, T. H., Sep 2016, In : JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING. 6, 9, p. 729-738

Research output: Contribution to journalArticleAcademicpeer-review

Vascular endothelial growth factor A (VEGF-A) decreases expression and secretion of pleiotrophin in a VEGF receptor-independent manner

Poimenidi, E., Theodoropoulou, C., Koutsioumpa, M., Skondra, L., Droggiti, E., van den Broek, M., Koolwijk, P. & Papadimitriou, E., May 2016, In : Vascular Pharmacology. 80, p. 11-19

Research output: Contribution to journalArticleAcademicpeer-review

2015

Hypoxia inducible factor 1 alpha down regulates cell surface expression of alpha 1,2-fucosylated glycans in human pancreatic adenocarcinoma cells

Da Silva Aresta Belo, A. I., van Vliet, S. J., Maus, A., Laan, L. C., Nauta, T., Koolwijk, P., Tefsen, B. & van Die, I., 2015, In : FEBS Letters. 589, 18, p. 2359-2366

Research output: Contribution to journalArticleAcademicpeer-review

IFN-beta affects the angiogenic potential of circulating angiogenic cells by activating calpain 1

Yildirim, C., Favre, J., Weijers, E. M., Fontijn, R. D., van Wijhe, M. H., van Vliet, S. J., Boon, R. A., Koolwijk, P., van der Pouw-Kraan, T. C. T. M. & Horrevoets, A. J., 2015, In : American Journal of Physiology. Heart and Circulatory Physiology. 309, 10, p. H1667-H1678

Research output: Contribution to journalArticleAcademicpeer-review

Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity

Tasev, D. V., van Wijhe, M. H., Weijers, E. M., van Hinsbergh, V. W. M. & Koolwijk, P., 2015, In : PLoS ONE. 10, 6, e0129935.

Research output: Contribution to journalArticleAcademicpeer-review

Specific Effects of Fibrinogen and the gamma A and gamma '-Chain Fibrinogen Variants on Angiogenesis and Wound Healing

Cheung, E. Y. L., Weijers, E. M., Tuk, B., Scheffer, R., Leebeek, F. W., van Neck, J. W., Koolwijk, P. & de Maat, M. P. M., 2015, In : Tissue Engineering Part A. 21, 1-2, p. 106-114

Research output: Contribution to journalArticleAcademicpeer-review

2014

Adipose tissue-derived stromal cells acquire endothelial-like features upon reprogramming with SOX18

Fontijn, R. D., Favre, J., Naaijkens, B. A., Meinster, E., Paauw, N. J., Ragghoe, S. L., Nauta, T. D., van den Broek, M. A., Weijers, E. M., Niessen, H. W. M., Koolwijk, P. & Horrevoets, A. J. G., Nov 2014, In : Stem Cell Research. 13, 3 Pt A, p. 367-378 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Expression, Regulation and Function of Human Metallothioneins in Endothelial Cells

Schulkens, I. A. E., Castricum, K. C. M., Weijers, E. M., Koolwijk, P., Griffioen, A. W. & Thijssen, V. L. J. L., 2014, In : Journal of Vascular Research. 51, 3, p. 231-238

Research output: Contribution to journalArticleAcademicpeer-review

Hypoxic Signaling During Tissue Repair and Regenerative Medicine

Nauta, T., van Hinsbergh, V. W. M. & Koolwijk, P., 2014, In : International Journal of Molecular Sciences. 15, 11, p. 19791-19815

Research output: Contribution to journalArticleAcademicpeer-review

NF-kappa B-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis

Noort, A. R., van Zoest, K. P. M., Weijers, E. M., Koolwijk, P., Maracle, C. X., Novack, D. V., Siemerink, M. J., Schlingemann, R. O., Tak, P. P. & Tas, S. W., 2014, In : Journal of Pathology. 234, 3, p. 375-385

Research output: Contribution to journalArticleAcademicpeer-review

Systemic toll-like receptor and interleukin-18 pathway activation in patients with acute ST elevation myocardial infarction

van der Pouw Kraan, C. T. M., Bernink, F. J. P., Yildirim, C., Koolwijk, P., Baggen, J. M., Timmers, L., Beek, A. M., Diamant, M., Chen, W. J. Y., van Rossum, A. C., van Royen, N., Horrevoets, A. J. G. & Appelman, J. E. A., 2014, In : Journal of Molecular and Cellular Cardiology. 67, p. 94-102

Research output: Contribution to journalArticleAcademicpeer-review

2013

Protein Arginine Methylation Is More Prone to Inhibition by S-Adenosylhomocysteine than DNA Methylation in Vascular Endothelial Cells

Esse, R., Rocha, M. S., Barroso, M., Florindo, C., Teerlink, T., Kok, R. M., Smulders, Y. M., Rivera, I., Leandro, P., Koolwijk, P., Castro, R., Blom, H. J. & de Almeida, I. T., 2013, In : PLoS ONE. 8, 2, e55483.

Research output: Contribution to journalArticleAcademicpeer-review

VEGF Levels in Plasma in Relation to Platelet Activation, Glycemic Control, and Microvascular Complications in Type 1 Diabetes

Schlingemann, R. O., van Noorden, C. J. F., Diekman, M. J. M., Tiller, A., Meijers, J. C. M., Koolwijk, P. & Wiersinga, W. M., 2013, In : Diabetes Care. 36, 6, p. 1629-1634

Research output: Contribution to journalArticleAcademicpeer-review

2012

Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone

Varinska, L., van Wijhe, M., Belleri, M., Mitola, S., Perjesi, P., Presta, M., Koolwijk, P., Ivanova, L. & Mojzis, J., 2012, In : European Journal of Pharmacology. 691, 1-3, p. 125-133

Research output: Contribution to journalArticleAcademicpeer-review

Endothelial insulin receptor expression in human atherosclerotic plaques: Linking micro- and macrovascular disease in diabetes?

Rensing, K. L., von der Thusen, J. H., Weijers, E. M., Bloemendaal, F. M. H., van Lammeren, G. W., Vink, A., van der Wal, A. C., van Hinsbergh, V. W. M., van der Loos, C. M., Stroes, E. S., Koolwijk, P. & Twickler, T. B., 2012, In : Atherosclerosis. 222, 1, p. 208-215

Research output: Contribution to journalArticleAcademicpeer-review

Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancer

van der Veldt, A. A. M., Vroling, L., de Haas, R. R., Koolwijk, P., van den Eertwegh, A. J. M., Haanen, J. B. A. G., van Hinsbergh, V. W. M., Broxterman, H. J. & Boven, E., 2012, In : International Journal of Cancer. 131, 4, p. E484-E493

Research output: Contribution to journalArticleAcademicpeer-review

2011

The Influence of Hypoxia and Fibrinogen Variants on the Expansion and Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells

Weijers, E. M., van den Broek, L. J., Waaijman, T., van Hinsbergh, V. W. M., Gibbs, S. & Koolwijk, P., 2011, In : Tissue Engineering Part A. 17, 21-22, p. 2675-2685

Research output: Contribution to journalArticleAcademicpeer-review

2010
36 Downloads (Pure)

Could recombinant insulin compounds contribute to adenocarcinoma progression by stimulating local angiogenesis?

Rensing, K. L., Bloemendaal, F. M. H., Weijers, E. M., Richel, D. J., Buller, H. R., Koolwijk, P., van der Loos, C. M., Twickler, T. B. & von der Thusen, J. H., 2010, In : Diabetologia. 53, 5, p. 966-970

Research output: Contribution to journalArticleAcademicpeer-review

File

Fibrin beta(15-42) domain is cryptic in intact fibrinogen: comment on the study by A. Sahni et al.

Weijers, E. M., Koolwijk, P., van Hinsbergh, V. W. M. & van Nieuw Amerongen, G. P., 2010, In : International Journal of Cancer. 127, 12, p. 2981-2982

Research output: Contribution to journalArticleAcademicpeer-review

Molecular weight fibrinogen variants alter gene expression and functional characteristics of human endothelial cells

Weijers, E. M., van Wijhe, M. H., Joosten, L., Horrevoets, A. J. G., de Maat, M. P. M., van Hinsbergh, V. W. M. & Koolwijk, P., 2010, In : Journal of Thrombosis and Haemostasis. 8, 12, p. 2800-2809

Research output: Contribution to journalArticleAcademicpeer-review

2009

Aprotinin stimulates angiogenesis and human endothelial cell migration through the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta

Koutsioumpa, M., Hatziapostolou, M., Mikelis, C., Koolwijk, P. & Papadimitriou, E., 2009, In : European Journal of Pharmacology. 602, 2-3, p. 245-249

Research output: Contribution to journalArticleAcademicpeer-review

Blood outgrowth endothelial cells from cord blood and peripheral blood: angiogenesis-related characteristics in vitro

van Beem, R. T., Verloop, R. E., Kleijer, M., Noort, W. A., Loof, N., Koolwijk, P., van der Schoot, C. E., van Hinsbergh, V. W. M. & Zwaginga, JJ., 2009, In : Journal of Thrombosis and Haemostasis. 7, 1, p. 217-226

Research output: Contribution to journalArticleAcademicpeer-review

Blood outgrowth endothelial cells from cord blood and peripheral blood: angiogenesis-related characteristics in vitro: reply to rebuttal

van Beem, R. T., Verloop, R. E., Koolwijk, P., van Hinsbergh, V. W. M. & Zwaginga, JJ., 2009, In : Journal of Thrombosis and Haemostasis. 7, 3, p. 506-508

Research output: Contribution to journalArticleAcademicpeer-review

Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions

Plaisier, M., Dennert, I., Rost, E., Koolwijk, P., van Hinsbergh, V. W. M. & Helmerhorst, F. M., 2009, In : Human Reproduction. 24, 1, p. 185-197

Research output: Contribution to journalArticleAcademicpeer-review

Modeling morphogenesis in silico and in vitro: Towards quantitative, predictive, cell-based modeling.

Merks, R. M. H. & Koolwijk, P., 2009, In : Mathematical Modelling of Natural Phenomena. 4, p. 149-171

Research output: Contribution to journalArticleAcademicpeer-review

Proteases and receptors in the recruitment of endothelial progenitor cells in neovascularization

Verloop, R. E., Koolwijk, P., van Zonneveld, A. J. & van Hinsbergh, V. W. M., 2009, In : European Cytokine Network. 20, 4, p. 207-219

Research output: Contribution to journalArticleAcademicpeer-review