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2020

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function

Van Der Steen, N., Keller, K., Dekker, H., Porcelli, L., Honeywell, R. J., Van Meerloo, J., Musters, R. J. P., Kathmann, I., Frampton, A. E., Liu, D. S. K., Ruijtenbeek, R., Rolfo, C., Pauwels, P., Giovannetti, E. & Peters, G. J., 1 Jan 2020, In : Journal of Cellular Physiology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin

Juni, R. P., Kuster, D. W. D., Goebel, M., Helmes, M., Musters, R. J. P., van der Velden, J., Koolwijk, P., Paulus, W. J. & van Hinsbergh, V. W. M., 1 Sep 2019, In : JACC: Basic to Translational Science. 4, 5, p. 575-591

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach

Bruijnen, S. T. G., Chandrupatla, D. M. S. H., Giovanonni, L., Neri, D., Vugts, D. J., Huisman, M. C., Hoekstra, O. S., Musters, R. J. P., Lammertsma, A. A., van Dongen, G. A. M. S., Jansen, G., Molthoff, C. F. M. & van der Laken, C. J., 7 Jan 2019, In : Molecular Pharmaceutics. 16, 1, p. 273-281

Research output: Contribution to journalArticleAcademicpeer-review

Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology

Wiersma, V. I., van Ziel, A. M., Vazquez-Sanchez, S., Nölle, A., Berenjeno-Correa, E., Bonaterra-Pastra, A., Clavaguera, F., Tolnay, M., Musters, R. J. P., van Weering, J. R. T., Verhage, M., Hoozemans, J. J. M. & Scheper, W., 1 Dec 2019, In : Acta Neuropathologica. 138, 6, p. 943-970 28 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

The human cytomegalovirus-encoded G protein- coupled receptor UL33 exhibits oncomodulatory properties

Van Senten, J. R., Bebelman, M. P., Fan, T. S., Heukers, R., Bergkamp, N. D., Van Gasselt, P., Langemeijer, E. V., Slinger, E., Lagerweij, T., Rahbar, A., Van Walsum, M. S., Maussang, D., Leurs, R., Musters, R. J. P., Van Dongen, G. A. M. S., Söderberg-Nauclér, C., Würdinger, T., Siderius, M. & Smit, M. J., 2019, In : Journal of Biological Chemistry. 294, 44, p. 16297-16308 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

An in vitro method to keep human aortic tissue sections functionally and structurally intact

Meekel, J. P., Groeneveld, M. E., Bogunovic, N., Keekstra, N., Musters, R. J. P., Zandieh-Doulabi, B., Pals, G., Micha, D., Niessen, H. W. M., Wiersema, A. M., Kievit, J. K., Hoksbergen, A. W. J., Wisselink, W., Blankensteijn, J. D. & Yeung, K. K., 1 Dec 2018, In : Scientific Reports. 8, 1, 8094.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate

Chandrupatla, D. M. S. H., Jansen, G., Mantel, E., Low, P. S., Matsuyama, T., Musters, R. P., Windhorst, A. D., Lammertsma, A. A., Molthoff, C. F. M. & van der Laken, C. J., 2018, In : Contrast media & molecular imaging. 2018, 8092781.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Indoleamine 2,3-dioxygenase expression pattern in the tumor microenvironment predicts clinical outcome in early stage cervical cancer

Heeren, A. M., van Dijk, I., Berry, D. R. A. I., Khelil, M., Ferns, D., Kole, J., Musters, R. J. P., Thijssen, V. L., Mom, C. H., Kenter, G. G., Bleeker, M. C. G., de Gruijl, T. D. & Jordanova, E. S., 11 Jul 2018, In : Frontiers in Immunology. 9, JUL, 1598.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

p47phox-Dependent Reactive Oxygen Species Stimulate Nuclear Translocation of the FoxO1 Transcription Factor During Metabolic Inhibition in Cardiomyoblasts

Ter Horst, E. N., Hahn, N. E., Geerts, D., Musters, R. J. P., Paulus, W. J., van Rossum, A. C., Meischl, C., Piek, J. J., Niessen, H. W. M. & Krijnen, P. A. J., 1 Sep 2018, In : Cell Biochemistry and Biophysics. 76, 3, p. 401-410 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers

Lindqvist, J., van den Berg, M., van der Pijl, R., Hooijman, P. E., Beishuizen, A., Elshof, J., de Waard, M., Girbes, A., Spoelstra-de Man, A., Shi, Z-H., van den Brom, C., Bogaards, S., Shen, S., Strom, J., Granzier, H., Kole, J., Musters, R. J. P., Paul, M. A., Heunks, L. M. A. & Ottenheijm, C. A. C., 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 4, p. 472-485 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate

Chandrupatla, D. M. S. H., Molthoff, C. F. M., Ritsema, W. I. G. R., Vos, R., Elshof, E., Matsuyama, T., Low, P. S., Musters, R. J. P., Hammond, A., Windhorst, A. D., Lammertsma, A. A., van der Laken, C. J., Brands, R. & Jansen, G., 2018, In : Translational research : the journal of laboratory and clinical medicine. 199, p. 24-38 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab

Krejcik, J., Frerichs, K. A., Nijhof, I. S., van Kessel, B., van Velzen, J. F., Bloem, A. C., Broekmans, M. E. C., Zweegman, S., van Meerloo, J., Musters, R. J. P., Poddighe, P. J., Groen, R. W. J., Chiu, C., Plesner, T., Lokhorst, H. M., Sasser, A. K., Mutis, T. & van de Donk, N. W. C. J., 15 Dec 2017, In : Clinical Cancer Research. 23, 24, p. 7498-7511 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment

Lagerweij, T., Dusoswa, S. A., Negrean, A., Hendrikx, E. M. L., de Vries, H. E., Kole, J., Garcia-Vallejo, J. J., Mansvelder, H. D., Vandertop, W. P., Noske, D. P., Tannous, B. A., Musters, R. J. P., van Kooyk, Y., Wesseling, P., Zhao, X. W. & Wurdinger, T., 1 Nov 2017, In : Angiogenesis. 20, 4, p. 533-546 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Peroxynitrite Footprint in Circulating Neutrophils of Abdominal Aortic Aneurysm Patients is Lower in Statin than in Non-statin Users

Groeneveld, M. E., van der Reijden, J. J., Tangelder, G. J., Westin, L. C., Renwarin, L., Musters, R. J. P., Wisselink, W. & Yeung, K. K., 1 Sep 2017, In : European Journal of Vascular and Endovascular Surgery. 54, 3, p. 331-339 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Rapid frequency-dependent changes in free mitochondrial calcium concentration in rat cardiac myocytes

Wust, R. C. I., Helmes, M., Martin, J. L., van der Wardt, T. J. T., Musters, R. J. P., van der Velden, J. & Stienen, G. J. M., 15 Mar 2017, In : Journal of Physiology - London. 595, 6, p. 2001-2019

Research output: Contribution to journalArticleAcademicpeer-review

The effects of hyperoxia on microvascular endothelial cell proliferation and production of vaso-active substances

Attaye, I., Smulders, Y. M., de Waard, M. C., Oudemans-van Straaten, H. M., Smit, B., Van Wijhe, M. H., Musters, R. J., Koolwijk, P. & Spoelstra-de Man, A. M. E., Apr 2017, In : Intensive Care Medicine Experimental. 5, 1, 22.

Research output: Contribution to journalArticleAcademicpeer-review

Transdifferentiation of Human Dermal Fibroblasts to Smooth Muscle-Like Cells to Study the Effect of MYH11 and ACTA2 Mutations in Aortic Aneurysms

Yeung, K. K., Bogunovic, N., Keekstra, N., Beunders, A. A. M., Pals, J., van der Kuij, K., Overwater, E., Wisselink, W., Blankensteijn, J. D., van Hinsbergh, V. W. M., Musters, R. J. P., Pals, G., Micha, D. & Zandieh-Doulabi, B., Apr 2017, In : Human Mutation. 38, 4, p. 439-450 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

α-B Crystallin Reverses High Diastolic Stiffness of Failing Human Cardiomyocytes

Franssen, C., Kole, J., Musters, R., Hamdani, N. & Paulus, W. J., Mar 2017, In : Circulation. Heart failure. 10, 3, e003626.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Development of a new therapeutic technique to direct stem cells to the infarcted heart using targeted microbubbles: StemBells

Woudstra, L., Krijnen, P. A. J., Bogaards, S. J. P., Meinster, E., Emmens, R. W., Kokhuis, T. J. A., Bollen, I. A. E., Baltzer, H., Baart, S. M. T., Parbhudayal, R., Helder, M. N., van Hinsbergh, V. W. M., Musters, R. J. P., de Jong, N., Kamp, O., Niessen, H. W. M., van Dijk, A. & Juffermans, L. J. M., Jul 2016, In : Stem Cell Research. 17, 1, p. 6-15

Research output: Contribution to journalArticleAcademicpeer-review

Dopamine induces lipid accumulation, NADPH oxidase-related oxidative stress, and a proinflammatory status of the plasma membrane in H9c2 cells

Begieneman, M. P. V., ter Horst, E. N., Rijvers, L., Meinster, E., Leen, R., Pankras, J. E., Fritz, J., Kubat, B., Musters, R. J. P., van Kuilenburg, A. B. P., Stap, J., Niessen, H. W. M. & Krijnen, P. A. J., 1 Nov 2016, In : American Journal of Physiology. Heart and Circulatory Physiology. 311, 5, p. H1097-H1107

Research output: Contribution to journalArticleAcademicpeer-review

Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors

Franke, N. E., Kaspers, G. L., Assaraf, Y. G., van Meerloo, J., Niewerth, D., Kessler, F. L., Poddighe, P. J., Kole, J., Smeets, S. J., Ylstra, B., Bi, C., Chng, W. J., Horton, T. M., Menezes, R. X., Musters, R., Zweegman, S., Jansen, G. & Cloos, J., 15 Nov 2016, In : Oncotarget. 7, 46, p. 74779-74796

Research output: Contribution to journalArticleAcademicpeer-review

Increased local delivery of antagomir therapeutics to the rodent myocardium using ultrasound and microbubbles

Kwekkeboom, R. F. J., Sluijter, J. P. G., van Middelaar, B. J., Metz, C. H., Brans, M. A., Kamp, O., Paulus, W. J. & Musters, R. J. P., 28 Jan 2016, In : Journal of Controlled Release. 222, p. 18-31

Research output: Contribution to journalArticleAcademicpeer-review

Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR

Verbrugge, C., Al, M., Assaraf, Y. G., Kammerer, S., Chandrupatla, D. M. S. H., Honeywell, R. J., Musters, R. P. J., Giovannetti, E., O'Toole, T., Scheffer, G. L., Krige, D., de Gruijl, T. D., Niessen, J., Lems, W. F., Kramer, P. A., Scheper, R. J., Cloos, J., Ossenkoppele, G. J., Peters, G. J. & Jansen, G., 2 Feb 2016, In : Oncotarget. 7, 5, p. 5240-5257

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction

Franssen, C., Chen, S., Unger, A., Korkmaz, H. I., De Keulenaer, G. W., Tschoepe, C., Leite-Moreira, A. F., Musters, R., Niessen, H. W. M., Linke, W. A., Paulus, W. J. & Hamdani, N., Apr 2016, In : JACC-HEART FAILURE. 4, 4, p. 312-324 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10

Ates, L. S., van der Woude, A. D., Bestebroer, J., van Stempvoort, G., Musters, R. J. P., Garcia-Vallejo, J. J., Picavet, D. I., van de Weerd, R., Maletta, M., Kuijl, C. P., van der Wel, N. N. & Bitter, W., Jun 2016, In : PLoS Pathogens. 12, 6, 1005696 .

Research output: Contribution to journalArticleAcademicpeer-review

The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions

Dorland, Y. L., Malinova, T. S., van Stalborch, A-M. D., Grieve, A. G., van Geemen, D., Jansen, N. S., de Kreuk, B-J., Nawaz, K., Kole, J., Geerts, D., Musters, R. J. P., de Rooij, J., Hordijk, P. L. & Huveneers, S., Jul 2016, In : Nature Communications. 7, 12210.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Acute myocardial infarction does not affect functional characteristics of adipose-derived stem cells in rats, but reduces the number of stem cells in adipose tissue

Naaijkens, B. A., Krijnen, P. A. J., Meinster, E., van der Horst, E., Vo, K., Musters, R. J. P., Kamp, O., Niessen, H. W. M., Juffermans, L. J. M. & van Dijk, A., Dec 2015, In : Cell and Tissue Research. 362, 3, p. 623-632 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nodal metastasis in cervical cancer occurs in clearly delineated fields of immune suppression in the pelvic lymph catchment area

Heeren, A. M., de Boer, E., Bleeker, M. C. G., Musters, R. J. P., Buist, M. R., Kenter, G. G., de Gruijl, T. D. & Jordanova, E. S., 2015, In : Oncotarget. 6, 32, p. 32484-32493

Research output: Contribution to journalArticleAcademicpeer-review

Ultrasound and Microbubble-Induced Local Delivery of Microrna-Based Therapeutics

Kwekkeboom, R. F. J., Lei, Z. Y., Bogaards, S. J. P., Aiazian, E., Kamp, O., Paulus, W. J., Sluijter, J. P. G. & Musters, R. J. P., 2015, In : Ultrasound in Medicine and Biology. 41, 1, p. 163-176

Research output: Contribution to journalArticleAcademicpeer-review

2014

Contrast-enhanced sonothrombolysis in a porcine model of acute peripheral arterial thrombosis and prevention of anaphylactic shock

Nederhoed, J. H., Slikkerveer, J., Meyer, K. W., Wisselink, W., Musters, R. J. P. & Yeung, K. K., 2014, In : Lab animal. 43, 3, p. 91-94

Research output: Contribution to journalArticleAcademicpeer-review

Early NADPH oxidase-2 activation is crucial in phenylephrine-induced hypertrophy of H9c2 cells

Hahn, N. E., Musters, R. J. P., Fritz, J. M., Pagano, P. J., Vonk, A. B. A., Paulus, W. J., van Rossum, A. C., Meischl, C., Niessen, H. W. M. & Krijnen, P. A. J., Sep 2014, In : Cellular Signalling. 26, 9, p. 1818-1824 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Targeted delivery of miRNA therapeutics for cardiovascular diseases: opportunities and challenges

Kwekkeboom, R. F. J., Lew, Z. Y., Doevendans, P. A., Musters, R. J. P. & Sluijter, J. P. G., 2014, In : Clinical Science. 127, 5-6, p. 351-365

Research output: Contribution to journalArticleAcademicpeer-review

2013

Homocysteine-induced apoptosis in endothelial cells coincides with nuclear NOX2 and peri-nuclear NOX4 activity

Sipkens, J. A., Hahn, N. E., van den Brand, C. S., Meischl, C., Cillessen, S. A. G. M., Smith, D. E. C., Juffermans, L. J. M., Musters, R. J. P., Roos, D., Jakobs, C., Blom, H. J., Smulders, Y. M., Krijnen, P. A. J., Stehouwer, C. D. A., Rauwerda, J. A., van Hinsbergh, V. W. M. & Niessen, H. W. M., Nov 2013, In : Cell Biochemistry and Biophysics. 67, 2, p. 341-352 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Localized RhoA GTPase activity regulates dynamics of endothelial monolayer integrity

Szulcek, R., Beckers, C. M. L., Hodzic, J., de Wit, J., Chen, Z. L., Grob, T., Musters, R. J. P., Minshall, R. D., van Hinsbergh, V. W. M. & van Nieuw Amerongen, G. P., 2013, In : Cardiovascular Research. 99, 3, p. 471-482

Research output: Contribution to journalArticleAcademicpeer-review

2012

Human platelet lysate as a fetal bovine serum substitute improves human adipose-derived stromal cell culture for future cardiac repair applications

Naaijkens, B. A., Niessen, H. W. M., Prins, H., Krijnen, P. A. J., Kokhuis, T. J. A., de Jong, N., van Hinsbergh, V. W. M., Kamp, O., Helder, M. N., Musters, R. J. P., van Dijk, A. & Juffermans, L. J. M., Apr 2012, In : Cell and Tissue Research. 348, 1, p. 119-130 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

NOX5 expression is increased in intramyocardial blood vessels and cardiomyocytes after acute myocardial infarction in humans

Hahn, N. E., Meischl, C., Kawahara, T., Musters, R. J. P., Verhoef, V. M. J., van der Velden, J., Vonk, A. B. A., Paulus, W. J., van Rossum, A. C., Niessen, H. W. & Krijnen, P. A. J., Jun 2012, In : The American Journal of Pathology. 180, 6, p. 2222-2229 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2011

Electron microscopic observation in case of platelet activation in a chronic haemodialysis subject

Schoorl, M., Bartels, P. C. M., Gritters, M., Fluitsma, D., Musters, R. J. P. & Nube, M. J., 2011, In : Hematology reports. 3, 2, e15.

Research output: Contribution to journalArticleAcademicpeer-review

Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)

Sipkens, J. A., Krijnen, P. A. J., Hahn, N. E., Wassink, M., Meischl, C., Smith, D. E. C., Musters, R. J. P., Stehouwer, C. D. A., Rauwerda, J. A., van Hinsbergh, V. W. M. & Niessen, H. W. M., Dec 2011, In : Molecular and Cellular Biochemistry. 358, 1-2, p. 229-239 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

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