1990 …2019
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Research Output 1990 2019

2016

Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women

De Strooper, L. M. A., Verhoef, V. M. J., Berkhof, J., Hesselink, A. T., de Bruin, H. M. E., van Kemenade, F. J., Bosgraaf, R. P., Bekkers, R. L. M., Massuger, L. F. A. G., Melchers, W. J. G., Steenbergen, R. D. M., Snijders, P. J. F., Meijer, C. J. L. M. & Heideman, D. A. M., May 2016, In : Gynecologic Oncology. 141, 2, p. 341-347

Research output: Contribution to journalArticleAcademicpeer-review

2015
41 Downloads (Pure)

Detection and relevance of focal chromosomal copy number aberrations in cancer

Krijgsman, O., 2015

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

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DNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approach

Hubers, A. J., Heideman, D. A. M., Burgers, S. A., Herder, G. J. M., Sterk, P. J., Rhodius, R. J., Smit, H. J., Krouwels, F., Welling, A., Witte, B. I., Duin, S., Koning, R., Comans, E. F. I., Steenbergen, R. D. M., Postmus, P. E., Meijer, G. A., Snijders, P. J. F., Smit, E. F. & Thunnissen, E., 2015, In : British Journal of Cancer. 112, 6, p. 1105-1113

Research output: Contribution to journalArticleAcademicpeer-review

Follow-up of high-risk HPV positive women by combined cytology and bi-marker CADM1/MAL methylation analysis on cervical scrapes

Verhoef, V. M. J., van Kemenade, F. J., Rozendaal, L., Heideman, D. A. M., Bosgraaf, R. P., Hesselink, A. T., Melchers, W. J. G., Massuger, L. F. A. G., Bekkers, R. L. M., Steenbergen, R. D. M., Berkhof, J., Snijders, P. J. F. & Meijer, C. J. L. M., 2015, In : Gynecologic Oncology. 137, 1, p. 55-59

Research output: Contribution to journalArticleAcademicpeer-review

HPV-negative carcinoma of the uterine cervix: a distinct type of cervical cancer with poor prognosis

Rodriguez-Carunchio, L., Soveral, I., Steenbergen, R. D. M., Torne, A., Martinez, S., Fuste, P., Pahisa, J., Marimon, L., Ordi, J. & Del Pino, M., 2015, In : BJOG: An International Journal of Obstetrics & Gynaecology. 122, 1, p. 119-127

Research output: Contribution to journalArticleAcademicpeer-review

31 Downloads (Pure)

Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer

Lando, M., Fjeldbo, C. S., Wilting, S. M., Snoek, B. C., Aarnes, E. K., Forsberg, M. F., Kristensen, G. B., Steenbergen, R. D. M. & Lyng, H., 2015, In : Epigenetics. 10, 10, p. 970-980

Research output: Contribution to journalArticleAcademicpeer-review

File
29 Downloads (Pure)

Longitudinal assessment of DNA methylation changes during HPVE6E7-induced immortalization of primary keratinocytes

Schütze, D. M., Kooter, J. M., Wilting, S. M., Meijer, C. J. L. M., Quint, W. G. V., Snijders, P. J. F. & Steenbergen, R. D. M., 2015, In : Epigenetics. 10, 1, p. 73-81

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Mining for viral fragments in methylation enriched sequencing data

Mensaert, K., van Criekinge, W. M. R., Thas, O., Schuuring, E., Steenbergen, R. D. M., Wisman, G. B. & Meyer, T., 2015, In : Frontiers in Genetics. 6, 16.

Research output: Contribution to journalArticleAcademicpeer-review

Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression

de Groen, F. L. M., Timmer, L. M., Menezes, R. X., Diosdado, B., Hooijberg, E., Meijer, G. A., Steenbergen, R. D. M. & Carvalho, B., 2015, In : PLoS ONE. 10, 7, e0132495.

Research output: Contribution to journalArticleAcademicpeer-review

8 Downloads (Pure)

Somatic mutation in PIK3CA is a late event in cervical carcinogenesis

Verlaat, W., Snijders, P. J. F., van Moorsel, M. I. H., Bleeker, M. C. G., Rozendaal, L., Sie, D. L. S., Ylstra, B., Meijer, C. J. L. M., Steenbergen, R. D. M. & Heideman, D. A. M., 2015, In : The Journal of Pathology: Clinical Research. 1, 4, p. 207-211

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2014
34 Downloads (Pure)

CADM1, MAL and miR124-2 methylation analysis in cervical scrapes to detect cervical and endometrial cancer

de Strooper, L. M. A., van Zummeren, M., Steenbergen, R. D. M., Bleeker, M. C. G., Hesselink, A. T., Wisman, G. B., Snijders, P. J. F., Heideman, D. A. M. & Meijer, C. J. L. M., 2014, In : Journal of Clinical Pathology. 67, 12, p. 1067-1071

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - A systematic review and meta-analysis

Thomas, L. K., Bermejo, J. L., Vinokurova, S., Jensen, K., Bierkens, M., Steenbergen, R. D. M., Bergmann, M., Doeberitz, M. & Reuschenbach, M., 2014, In : European Journal of Cancer. 50, 1, p. 85-98

Research output: Contribution to journalArticleAcademicpeer-review

35 Downloads (Pure)
Open Access
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29 Downloads (Pure)

Combined CADM1/MAL methylation and cytology testing for colposcopy triage of high-risk HPV-positive women

de Strooper, L. M. A., Hesselink, A. T., Berkhof, J., Meijer, C. J. L. M., Snijders, P. J. F., Steenbergen, R. D. M. & Heideman, D. A. M., 2014, In : Cancer Epidemiology Biomarkers and Prevention. 23, 9, p. 1933-1937

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Combined sputum hypermethylation and eNose analysis for lung cancer diagnosis

Hubers, A. J., Brinkman, P., Boksem, R. J., Rhodius, R. J., Witte, B. I., Zwinderman, A. H., Heideman, D. A. M., Duin, S., Koning, R., Steenbergen, R. D. M., Snijders, P. J. F., Smit, E. F., Sterk, P. J. & Thunnissen, E., 2014, In : Journal of Clinical Pathology. 67, 8, p. 707-711

Research output: Contribution to journalArticleAcademicpeer-review

Differential In Vitro Immortalization Capacity of Eleven, Probable High-Risk Human Papillomavirus Types

Schütze, D. M., Snijders, P. J. F., ten Bosch, L., Kramer, D., Meijer, C. J. L. M. & Steenbergen, R. D. M., 2014, In : Journal of Virology. 88, 3, p. 1714-1724

Research output: Contribution to journalArticleAcademicpeer-review

Focal chromosomal copy number aberrations in cancer-Needles in a genome haystack

Krijgsman, O., Carvalho, B., Meijer, G. A., Steenbergen, R. D. M. & Ylstra, B., 2014, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1843, 11, p. 2698-2704

Research output: Contribution to journalArticleAcademicpeer-review

Gene-Dosage Dependent Overexpression at the 13q Amplicon Identifies DIS3 as Candidate Oncogene in Colorectal Cancer Progression

de Groen, F. L. M., Krijgsman, O., Tijssen, M., Vriend, L. E. M., Ylstra, B., Hooijberg, E., Meijer, G. A., Steenbergen, R. D. M. & Carvalho, B., 2014, In : Genes, Chromosomes and Cancer. 53, 4, p. 339-348

Research output: Contribution to journalArticleAcademicpeer-review

Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix

Pinheiro, C., Garcia, E. A., Morais-Santos, F., Scapulatempo-Neto, C., Mafra, A., Steenbergen, R. D. M., Boccardo, E., Villa, L. L., Baltazar, F. & Longatto, A., 2014, In : BMC Cancer. 14, 751.

Research output: Contribution to journalArticleAcademicpeer-review

30 Downloads (Pure)
Open Access
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Methylation marker analysis and HPV16/18 genotyping in high-risk HPV positive self-sampled specimens to identify women with high grade CIN or cervical cancer

Verhoef, V. M. J., Heideman, D. A. M., van Kemenade, F. J., Rozendaal, L., Bosgraaf, R. P., Hesselink, A. T., Bekkers, R. L. M., Massuger, L. F. A. G., Steenbergen, R. D. M., Snijders, P. J. F., Berkhof, J. & Meijer, C. J. L. M., 2014, In : Gynecologic Oncology. 135, 1, p. 58-63

Research output: Contribution to journalArticleAcademicpeer-review

Methylation marker analysis of self-sampled cervico-vaginal lavage specimens to triage high-risk HPV-positive women for colposcopy

Hesselink, A. T., Heideman, D. A. M., Steenbergen, R. D. M., Gok, M., van Kemenade, F. J., Wilting, S. M., Berkhof, J., Meijer, C. J. L. M. & Snijders, P. J. F., 2014, In : International Journal of Cancer. 135, 4, p. 880-886

Research output: Contribution to journalArticleAcademicpeer-review

Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers

Snellenberg, S., Cillessen, S. A. G. M., van Criekinge, W. M. R., Bosch, L., Meijer, C. J. L. M., Snijders, P. J. F. & Steenbergen, R. D. M., 2014, In : Carcinogenesis. 35, 11, p. 2611-2618

Research output: Contribution to journalArticleAcademicpeer-review

tigaR: integrative significance analysis of temporal differential gene expression induced by genomic abnormalities

Miok, V., Wilting, S. M., van de Wiel, M. A., Jaspers, A., van Noort, P. I., Brakenhoff, R. H., Snijders, P. J. F., Steenbergen, R. D. M. & van Wieringen, W. N., 2014, In : BMC Bioinformatics. 15, p. 327 327.

Research output: Contribution to journalArticleAcademicpeer-review

Triage by methylation-marker testing versus cytology in women who test HPV-positive on self-collected cervicovaginal specimens (PROHTECT-3): a randomised controlled non-inferiority trial

Verhoef, V. M. J., Bosgraaf, R. P., van Kemenade, F. J., Rozendaal, L., Heideman, D. A. M., Hesselink, A. T., Bekkers, R. L. M., Steenbergen, R. D. M., Massuger, L. F. A. G., Melchers, W. J. G., Bulten, J., Overbeek, L. I. H., Berkhof, J., Snijders, P. J. F. & Meijer, C. J. L. M., 2014, In : Lancet Oncology. 15, 3, p. 315-322

Research output: Contribution to journalArticleAcademicpeer-review

43 Downloads (Pure)

Uncovering epigenetic alterations of tumour suppressor and viral genes during HPV-induced cervical carcinogenesis

Snellenberg, S., 2014

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File
2013

Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis

Wilting, S. M., Snijders, P. J. F., Verlaat, W., Jaspers, A., van de Wiel, M. A., van Wieringen, W. N., Meijer, G. A., Kenter, G. G., Yi, Y., le Sage, C., Agami, R., Meijer, C. J. L. M. & Steenbergen, R. D. M., 2013, In : Oncogene. 32, p. 106-116

Research output: Contribution to journalArticleAcademicpeer-review

CADM1 and MAL promoter methylation levels in hrHPV-positive cervical scrapes increase proportional to degree and duration of underlying cervical disease

Bierkens, M., Hesselink, A. T., Meijer, C. J. L. M., Heideman, D. A. M., Wisman, G. B., van der Zee, A. G. J., Snijders, P. J. F. & Steenbergen, R. D. M., 2013, In : International Journal of Cancer. 133, 6, p. 1293-1299

Research output: Contribution to journalArticleAcademicpeer-review

Detection limits of DNA copy number alterations in heterogeneous cell populations

Krijgsman, O., Israeli, D., van Essen, H. F. B., Eijk, P. P., Berens, M. L. M., Mellink, C. H. M., Nieuwint, A. W. M., Weiss, M. M., Steenbergen, R. D. M., Meijer, G. A. & Ylstra, B., 2013, In : Cellular Oncology. 36, 1, p. 27-36

Research output: Contribution to journalArticleAcademicpeer-review

Focal aberrations indicate EYA2 and hsa-miR-375 as oncogene and tumor suppressor in cervical carcinogenesis.

Bierkens, M., Krijgsman, O., Wilting, S. M., Bosch, L. J. W., Jaspers, A., Meijer, G. A., Meijer, C. J. L. M., Snijders, P. J. F., Ylstra, B. & Steenbergen, R. D. M., 2013, In : Genes, Chromosomes and Cancer. 52, 1, p. 56-68

Research output: Contribution to journalArticleAcademicpeer-review

Identification of eight candidate target genes of the recurrent 3p12-p14 loss in cervical cancer by integrative genomic profiling

Lando, M., Wilting, S. M., Snipstad, K., Clancy, T., Bierkens, M., Aarnes, E. K., Holden, M., Stokke, T., Sundfor, K., Holm, R., Kristensen, G. B., Steenbergen, R. D. M. & Lyng, H., 2013, In : Journal of Pathology. 230, 1, p. 59-69

Research output: Contribution to journalArticleAcademicpeer-review

Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis

Wilting, S. M., Verlaat, W., Jaspers, A., Makazaji, N. A., Agami, R., Meijer, C. J. L. M., Snijders, P. J. F. & Steenbergen, R. D. M., 2013, In : Epigenetics. 8, 2, p. 220-228

Research output: Contribution to journalArticleAcademicpeer-review

Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis

Steenbergen, R. D. M., Ongenaert, M., Snellenberg, S., Trooskens, G., van der Meide, W. F., Pandey, D., Bloushtain-Qimron, N., Polyak, K., Meijer, C. J. L. M., Snijders, P. J. F. & Van Criekinge, W., 2013, In : Journal of Pathology. 231, 1, p. 53-62

Research output: Contribution to journalArticleAcademicpeer-review

Methylering, een veelbelovende biomarker voor het opsporenvan tumoren in lichaamsvloeistoffen

Moelans, C. B., de Groot, J. S., Steenbergen, R. D. M., Bosch, L. J. W., Carvalho, B., van der Wall, E. & van Diest, P. J., 2013, In : Kanker Breed. 5, 1, p. 24-27

Research output: Contribution to journalArticleProfessional

Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas

Voorham, Q. J. M., Janssen, J., Tijssen, M., Snellenberg, S., Mongera, S., van Grieken, N. C. T., Grabsch, H., Kliment, M., Rembacken, B. J., Mulder, C. J. J., van Engeland, M., Meijer, G. A., Steenbergen, R. D. M. & Carvalho, B., 2013, In : BMC Cancer. 13, 1, p. 603-611 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

22 Downloads (Pure)

Understanding the heterogeneity of high-grade CIN lesions. Chromosomal and epigenetic analysis

Bierkens, M., 2013

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File
2012

CGH arrays compared for DNA isolated from formalin-fixed, paraffin-embedded material

Krijgsman, O., Israeli, D., Haan, J. C., van Essen, H. F. B., Smeets, S. J., Eijk, P. P., Steenbergen, R. D. M., Kok, K., Tejpar, S., Meijer, G. A. & Ylstra, B., 2012, In : Genes, Chromosomes and Cancer. 51, 4, p. 344-352

Research output: Contribution to journalArticleAcademicpeer-review

Comprehensive analysis of human papillomavirus prevalence and the potential role of low-risk types in verrucous carcinoma

Del Pino, M., Bleeker, M. C. G., Quint, W. G., Snijders, P. J. F., Meijer, C. J. L. M. & Steenbergen, R. D. M., 2012, In : Modern Pathology. 25, 10, p. 1354-1363

Research output: Contribution to journalArticleAcademicpeer-review

Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape

Snellenberg, S., de Strooper, L. M. A., Hesselink, A. T., Meijer, C. J. L. M., Snijders, P. J. F., Heideman, D. A. M. & Steenbergen, R. D. M., 2012, In : BMC Cancer. 12, 551.

Research output: Contribution to journalArticleAcademicpeer-review

HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia

Bierkens, M., Wilting, S. M., van Wieringen, W. N., van de Wiel, M., Ylstra, B., Meijer, C. J. L. M., Snijders, P. J. F. & Steenbergen, R. D. M., 2012, In : BMC Cancer. 12, 36.

Research output: Contribution to journalArticleAcademicpeer-review

Methylation status of the E2 binding sites of HPV16 in cervical lesions determined with the Luminex® xMAP™ system

Snellenberg, S., Schütze, D. M., Claassen-Kramer, D., Meijer, C. J. L. M., Snijders, P. J. F. & Steenbergen, R. D. M., 2012, In : Virology. 422, 2, p. 357-365

Research output: Contribution to journalArticleAcademicpeer-review

Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7

Henken, F. E., Oosterhuis, K., Ohlschlager, P., Bosch, L., Hooijberg, E., Haanen, J. B. A. G. & Steenbergen, R. D. M., 2012, In : Vaccine. 30, 28, p. 4259-4266

Research output: Contribution to journalArticleAcademicpeer-review

The functional role of Notch signaling in HPV-mediated transformation is dose-dependent and linked to AP-1 alterations

Henken, F. E., De-Castro Arce, J., Rosl, F., Bosch, L., Meijer, C. J. L. M., Snijders, P. J. F. & Steenbergen, R. D. M., 2012, In : Cellular Oncology. 35, 2, p. 77-84

Research output: Contribution to journalArticleAcademicpeer-review

2011
17 Downloads (Pure)

Altered DNA methylation during HPV-induced cervical carcinogenesis: basic aspects and diagnostic implications

Overmeer, R. M., 2011

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women

Overmeer, R. M., Louwers, J. A., Meijer, C. J. L. M., van Kemenade, F. J., Hesselink, A. T., Daalmeijer, N. F., Wilting, S. M., Heideman, D. A. M., Verheijen, R. H., Zaal, A., van Baal, W. M., Berkhof, J., Snijders, P. J. F. & Steenbergen, R. D. M., 2011, In : International Journal of Cancer. 129, 9, p. 2218-2225

Research output: Contribution to journalArticleAcademicpeer-review

Combined Promoter Methylation Analysis of CADM1 and MAL: An Objective Triage Tool for High-Risk Human Papillomavirus DNA-Positive Women.

Hesselink, A. T., Heideman, D. A. M., Steenbergen, R. D. M., Coupé, V. M. H., Overmeer, R. M., Rijkaart, D. C., Berkhof, J., Meijer, C. J. L. M. & Snijders, P. J. F., 2011, In : Clinical Cancer Research. 17, 8, p. 2459-2465

Research output: Contribution to journalArticleAcademicpeer-review

Comprehensive CADM1 promoter methylation analysis in NSCLC and normal lung specimens

van den Berg, R. M., Snijders, P. J. F., Grünberg, K., Kooi, C., Spreeuwenberg, M. D., Meijer, C. J. L. M., Postmus, P. E., Smit, E. F. & Steenbergen, R. D. M., 2011, In : Lung Cancer. 72, 3, p. 316-321

Research output: Contribution to journalArticleAcademicpeer-review

29 Downloads (Pure)

Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population.

Hutajulu, S. H., Indrasari, S. R., Indrawati, L. P. L., Hariadi, A., Duin, S., Haryana, S. M., Steenbergen, R. D. M., Greijer, A. E. & Middeldorp, J. M., 2011, In : Molecular Cancer. 10, 9 p., 48.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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