1990 …2019
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Research Output 1990 2019

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2019

A two-gene methylation signature for the diagnosis of bladder cancer in urine

Bosschieter, J., Nieuwenhuijzen, J. A., Hentschel, A., van Splunter, A. P., Segerink, L. I., Vis, A. N., Wilting, S. M., Lissenberg-Witte, B. I., A van Moorselaar, R. J. & Steenbergen, R. D., 1 Feb 2019, In : Epigenomics.

Research output: Contribution to journalArticleAcademicpeer-review

Cervical cancer detection by DNA methylation analysis in urine

Snoek, B. C., Splunter, A. P. V., Bleeker, M. C. G., Ruiten, M. C. V., Heideman, D. A. M., Rurup, W. F., Verlaat, W., Schotman, H., Gent, M. V., Trommel, N. E. V. & Steenbergen, R. D. M., 28 Feb 2019, In : Scientific Reports. 9, 1, p. 3088

Research output: Contribution to journalArticleAcademicpeer-review

Complementarity between miRNA expression analysis and DNA methylation analysis in hrHPV-positive cervical scrapes for the detection of cervical disease

Babion, I., De Strooper, L. M. A., Luttmer, R., Bleeker, M. C. G., Meijer, C. J. L. M., Heideman, D. A. M., Wilting, S. M. & Steenbergen, R. D. M., 8 Apr 2019, In : Epigenetics. p. 1-10 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

FAM19A4/miR124-2 methylation in invasive cervical cancer: A retrospective cross-sectional worldwide study

Vink, F. J., Meijer, C. J. L. M., Clifford, G. M., Poljak, M., Oštrbenk, A., Petry, K. U., Rothe, B., Bonde, J., Pedersen, H., de Sanjosé, S., Torres, M., Del Pino, M., Quint, W. G. V., Cuschieri, K., Alcañiz Boada, E., van Trommel, N. E., Lissenberg-Witte, B. I., Floore, A. N., Hesselink, A. T., Steenbergen, R. D. M. & 2 othersBleeker, M. C. G. & Heideman, D. A. M., 7 Aug 2019, In : International Journal of Cancer.

Research output: Contribution to journalArticleAcademicpeer-review

Genome-wide microRNA analysis of HPV-positive self-samples yields novel triage markers for early detection of cervical cancer

Snoek, B. C., Verlaat, W., Babion, I., Novianti, P. W., van de Wiel, M. A., Wilting, S. M., van Trommel, N. E., Bleeker, M. C. G., Massuger, L. F. A. G., Melchers, W. J. G., Sie, D., Heideman, D. A. M., Snijders, P. J. F., Meijer, C. J. L. M. & Steenbergen, R. D. M., 15 Jan 2019, In : International Journal of Cancer. 144, 2, p. 372-379 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Host Cell Deoxyribonucleic Acid Methylation Markers for the Detection of High-grade Anal Intraepithelial Neoplasia and Anal Cancer

van der Zee, R. P., Richel, O., van Noesel, C. J. M., Novianti, P. W., Ciocanea-Teodorescu, I., van Splunter, A. P., Duin, S., van den Berk, G. E. L., Meijer, C. J. L. M., Quint, W. G. V., de Vries, H. J. C., Prins, J. M. & Steenbergen, R. D. M., 2019, In : Clinical Infectious Diseases. 68, 7, p. 1110-1117

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

HPV16 variant analysis in primary and recurrent CIN2/3 lesions demonstrates presence of the same consensus variant

van der Weele, P., King, A. J., Meijer, C. J. L. M. & Steenbergen, R. D. M., 2019, In : PAPILLOMAVIRUS RESEARCH. 7, p. 168-172 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Long-term CIN3+ risk of HPV positive women after triage with FAM19A4/miR124-2 methylation analysis

Dick, S., Kremer, W. W., De Strooper, L. M. A., Lissenberg-Witte, B. I., Steenbergen, R. D. M., Meijer, C. J. L. M., Berkhof, J. & Heideman, D. A. M., 7 Jun 2019, In : Gynecologic Oncology.

Research output: Contribution to journalArticleAcademicpeer-review

The use of molecular markers for cervical screening of women living with HIV in South Africa

Kremer, W. W., van Zummeren, M., Breytenbach, E., Richter, K. L., Steenbergen, R. D. M., Meijer, C. J. L. M. & Dreyer, G., 2019, In : AIDS. 33, 13, p. 2035-2042

Research output: Contribution to journalArticleAcademicpeer-review

2018

A protocol for urine collection and storage prior to DNA methylation analysis

Bosschieter, J., Bach, S., Bijnsdorp, I. V., Segerink, L. I., Rurup, W. F., van Splunter, A. P., Bahce, I., Novianti, P. W., Kazemier, G., van Moorselaar, R. J. A., Steenbergen, R. D. M. & Nieuwenhuijzen, J. A., 2018, In : PLoS ONE. 13, 8, p. e0200906

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Detection of hypermethylated genes as markers for cervical screening in women living with HIV

Kremer, W. W., Van Zummeren, M., Novianti, P. W., Richter, K. L., Verlaat, W., Snijders, P. J., Heideman, D. A., Steenbergen, R. D., Dreyer, G. & Meijer, C. J., Aug 2018, In : Journal of the international aids society. 21, 8, p. e25165

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Het effect van antiretrovirale therapie op voorstadia van cervixcarcinoom bij hiv-positieve vrouwen

de Vries, H. & Steenbergen, RDM., 1 Dec 2018, In : Tijdschrift voor infectieziekten. jaargang 13, 6, p. 186-191 6 p.

Research output: Contribution to journalArticleProfessional

Host-cell DNA methylation patterns during high-risk HPV-induced carcinogenesis reveal a heterogeneous nature of cervical pre-cancer

Verlaat, W., van Leeuwen, R. W., Novianti, P. W., Schuuring, E., Meijer, C. J. L. M., van der Zee, A. G. J., Snijders, P. J. F., Heideman, D. A. M., Steenbergen, R. D. M. & Wisman, G. B. A., 3 Jul 2018, In : Epigenetics. 13, 7, p. 769-778 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

HPV E4 expression and DNA hypermethylation of CADM1, MAL, and miR124-2 genes in cervical cancer and precursor lesions

Zummeren, M. V., Kremer, W. W., Leeman, A., Bleeker, M. C. G., Jenkins, D., Sandt, M. V. D., Doorbar, J., Heideman, D. A. M., Steenbergen, R. D. M., Snijders, P. J. F., Kenter, G. G., Quint, W. G. V., Berkhof, J. & Meijer, C. J. L. M., 1 Dec 2018, In : Modern Pathology. 31, 12, p. 1842-1850 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Identification and validation of a 3-gene methylation classifier for HPV-based cervical screening on self-samples

Verlaat, W., Snoek, B. C., Heideman, D. A. M., Wilting, S. M., Snijders, P. J. F., Novianti, P. W., van Splunter, A. P., Peeters, C. F. W., van Trommel, N. E., Massuger, L. F. A. G., Bekkers, R. L. M., Melchers, W. JG., van Kemenade, F. J., Berkhof, J., van de Wiel, M. A., Meijer, C. J. L. M. & Steenbergen, R. D. M., 9 Apr 2018, In : Clinical Cancer Research. p. clincanres.3615.2017

Research output: Contribution to journalArticleAcademicpeer-review

Molecular heterogeneity in human papillomavirus-dependent and -independent vulvar carcinogenesis

Swarts, D. R. A., Voorham, Q. J. M., van Splunter, A. P., Wilting, S. M., Sie, D., Pronk, D., van Beurden, M., Heideman, D. A. M., Snijders, P. J. F., Meijer, C. J. L. M., Steenbergen, R. D. M. & Bleeker, M. C. G., 2018, In : Cancer Medicine. 7, 9, p. 4542-4553

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The diagnostic accuracy of methylation markers in urine for the detection of bladder cancer: a systematic review

Bosschieter, J., Lutz, C., Segerink, L. I., Vis, A. N., Zwarthoff, E. C., A van Moorselaar, R. J., van Rhijn, B. W., Heymans, M. W., Jansma, E. P., Steenbergen, R. D. & Nieuwenhuijzen, J. A., May 2018, In : Epigenomics. 10, 5, p. 673-687 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

The effect of ART on cervical cancer precursor lesions

de Vries, H. J. C. & Steenbergen, R. D. M., Jan 2018, In : The Lancet HIV. 5, 1, p. e6-e8

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Three-tiered score for Ki-67 and p16 improves accuracy and reproducibility of grading CIN lesions

van Zummeren, M., Leeman, A., Kremer, W. W., Bleeker, M. C. G., Jenkins, D., van de Sandt, M., Heideman, D. A. M., Steenbergen, R., Snijders, P. J. F., Quint, W. G. V., Berkhof, J. & Meijer, C. J. L. M., 1 Nov 2018, In : Journal of Clinical Pathology. 71, 11, p. 981-988 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Triage of high-risk HPV-positive women in population-based screening by miRNA expression analysis in cervical scrapes; a feasibility study

Babion, I., Snoek, B. C., Novianti, P. W., Jaspers, A., van Trommel, N., Heideman, D. A. M., Meijer, C. J. L. M., Snijders, P. J. F., Steenbergen, R. D. M. & Wilting, S. M., 2018, In : Clinical epigenetics. 10, p. 76

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Development of a replication-deficient adenoviral vector-based vaccine candidate for the interception of HPV16- and HPV18-induced infections and disease

Khan, S., Oosterhuis, K., Wunderlich, K., Bunnik, E. M., Bhaggoe, M., Boedhoe, S., Karia, S., Steenbergen, R. D. M., Bosch, L., Serroyen, J., Janssen, S., Schuitemaker, H., Vellinga, J., Scheper, G., Zahn, R. & Custers, J., 15 Jul 2017, In : International Journal of Cancer. 141, 2, p. 393-404 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

31 Downloads (Pure)

Genome-wide DNA methylation profiling reveals methylation markers associated with 3q gain for detection of cervical precancer and cancer

Verlaat, W., Snijders, P. J. F., Novianti, P. W., Wilting, S. M., De Strooper, L. M. A., Trooskens, G., Vandersmissen, J., Van Criekinge, W., Wisman, G. B. A., Meijer, C. J. L. M., Heideman, D. A. M. & Steenbergen, R. D. M., 15 Jul 2017, In : Clinical Cancer Research. 23, 14, p. 3813-3822 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Good performance of p16/ki-67 dual-stained cytology for surveillance of women treated for high-grade CIN

Polman, N. J., Uijterwaal, M. H., Witte, B. I., Berkhof, J., van Kemenade, F. J., Spruijt, JWM., van Baal, W. M., Graziosi, P. G. C. M., van Dijken, D. K. E., Verheijen, R. H. M., Helmerhorst, T. J. M., Steenbergen, R. D. M., Heideman, D. A. M., Ridder, R., Snijders, P. J. F. & Meijer, C. J. L. M., 15 Jan 2017, In : International Journal of Cancer. 140, 2, p. 423-430 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

High Levels of EBV-Encoded RNA 1 (EBER1) Trigger Interferon and Inflammation-Related Genes in Keratinocytes Expressing HPV16 E6/E7

Aromseree, S., Middeldorp, J. M., Pientong, C., van Eijndhoven, M., Ramayanti, O., Lougheed, S. M., Pegtel, D. M., Steenbergen, R. D. M. & Ekalaksananan, T., 2017, In : PLoS ONE. 12, 1, p. e0169290

Research output: Contribution to journalArticleAcademicpeer-review

Selection of women at risk for cervical cancer in an HIV-infected South African population

Van Zummeren, M., Kremer, W. W., Van Aardt, M. C., Breytenbach, E., Richter, K. L., Rozendaal, L., Witte, B. I., De Strooper, L. M. A., Hesselink, A. T., Heideman, D. A. M., Snijders, P. J. F., Steenbergen, R. D. M., Dreyer, G. & Meijer, C. J. L. M., 10 Sep 2017, In : AIDS. 31, 14, p. 1945-1953 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence

Wilting, S. M., Miok, V., Jaspers, A., Boon, D., Sorgard, H., Lando, M., Snoek, B. C., van Wieringen, W. N., Meijer, C. J. L. M., Lyng, H., Snijders, P. J. F. & Steenbergen, R. D. M., 12 Jul 2016, In : Oncotarget. 7, 28, p. 43805-43819

Research output: Contribution to journalArticleAcademicpeer-review

Association Between Type-specific HPV Infections and hTERT DNA Methylation in Patients with Invasive Cervical Cancer

Molano, M., Moreno-Acosta, P., Morales, N., Burgos, M., Buitrago, L., Gamboa, O., Alvarez, R., Garland, S. M., Tabrizi, S. N., Steenbergen, R. D. M. & Carlos Mejia, J., 2016, In : CANCER GENOMICS & PROTEOMICS. 13, 6, p. 483-491

Research output: Contribution to journalArticleAcademicpeer-review

11 Downloads (Pure)

Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study).

Luttmer, R., de Strooper, L. M. A., Berkhof, J., Snijders, P. J. F., Dijkstra, M. G., Uijterwaal, M. H., Steenbergen, R. D. M., van Kemenade, F. J., Rozendaal, L., Helmerhorst, T. J. M., Verheijen, R. H. M., ter Harmsel, W. A., van Baal, W. M., Graziosi, G. C. M., Quint, W. G. V., Heideman, D. A. M. & Meijer, C. J. L. M., 2016, In : International Journal of Cancer. 138, 4, p. 992-1002

Research output: Contribution to journalArticleAcademicpeer-review

File

Disc large 1 expression is altered by human papillomavirus E6/E7 proteins in organotypic cultures of human keratinocytes

Bugnon Valdano, M., Cavatorta, A. L., Morale, M. G., Marziali, F., de Souza Lino, V., Steenbergen, R. D. M., Boccardo, E. & Gardiol, D., Feb 2016, In : Journal of General Virology. 97, p. 453-462

Research output: Contribution to journalArticleAcademicpeer-review

DNA hypermethylation analysis in sputum of asymptomatic subjects at risk for lung cancer participating in the NELSON trial: argument for maximum screening interval of 2 years

Hubers, A. J., Heideman, D. A. M., Duin, S., Witte, B. I., de Koning, H. J., Groen, H. J. M., Prinsen, C. F. M., Bolijn, A. S., Wouters, M., van der Meer, S. E., Steenbergen, R. D. M., Snijders, P. J. F., Uyterlinde, A., Berkhof, H., Smit, E. F. & Thunnissen, E., 5 Aug 2016, In : Journal of Clinical Pathology.

Research output: Contribution to journalArticleAcademicpeer-review

FAM19A4 methylation analysis in self-samples compared with cervical scrapes for detecting cervical (pre)cancer in HPV-positive women

Luttmer, R., De Strooper, L. M. A., Dijkstra, M. G., Berkhof, J., Snijders, P. J. F., Steenbergen, R. D. M., van Kemenade, F. J., Rozendaal, L., Helmerhorst, T. J. M., Verheijen, R. H. M., ter Harmsel, W. A., van Baal, W. M., Graziosi, P. G. C. M., Quint, W. G. V., Spruijt, J. W. M., van Dijken, D. K. E., Heideman, D. A. M. & Meijer, C. J. L. M., 23 Aug 2016, In : British Journal of Cancer. 115, 5, p. 579-587

Research output: Contribution to journalArticleAcademicpeer-review

Genome-wide methylome analysis using MethylCap-seq uncovers 4 hypermethylated markers with high sensitivity for both adeno- and squamous-cell cervical carcinoma

Wang, R., van Leeuwen, R. W., Boers, A., Klip, H. G., Meyer, T. D., Steenbergen, R. D. M., van Criekinge, W., van der Zee, A. G. J., Schuuring, E. & Wisman, G. B. A., 2016, In : Oncotarget.

Research output: Contribution to journalArticleAcademicpeer-review

Immortalization capacity of HPV types is inversely related to chromosomal instability

Schutze, D. M., Krijgsman, O., Snijders, P. J. F., Ylstra, B., Weischenfeldt, J., Mardin, B. R., Stutz, A. M., Korbel, J. O., de Winter, J. P., Meijer, C. J. L. M., Quint, W. G. V., Bosch, L., Wilting, S. M. & Steenbergen, R. D. M., 21 Jun 2016, In : Oncotarget. 7, 25, p. 37608-37621

Research output: Contribution to journalArticleAcademicpeer-review

Management of high-risk HPV-positive women for detection of cervical (pre)cancer

Luttmer, R., De Strooper, L. M. A., Steenbergen, R. D. M., Berkhof, J., Snijders, P. J. F., Heideman, D. A. M. & Meijer, C. J. L. M., Sep 2016, In : Expert review of molecular diagnostics. 16, 9, p. 961-974

Research output: Contribution to journalArticleAcademicpeer-review

Molecular events leading to HPV-induced high grade neoplasia

Wilting, S. M. & Steenbergen, R. D. M., Dec 2016, In : PAPILLOMAVIRUS RESEARCH. 2, p. 85-88

Research output: Contribution to journalArticleAcademicpeer-review

37 Downloads (Pure)

Performance of CADM1/MAL-methylation analysis for monitoring of women treated for high-grade CIN

Uijterwaal, M. H., van Zummeren, M., Kocken, M., Luttmer, R., Berkhof, J., Witte, B. I., van Baal, W. M., Graziosi, G. C. M., Verheijen, R. H. M., Helmerhorst, T. J. M., van Dijken, D. K. E., Spruijt, J. W. M., van Kemenade, F. J., Fransen-Daalmeijer, N., Bekker-Lettink, M., Heideman, D. A. M., Snijders, P. J. F., Steenbergen, R. D. M. & Meijer, C. J. L. M., Oct 2016, In : Gynecologic Oncology. 143, 1, p. 135-142

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women

De Strooper, L. M. A., Verhoef, V. M. J., Berkhof, J., Hesselink, A. T., de Bruin, H. M. E., van Kemenade, F. J., Bosgraaf, R. P., Bekkers, R. L. M., Massuger, L. F. A. G., Melchers, W. J. G., Steenbergen, R. D. M., Snijders, P. J. F., Meijer, C. J. L. M. & Heideman, D. A. M., May 2016, In : Gynecologic Oncology. 141, 2, p. 341-347

Research output: Contribution to journalArticleAcademicpeer-review

2015

DNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approach

Hubers, A. J., Heideman, D. A. M., Burgers, S. A., Herder, G. J. M., Sterk, P. J., Rhodius, R. J., Smit, H. J., Krouwels, F., Welling, A., Witte, B. I., Duin, S., Koning, R., Comans, E. F. I., Steenbergen, R. D. M., Postmus, P. E., Meijer, G. A., Snijders, P. J. F., Smit, E. F. & Thunnissen, E., 2015, In : British Journal of Cancer. 112, 6, p. 1105-1113

Research output: Contribution to journalArticleAcademicpeer-review

Follow-up of high-risk HPV positive women by combined cytology and bi-marker CADM1/MAL methylation analysis on cervical scrapes

Verhoef, V. M. J., van Kemenade, F. J., Rozendaal, L., Heideman, D. A. M., Bosgraaf, R. P., Hesselink, A. T., Melchers, W. J. G., Massuger, L. F. A. G., Bekkers, R. L. M., Steenbergen, R. D. M., Berkhof, J., Snijders, P. J. F. & Meijer, C. J. L. M., 2015, In : Gynecologic Oncology. 137, 1, p. 55-59

Research output: Contribution to journalArticleAcademicpeer-review

HPV-negative carcinoma of the uterine cervix: a distinct type of cervical cancer with poor prognosis

Rodriguez-Carunchio, L., Soveral, I., Steenbergen, R. D. M., Torne, A., Martinez, S., Fuste, P., Pahisa, J., Marimon, L., Ordi, J. & Del Pino, M., 2015, In : BJOG: An International Journal of Obstetrics & Gynaecology. 122, 1, p. 119-127

Research output: Contribution to journalArticleAcademicpeer-review

36 Downloads (Pure)

Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer

Lando, M., Fjeldbo, C. S., Wilting, S. M., Snoek, B. C., Aarnes, E. K., Forsberg, M. F., Kristensen, G. B., Steenbergen, R. D. M. & Lyng, H., 2015, In : Epigenetics. 10, 10, p. 970-980

Research output: Contribution to journalArticleAcademicpeer-review

File
30 Downloads (Pure)

Longitudinal assessment of DNA methylation changes during HPVE6E7-induced immortalization of primary keratinocytes

Schütze, D. M., Kooter, J. M., Wilting, S. M., Meijer, C. J. L. M., Quint, W. G. V., Snijders, P. J. F. & Steenbergen, R. D. M., 2015, In : Epigenetics. 10, 1, p. 73-81

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Mining for viral fragments in methylation enriched sequencing data

Mensaert, K., van Criekinge, W. M. R., Thas, O., Schuuring, E., Steenbergen, R. D. M., Wisman, G. B. & Meyer, T., 2015, In : Frontiers in Genetics. 6, 16.

Research output: Contribution to journalArticleAcademicpeer-review

Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression

de Groen, F. L. M., Timmer, L. M., Menezes, R. X., Diosdado, B., Hooijberg, E., Meijer, G. A., Steenbergen, R. D. M. & Carvalho, B., 2015, In : PLoS ONE. 10, 7, e0132495.

Research output: Contribution to journalArticleAcademicpeer-review